Nostalgic Memories

Stories by Chloe Perry Mitchell, a member of the Bulloch County Historical Society and a writer for the Claxton Enterprise. This collection includes articles from the Enterprise as well as stories about her birthparents and her stepfather that reflect the social and economic climate of the time period.https://digitalcommons.georgiasouthern.edu/bchs-pubs/1024/thumbnail.jp

Identity Construction in a Misogynist Incels Forum

Online communities of involuntary celibates (incels) are a prominent source of misogynist hate speech. In this paper, we use quantitative text and network analysis approaches to examine how identity groups are discussed on incels.is, the largest black-pilled incels forum. We find that this community produces a wide range of novel identity terms and, while terms for women are most common, mentions of other minoritized identities are increasing. An analysis of the associations made with identity groups suggests an essentialist ideology where physical appearance, as well as gender and racial hierarchies, determine human value. We discuss implications for research into automated misogynist hate speech detection.Comment: Workshop on Online Abuse and Harms (WOAH) 202

A phase IV randomised, open-label pilot study to evaluate switching from protease-inhibitor based regimen to Bictegravir/Emtricitabine/Tenofovir Alafenamide single tablet regimen in Integrase inhibitor-naïve, virologically suppressed HIV-1 infected adults harbouring drug resistance mutations (PIBIK study): study protocol for a randomised trial

Background Currently recommended boosted protease-inhibitor (bPI) regimens may be associated with increased risk of cardiovascular or chronic kidney diseases; in addition, boosted regimens are particularly associated with drug-drug interactions. Since both cardiovascular and renal disease, and polypharmacy, are common in ageing people with HIV, there is a need for alternative efficacious regimens. bPI-based regimens are often the treatment of choice for individuals with pre-treatment or treatment-acquired resistance but it is plausible that carefully selected HIV-positive individuals with drug resistance, who are virologically suppressed on their current bPI regimen, could maintain virological efficacy when switched to bictegravir, emtricitabine and tenofovir alafenamide (B/F/TAF) fixed dose combination (FDC). Methods/design A phase IV, investigator-initiated, multicentre, open label pilot, randomised two-arm study to assess the safety and efficacy of switching from bPI regimen to B/F/TAF single tablet regimen in integrase inhibitor-naïve, virologically suppressed adults with HIV-1 infection harbouring drug resistance mutations. Eligible individuals will either continue on their bPI regimen or switch to B/F/TAF FDC. After 24 weeks, all participants in the bPI arm will be switched to B/F/TAF and followed for a further 24 weeks and all participants will be followed for 48 weeks. The primary efficacy endpoint is the proportion of participants with HIV-1 RNA < 50 copies/mL at week 24 using pure virologic response whilst the secondary efficacy endpoint is the proportion of participants with HIV-1 RNA < 50 copies/mL at Week 48. Other secondary outcome measures include between arm comparisons of drug resistance at virological failure, safety and tolerability and patient-reported outcome measures. Discussion We aim to provide preliminary evidence of the efficacy of switching to B/F/TAF in patients with virological suppression on a bPI-based regimen who harbour select drug resistance mutations

FEATURE-BASED METHOD TO FORMALISE ADDITIVE MANUFACTURING RELATED DATA AT THE MESOSCALE BASED ON A MEREOTOPOLOGICAL DESCRIPTION

AbstractResearch on additive manufacturing has highlighted methods and guidelines to optimise the design process and improving finished product quality. There is still room for improvement in making AM as reliable as more traditional processes when considering industrial use. In terms of manufacturing, managing print parameters properly can improve reproducibility and repeatability of a part, in addition to its fidelity to the basic geometric model. However, a topological optimised geometry requires more than good parameterisation. Efforts are therefore being made to formalise knowledge so that it is explicit and accessible to designers. This paper proposes an approach based on the spatio-temporal evolution of a geometry during printing to quantify data at the meso scale. Previous studies have been conducted on the description of features in time, space and space-time, and on the influence of their arrangement within a part. Building on this work, a parameterised test specimen was designed to measure the quantitative impact of these arrangements on the final product. The method is then presented and illustrated through a case study to help the designer with quantitative predictive values of geometric parameters

Evaluation des types d’informations et des supports de transmission pour favoriser l’assimilation de connaissances liées à la fabrication additive

La transmission de connaissances est un facteur clé pour le développement de la Fabrication Additive (FA) dans l'industrie. Pour des concepteurs n'étant pas spécialisés dans ce domaine, beaucoup de cycles de prototypage peuvent être nécessaires avant l'obtention d'un résultat satisfaisant le cahier des charges. Concevoir pour la FA implique la prise en compte des restrictions et règles spécifiques au procédé. La production ainsi que le temps de conception doivent-être optimisés, en utilisant par exemple un système automatisé d’analyse de fabricabilité

