Cosmic voids in modified gravity scenarios

Modified gravity (MG) theories aim to reproduce the observed acceleration of the Universe by reducing the dark sector while simultaneously recovering General Relativity (GR) within dense environments. Void studies appear to be a suitable scenario to search for imprints of alternative gravity models on cosmological scales. Voids cover an interesting range of density scales where screening mechanisms fade out, which reaches from a density contrast $\delta \approx -1$ close to their centers to $\delta \approx 0$ close to their boundaries. We present an analysis of the level of distinction between GR and two modified gravity theories, the Hu-Sawicki $f(R)$ and the symmetron theory. This study relies on the abundance, linear bias, and density profile of voids detected in n-body cosmological simulations. We define voids as connected regions made up of the union of spheres with a {\it \textup{mean}} density given by $\overline\rho_v=0.2\,\overline\rho_m$, but disconnected from any other voids. We find that the height of void walls is considerably affected by the gravitational theory, such that it increases for stronger gravity modifications. Finally, we show that at the level of dark matter n-body simulations, our constraints allow us to distinguish between GR and MG models with $|f_{R0}| > 10^{-6}$ and $z_{SSB} > 1$. Differences of best-fit values for MG parameters that are derived independently from multiple void probes may indicate an incorrect MG model. This serves as an important consistency check.Comment: 15 pages, 12 figure

Mycophenolate mofetil versus azathioprine for prevention of acute rejection in renal transplantation (MYSS): a randomised trial.

BACKGROUND: Mycophenolate mofetil has replaced azathioprine in immunosuppression regimens worldwide to prevent graft rejection. However, evidence that its antirejection activity is better than that of azathioprine has been provided only by registration trials with an old formulation of ciclosporin and steroid. We aimed to compare the antirejection activity of these two drugs with a new formulation of ciclosporin. METHODS: The mycophenolate steroids sparing multicentre, prospective, randomised, parallel-group trial compared acute rejections and adverse events in recipients of cadaver-kidney transplants over 6-month treatment with mycophenolate mofetil or azathioprine along with ciclosporin microemulsion (Neoral) and steroids (phase A), and over 15 more months without steroids (phase B). The primary endpoint was occurrence of acute rejection episodes. Analysis was by intention to treat. FINDINGS: 168 patients per group entered phase A. 56 (34%) assigned mycophenolate mofetil and 58 (35%) assigned azathioprine had clinical rejections (risk reduction [RR] on mycophenolate mofetil compared with azathioprine 13.7% [95% CI -25.7% to 40.7%], p=0.44). 88 patients in the mycophenolate mofetil group and 89 in the azathioprine group entered phase B. 14 (16%) taking mycophenolate mofetil and 11 (12%) taking azathioprine had clinical rejections (RR -16.2%, [-157.5% to 47.5%], p=0.71). Average per-patient costs of mycophenolate mofetil treatment greatly exceeded those of azathioprine (phase A 2665 Euros [SD 586] vs Euros 184 [62]; phase B 5095 Euros [2658] vs 322 Euros [170], p<0.0001 for both). INTERPRETATION: In recipients of cadaver kidney-transplants given ciclosporin microemulsion, mycophenolate mofetil offers no advantages over azathioprine in preventing acute rejections and is about 15 times more expensive. Standard immunosuppression regimens for transplantation should perhaps include azathioprine rather than mycophenolate mofetil, at least for kidney graft

Complete Cosmic History with a dynamical Lambda(H) term

In the present mainstream cosmology, matter and spacetime emerged from a singularity and evolved through four distinct periods: early inflation, radiation, dark matter and late-time inflation (driven by dark energy). During the radiation and dark matter dominated stages, the universe is decelerating while the early and late-time inflations are accelerating stages. A possible connection between the accelerating periods remains unknown, and, even more intriguing, the best dark energy candidate powering the present accelerating stage (Lambda-vacuum) is plagued with the cosmological constant and coincidence puzzles. Here we propose an alternative solution for such problems based on a large class of time-dependent vacuum energy density models in the form of power series of the Hubble rate, Lambda=Lambda(H). The proposed class of Lambda(H)-decaying vacuum model provides: i) a new mechanism for inflation (different from the usual inflaton models), (ii) a natural mechanism for a graceful exit, which is universal for the whole class of models; iii) the currently accelerated expansion of the universe, iv) a mild dynamical dark energy at present; and v) a final de Sitter stage. Remarkably, the late-time cosmic expansion history of our class of models is very close to the concordance LambdaCDM model, but above all it furnishes the necessary smooth link between the initial and final de Sitter stages through the radiation- and matter-dominated epochs.Comment: Accepted in Phys. Rev. D. (2013

Complete cosmic history with a dynamical Λ = Λ(H) term

In the present mainstream cosmology, matter and space-time emerged from a singularity and evolved through four distinct periods: early inflation, radiation, dark matter, and late-time inflation (driven by dark energy). During the radiation and dark matter dominated stages, the universe is decelerating while the early and late-time inflations are accelerating stages. A possible connection between the accelerating periods remains unknown, and, even more intriguing, the best dark energy candidate powering the present accelerating stage ( Λ -vacuum) is plagued with the cosmological constant and coincidence puzzles. Here we propose an alternative solution for such problems based on a large class of time-dependent vacuum energy density models in the form of power series of the Hubble rate, Λ = Λ ( H ) . The proposed class of Λ ( H ) -decaying vacuum model provides: (i) a new mechanism for inflation (different from the usual inflaton models), (ii) a natural mechanism for a graceful exit, which is universal for the whole class of models; (iii) the currently accelerated expansion of the universe, (iv) a mild dynamical dark energy at present; and (v) a final de Sitter stage. Remarkably, the late-time cosmic expansion history of our class of models is very close to the concordance Λ CDM model, but above all it furnishes the necessary smooth link between the initial and final de Sitter stages through the radiation- and matter-dominated epochs