A Desert Tortoise–Common Raven Viable Conflict Threshold

Since 1966, common raven (Corvus corax; raven) abundance has increased throughout much of this species’ Holarctic distribution, fueled by an ever-expanding supply of anthropogenic resource subsidies (e.g., water, food, shelter, and nesting substrate) to ecoregion specific raven population carrying capacities. Consequently, ravens are implicated in declines of both avian and reptilian species of conservation concern, including the California (USA) endangered and federally threatened Mojave desert tortoise (Gopherus agassizii; desert tortoise). While ravens are a natural predator of desert tortoises, the inter-generational stability of desert tortoise populations is expected to be compromised as annual juvenile survival is suppressed below 0.77 through a combination of raven depredation and other sources of mortality. To estimate the extent to which raven depredation suppresses desert tortoise recruitment within the Mojave Desert of California, we collected data from 274 variable-radius point counts, 78 desert tortoise decoy stations, and 8 control stations during the spring of 2020. Additionally, we complied a geodatabase of previously active raven nests, observed between 2013 and 2020. Raven density estimates from 4 monitoring areas ranged between 0.63 (eastern most) and 2.44 (western most) raven km-2 (95% CI: 0.35–1.14 and 1.33–4.48, respectively). We used a Bayesian shared frailty model to estimate the effects of raven density and distance to the nearest previously active raven nest on the annual “survival” of juvenile desert tortoise decoys (75-mm Midline Carapace Length), which we then converted into survival estimates for 0- to 10-year-old desert tortoises by adjusting exposure to reflect natural activity patterns. At the 1.72-km median distance from the nearest previously active raven nest, the estimated annual survival of desert tortoises decreased as raven density increased, ranging among conservation areas from 0.774 (eastern most) to 0.733 (western most). Accordingly, our model predicts that desert tortoise populations exposed to raven densities in excess of 0.89 raven km-2, at a distanc

Quantified Effects of the Laser Seeding Attack in Quantum Key Distribution

Quantum key distribution (QKD) enables private communications with information-theoretic security. To guarantee the practical security of QKD, it is essential that QKD systems are implemented in accordance to theoretical requirements and robust against side-channel attacks. Here we study a prominent attack on QKD transmitters known as the laser seeding attack (LSA). It consists in injecting photons into the laser of the transmitter in an attempt to modify the outgoing light in some way that is beneficial to the eavesdropper. In this work we measure the response of a QKD transmitter to the LSA as a function of the optical power injected, allowing us to quantify the level of optical attenuation required to mitigate the attack. Further, we employ a laser rate equation model to numerically simulate the effects of the LSA on a gain-switched laser. With this model we are able to reproduce previous experimental results, as well as generate new insight into the LSA by examining the effects of the LSA when the QKD transmitter is operated with different laser current driving parameters

Know Your Value: Negotiation Skill Development for Junior Investigators in the Academic Environment—A Report from the American Society of Preventive Oncology\u27s Junior Members Interest Group

The American Society of Preventive Oncology (ASPO) is a professional society for multidisciplinary investigators in cancer prevention and control. One of the aims of ASPO is to enable investigators at all levels to create new opportunities and maximize their success. One strategy adopted by ASPO was to develop the Junior Members Interest Group in 1999. The Interest Group membership includes predoctoral fellows, postdoctoral fellows, and junior faculty members who are provided career development and training opportunities (1). Responsibilities of the members of the Junior Members Interest Group include serving on the ASPO Executive Committee and the Program Planning Committee and organizing professional development sessions at ASPO\u27s annual meeting. As part of the 2014 ASPO annual meeting, the Junior Members Interest Group organized a session entitled “Negotiation Skill Development for Junior Investigators in the Academic Environment.” This interactive session was designed to provide early-career investigators an opportunity to practice their negotiation skills and to receive expert advice and strategies to effectively negotiate new faculty positions in an academic environment. The session focused primarily on negotiating an initial academic appointment from a graduate student or postdoctoral fellow to an assistant professor–level position. In addition to the main focus, the session also covered renegotiation for assistant and associate-level investigators as they navigate through their careers. The session began with an interactive exercise led by Dr. Stephanie A.N. Silvera (Associate Professor of Public Health, Montclair State University, Montclair, NJ) where participants engaged in a mock salary negotiation session with another member of the audience (Table 1). Following the negotiation exercise, Dr. Silvera led a debriefing session. Next, four panelists at different levels in their academic careers were invited to provide their personal perspectives on the topic of effective negotiation: Dr. Faith Fletcher (Assistant Professor of Community Health Sciences, the University of Illinois at Chicago, Chicago, IL) to provide the perspective of a first-year faculty member; Dr. Stephanie A.N. Silvera (Associate Professor of Public Health, Montclair State University, Montclair, NJ) to provide the perspective of a recently tenured faculty member; Dr. Karen Basen-Engquist (Professor of Behavioral Science and Director of the Center for Energy Balance, University of Texas MD Anderson Cancer Center, Houston, TX) to provide the perspective of a senior faculty member; and Dr. Peter G. Shields (Professor and Deputy Director of the Ohio State University Comprehensive Cancer Center, Columbus, OH) to provide the perspective of a senior faculty member with extensive experience on the employer side of an academic appointment negotiation. This report summarizes the main themes that emerged from the negotiation exercise debriefing, the speakers\u27 advice and recommendations, and responses to audience questions during the session

