The effect of delta 3 on a yawing HAWT blade and on yaw dynamics

A single degree of freedom aeroelastic computer model, WMSTAB3, was employed to perform a parametric analysis of HAWT blade behavior during yaw maneuvers. Over 1,000 different combinations of delta sub 3 and normal frequency were analyzed. The effect of delta sub 3 and flapping stiffness on flapping frequency, phase, and magnitude are discussed. The moments transmitted to the fixed system during yaw maneuvers were calculated and reduced to time constants of response to step changes in wind direction. The significance of the time constants for the configurations considered relative to yaw response rate and lag angle is discussed, along with their possible significance for large HAWT

Open string axions and the flavor problem

We consider extensions of the standard model inspired by intersecting D-brane constructions, in order to address flavor mass textures. We include additional anomalous gauge symmetries, and scalar fields to break them and to generate Froggatt-Nielsen mass terms. Green-Schwarz axions are included to cancel mixed anomalies rendering the models consistent. At low energies, a residual anomalous global symmetry remains, and its associated pseudo-Goldstone mode becomes the physical axion, which can be interpreted as an axion arising from open string modes. General considerations show that such axions are very common in D-brane models and can be completely incompatible with current bounds. Astrophysical constraints are placed on the axion both by including neutrino masses in the Froggatt-Nielsen scheme and considering QCD instanton contributions to the axion mass. We find simple models where the axion decay constant is in the allowed range, but only one such minimal model with this property is free from excessive fine tunings elsewhere. We also note that generically addressing flavor textures for the CKM matrix leads to deconstructed extra dimensions.Comment: 30 pages, 2 figures. v2: references added. v3:typos fixe

Infinite dimensional stochastic differential equations of Ornstein-Uhlenbeck type

We consider the operator \sL f(x)=\tfrac12 \sum_{i,j=1}^\infty a_{ij}(x)\frac{\del^2 f}{\del x_i \del x_j}(x)-\sum_{i=1}^\infty \lam_i x_i b_i(x) \frac{\del f}{\del x_i}(x). We prove existence and uniqueness of solutions to the martingale problem for this operator under appropriate conditions on the $a_{ij}, b_i$, and \lam_i. The process corresponding to \sL solves an infinite dimensional stochastic differential equation similar to that for the infinite dimensional Ornstein-Uhlenbeck process

In vitro and in vivo effects of salbutamol on neutrophil function in acute lung injury

Background: Intravenous salbutamol (albuterol) reduces lung water in patients with the acute respiratory distress syndrome (ARDS). Experimental data show that it also reduces pulmonary neutrophil accumulation or activation and inflammation in ARDS. Aim: To investigate the effects of salbutamol on neutrophil function. Methods: The in vitro effects of salbutamol on neutrophil function were determined. Blood and bronchoalveolar lavage (BAL) fluid were collected from 35 patients with acute lung injury (ALI)/ARDS, 14 patients at risk from ARDS and 7 ventilated controls at baseline and after 4 days’ treatment with placebo or salbutamol (ALI/ARDS group). Alveolar–capillary permeability was measured in vivo by thermodilution (PiCCO). Neutrophil activation, adhesion molecule expression and inflammatory cytokines were measured. Results: In vitro, physiological concentrations of salbutamol had no effect on neutrophil chemotaxis, viability or apoptosis. Patients with ALI/ARDS showed increased neutrophil activation and adhesion molecule expression compared with at risk-patients and ventilated controls. There were associations between alveolar– capillary permeability and BAL myeloperoxidase (r = 0.4, p = 0.038) and BAL interleukin 8 (r = 0.38, p = 0.033). In patients with ALI/ARDS, salbutamol increased numbers of circulating neutrophils but had no effect on alveolar neutrophils. Conclusion: At the onset of ALI/ARDS, there is increased neutrophil recruitment and activation. Physiological concentrations of salbutamol did not alter neutrophil chemotaxis, viability or apoptosis in vitro. In vivo, salbutamol increased circulating neutrophils, but had no effect on alveolar neutrophils or on neutrophil activation. These data suggest that the beneficial effects of salbutamol in reducing lung water are unrelated to modulation of neutrophil-dependent inflammatory pathways

Regulation of vascular endothelial growth factor bioactivity in patients with acute lung injury

