Studies of Corrosion Resistance of Passive Layers on Al-Ni Alloys in the Presence of Chloride Ions

The corrosion resistance of passive layers was studied on cast Al-Ni alloys with an ever-increasing mass content of nickel («;(Ni) = 0.54 - 4.30%). The method of potentiodynamic polarization, measuring to 10 V, the method of measuring the changes of the current at a constant potential of 0 V, and the method of determining the critical concentrations of chloride ion gave identical dependence of the corrosive resistance of the passive layers on the mass content of nickel in the alloy. The method of potentiodynamic polarization at low potentials to 1 V was applied to obtain the dependence of insulating properties of the passive layers on the mass content of nickel in alloy

Ispitivanje funkcionalnih i morfoloških poremećaja centralnog nervnog sistema kod bolesnika sa miotoničnom distrofijom tipa 1

Uvod: Miotonična distrofija tipa 1 (MD1) je autozomno-dominantno nasledno oboljenje, koje pored mišića, zahvata mnoga druga tkiva i organe, uključujući i mozak. Zahvaćenost centralnog nervnog sistema (CNS) u MD1 podrazumeva neuropsihološke i bihevioralne poremećaje. Razvoj savremenih neurovizualizacionih tehnika i molekularne medicine omogućava bolje sagledavanje uzroka moždanih poremećaja. Ciljevi: Određivanje neuropsihološkog i bihevioralnog profila bolesnika sa MD1, ispitivanje morfoloških specifičnosti njihovog mozga i analiza nivoa biomarkera neurodegeneracije u likvoru. Materijal i metode: Ispitivano je 66 bolesnika kod kojih je dijagnoza MD1 potvrđena molekularno-genetskom analizom. Stepen mišićne slabosti određivan je prema MIRS (Muscular Impairment Rating Scale). U istraživanju je korišćena opsežna baterija klasičnih neuropsiholoških testova, kao i obiman set kompjuterskih testova iz baterije CANTAB (Cambridge Neuropsychological Test Automated Battery). U studiji su korišćene sledeće skale: Hamiltonove skale za procenu depresije i anksioznosti, Milonov multiaksijalni klinički upitnik (MMCI) za poremećaje ličnosti, DSS skala za merenje prekomerne dnevne pospanosti (PDP) i Kruppova skala za težinu zamora (FSS). Kod bolesnika i 38 zdravih kontrola pregled mozga je obavljen na aparatu za magnetnu rezonanciju (MR) jačine 1,5 T. Na snimcima je određivano ukupno opterećenje hiperintenznim lezijama bele mase (HLBM), zapremina sive mase mozga pomoću morfometrije zasnovane na vokselu (VBM) i analiza puteva bele mase metodom difuzionog tenzorskog imidžinga (DTI). Transkranijalna sonografija mozga (TCS) korišćena je za analizu struktura srednje linije moždanog stabla kod bolesnika i 55 zdravih kontrola. Nivo ukupnog i fosforilisanog tau proteina (T-tau i P-tau) i beta amiloida 42 (Aβ42) u likvoru bolesnika i 26 neurološki zdravih kontrola određivan je metodom sendvič ELISA. Rezultati: Vizuospacijalna disfunkcija je uočena kod 80 %, egzekutivna disfunkcija kod 67 %, a oštećenje jezičke funkcije imenovanja kod 62 % obolelih. Značajna depresivnost je registrovana kod 15 %, anksioznost kod 11 %, PDP kod 44 %, a zamor kod 52 % bolesnika. Klinički značajan poremećaj ličnosti je imalo 60 % obolelih (zavisan tip ličnosti 52 %, a paranoidan 39 %). Lošiji rezultati na pojedinim neuropsihološkim i bihevioralnim testovima bili su u korelaciji sa većim brojem CTG ponovaka (p<0,05). MD1 bolesnici su imali veće opterećenje HLBM u odnosu na zdrave kontrole (0,30 ± 0,80 prema 0,04 ± 0,10; p<0,01)...Background: Myotonic dystrophy type 1 (DM1) is an autosomal dominant disease, that besides muscle affects many other tissues and organs, including the central nervous system. Brain manifestations in DM1 include neuropsychological and behavioral impairment. Development of modern neuroimaging and molecular medicine enables better insight in possible causes of the central nervous system involvement in DM1. Aims: Assessment of neuropsychological and behavioral profile of DM1 patients, structural analysis of their brain and investigation of cerebrospinal fluid biomarkers of neurodegeneration. Material and methods: Study comprised 66 genetically confirmed DM1 patients. Severity of muscle weakness was assessed using the Muscular Impairment Rating Scale (MIRS). Extensive battery of classic pen and pencil tests and Cambridge Neuropsychological Test Automated Battery (CANTAB) were used. Following measures were also administered: Hamilton depression and anxiety scales, Millon Multiaxial Clinical Inventory (MMCI) for personality pattern, Daytime Sleepiness Scale (DSS) and Krupp’s Fatigue Severity Scale (FSS). Magnetic resonance imaging on 1.5 T equipment was performed in patients and 38 healthy controls (HCs). Images were used for analysis of the white matter hyperintense lesions (WMHL) load, grey matter volume using voxel-based morphometry (VBM) and assessment of white matter tracts with diffusion tensor imaging (DTI). Transcranial sonography (TCS) was used for analysis of the brainstem midline structures in patients and 55 HCs. Cerebrospinal fluid levels of total and phosphorylated tau protein (T-tau and P-tau) as well as beta amyloid 42 (Aβ42) were analyzed in patients and 26 HCs using sandwich ELISA. Results: Visuospatial dysfunction was observed in 80 % of DM1 patients, executive dysfunction in 67 % and naming was impaired in 62 %. Significant depressiveness was registered in 15 % and anxiety in 11 % of patients, excessive daytime sleepiness in 44 % and fatigue in 52 %. Clinically significant personality impairment was registered in 60 % of patients (dependent personality in 52 % and paranoid in 39 %). Worse results on certain neuropsychological and behavioral tests correlated with longer CTG expansion (p<0.05). DM1 patients had higher WMHL load compared to HCs (0.30 ± 0.80 vs. 0.04 ± 0.10; p<0.01). VBM showed decrease in grey matter volume in almost all parts of the brain, including cerebral cortex, cerebellum, basal ganglia and thalami (p<0.05)..

