LauncherOne Now in Orbit: Dedicated Air-Launch Brings Proven, Responsive Space Access with Historic NASA VCLS Demonstration Mission

The Launcher One air-launched rocket system, under commercial development by Virgin Orbit since 2015, is now fully flight-qualified. This small, dedicated launch vehicle first reached orbit on January 17th, 2021 as part of the NASA Venture Class Launch Services (VCLS) ELaNa 20 mission, injecting ten small satellites into orbit. This historic mission saw the world’s first liquid-propulsion, orbital class air-launched vehicle succeed with incredible performance and accuracy. Founded upon the capabilities of the Boeing 747-400 carrier aircraft, LauncherOne maintains safe operations using flight controls and an Autonomous Flight Safety System (AFSS) that have been fully internally-developed and certified by the Federal Aviation Administration (FAA) of the United States. T his uniquely mobile launch system is designed to bring tailored small satellite launch services to any corner of the globe. This paper details the inaugural NASA VCLS LauncherOne mission. Review of the mission and customer outcome will reveal how some of the most challenging aspects of air-launch have now been achieved by the LauncherOne design. In successfully overcoming the design challenges of a cryogenic air-launch vehicle, the substantial accompanying rewards can now be realized. We have shown how such a modular launch system can be replicated and disaggregated across many sites, offering flexibility and extreme orbital access for small satellites without a fixed infrastructure or permanent footprint. Accordingly, we have continued to grow our spaceport network to support domestic and international mission planners that benefit from such a capability. The status of these activities and facilities will be discussed. Following extensive qualification testing, the NASA VCLS mission success, and all of the associated cryogenic loading and vehicle preparation operations successfully completed from an austere runway apron, LauncherOne’s air-launch approach is now proven to be foundationally responsive. Virgin Orbit and the dedicated, flight-proven LauncherOne system are now uniquely positioned to both serve and grow the global small satellite market from spaceports around the world

Corn Germ as a Source of Supplemental Fat for Cows in late Gestation

To evaluate corn germ as a source of supplemental fat, 217 two to twelve-year-old cows receiving grass hay free choice were supplemented with either 2.75 lb of corn germ (dry basis) or an equal amount of crude protein from soybean meal (0.80 lb dry matter) starting approximately 50 days prior to the first expected calving. Cows were removed from treatment the day they calved and where managed as a group through the breeding season. Supplement treatment did not affect cow weight change or body condition score. Corn germ did not improve any measure of reproduction, including the percentage of cows cycling or conceiving in the first 21 days of the breeding season or the days from calving to the onset of cyclicity or conception. Calf performance, calf health or indicators of colostrum absorption (total serum protein or IgG) were not influenced by supplement treatment. The results were similar whether all age groups were included in the analysis or when only data for the two and three year old cows were included in the data set. Under the conditions of this study there was no advantage to feeding a source of supplemental fat from corn germ during late gestation

MyoD induces myogenic differentiation through cooperation of its NH2- and COOH-terminal regions

MyoD and Myf5 are basic helix-loop-helix transcription factors that play key but redundant roles in specifying myogenic progenitors during embryogenesis. However, there are functional differences between the two transcription factors that impact myoblast proliferation and differentiation. Target gene activation could be one such difference. We have used microarray and polymerase chain reaction approaches to measure the induction of muscle gene expression by MyoD and Myf5 in an in vitro model. In proliferating cells, MyoD and Myf5 function very similarly to activate the expression of likely growth phase target genes such as L-myc, m-cadherin, Mcpt8, Runx1, Spp1, Six1, IGFBP5, and Chrnβ1. MyoD, however, is strikingly more effective than Myf5 at inducing differentiation-phase target genes. This distinction between MyoD and Myf5 results from a novel and unanticipated cooperation between the MyoD NH2- and COOH-terminal regions. Together, these results support the notion that Myf5 functions toward myoblast proliferation, whereas MyoD prepares myoblasts for efficient differentiation

The Grizzly, October 7, 1983

Career Workshops Held • What\u27s in a Name • Fago Opens Lecture Series • Lantern Makes National Anthology • Campus Memo • Letters to the Editor • Red and Gold Days Inaugurated • Sorority Pledging Underway • Half-Price Student Rushes for Genty! • Keep it Clean • Renaissance Play at Ursinus Commemoration • ATO Incident at Penn • Politics Sells Papers • Yearbook Sale Begins Monday • Ursinus Soccer Romps Over Hopkins • Volleyball Scores Second Victory • Grizzlies Fall to Swarthmorehttps://digitalcommons.ursinus.edu/grizzlynews/1103/thumbnail.jp