Background: Reduced bioactive vascular endothelial growth factor (VEGF) has been demonstrated in several inflammatory lung conditions including the acute respiratory distress syndrome (ARDS). sVEGFR-1, a soluble form of VEGF-1 receptor, is a potent natural inhibitor of VEGF. We hypothesised that sVEGFR-1 plays an important role in the regulation of the bioactivity of VEGF within the lung in patients with ARDS. Methods: Forty one patients with ARDS, 12 at risk of developing ARDS, and 16 normal controls were studied. Bioactive VEGF, total VEGF, and sVEGFR-1 were measured by ELISA in plasma and bronchoalveolar lavage (BAL) fluid. Reverse transcriptase polymerase chain reaction for sVEGFR-1 was performed on BAL cells. Results: sVEGFR-1 was detectable in the BAL fluid of 48% (20/41) of patients with early ARDS (1.4– 54.8 ng/ml epithelial lining fluid (ELF)) compared with 8% (1/12) at risk patients (p = 0.017) and none of the normal controls (p = 0.002). By day 4 sVEGFR-1 was detectable in only 2/18 ARDS patients (p = 0.008). Patients with detectable sVEGFR-1 had lower ELF median (IQR) levels of bioactive VEGF than those without detectable sVEGFR-1 (1415.2 (474.9–3192) pg/ml v 4761 (1349–7596.6) pg/ml, median difference 3346 pg/ml (95% CI 305.1 to 14711.9), p = 0.016), but there was no difference in total VEGF levels. BAL cells expressed mRNA for sVEGFR-1 and produced sVEGFR-1 protein which increased following incubation with tumour necrosis factor a. Conclusion: This study shows for the first time the presence of sVEGFR-1 in the BAL fluid of patients with ARDS. This may explain the presence of reduced bioactive VEGF in patients early in the course of ARDS

Youth and Adult Perceptions of Their Relationships Within Community-Based Youth Programs

This study examined perceptions and experiences of youth and adults engaged in various types of community-based youth-adult relationships. Involvement and interaction rating scales were completed by 108 participants involved in community groups from 12 communities in 10 states. The rating scale measured three constructs: youth involvement, adult involvement, and youth- adult interaction. Significant gender differences in participants’ perceptions were found on all three constructs, with females being more positive. Rural participants were found to be significantly more positive than urban participants on the construct of youth involvement. Finally, significant differences were found between all participants within categories of the youth-adult relationship continuum. Participants in youth-led collaborations were significantly more positive toward youth involvement than participants in adult-led collaborations. Moreover, adults in youth-adult partnerships were significantly more positive toward youth involvement and youth-adult interaction than those adults in adult-led collaborations

CAYDO: Connecting the Gaps of Community Youth Assessments

Community-based assessments can be strategies that aim to work in partnership with individuals and organizations to empower communities. Often identified as a comparable alternative to needs assessments, Community YouthMapping has been developed to include youth in the community youth development process. However, the authors note significant gaps in Community YouthMapping and offer a new assessment technique that includes an adapted youth mapping process, Comprehensive Assessment of Youth Development Opportunities (CAYDO). This article takes an investigative look at the relevance of including this procedure as a needs assessment tool in the program planning and community development process

Determining the Quality of Youth-Adult Relationships Within Community-Based Youth Programs

There is a lack of research on assessing how society views youth voice and participation in youth programs. Youth taking on leadership roles and interacting with adults have shown success in establishing positive youth-adult relationships. This article introduces the Involvement and Interaction Rating Scale, a new measure that assesses the perceptions and experiences of youth and adult participants working together in various community-based efforts. The scale serves as a means to empower participants by enabling them to evaluate their own experiences to determine the quality of these experiences and acknowledge areas that need strengthening

Patient Understanding of Benefits, Risks, and Alternatives to Screening Colonoscopy

While several tests and strategies are recommended for colorectal cancer (CRC) screening, studies suggest that primary care providers often recommend colonoscopy without providing information about its risks or alternatives. These observations raise concerns about the quality of informed consent for screening colonoscopy

The effect of sex hormones on the growth of HeLa tumour nodules in male and female mice.

The effect of exogenous sex hormones on the cell mediated response in male and female mice has been studied by measuring the subcutaneous growth of HeLa tumour nodules and the variation in the total lymphocyte count. It was found that oestrogen treated male and female mice experienced a profound lymphopenia which was vary rapid in onset. Concurrent with the lymphopenia there was prolongation of HeLa tumour nodule growth in female mice, but not in males. A lymphopenia occurred in androgen treated male mice with subsequent prolongation of HeLa tumour nodule growth, and a lymphocytosis in female mice, with reduction of HeLa tumour nodule growth