Theoretical Study of Spin-dependent Electron Transport in Atomic Fe Nanocontacts

We present theoretical predictions of spintronic transport phenomena that should be observable in ferromagnetic Fe nanocontacts bridged by chains of Fe atoms. We develop appropriate model Hamiltonians based on semi-empirical considerations and the known electronic structure of bulk Fe derived from ab initio density functional calculations. Our model is shown to provide a satisfactory description of the surface properties of Fe nano-clusters as well as bulk properties. Lippmann-Schwinger and Green's function techniques are used together with Landauer theory to predict the current, magneto-resistance, and spin polarization of the current in Fe nanocontacts bridged by atomic chains under applied bias. Unusual device characteristics are predicted including negative magneto-resistance and spin polarization of the current, as well as spin polarization of the current for anti-parallel magnetization of the Fe nanocontacts under moderate applied bias. We explore the effects that stretching the atomic chain has on the magneto-resistance and spin polarization and predict a cross-over regime in which the spin polarization of the current for parallel magnetization of the contacts switches from negative to positive. We find resonant transmission due to dangling bond formation on tip atoms as the chain is stretched through its breaking point to play an important role in spin-dependent transport in this regime. The physical mechanisms underlying the predicted phenomena are discussed.Comment: 13 pages, 6 figures, Accepted for publication in Physical Review

Even-odd parity effects in conductance and shot noise of metal-atomic wire-metal(superconducting) junctions

In this paper, we study the conductance and shot noise in transport through a multi-site system in a two terminal configuration. The dependence of the transport on the number of atoms in the atomic wire is investigated using a tight-binding Hamiltonian and the nonequilibrium Green's function method. In addition to reproducing the even-odd behavior in the transmission probability at the Fermi energy or the linear response conductance in the normal-atomic wire-normal metallic(NAN) junctions, we find the following: (i) The shot noise is larger in the even-numbered atomic wire than in the odd-numbered wire. (ii) The Andreev conductance displays the same even-odd parity effects in the normal-atomic wire-superconducting(NAS) junctions. In general, the conductance is higher in the odd-numbered atomic wire than in the even-numbered wire. When the number of sites ($N$) is odd and the atomic wire is mirror symmetric with respect to the center of the atomic wire, the conductance does not depend on the details of the hopping matrices in the atomic wire, but is solely determined by the coupling strength to the two leads. When $N$ is even, the conductance is sensitive to the values of the hopping matrices.Comment: 12 pages, 9 figure

APLICACIONES DEL SUERO AUTÓLOGO EN LA CONSULTA DEL SERVICIO DE OFTALMOLOGÍA EN EL HOSPITAL DONOSTIA

Introduction: The etiology of a dry eye is related to the lack of growth factors, responsible of keeping an adequate spread of the ocular epithelium surface. These components are found in blood. That is the reason why, the use of autologous serum is a therapeutic option for a dry eye. The autologous serum is a preparation of centrifuged own blood-based 3,000 revs per minute. Objetive: Registering the prescription procedure, preparation, and dispensing of autologous serum collyrium. Material and Method: In 2004 it was agreed with the Ophthalmology Service to define a protocol for the autologous serum collyrium. Results: From May 2004 to April 2006, 42 patients have been treated. In 2004 collyrium was elaborated for 11 patients, in 2005 for 32 patients and until April 2006 for 22 patients. A half of the patients needed to be described at least once, being the cases with GVHD the most described: an average of 8 exemptions for every patient. Conclusions: The increase of the demand justifies the registration of this preparation. The collyrium preparation and dispensing by the Pharmacy Service assure its sterility and stability and it makes possible more efficient pharmaceutics assistance and a correct collyrium use. All treated patients with autologous serum got better from their pathology of dry eye. Likewise, their life quality has been improved, having less vision upsets and a better vision.Introducción: La etiología del ojo seco se relaciona con la falta de factores de crecimiento, responsables de mantener una adecuada proliferación de la superficie del epitelio ocular. En la sangre se encuentran estos componentes, por lo que la utilización del suero autólogo es una opción terapéutica para el ojo seco. El suero autólogo es un preparado a base de tu propia sangre centrifugada a 3.000 rev/minuto. Objetivo: Protocolizar el procedimiento de prescripción, elaboración, y dispensación de colirio de suero antólogo. Material y Métodos: En el año 2004 se acordó con el Servicio de Oftalmología definir la protocolización del colirio de suero autólogo. Resultados: Entre mayo de 2004 y abril de 2006 se ha tratado a 42 pacientes. En el 2004 se elaboraron colirios para 11 pacientes, en el 2005 para 32, y hasta abril del 2006 para 22. El 50% de los pacientes ha necesitado ser retratado al menos una vez, siendo los casos con EICH, con una media de 8 dispensaciones por paciente, los más retratados. Conclusiones: El aumento de la demanda justifica la protocolización de este preparado. La elaboración y dispensación del colirio por parte del Servicio de Farmacia garantiza la esterilidad y estabilidad del mismo, y posibilita la atención farmacéutica orientada a la mejora de la eficacia y correcto uso del colirio. Todos los pacientes tratados con Suero Autólogo han mejorado de su patología de ojo seco. Han mejorado en su calidad de vida (menos molestias en la visión, mejor visión)

Caracterización epidemiológica, clínica y virológica de los nuevos diagnósticos de infección por VHC en Galicia (2014-2015)

Abstrac

Perturbation Study of the Conductance through an Interacting Region Connected to Multi-Mode Leads

We study the effects of electron correlation on transport through an interacting region connected to multi-mode leads based on the perturbation expansion with respect to the inter-electron interaction. At zero temperature the conductance defined in the Kubo formalism can be written in terms of a single-particle Green's function at the Fermi energy, and it can be mapped onto a transmission coefficient of the free quasiparticles described by an effective Hamiltonian. We apply this formulation to a two-dimensional Hubbard model of finite size connected to two noninteracting leads. We calculate the conductance in the electron-hole symmetric case using the order $U^2$ self-energy. The conductance shows several maximums in the $U$ dependence in some parameter regions of $t_y/t_x$, where $t_x$ ($t_y$) is the hopping matrix element in the $x$- ($y$-) directions. This is caused by the resonance occurring in some of the subbands, and is related with the $U$ dependence of the eigenvalues of the effective Hamiltonian.Comment: 17 pages, 12 figures, to be published in J.Phys.Soc.Jpn. 71(2002)No.