The Grizzly, October 28, 1983

CampusBooks Speaks Out • C and C Course Offered • Zack Is Back In Bronze • Peace Rally Held • Give Us A Little Bit Of Credit • Respect Is Goal Of Liberal Education • Homecoming: A Big Success • Nobel Prize Awarded • Spirit Week Begins • The Talented Two-Some • The Stone Age is Back • Crown Royal Features Ultimate Competition • Lady Bears Prepare For Penn State Rivalry • U.C. Soccer Continues Winning Ways • Grizziles Roll Over Lebanon Valleyhttps://digitalcommons.ursinus.edu/grizzlynews/1105/thumbnail.jp

Type I Interferon Production Enhances Susceptibility to Listeria monocytogenes Infection

Numerous bacterial products such as lipopolysaccharide potently induce type I interferons (IFNs); however, the contribution of this innate response to host defense against bacterial infection remains unclear. Although mice deficient in either IFN regulatory factor (IRF)3 or the type I IFN receptor (IFNAR)1 are highly susceptible to viral infection, we show that these mice exhibit a profound resistance to infection caused by the Gram-positive intracellular bacterium Listeria monocytogenes compared with wild-type controls. Furthermore, this enhanced bacterial clearance is accompanied by a block in L. monocytogenes–induced splenic apoptosis in IRF3- and IFNAR1-deficient mice. Thus, our results highlight the disparate roles of type I IFNs during bacterial versus viral infections and stress the importance of proper IFN modulation in host defense

WFPC2 Observations of Compact Star Cluster Nuclei in Low Luminosity Spiral Galaxies

We have used the Wide Field Planetary Camera 2 aboard the Hubble Space Telescope to image the compact star cluster nuclei of the nearby, late-type, low-luminosity spiral galaxies NGC 4395, NGC 4242, and ESO 359-029. We also analyze archival WFPC2 observations of the compact star cluster nucleus of M33. A comparative analysis of the structural and photometric properties of these four nuclei is presented. All of the nuclei are very compact, with luminosity densities increasing at small radii to the resolution limit of our data. NGC 4395 contains a Seyfert 1 nucleus with a distinct bipolar structure and bright associated filaments which are likely due to [OIII] emission. The M33 nucleus has a complex structure, with elongated isophotes and possible signatures of weak activity, including a jet-like component. The other two nuclei are not known to be active, but share similar physical size scales and luminosities to the M33 and NGC 4395 nuclei. The circumnuclear environments of all four of our program galaxies are extremely diffuse, have only low-to-moderate star formation, and appear to be devoid of large quantities of dust. The central gravitational potentials of the galaxies are also quite shallow, making the origin of these types of `naked' nuclei problematic.Comment: to appear in the July 1999 Astronomical Journal; 38 pages (Latex), 5 tables (postscript), 21 figures (gif); postscript versions of the figures may be obtained via anonymous ftp at ftp://ftp.cv.nrao.edu/NRAO-staff/lmatthew/lanl-nucle

Longitudinal impact of a youth tobacco education program

BACKGROUND: Information on the effectiveness of elementary school level, tobacco-use prevention programs is generally limited. This study assessed the impact of a structured, one-time intervention that was designed to modify attitudes and knowledge about tobacco. Participants were fifth-grade students from schools in western New York State. METHODS: Twenty-eight schools, which were in relatively close geographic proximity, were randomized into three groups; Group 1 was used to assess whether attitudes/knowledge were changed in the hypothesized direction by the intervention, and if those changes were retained four months later. Groups 2 and 3, were used as comparison groups to assess possible test-retest bias and historical effects. Groups 1 and 3 were pooled to assess whether attitudes/knowledge were changed by the intervention as measured by an immediate post-test. The non-parametric analytical techniques of Wilcoxon-Matched Pairs/Sign Ranks and the Mann-Whitney-Wilcoxon Rank Sums Tests were used to compare proportions of correct responses at each of the schools. RESULTS: Pooled analyses showed that short-term retention on most items was achieved. It was also found that retention on two knowledge items 'recognition that smokers have yellow teeth and fingers' and 'smoking one pack of cigarettes a day costs several hundred dollars per year' was maintained for four months. CONCLUSIONS: The findings suggest that inexpensive, one-time interventions for tobacco-use prevention can be of value. Changes in attitudes and knowledge conducive to the goal of tobacco-use prevention can be achieved for short-term retention and some relevant knowledge items can be retained for several months