Generalising the logistic map through the qq-product

We investigate a generalisation of the logistic map as $x_{n+1}=1-ax_{n}\otimes_{q_{map}} x_{n}$ ($-1 \le x_{n} \le 1$, $0<a\le2$) where $\otimes_q$ stands for a generalisation of the ordinary product, known as $q$-product [Borges, E.P. Physica A {\bf 340}, 95 (2004)]. The usual product, and consequently the usual logistic map, is recovered in the limit $q\to 1$, The tent map is also a particular case for $q_{map}\to\infty$. The generalisation of this (and others) algebraic operator has been widely used within nonextensive statistical mechanics context (see C. Tsallis, {\em Introduction to Nonextensive Statistical Mechanics}, Springer, NY, 2009). We focus the analysis for $q_{map}>1$ at the edge of chaos, particularly at the first critical point $a_c$, that depends on the value of $q_{map}$. Bifurcation diagrams, sensitivity to initial conditions, fractal dimension and rate of entropy growth are evaluated at $a_c(q_{map})$, and connections with nonextensive statistical mechanics are explored.Comment: 12 pages, 23 figures, Dynamics Days South America. To be published in Journal of Physics: Conference Series (JPCS - IOP

Histone H4 lysine 16 acetylation controls central carbon metabolism and diet-induced obesity in mice

Noncommunicable diseases (NCDs) account for over 70% of deaths world-wide. Previous work has linked NCDs such as type 2 diabetes (T2D) to disruption of chromatin regulators. However, the exact molecular origins of these chronic conditions remain elusive. Here, we identify the H4 lysine 16 acetyltransferase MOF as a critical regulator of central carbon metabolism. High-throughput metabolomics unveil a systemic amino acid and carbohydrate imbalance in Mof deficient mice, manifesting in T2D predisposition. Oral glucose tolerance testing (OGTT) reveals defects in glucose assimilation and insulin secretion in these animals. Furthermore, Mof deficient mice are resistant to diet-induced fat gain due to defects in glucose uptake in adipose tissue. MOF-mediated H4K16ac deposition controls expression of the master regulator of glucose metabolism, Pparg and the entire downstream transcriptional network. Glucose uptake and lipid storage can be reconstituted in MOF-depleted adipocytes in vitro by ectopic Glut4 expression, PPARγ agonist thiazolidinedione (TZD) treatment or SIRT1 inhibition. Hence, chronic imbalance in H4K16ac promotes a destabilisation of metabolism triggering the development of a metabolic disorder, and its maintenance provides an unprecedented regulatory epigenetic mechanism controlling diet-induced obesity

Pion-Muon Asymmetry Revisited

Long ago an unexpected and unexplainable phenomena was observed. The distribution of muons from positive pion decay at rest was anisotropic with an excess in the backward direction relative to the direction of the proton beam from which the pions were created. Although this effect was observed by several different groups with pions produced by different means, the result was not accepted by the physics community, because it is in direct conflict with a large set of other experiments indicating that the pion is a pseudoscalar particle. It is possible to satisfy both sets of experiments if helicity-zero vector particles exist and the pion is such a particle. Helicity-zero vector particles have direction but no net spin. For the neutral pion to be a vector particle requires an additional modification to conventional theory as discussed herein. An experiment is proposed which can prove that the asymmetry in the distribution of muons from pion decay is a genuine physical effect because the asymmetry can be modified in a controllable manner. A positive result will also prove that the pion is NOT a pseudoscalar particle.Comment: 9 pages, 3 figure

A TOMM40 poly-T variant modulates gene expression and is associated with vocabulary ability and decline in nonpathologic aging