Microscopic Theory of Josephson Mesoscopic Constrictions

We present a microscopic theory for the d.c. Josephson effect in model mesoscopic constrictions. Our method is based on a non-equilibrium Green function formalism which allows for a self-consistent determination of the order parameter profile along the constriction. The various regimes defined by the different length scales (Fermi wavelength $\lambda_F$, coherence length $\xi_0$ and constriction length $L_C$) can be analyzed, including the case where all these lengths are comparable. For the case $\lambda_F \tilde{<} (L_C,\xi_0)$ phase oscillations with spatial period $\lambda_F/2$ can be observed. In the case of $L_C>\xi_0$ solutions with a phase-slip center inside the constriction can be found, in agreement with previous phenomenological theories.Comment: 4 pages (RevTex 3.0), 3 postscript figures available upon request, 312456-C

Expression of a barley cystatin gene in maize enhances resistance against phytophagous mites by altering their cysteine-proteases

Phytocystatins are inhibitors of cysteine-proteases from plants putatively involved in plant defence based on their capability of inhibit heterologous enzymes. We have previously characterised the whole cystatin gene family members from barley (HvCPI-1 to HvCPI-13). The aim of this study was to assess the effects of barley cystatins on two phytophagous spider mites, Tetranychus urticae and Brevipalpus chilensis. The determination of proteolytic activity profile in both mite species showed the presence of the cysteine-proteases, putative targets of cystatins, among other enzymatic activities. All barley cystatins, except HvCPI-1 and HvCPI-7, inhibited in vitro mite cathepsin L- and/or cathepsin B-like activities, HvCPI-6 being the strongest inhibitor for both mite species. Transgenic maize plants expressing HvCPI-6 protein were generated and the functional integrity of the cystatin transgene was confirmed by in vitro inhibitory effect observed against T. urticae and B. chilensis protein extracts. Feeding experiments impaired on transgenic lines performed with T. urticae impaired mite development and reproductive performance. Besides, a significant reduction of cathepsin L-like and/or cathepsin B-like activities was observed when the spider mite fed on maize plants expressing HvCPI-6 cystatin. These findings reveal the potential of barley cystatins as acaricide proteins to protect plants against two important mite pests

High Levels of Receptor Tyrosine Kinases in CCM3-Deficient Cells Increase Their Susceptibility to Tyrosine Kinase Inhibition

Cerebral cavernous malformations (CCMs) are vascular malformations that can be the result of the deficiency of one of the CCM genes. Their only present treatment is surgical removal, which is not always possible, and an alternative pharmacological strategy to eliminate them is actively sought. We have studied the effect of the lack of one of the CCM genes, CCM3, in endothelial and non-endothelial cells. By comparing protein expression in control and CCM3-silenced cells, we found that the levels of the Epidermal Growth Factor Receptor (EGFR) are higher in CCM3-deficient cells, which adds to the known upregulation of Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) in these cells. Whereas VEGFR2 is upregulated at the mRNA level, EGFR has a prolonged half-life. Inhibition of EGFR family members in CCM3-deficient cells does not revert the known cellular effects of lack of CCM genes, but it induces significantly more apoptosis in CCM3-deficient cells than in control cells. We propose that the susceptibility to tyrosine kinase inhibitors of CCM3-deficient cells can be harnessed to kill the abnormal cells of these lesions and thus treat CCMs pharmacologically

Electron transport across a quantum wire in the presence of electron leakage to a substrate

We investigate electron transport through a mono-atomic wire which is tunnel coupled to two electrodes and also to the underlying substrate. The setup is modeled by a tight-binding Hamiltonian and can be realized with a scanning tunnel microscope (STM). The transmission of the wire is obtained from the corresponding Green's function. If the wire is scanned by the contacting STM tip, the conductance as a function of the tip position exhibits oscillations which may change significantly upon increasing the number of wire atoms. Our numerical studies reveal that the conductance depends strongly on whether or not the substrate electrons are localized. As a further ubiquitous feature, we observe the formation of charge oscillations.Comment: 7 pages, 7 figure

In Vitro Antibacterial Activity of Cysteine Protease Inhibitor from Kiwifruit (Actinidia deliciosa)

The need for replacing traditional pesticides with alternative agents for the management of agricultural pathogens is rising worldwide. In this study, a cysteine proteinase inhibitor (CPI), 11 kDa in size, was purified from green kiwifruit to homogeneity. We examined the growth inhibition of three plant pathogenic Gram-negative bacterial strains by kiwi CPI and attempted to elucidate the potential mechanism of the growth inhibition. CPI influenced the growth of phytopathogenic bacteria Agrobacterium tumefaciens (76.2 % growth inhibition using 15 mu M CPI), Burkholderia cepacia (75.6 % growth inhibition) and, to a lesser extent, Erwinia carotovora (44.4 % growth inhibition) by inhibiting proteinases that are excreted by these bacteria. Identification and characterization of natural plant defense molecules is the first step toward creation of improved methods for pest control based on naturally occurring molecules