Women, Equity and Participatory Water Management in Brazil

Public participation in resource management is regarded as a central pillar of sustain- able development. Water management is a foremost example, and women globally are prime users and protectors of water. Yet the effectiveness of participatory water man- agement practices is seldom examined from a feminist perspective. This article estab- lishes a methodological framework for such an inquiry, drawing on ecofeminist theory and the Brazilian concept of ‘feminist transformative leadership’ to consider gender, race and class aspects of participatory water management in Brazil.This research was supported by the Social Sciences and Humanities Research Council of Canad

Women and Deliberative Water Management in Brazil

In this paper we consider some gender aspects of the evolution of water management in Brazil. In our work on women and water, we have been inspired by ecofeminist philosophy and the concept of 'feministThis research was supported by the Social Sciences and Humanities Research Council of Canad

Strengthening the role of civil society in water sector governance towards climate change adaptation in African cities – Durban, Maputo, Nairobi

Water resources management is one of the most important climate change-related issues on international, national and urban public policy agendas. Income inequality in South Africa, Mozambique, and Kenya is among the largest in the world; in all three countries, equity struggles related to water are growing in social, political and ecological significance, which is both a symptom and a cause of urban vulnerabilities related to climate change. Democratic mediation of these conflicts, and sustainable long-term management of water resources in the face of climate change, requires public participation. But those most affected by water issues such as scarcity and flooding are also those least likely to be able to participate in governance and policy institutions. In particular, members of economically disadvantaged groups – especially women, in general – tend to be gravely impacted by poor water management, but also face great difficulties in participating effectively in governance bodies. This project responded to that particular need, and has developed practical strategies for strengthening urban governments in planning investments in climate change adaptation. The project linked university researchers with community-based NGOs conducting environmental education and organizing participatory workshops in low-income urban areas with pressing climate change and water-related problems; built on proven methods of community-university collaboration to strengthen urban watershed governance; increased equity in public participation processes related to urban climate change adaptation; and fostered progressive local, national and international policy development on climate change-related water management – while training students, university researchers, NGO staff members, and community participants. The major research outcome of the project is its contribution to understanding effective ways of strengthening local governments, NGOs and civil society organizations involved in environmental education and organizing for improved public participation in watershed governance and climate change adaptation in African urban areas.This research was supported by the International Development Research Centre, grant number IDRC GRANT NO. 106002-00

How will disenfranchised Peoples adapt to Climate Change? Strengthening the Ecojustice Movement

The Fourth assessment of the Intergovernmental Panel on Climate Change (IPCC) acknowledged That millions of people are currently, and will increasingly be, affected by the impacts of climate change, in the form of floods, droughts and other extreme events, as well as related threats to food security. In response to these global environmental changes, the international community, including civil society, is acting on the need for immediate adaptation measures and is developing strategies for future adaptation. However, the impacts of climate change are unevenly distributed, with many of the poorest, most vulnerable peoples experiencing the immediate effects of climate change, in the here and now. As the IPCC noted, developing countries are disproportionately affected by climate change and often, the least able to adapt due to lack of infrastructure and resources

Bcl-xL-mediated remodeling of rod and cone synaptic mitochondria after postnatal lead exposure: electron microscopy, tomography and oxygen consumption.