Differential cytopathogenesis of respiratory syncytial virus prototypic and clinical isolates in primary pediatric bronchial epithelial cells

<p>Abstract</p> <p>Background</p> <p>Human respiratory syncytial virus (RSV) causes severe respiratory disease in infants. Airway epithelial cells are the principle targets of RSV infection. However, the mechanisms by which it causes disease are poorly understood. Most RSV pathogenesis data are derived using laboratory-adapted prototypic strains. We hypothesized that such strains may be poorly representative of recent clinical isolates in terms of virus/host interactions in primary human bronchial epithelial cells (PBECs).</p> <p>Methods</p> <p>To address this hypothesis, we isolated three RSV strains from infants hospitalized with bronchiolitis and compared them with the prototypic RSV A2 in terms of cytopathology, virus growth kinetics and chemokine secretion in infected PBEC monolayers.</p> <p>Results</p> <p>RSV A2 rapidly obliterated the PBECs, whereas the clinical isolates caused much less cytopathology. Concomitantly, RSV A2 also grew faster and to higher titers in PBECs. Furthermore, dramatically increased secretion of IP-10 and RANTES was evident following A2 infection compared with the clinical isolates.</p> <p>Conclusions</p> <p>The prototypic RSV strain A2 is poorly representative of recent clinical isolates in terms of cytopathogenicity, viral growth kinetics and pro-inflammatory responses induced following infection of PBEC monolayers. Thus, the choice of RSV strain may have important implications for future RSV pathogenesis studies.</p

Single-Nucleotide Polymorphisms and Markers of Oxidative Stress in Healthy Women

Purpose There is accumulating evidence that oxidative stress is an important contributor to carcinogenesis. We hypothesized that genetic variation in genes involved in maintaining antioxidant/ oxidant balance would be associated with overall oxidative stress. Methods We examined associations between single nucleotide polymorphisms (SNPs) in MnSOD, GSTP1, GSTM1, GPX1, GPX3, and CAT genes and thiobarbituric acid-reactive substances (TBARS), a blood biomarker of oxidative damage, in healthy white women randomly selected from Western New York (n = 1402). We used general linear models to calculate age-adjusted geometric means of TBARS across the variants. We also examined the associations within strata of menopausal status. Results For MnSOD, being heterozygous was associated with lower geometric means of TBARS (less oxidative stress), 1.28 mg/dL, compared to homozygous T-allele or homozygous Callele, 1.35 mg/dL, and 1.31 mg/dL correspondingly (p for trend = 0.01). This difference remained among postmenopausal women, 1.40 mg/dL for TT, 1.32 mg/dL for TC, and 1.34mg/dL for CC (p for trend 0.015); it was attenuated among premenopausal women. SNPs in the other genes examined (GSTP1, GSTM1, GPX1, GPX3, and CAT) were not associated with TBARS. Conclusions Our findings suggest that genetic variation in MnSOD gene may be associated with oxidative status, particularly among postmenopausal women

