Zur Reform des einstweiligen Rechtsschutzes im geistigen Eigentum Chinas

Der einstweilige Rechtsschutz des geistigen Eigentums, also insbesondere Anordnungen zur Unterlassung von Verletzungshandlungen, außerdem die Beweissicherung und die Sicherung von Vermögen, ist zwar im chinesischen Zivilprozessrecht wie auch in Spezialvorschriften umfassend geregelt, wird aber selten in Anspruch genommen. Der Beitrag beleuchtet neuere Entwicklungen in der Rechtsprechung, die auf einen erleichterten Zugang zu diesem Schutzinstrument hoffen lassen.On the reform of the Chinese system of provisional measures to protect intellectual propertyProvisional measures to protect intellectual property, in particular injunctions to cease infringement, but also evidence preservation orders and orders to secure or to freeze assets, are comprehensively regulated by civil procedure law and special provisions but rarely resorted to. This article illustrates new case law that gives reason to expect that access to this instrument of protection will be facilitated in the near future.

Epigallocatechin 3‑<i>O</i>‑gallate Induces 67 kDa Laminin Receptor-Mediated Cell Death Accompanied by Downregulation of ErbB Proteins and Altered Lipid Raft Clustering in Mammary and Epidermoid Carcinoma Cells

Since the administration of synthetic medicines is associated with drug resistance and undesired side effects, utilization of natural compounds could be an alternative and complementary modality to inhibit or prevent the development of tumors. Epigallocatechin 3-<i>O</i>-gallate (EGCG, <b>1</b>), the major flavan component of green tea, and genistein (<b>2</b>), a soy isoflavonoid, are known to have chemopreventive and chemotherapeutic effects against cancer. This study demonstrated that both flavonoids inhibit cell proliferation, an effect enhanced under serum-free conditions. Compound <b>1</b>, but not <b>2</b>, induced downregulation of ErbB1 and ErbB2 in mammary and epidermoid carcinoma cells, and its inhibitory effect on cell viability was mediated by the 67 kDa laminin receptor (67LR). While <b>1</b> was superior in inducing cell death, <b>2</b> was more efficient in arresting the tumor cells in the G₂/M phase. Furthermore, number and brightness analysis revealed that <b>1</b> decreased the homoclustering of a lipid raft marker, glycosylphosphatidylinositol-anchored GFP, and it also reduced the co-localization between lipid rafts and 67LR. The main conclusion made is that the primary target of <b>1</b> may be the lipid raft component of the plasma membrane followed by secondary changes in the expression of ErbB proteins. Compound <b>2</b>, on the other hand, must have other unidentified targets