Analysis of Kaba using Computed Tomography and 3D Laser Imaging Techniques

The Tenth Symposium on Polar Science/Poster presentations: [OA] Antarctic meteorites, Wed. 4 Dec. / Entrance Hall (1st floor), National Institute of Polar Researc

Women’s Bodies and Global Poverty Eradication

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Ferromagnetic Luttinger Liquids

We study weak itinerant ferromagnetism in one-dimensional Fermi systems using perturbation theory and bosonization. We find that longitudinal spin fluctuations propagate ballistically with velocity v_m << v_F, where v_F is the Fermi velocity. This leads to a large anomalous dimension in the spin-channel and strong algebraic singularities in the single-particle spectral function and in the transverse structure factor for momentum transfers q ~ 2 Delta/v_F, where 2 Delta is the exchange splitting.Comment: 4 pages, 3 figure

Proline-based carbamates as cholinesterase inhibitors

Series of twenty-five benzyl (2S)-2-(arylcarbamoyl)pyrrolidine-1-carboxylates was prepared and completely characterized. All the compounds were tested for their in vitro ability to inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), and the selectivity of compounds to individual cholinesterases was determined. Screening of the cytotoxicity of all the compounds was performed using a human monocytic leukaemia THP-1 cell line, and the compounds demonstrated insignificant toxicity. All the compounds showed rather moderate inhibitory effect against AChE; benzyl (2S)-2-[(2-chlorophenyl)carbamoyl]pyrrolidine-1-carboxylate (IC50 = 46.35 M) was the most potent agent. On the other hand, benzyl (2S)-2-[(4-bromophenyl)-] and benzyl (2S)-2-[(2-bromophenyl)carbamoyl]pyrrolidine-1-carboxylates expressed anti-BChE activity (IC50 = 28.21 and 27.38 M, respectively) comparable with that of rivastigmine. The ortho-brominated compound as well as benzyl (2S)-2-[(2-hydroxyphenyl)carbamoyl]pyrrolidine-1-carboxylate demonstrated greater selectivity to BChE. The in silico characterization of the structure–inhibitory potency for the set of proline-based carbamates considering electronic, steric and lipophilic properties was provided using comparative molecular surface analysis (CoMSA) and principal component analysis (PCA). Moreover, the systematic space inspection with splitting data into the training/test subset was performed to monitor the statistical estimators performance in the effort to map the probability-guided pharmacophore pattern. The comprehensive screening of the AChE/BChE profile revealed potentially relevant structural and physicochemical features that might be essential for mapping of the carbamates inhibition efficiency indicating qualitative variations exerted on the reaction site by the substituent in the 30-/40-position of the phenyl ring. In addition, the investigation was completed by a molecular docking study of recombinant human AChE

Fe/MgO Powder Composite Sintered by Microwave Heating

This work was supported by projects: APVV 0115-15 and VEGA 2/0108/18.Bureš, R.; Fáberová, M.; Birčáková, Z.; Kovaľ, V.; Kollar, P.; Fuzer, J.; Jakubcin, M.... (2019). Fe/MgO Powder Composite Sintered by Microwave Heating. En AMPERE 2019. 17th International Conference on Microwave and High Frequency Heating. Editorial Universitat Politècnica de València. 448-456. https://doi.org/10.4995/AMPERE2019.2019.9946OCS44845

Zuchtmaterialerstellung durch Erschließung und Selektion bisher nicht erfasster Anbau - und Verwertungsmerkmale in bisher nicht genutzten genetischen Ressourcen der Schmalblättrigen Lupine (Lupinus angustifolius L.)

