Factorization of 3-point static structure functions in 3D Yukawa liquids

In many-body systems the convolution approximation states that the 3-point static structure function, $S^{(3)}(\textbf{k}_{1},\textbf{k}_{2})$, can approximately be "factorized" in terms of the 2-point counterpart, $S^{(2)}(\textbf{k}_{1})$. We investigate the validity of this approximation in 3-dimensional strongly-coupled Yukawa liquids: the factorization is tested for specific arrangements of the wave vectors $\textbf{k}_{1}$ and $\textbf{k}_{2}$, with molecular dynamics simulations. With the increase of the coupling parameter we find a breakdown of factorization, of which a notable example is the appearance of negative values of $S^{(3)}(\textbf{k}_{1},\textbf{k}_{2})$, whereas the approximate factorized form is restricted to positive values. These negative values -- based on the quadratic Fluctuation-Dissipation Theorem -- imply that the quadratic part of the density response of the system changes sign with wave number. Our simulations that incorporate an external potential energy perturbation clearly confirm this behavior

Interfacing to Biological Systems Using Microfluidics

Biological systems operate on scales ranging from nanoscale chemical reactions to the global flow of nutrients and energy. Building knowledge of each level requires techniques and technologies that can address the biological system at the chosen level of interest. On the cellular and community levels, microfluidics are able to replicate the spatial scales of the natural system from the cellular, to community through the local microenvironment while providing engineering solutions to control flow through the system and interfaces with the system through microscopy and chemical sampling. Herein, biological interfaces were created using microfluidics to control cellular interactions and chemical reactions. At the subcellular scale, molecular exchange bioreactors enhanced the protein production of a cell-free protein synthesis system by using a microscale serpentine channel to reduce lateral diffusion distances. Size dependent transport of reactants into, and byproducts out of, the reaction channel through the nanoporous barrier extended the reaction time and enhanced protein yield. Nanoporous membranes were also developed for studying cellular interactions. Membranes confined cells within culture chambers while allowing transport of nutrients and signal molecules between the chambers and support channels. Quorum sensing within the microfluidic chambers was modeled using a quasi-steady-state PDE based approach to estimate relative concentrations. The platform facilitated the use of brightfield imaging and analysis to characterize morphological changes of a growing biofilm as the oral microbe Streptococcus gordonii formed aggregates only when co-cultured adjacent to Fusobacterium nucleatum. The investment of capital and time to start incorporating microfluidic into research can be prohibitive. To combat this, tools were created to provide researchers the ability to create microfluidics using 3D printing to simplify the process and remove the need for cumbersome and expensive cleanroom facilities. The technique was used in two common microfluidic applications of chemical gradient and droplet formation in addition to building 3D fluidics that cannot be replicated directly with microfabrication techniques. These microfluidics controlled the spatiotemporal environment on the scales of biological systems to enhance the effectiveness of protein synthesis, give insight to morphological effects of cell signaling, and introduced technology to enable others to do the same

Boston Writing Project

The Boston Writing Project focuses on the core mission of improving the teaching of writing and improving the use of writing across the disciplines by offering high-quality professional development programs for educators, at all grade levels, K–16 and across the curriculum

Foundations of Clinical Neuropsychology

In the last decade, neuropsychology has grown from a small subspecialty to a major component in the practice of clinical and medical psychology. This growth has been caused by advances in psychological testing (such as the Halstead-Reitan neuropsychological battery, as discussed in Chapter 5) that have made evaluation techniques in the field available to a wider audience, by advances in neuroradiol­ ogy and related medical areas that have enabled us to better understand the struc­ ture and function of the brain in living individuals without significant potential harm to those individuals, and by increased interest by psychologists and other scientists in the role that the brain plays in determining behavior. Many disorders that were believed by many to be caused purely by learning or environment have been shown to relate, at least in some cases, to brain dysfunction or damage. With the growth of the field, there has been increased interest in the work of neuropsychologists by many who are not in the field.https://nsuworks.nova.edu/cps_facbooks/1046/thumbnail.jp

Evaluation of Increased Flexibility for 14 to 16 Year Olds Programme : Outcomes for the Second Cohort - Research Brief

The Increased Flexibility Programme (IFP) was the first national programme which formalised partnership working between post-16 and pre-16 education providers to deliver a broader curriculum for young people at key stage 4. Since its inception, the programme has expanded in the context of a continuing focus on improving the curriculum and qualification routes for 14 to 16 year olds and integrating these into a 14 to 19 framework. The Department for Education and Skills (DfES) commissioned the National Foundation for Educational Research (NFER) to undertake a national evaluation of the first and second cohorts of IFP students, in order to examine the extent to which the aims and objectives of the IFP were being met. This research brief focuses on the outcomes for young people who participated in the programme between 2003 and 2005 (cohort 2) during a time of change in 14 to 19 policy

Collecting Histories of Education and Employment Activities from Young Adults with Serious Mental Health Conditions

Young adulthood is a critical time for establishing the foundation of an adult working life. As adolescents mature and explore career interests, they also begin to focus in on particular career pathways. However, lower levels of employment and educational attainment, as well as the demands of parenting, prevent and delay Youth and Young adults (Y&YAs) with serious mental health conditions (SMHCs) from participating in settings where career development and exploration activities typically occur. Of Y&YA parents who do work, the majority will work part-time, at low-level service jobs, and at low salaries (Osgood, et al., 2005). Y&YA parents with SMHCs are particularly vulnerable as they are more likely than their normative peers to experience unemployment, poverty, and dependence on government assistance (Luciano, et al., 2013). Through a one-time, semi-structured interview, this study seeks to describe the education and employment activities of Y&YAs between the ages of 25-30 with SMHCs, explore barriers and facilitators to these activities, and understand how parenting affects these experiences. Preliminary findings will be presented as they relate to themes of career exploration/development, the barriers and facilitators to education and employment activities this population encounters, including the impact that parenthood can have on these activities in young adulthood. We will also describe the education and employment activities and trajectories that were obtained as part of these interviews

A New Familial Chondrodystrophy Simulating Parastremmatic Dwarfism

Recent developments in tissue culture and enzyme analysis have made it possible to classify more precisely some of the skeletal dysplasias and to understand their pathophysiology; thus almost all seven clinical types of mucopolysaccharidoses are due to separate single enzyme deficiencies – one type, the Sanfilippo syndrome, has three subtypes, each with a different enzyme deficiency. The majority of the skeletal dysplasias have no definable biochemical abnormality and are classified on the basis of clinical and radiological findings and the mode of inheritance. The purpose of this report is to present a family with an apparently new type of chondrodystrophy