A GUIDE FOR THE CO-ORDINATION IN THE FRONT CRAWL VARIANTS

In this presentation an interactive cd-rom, describing and discussing the front crawl of high level swimmers, is introduced; more specifically several variants (e.g. 6-beat, 2-beat, 2 beat crossover) and different technique aspects. The intention is that the coach corrects the own competition swimmers and triathletes, based on a careful video observation. Therefore, only practical knowledge is collected, confirmed by expertise and applied research at the K.U.Leuven Evaluation Centre. Different variants and technique aspects are clarified by video images of recent swimmers at national level in different speeds, obtained with 5 rotating cameras from 5 points of view. To be able to start with an Evaluation Centre, in the movement analysis of high level swimmers special attention was given to the co-ordination of the arm, leg and head movements (relative to the body) and of the body movements (relative to the water surface). Since the Olympic Games in Munich (1972), for each segment clearly delimited phases were studied in the stroke cycle of each variant. An interesting criterion for propulsion is the speed variation of the body from phase to phase. Each swimmer can feel propulsion per phase, estimated by the coach on video, from bubbles displaced backward; each swimmer can also feel the coordination, observable by the coach on video. Although the optimal variant per distance of a swimmer could be determined from his physical profile (e.g.; body structure, buoyancy, flexibility, strength,,,), each individual is advised to experiment with the different variants and technique aspects. Speed and/or economy remain the essential criterions. The body control of swimmers must thus be very adaptable

Paradoksien hallinta tuoteportfolion hallinnassa

Tiivistelmä. Tämän työn tarkoituksena on tutkia tuoteportfolion hallintaa ja siihen liittyviä paradoksaalisia jännitteitä. Paradoksien tutkiminen avaa mahdollisuuden tarkastella yleisesti liike-elämässä esiintyviä ongelmia monelta eri kantilta. Paradoksit ovat ristiriitoja eri menetelmien, ajattelutapojen, toiminnan ja strategioiden välillä. Tuoteportfolion hallinnassa vaaditaan paljon data-analyysiä ja jatkuvaa päätöksentekoa ryhmissä. Tuotehallintamanagerin on hyvä tiedostaa paradoksit ja hallita niiden synnyttämiä jännitteitä. Tuoteportfolion hallintaan on käytössä erilaisia viitekehyksiä ja strategioita, joista tässä työssä tutustutaan erityisesti Oulun yliopiston tuotantotalouden yksikössä kehitettyyn tuoteportfolion viitekehykseen. Tärkeimpänä tuloksena löydettiin, miten tarkasteltavat paradoksit sijoittuvat kyseisen viitekehyksen sisälle. Työ suoritetiin kirjallisuuskatsauksena ja tietoa kerättiin pääosin Google Scholar-tietokannasta aihehaulla ja sanahauilla. Tässä työssä esitellään kirjallisuudesta löydettyjä teorioita ja malleja tuotteiden elinkaaresta, tuoteportfolion hallinnasta, sen paradokseista ja paradoksaalisten jännitteiden hallinnastaManaging paradoxes in product portfolio management. Abstract. The purpose of this work is to explore the management of product portfolios and the paradoxical tensions involved. Exploring paradoxes opens the possibility of looking at common problems in product management from many angles. Paradoxes are conflicts between different methods, mindsets, activities, and strategies. Product portfolio management requires a lot of data analysis and continuous decisionmaking in teams. The product portfolio manager needs to be aware of the paradoxes and manage the tensions they create within the team. There are different frameworks and strategies for product portfolio management, of which this paper will focus on the product portfolio framework developed at the University of Oulu’s Faculty of Industrial Engineering and Management. The most important result was the identification of how the paradoxes under consideration fit within this framework. The work is carried out as a literature review, in which information was mainly collected from Google Scholar database through subject and word searches. This work presents the theories and models found in the literature on product life cycle, product portfolio management, paradoxes, and paradoxical tension management

An atlas of genetic scores to predict multi-omic traits

The use of omic modalities to dissect the molecular underpinnings of common diseases and traits is becoming increasingly common. But multi-omic traits can be genetically predicted, which enables highly cost-effective and powerful analyses for studies that do not have multi-omics. Here we examine a large cohort (the INTERVAL study; n = 50,000 participants) with extensive multi-omic data for plasma proteomics (SomaScan, n = 3,175; Olink, n = 4,822), plasma metabolomics (Metabolon HD4, n = 8,153), serum metabolomics (Nightingale, n = 37,359) and whole-blood Illumina RNA sequencing (n = 4,136), and use machine learning to train genetic scores for 17,227 molecular traits, including 10,521 that reach Bonferroni-adjusted significance. We evaluate the performance of genetic scores through external validation across cohorts of individuals of European, Asian and African American ancestries. In addition, we show the utility of these multi-omic genetic scores by quantifying the genetic control of biological pathways and by generating a synthetic multi-omic dataset of the UK Biobank to identify disease associations using a phenome-wide scan. We highlight a series of biological insights with regard to genetic mechanisms in metabolism and canonical pathway associations with disease; for example, JAK-STAT signalling and coronary atherosclerosis. Finally, we develop a portal ( https://www.omicspred.org/ ) to facilitate public access to all genetic scores and validation results, as well as to serve as a platform for future extensions and enhancements of multi-omic genetic scores

SERENA:Particle Instrument Suite for Determining the Sun-Mercury Interaction from BepiColombo

International audienceThe ESA-JAXA BepiColombo mission to Mercury will provide simultaneous measurements from two spacecraft, offering an unprecedented opportunity to investigate magnetospheric and exospheric particle dynamics at Mercury as well as their interactions with solar wind, solar radiation, and interplanetary dust. The particle instrument suite SERENA (Search for Exospheric Refilling and Emitted Natural Abundances) is flying in space on-board the BepiColombo Mercury Planetary Orbiter (MPO) and is the only instrument for ion and neutral particle detection aboard the MPO. It comprises four independent sensors: ELENA for neutral particle flow detection, Strofio for neutral gas detection, PICAM for planetary ions observations, and MIPA, mostly for solar wind ion measurements. SERENA is managed by a System Control Unit located inside the ELENA box. In the present paper the scientific goals of this suite are described, and then the four units are detailed, as well as their major features and calibration results. Finally, the SERENA operational activities are shown during the orbital path around Mercury, with also some reference to the activities planned during the long cruise phase

Correction to: SERENA: Particle Instrument Suite for Determining the Sun-Mercury Interaction from BepiColombo

International audienc