Design and analysis of low boom concepts at Langley Research Center

The objective of the sonic boom research in the current High Speed Research Program is to ultimately make possible overland supersonic flight by a high speed civil transport. To accomplish this objective, it is felt that results in four areas must demonstrate that such a vehicle would be acceptable by the general public, by the airframers, and by the airlines. It should be demonstrated: (1) that some waveform shape has the possibility of being acceptable to the general public; (2) that the atmosphere would not totally destroy such a waveform during propagation; (3) that a viable airplane could be built which produces such a waveform; and (4) that any performance penalty suffered by a low boom aircraft would be counteracted by the economic benefit of overland supersonic flight. The work being done at LaRC is in support of the third element listed above--the area of configuration design. The initial part of the paper will give a review of the theory being used for configuration designs and discuss two theory validation models which were built and tested within the past two years. Discussion of the wind tunnel and theoretical results (linear theory and higher order methods) and their implications for future designs will be included

Non-resonant dot-cavity coupling and its applications in resonant quantum dot spectroscopy

We present experimental investigations on the non-resonant dot-cavity coupling of a single quantum dot inside a micro-pillar where the dot has been resonantly excited in the s-shell, thereby avoiding the generation of additional charges in the QD and its surrounding. As a direct proof of the pure single dot-cavity system, strong photon anti-bunching is consistently observed in the autocorrelation functions of the QD and the mode emission, as well as in the cross-correlation function between the dot and mode signals. Strong Stokes and anti-Stokes-like emission is observed for energetic QD-mode detunings of up to ~100 times the QD linewidth. Furthermore, we demonstrate that non-resonant dot-cavity coupling can be utilized to directly monitor and study relevant QD s-shell properties like fine-structure splittings, emission saturation and power broadening, as well as photon statistics with negligible background contributions. Our results open a new perspective on the understanding and implementation of dot-cavity systems for single-photon sources, single and multiple quantum dot lasers, semiconductor cavity quantum electrodynamics, and their implementation, e.g. in quantum information technology.Comment: 17 pages, 4 figure

Improving the performance of bright quantum dot single photon sources using amplitude modulation

Single epitaxially-grown semiconductor quantum dots have great potential as single photon sources for photonic quantum technologies, though in practice devices often exhibit non-ideal behavior. Here, we demonstrate that amplitude modulation can improve the performance of quantum-dot-based sources. Starting with a bright source consisting of a single quantum dot in a fiber-coupled microdisk cavity, we use synchronized amplitude modulation to temporally filter the emitted light. We observe that the single photon purity, temporal overlap between successive emission events, and indistinguishability can be greatly improved with this technique. As this method can be applied to any triggered single photon source, independent of geometry and after device fabrication, it is a flexible approach to improve the performance of solid-state systems, which often suffer from excess dephasing and multi-photon background emission

Efficacy of Manipulating Reproduction of Common Ravens to Conserve Sensitive Prey Species: Three Case Studies

Expansion of human enterprise across western North America has resulted in an increase in availability of anthropogenic resource subsidies for generalist species. This has led to increases in generalists’ population numbers across landscapes that were previously less suitable for their current demographic rates. Of particular concern are growing populations of common ravens (Corvus corax; ravens), because predation by ravens is linked to population declines of sensitive species. Ecosystem managers seek management options for mitigating the adverse effects of raven predation where unsustainable predator–prey conflicts exist. We present 3 case studies examining how manipulating reproductive success of ravens influences demographic rates of 2 sensitive prey species. Two case studies examine impacts of removing raven nests or oiling raven eggs on nest survival of greater sage-grouse (Centrocercus urophasianus; sage-grouse) within Wyoming and the Great Basin of California and Nevada, USA, respectively. The third case study uses Mojave desert tortoise (Gopherus agassizii; tortoise) decoys to examine effects of oiling raven eggs on depredation rates of juvenile tortoises in the Mojave Desert in California. Initial trial years from all 3 case studies were consistent in finding improved vital rates associated with the application of strategies for reducing reproductive success of ravens. Specifically, removal of raven nests resulted in increased nest survival of sage-grouse within treatment areas where predation by ravens was the primary cause of nest failure. In addition, nest survival of sage-grouse and survival of juvenile tortoise decoys was higher following a treatment of oiling the eggs of ravens in their nests at 2 sites within the Great Basin and 4 tortoise conservation areas in the Mojave Desert in California. Along with specialized technologies that can make techniques such as egg-oiling more feasible, these findings support these management practices as important tools for managing ravens, especially in areas where breeding ravens have negative impacts on sensitive prey species