An züchterisch bisher nicht genutzten, alkaloidreichen Genbankakzessionen der Schmalblättrigen Lupine des Vavilov Institutes der Pflanzenindustrie, St. Petersburg, wurden neben agronomischen Merkmalen die Merkmalskomplexe Rhizodeposition und Methioningehalt evaluiert. Für diese Merkmale wird im aktuellen, bitterstoffarmen Zuchtmaterial keine ausreichende, züchterisch nutzbare Variabilität mehr gefunden. Für den Merkmalskomplex Rhizodeposite konnten mittels Pyrolyse-Feldionisation Massenspektrometrie (Py-FIMS) lyophilisierter Rhizodeposite sowohl Genotypen mit erhöhter mikrobieller Abbaubarkeit zur Förderung der Rhizosphärenaktivität als auch mit erhöhten Konzentrationen antimikrobieller Komponenten identifiziert werden. Für den Merkmalskomplex Methioningehalt konnten die Schlüsselgene des Methioninstoffwechsels identifiziert und sequenziert werden. Für zwei der vier Schlüsselgene liegen allerdings so viele Kopien im Genom vor, dass sie züchterisch nur sehr schwer nutzbar sind. Es konnten mittels Transkript-Profiling keine hoch aktiven Allele der Schlüsselgene der Methioninbiosynthese identifiziert werden. Demgegenüber konnten in jungen Samen jedoch hochaktive Allele von Genen gefunden werden, die für methioninreiche Speicherproteine codieren. Für die folgenden agronomisch wichtigen Merkmale konnte im untersuchten Schmalblättrigen Lupinenmaterial eine erhebliche Variabilität gefunden werden, die weit über die in Blauen Süßlupinen noch gefundene Streuung hinaus geht: Kornertrag, Kornform, Grünmasseleistung, Rohproteingehalt, Boden-pH-Toleranz, sichere und synchrone Abreife der Hülsen, synchrone Laub- und Strohreife, Standfestigkeit, Platzfestigkeit, Resistenz gegenüber Anthraknose und Verticillium, Kornform. Die gefundene Variabilität gilt es jetzt züchterisch zu nutzen und die positiven Merkmalseigenschaften in neuen Sorten zu kombinieren

Antimycobacterial and Photosynthetic Electron Transport Inhibiting Activity of Ring-Substituted 4-Arylamino-7-Chloroquinolinium Chlorides

In this study, a series of twenty-five ring-substituted 4-arylamino-7-chloroquinolinium chlorides were prepared and characterized. The compounds were tested for their activity related to inhibition of photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts and also primary in vitro screening of the synthesized compounds was performed against mycobacterial species. 4-[(2-Bromophenyl)amino]-7-chloroquinolinium chloride showed high biological activity against M. marinum, M. kansasii, M. smegmatis and 7-chloro-4-[(2-methylphenyl)amino]quinolinium chloride demonstrated noteworthy biological activity against M. smegmatis and M. avium subsp. paratuberculosis. The most effective compounds demonstrated quite low toxicity (LD50 \u3e 20 μmol/L) against the human monocytic leukemia THP-1 cell line within preliminary in vitro cytotoxicity screening. The tested compounds were found to inhibit PET in photosystem II. The PET-inhibiting activity expressed by IC50 value of the most active compound 7-chloro-4-[(3-trifluoromethylphenyl)amino]quinolinium chloride was 27 μmol/L and PET-inhibiting activity of ortho-substituted compounds was significantly lower than this of meta- and para-substituted ones. The structure-activity relationships are discussed for all compound

Doing quantitative research in the learning sciences and CSCL:current developments and applications

While quantitative methods are continuously developed in various fields of origin,such as psychology, the specific applications in the core field of learning sciences and CSCL are less well advanced. In this workshop, we explore and discuss current methodological topics in three relevant fields of empirical research: (1) obtaining data, (2) analyzing data, and (3) sharing data, replicating and integrating findings. Outcomes of the discussions are planned to be published in short guidelines facilitating the application of latest developments in quantitative methods in the learning sciences and CSCL research.<br/

Doing quantitative research in the learning sciences and CSCL:current developments and applications

While quantitative methods are continuously developed in various fields of origin,such as psychology, the specific applications in the core field of learning sciences and CSCL are less well advanced. In this workshop, we explore and discuss current methodological topics in three relevant fields of empirical research: (1) obtaining data, (2) analyzing data, and (3) sharing data, replicating and integrating findings. Outcomes of the discussions are planned to be published in short guidelines facilitating the application of latest developments in quantitative methods in the learning sciences and CSCL research.<br/