ТИПСКИ И АТИПИЧНИ СТАРЦИ СРПСКЕ УСМЕНЕ ЕПИКЕ

The main aim of this paper is to show in which role and how the characters of the old men can appear. This research was conducted on the material of Viennese edition of Vuk`s collections (SNP II–IV), the State Edition (SNP VI– IX), as well as records of Vuk and his associates from the so called manuscript edition (SNPr II–IV).1 Тhe epic stylization оf an old hero was monitored in a diachronic perspective, in consultation of Bogišić`s (Bogišić, 2003) and Pantić`s (Pantić, 2002) collections, and the Erlangen manuscript (ER). The comparativetypological and structural-semiotic methods were functionalized for the purpose of this research. The research shows that the old man in epic emerges in two ways – from a typical to atypical – either as an honorable elder, supreme authority and wise man, i.e. „old wolf“, or as power-hungry weakling, with inappropriate materialistic or sexual appetites – on the negative characterization scale. The different mythical, ritual and social elements, assimilated in the notion of community about a certain historical epoch where the characters are situated in and the procedures of epic stylization build some of the most recognizable figures in Serbian oral poetic gallery which reveal full complexity and „layering structure“ of the epic characters of the old men.Основна намера овога рада јесте да покаже у оквиру којих делокруга и на који начин се реализују ликови епских стараца. Грађу на којој је истраживање спроведено чини лајпцишко издање Вукових збирки (СНП II–IV), чему је придружено Државно издање (СНП VI– IX), као и записи Вука и његових сарадника из тзв. рукописног издања (СНПр II–IV). Праћен је начин епске стилизације старог јунака у дијахроној перспективи, уз консултовање Богишићеве (Богишић, 2003) и Пантићеве збирке (Пантић, 2002), као Ерлангенског рукописа (ЕР). За потребе рада функционализоване су компаративно-типолошка и структурално-семиотичка метода. Исходи истраживања показују да се епски старац реализује двојако – од типског до атипичног – или као часна старина, врховни ауторитет и мудрац, односно „стари вук“, или на скали негативне карактеризације – као властољубиви слабић, с непримереним материјалним или сексуалним апетитима. Сложеност и слојевитост епских стараца показују и различити митски, обредни и социјални елементи, који, саображени представи колектива о датој историјској епоси у коју се дати ликови ситуирају, као и поступцима епске стилизације, граде неке од најпрепознатљивијих фигура српске усменопоетске галерије

Tempering/ageing in region 50 – 600 °C of quenched and cold deformed 585 GOLD alloy for jewelry production

Numerous gold alloys posses the ability for thermal hardening, and this property is attractive for improving jewels strength, because the most noble alloys are weak. The thermal treating below the recrystallization temperature, is kind of tempering but also age-hardening. In this paper is made an attempt for studying the possibility for thermal hardening of 585 golden alloy. The goal is to increase the mechanical properties. Those demands could be reached by metallurgical controlling of phase transformations аnd proper thermal treating. Here is studied behavior of quenched and cold deformed gold alloy 585 after tempering/ageing in temperature region 50 - 600 °C, in intervals of 50 °C. The highest hardness values are obtained at temperatures about 200 °C for both initial states

MAGE-A3/4 and NY-ESO-1 antigens expression in metastatic esophageal squamous cell carcinoma

In the present study we analyzed immunohistochemical expression of MAGE-A 3/4 and NY-ESO-1 in 55 samples of esophageal squamous cell carcinomas (ESCC) and their respective lymph node metastases. To our knowledge this is the first study to assess and compare the expression of these antigens in ESCC lymph node metastases

Survey of the family Russulaceae (Agaricomycetes, Fungi) in Montenegro

The paper shows that there are 84 known species of the family Russulaceae in Montenegro, 39 of them belonging to the genus Lactarius and 45 to the genus Russula

Influence of a trout farm on antioxidant defense in larvae of Ephemera danica (Insecta: Ephemeroptera)

The aim of this study was to establish the influence of a trout farm on the activity of enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPx), and total glutathione concentration (GSH), in larvae of Ephemera danica, and on environmental parameters in the receiving watercourse. The investigations were carried out seasonally (April, July, and October of 2016 and January of 2017) at four localities (SK1 - control, and SK2, SK3, and SK4 - 30 m, 330 m and 630 m below the fish farm, respectively) along the Skrapez River. Discharged water had the greatest effect on the concentrations of dissolved oxygen (DO), ammonium ions, nitrates (NO3-), and total phosphorus. In the case of SOD and GSH, seasonal changes were greater than longitudinal, with maximal values attained in spring and summer and minimal in autumn and winter. SOD showed the strongest correlation with DO, and GSH with total nitrogen. Activity of GPx demonstrated greater longitudinal variability with maximum at SK2 in all seasons and the strongest correlation with NO3-. The obtained results indicate that GPx activity was the most sensitive to the trout farm effects, while SOD and GSH were more influenced by natural seasonal changes of environmental parameters