The Translocase of Outer Mitochondrial Membrane 40 Homolog and Apolipoprotein E (TOMM40-APOE) locus has been associated with a number of age-related phenotypes in humans including nonpathologic cognitive aging, late-onset Alzheimer's disease, and longevity. Here, we investigate the influence of the TOMM40 intron 6 poly-T variant (rs10524523) on TOMM40 gene expression and cognitive abilities and decline in a cohort of 1613 community-dwelling elderly volunteers who had been followed for changes in cognitive functioning over a period of 14 years (range = 12–18 years). We showed that the shorter length poly-T variants were found to act as a repressor of luciferase gene expression in reporter gene constructs. Expression was reduced to approximately half of that observed for the very long variant. We further observed that the shorter poly-T variant was significantly associated with reduced vocabulary ability and a slower rate of vocabulary decline with age compared to the very long poly-T variants. No significant associations were observed for memory, fluid intelligence or processing speed, although the direction of effect, where the short variant was correlated with reduced ability and slower rate of decline was observed for all tests. Our results indicate that the poly-T variant has the ability to interact with transcription machinery and differentially modulate reporter gene expression and influence vocabulary ability and decline with age

Intensificações de doenças em pomares de uva na Zona da Mata de Pernambuco tem causas externas.

Objetivando-se avaliar a causa das perdas dos frutos de uva no Município de São Vicente Férrer, realizou-se uma inspeção com coletas de material vegetal para análises patológicas em laboratório da UFRPE, bem como também foram realizadas análises "in loco

Determinação espectrofotométrica de dipirona em um sistema FIA empregando um microssistema analítico construído com LTCC.

Nos últimos anos um grande interesse no desenvolvimento de microssistema para análises totais (?-TAS) tem sido amplamente descrito na literatura, pois é possível integrar várias etapas analíticas em um mesmo dispositivo como: introdução e pré-tratamento da amostra, reações químicas, separação analítica e detecção. Recentemente, um novo material denominado cerâmica verde ou LTCC (Low temperature co-fired ceramics)1,2 está sendo utilizado como uma tecnologia alternativa para a fabricação de ?-TAS, devido a possibilidade de construir estruturas tridimensionais utilizando múltiplas camadas de cerâmica verde, canais com dimensão reduzida sem limitação geométrica, além de um baixo custo de fabricação. O objetivo deste trabalho foi à aplicação de um microssistema analítico construído com LTCC para a determinação espectrofotométrica de dipirona em formulações farmacêuticas empregando um sistema FIA

Thermal Diffusion of a Two Layer System

In this paper thermal conductivity and thermal diffusivity of a two layer system is examined from the theoretical point of view. We use the one dimensional heat diffusion equation with the appropriate solution in each layer and boundary conditions at the interfaces to calculate the heat transport in this bounded system. We also consider the heat flux at the surface of the samle as boundary condition instead of using a fixed tempertaure. From this, we obtain an expression for the efective thermal diffusivity of the composite sample in terms of the thermal diffusivity of its constituent materials whithout any approximations.Comment: 16 pages, 1 figure, RevTeX v. 3.0 macro packag

Study of solid 4He in two dimensions. The issue of zero-point defects and study of confined crystal

Defects are believed to play a fundamental role in the supersolid state of 4He. We report on studies by exact Quantum Monte Carlo (QMC) simulations at zero temperature of the properties of solid 4He in presence of many vacancies, up to 30 in two dimensions (2D). In all studied cases the crystalline order is stable at least as long as the concentration of vacancies is below 2.5%. In the 2D system for a small number, n_v, of vacancies such defects can be identified in the crystalline lattice and are strongly correlated with an attractive interaction. On the contrary when n_v~10 vacancies in the relaxed system disappear and in their place one finds dislocations and a revival of the Bose-Einstein condensation. Thus, should zero-point motion defects be present in solid 4He, such defects would be dislocations and not vacancies, at least in 2D. In order to avoid using periodic boundary conditions we have studied the exact ground state of solid 4He confined in a circular region by an external potential. We find that defects tend to be localized in an interfacial region of width of about 15 A. Our computation allows to put as upper bound limit to zero--point defects the concentration 0.003 in the 2D system close to melting density.Comment: 17 pages, accepted for publication in J. Low Temp. Phys., Special Issue on Supersolid