PurposePostnatal lead exposure produces rod-selective and Bax-mediated apoptosis, decreased scotopic electroretinograms (ERGs), and scotopic and mesopic vision deficits in humans and/or experimental animals. Rod, but not cone, inner segment mitochondria were considered the primary site of action. However, photoreceptor synaptic mitochondria were not examined. Thus, our experiments investigated the structural and functional effects of environmentally relevant postnatal lead exposure on rod spherule and cone pedicle mitochondria and whether Bcl-xL overexpression provided neuroprotection.MethodsC57BL/6N mice pups were exposed to lead only during lactation via dams drinking water containing lead acetate. The blood [Pb] at weaning was 20.6±4.7 µg/dl, which decreased to the control value by 2 months. To assess synaptic mitochondrial structural differences and vulnerability to lead exposure, wild-type and transgenic mice overexpressing Bcl-xL in photoreceptors were used. Electron microscopy, three-dimensional electron tomography, and retinal and photoreceptor synaptic terminal oxygen consumption (QO(2)) studies were conducted in adult control, Bcl-xL, lead, and Bcl-xL/lead mice.ResultsThe spherule and pedicle mitochondria in lead-treated mice were swollen, and the cristae structure was markedly changed. In the lead-treated mice, the mitochondrial cristae surface area and volume (abundance: measure correlated with ATP (ATP) synthesis) were decreased in the spherules and increased in the pedicles. Pedicles also had an increased number of crista segments per volume. In the lead-treated mice, the number of segments/crista and fraction of cristae with multiple segments (branching) similarly increased in spherule and pedicle mitochondria. Lead-induced remodeling of spherule mitochondria produced smaller cristae with more branching, whereas pedicle mitochondria had larger cristae with more branching and increased crista junction (CJ) diameter. Lead decreased dark- and light-adapted photoreceptor and dark-adapted photoreceptor synaptic terminal QO(2). Bcl-xL partially blocked many of the lead-induced alterations relative to controls. However, spherules still had partially decreased abundance, whereas pedicles still had increased branching, increased crista segments per volume, and increased crista junction diameter. Moreover, photoreceptor and synaptic QO(2) were only partially recovered.ConclusionsThese findings reveal cellular and compartmental specific differences in the structure and vulnerability of rod and cone inner segment and synaptic mitochondria to postnatal lead exposure. Spherule and pedicle mitochondria in lead-exposed mice displayed complex and distinguishing patterns of cristae and matrix damage and remodeling consistent with studies showing that synaptic mitochondria are more sensitive to Ca(2+) overload, oxidative stress, and ATP loss than non-synaptic mitochondria. The lead-induced decreases in QO(2) likely resulted from the decreased spherule cristae abundance and smaller cristae, perhaps due to Bax-mediated effects as they occurred in apoptotic rod inner segments. The increase in pedicle cristae abundance and CJ diameter could have resulted from increased Drp1-mediated fission, as small mitochondrial fragments were observed. The mechanisms of Bcl-xL-mediated remodeling might occur via interaction with formation of CJ protein 1 (Fcj1), whereas the partial protection of synaptic QO(2) might result from the enhanced efficiency of energy metabolism via Bcl-xL's direct interaction with the F1F0 ATP synthase and/or regulation of cellular redox status. These lead-induced alterations in photoreceptor synaptic terminal mitochondria likely underlie the persistent scotopic and mesopic deficits in lead-exposed children, workers, and experimental animals. Our findings stress the clinical and scientific importance of examining synaptic dysfunction following injury or disease during development, and developing therapeutic treatments that prevent synaptic degeneration in retinal and neurodegenerative disorders even when apoptosis is blocked

Expression of PEG11 and PEG11AS transcripts in normal and callipyge sheep

BACKGROUND: The callipyge mutation is located within an imprinted gene cluster on ovine chromosome 18. The callipyge trait exhibits polar overdominant inheritance due to the fact that only heterozygotes inheriting a mutant paternal allele (paternal heterozygotes) have a phenotype of muscle hypertrophy, reduced fat and a more compact skeleton. The mutation is a single A to G transition in an intergenic region that results in the increased expression of several genes within the imprinted cluster without changing their parent-of-origin allele-specific expression. RESULTS: There was a significant effect of genotype (p < 0.0001) on the transcript abundance of DLK1, PEG11, and MEG8 in the muscles of lambs with the callipyge allele. DLK1 and PEG11 transcript levels were elevated in the hypertrophied muscles of paternal heterozygous animals relative to animals of the other three genotypes. The PEG11 locus produces a single 6.5 kb transcript and two smaller antisense strand transcripts, referred to as PEG11AS, in skeletal muscle. PEG11AS transcripts were detectable over a 5.5 kb region beginning 1.2 kb upstream of the PEG11 start codon and spanning the entire open reading frame. Analysis of PEG11 expression by quantitative PCR shows a 200-fold induction in the hypertrophied muscles of paternal heterozygous animals and a 13-fold induction in homozygous callipyge animals. PEG11 transcripts were 14-fold more abundant than PEG11AS transcripts in the gluteus medius of paternal heterozygous animals. PEG11AS transcripts were expressed at higher levels than PEG11 transcripts in the gluteus medius of animals of the other three genotypes. CONCLUSIONS: The effect of the callipyge mutation has been to alter the expression of DLK1, GTL2, PEG11 and MEG8 in the hypertrophied skeletal muscles. Transcript abundance of DLK1 and PEG11 was highest in paternal heterozygous animals and exhibited polar overdominant gene expression patterns; therefore, both genes are candidates for causing skeletal muscle hypertrophy. There was unique relationship of PEG11 and PEG11AS transcript abundance in the paternal heterozygous animals that suggests a RNA interference mechanism may have a role in PEG11 gene regulation and polar overdominance in callipyge sheep

Global atmospheric sampling program

Automated instruments were installed on a commercial B-747 aircraft, during the program, to obtain baseline data and to monitor key atmospheric constituents associated with emissions of aircraft engines in order to determine if aircraft are contributing to pollution of the upper atmosphere. Data thus acquired on a global basis over the commercial air routes for 5 to 10 years will be analyzed. Ozone measurements in the 29,000 to 45,000 foot altitude were expanded over what has been available from ozonesondes. Limited aerosol composition measurements from filter samples show low levels of sulfates and nitrates in the upper troposphere. Recently installed instruments for measurement of carbon monoxide and condensation nuclei are beginning to return data