Assessing the accuracy of free automated plant identification applications

1. Widely available and inexpensive mobile phone applications offer users, whether professional ecologists or interested amateurs, the potential for simple and rapid automated identification of species, without the need to use field guides and identification keys. The increasing accuracy of machine learning is well established, but it is currently unclear if, and under what circumstances, free-to-use mobile phone applications are accurate for identifying plants to species level in real-world field conditions. 2. We test five popular and free identification applications for plants using 857 professionally identified images of 277 species from 204 genera. Across all applications, 85% of images were identified correctly in the top five suggestions, and 69% were correct with the first suggestion. Plant type (woody, forbs, grasses, rushes/sedges, ferns/horsetails) was a significant determinant of identification performance for each application. For some applications, image saliency was also important; exposure and focus were not significant. 3. Applications performed well, with at least one of the three best-performing applications identifying 96% of images correctly as their first suggestion. We conclude that, subject to some caveats, free phone-based plant identification applications are valid and useful tools for those wanting rapid identification and for anyone wanting to engage with the natural world

Opportunities to engage in positive activities during the COVID-19 pandemic: Perspectives of individuals with mood disorders

Background Despite cross-sectional population and clinical studies finding individuals with existing mood disorders being adversely impacted by the COVID-19 pandemic, longitudinal studies have not shown a worsening of psychiatric symptoms. In response to these findings, we explored opportunities to engage in positive activities during the pandemic from the perspectives of individuals with mood disorders. Methods A bespoke survey, containing closed and open questions, was sent to participants with mood disorders who were part of the UK Bipolar Disorder Research Network (BDRN). Questions related to experiences of positive impacts of the pandemic, levels of engagement in positive activities and coping strategies. Results Response rate was 46.4 % (N = 1688). 61.9 % reported positive life changes during the pandemic, with slower pace of life reported most frequently (52.8 %). 47.3 % reported no adverse impact of the pandemic on implementing their usual coping strategies. Activities that respondents most commonly reported the same or greater level of engagement in compared to before the pandemic were avoiding known mood triggers (82.3 %), relaxation techniques (78.8 %) and the ability to maintain set routines (69.4 %). Limitations Responder bias may be present and experiences during the pandemic are likely to differ among other clinical and research mood disorders cohorts. Conclusions Our findings may help to explain why longitudinal studies have not found a worsening of mental health symptoms during the COVID-19 pandemic. Identifying potential facilitators to maintaining mental health have wider applicability, and may help to inform future evidence-based psychoeducation and self-management programmes for mood disorders

Investigating the effect of providing monetary incentives to participants on completion rates of referred co-respondents: an embedded randomized controlled trial. Study within a trial (SWAT) protocol

Background Parent-report questionnaires are a common method of generating data on child outcomes in mental health studies. A second report from another person who knows the child (co-respondent) is implemented to reduce bias and increase objectivity. The success of this approach is dependent on the engagement of co-respondents, which can be difficult. Financial incentives are used to increase data return in clinical trials, and to promote referral rates in online marketing. This protocol describes the use of an embedded randomised controlled trial (RCT) to investigate the effect of financial incentives on rates of co-respondent data completion. In the host RCT (of an online intervention designed to reduce the impact of a parent's anxiety on their child) index participants (i.e. parents) are asked to invite a co-respondent to complete measures on the index child. This study will test the hypothesis that providing monetary incentives to index participants will increase the outcome measure completion rate of co-respondents. Methods Embedded RCT of two parallel groups. Participants in the intervention arm will be sent a £10 voucher if their chosen co-respondent completes online baseline measures. Participants in the control arm will not be offered payment regardless of their chosen co-respondent's behaviour. 1754 participants will take part. Analysis will compare co-respondent outcome measure completion rates between the two arms at baseline and follow-up. Conclusion Findings from this study will provide evidence on the impact of offering payment to index participants on return rates of co-respondent data. This will inform resource allocation within future clinical trials

Correction to:The genetic architecture of Plakophilin 2 cardiomyopathy (Genetics in Medicine, (2021), 23, 10, (1961-1968), 10.1038/s41436-021-01233-7)

Due to a processing error Cynthia James, Brittney Murray, and Crystal Tichnell were assigned to the wrong affiliation. Cynthia James, Brittney Murray, and Crystal Tichnell have as their affiliation 5 Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA. In addition Hana Zouk, Megan Hawley, and Birgit Funke were assigned only to affiliation 3; they also have affiliation 4 Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. The original article has been corrected

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy