Simulación con Monte Carlo para dosimetría de 153Samario-HM en un modelo anatómico geométrico de rodilla humana

El 153Sm-hm es una nueva opción para realizar sinovectomía por radiación, que actualmente se encuentra en valoración. Este trabajo tiene como objetivo calcular la dosis absorbida en tejidos articulares proporcionada por la administración de 153Sm-hm intraarticular, utilizando la simulación de Monte Carlo, en una propuesta de un modelo simplificado anatómico geométrico de la articulación de la rodilla. Esto con el propósito de aportar datos que apoyen la administración segura y eficaz del radiofármaco en estudio a pacientes con enfermedad reumática de la articulación de la rodilla. Se concluye que la actividad administrada de 153Sm-hm por vía intra-articular es de 370 MBq para conseguir una dosis absorbida en membrana sinovial de 110 Gy, considerada como la dosis de ablación de la mencionada membrana

Preliminary clinical experience of the systemic use of 153Sm-EDTMP as a pain palliation agent in arthrosis and as an option for bone scanning in patients with bone metastases

Introducción: Muchos pacientes con artrosis tienen efectos secundarios producidos por los tratamientos convencionales. Estos pacientes son candidatos para tratamiento paliativo del dolor con 153Sm-EDTMP. Los pacientes con metástasis ósea, por lo general, requieren un rastreo utilizando ‘Tc-MDP, antes del tratamiento paliativo con 3Sm-EDTMP. Este trabajo tiene 2 objetivos: 1) evaluar el uso de 153Sm-EDTMP como alternativa en Los procedimientos de rastreo óseo en pacientes con metástasis ósea y, 2) si el 153Sm-EDTMP es captado en la articulación lesionada con artrosis, entonces se evalúa el uso eficiente y seguro de la administración sistémica de este radiofármaco, para Ia paliación del dolor por artrosis. Métodos y materiales: Una muestra no probabilística, de oportunidad y secuencial de 10 pacientes con artrosis fue seleccionada, así como, un paciente con metástasis ósea secundaria a cáncer de próstata. En Los 11 pacientes se realizaron gammagrafias óseas con Los radiofármacos “Tc-MDP y ls3mEDTMP, para comparar [a calidad de imagen y sitios de captación. En los pacientes con artrosis se administró por vía sistémica una dosis terapéutica de ‘Sm-EDTMP para la paliación del dolor. Se realizaron perfiles hematológicos con el fin de garantizar La seguridad de la médula ósea. La evolución del dolor y de la motilidad se utilizó para evaluar La eficacia analgésica 3Sm-EDTMR Resultados y conclusión: La calidad de imagen obtenida en Los 11 pacientes con ‘3Snì-EDTMP es similar desde el punto de vista clínico, a Ias obtenidas con ‘“Tc-MDR EL 3Sm-EDTMP es captado por las articulaciones con artrosis y metástasis óseas. La dosis terapéutica de 1’Sm-EDTMP administrada por vía intravenosa fue bien tolerada por Ia médula ósea en todos Los pacientes, así como hubo un efecto analgésico, por lo que mejoró la motilidad y la calidad de vida en los pacientes con artrosis.Introduction: Many patients with arthrosis have side effects produced by conventional treatments. These patients are candidates for pain palliation with 153Sm-EDTMP. Patients with cancer bone metastases usuaLly require a bone scanning procedure using ““Tc-MDP, prior to treatment through 153Sm-EDTMP. This work has two aims. Firstly, to assess the use of 153Sm- EDTMP as an alternative in bone scanning procedures in patients with bones metastases. Se condly, if the 153Sm-EDTMP is uptaken by the arthrosis injured joint, then the efficient and safe use of the systemic administration of this radiopharmaceutical is evaluated for pain palliation. Methods and materials: A non-probabilistic, of opportunity and sequential sample of 10 patients with arthrosis was selected, as well as, one patient with bone metastasis secondary to prostate cancer. In the li patients, bone scans were performed using both radiopharmaceuticals “‘T1Tc- MDP and 153Sm-EDTMP to compare image quality and uptake sites. In patients with arthrosis a therapeutic dose with ‘53Sm-EDTMP was systemically administered for pain palliation. Hemato logic profiles were performed in order to assure security to the bone marrow. Pain and motility evaluations were carried out to assess the Sm-EDTMP analgesic efficacy. Results and conclusion: The Image qualities obtained with 13Sm-EDTMP are similar from the cLinical point of view to those obtained with ““Tc-MDR Sm-EDTMP is captured by joints with arthrosis and bone metastases. Therapeutic doses of 1Sm-EDTMP intravenously administered are well tolerated by the bone marrow, while an analgesic effect is present which improves motility and quality of Life in patients with arthrosis

Catalytic feasibility of Ce-doped LaCoO3 systems for chlorobenzene oxidation: An analysis of synthesis method

A family of Ce-doped LaCoO3 perovskites are presented as possible catalysts for Cl–VOCs elimination. These materials with different contents of Ce were obtained through the citrate and the reactive grinding methods. The insertion of Ce in the original perovskite structure favours the presence of Co2+/Co3+ and Ce3+/Ce4+ redox pairs and a higher content of oxygen vacancies that enhances the catalytic performance in chlorobenzene combustion based on differential kinetics studies. The family obtained by the grinding method presents a performance as high as that synthesized by citrate method. Thus, the reactive grinding is a feasible green chemistry alternative to obtain a catalyst with the same performance as that obtained from traditional methods. Finally, the stability of samples was evaluated under total combustion reaction conditions showing an excellent activity during 45 h time on stream.Fil: Acosta Perez, Hector. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Investigaciones en Tecnología Química. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Investigaciones en Tecnología Química; ArgentinaFil: Lopez, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Investigaciones en Tecnología Química. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Investigaciones en Tecnología Química; ArgentinaFil: Cadus, Luis Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Investigaciones en Tecnología Química. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Investigaciones en Tecnología Química; ArgentinaFil: Aguero, Fabiola Nerina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Investigaciones en Tecnología Química. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Investigaciones en Tecnología Química; Argentin

Exploración posturográfica de pacientes simuladores

Introduction: An aphysiological pattern in computerized dynamic posturography (CDP) may be produced by numerous causes. We analyze the results obtained in this test by a group of malingering patients. Patients and method: This study analyzes a particular group of 7 malingerers, ie patients simulating a false and unreal equilibrium disorder, without any a priori awareness of the gain expected from a pathological report. The condition can only be identified with the very complex postural disorder known as “continuous imbalance.” We analyze the results of the dynamic posturography test following the diagnostic criteria described by other authors. Results: Of the criteria analyzed, we found Cevette’s to be the most frequently positive for our study group. Conclusions: The wide diversity in the criteria used makes it necessary to apply them together, assuming a high level of suspicion and great care in the diagnostic process

The acute effect of match-play on hip range of motion and isometric strength in elite tennis players

Background: Groin injuries are some of the most common injuries tennis players suffer. Several factors (e.g., post-match decrease in hip adductor (ADD) strength) have been proposed as possible mechanisms for increasing the incidence of this type of injury. However, the risk factors of developing groin injuries after a tennis match have not yet been delineated. Objective: The aim of this study was to determine the effect of tennis match-play on isometric ADD and abductor (ABD) strength and passive hip range of motion (ROM). Methods: Twenty-six male tennis players (20.30 +/- 4.98 years) took part in this study. Participants completed an evaluation of strength and flexibility hip measurements before and after a simulated tennis match. Dominant and non-dominant passive hip ROM, ADD and ABD isometric strength, and the ADD/ABD strength ratio were measured before and immediately post-match. A global positioning system (GPS) and a session rating of perceived exertion (RPE) were used to assess the locomotive demands and internal match load. Results: Isometric dominant ADD strength (17.8%, p <= 0.01) and ADD/ABD strength ratio (11.6%, p = 0.04) were lower post-match compared to the pre-match values. No between-limbs differences were observed for isometric ADD strength, ABD strength, and passive hip ROM tests. RPE showed an expected increase between pre- vs. post-match (pre- vs. post-warming-up, 3.42 +/- 2.08 vs. 5.62 +/- 2.29, p < 0.01). In addition, a significant relationship between ADD strength and the volume of tennis practice per week was found, stablishing that tennis players with lower volume of training per week suffered a reduction in ADD strength in their dominant limb after match-play (r = 0.420, p = 0.04). Conclusion: The assessment of ADD strength and the ADD/ABD strength ratio in the dominant limb may be considered a post-match tool that can be used to identify players who require rest and additional recovery strategies before competing again

Immunomodulation induced by synthetic peptides derived from Staphylococcus aureus protein A

Peptides from 10 to 22 amino acids containing sequences encompassed by Staphylococcus aureus protein A were synthesized. Some of these peptides, when present in cultures of lymphomononuclear cells from healthy donors or from cancer patients (melanoma, breast carcinoma, non-Hodgkin lymphoma and renal cell carcinoma) promoted: (i) changes in the phenotype of the lymphomononuclear population, (ii) stimulation of monocytes (release of IL-1 and TNF-alpha), and (iii) an increase in cytotoxicity against K562, Daudi and HT-29 cells. Isolated monocytes responded also to those peptides with a release of IL-1 and TNF alpha and an increase of cytotoxicity against HT-29 cells. It was found that the active peptides had the following structural pattern: a length of at least 15 amino-acid residues with a proline at position 6, valine, leucine, isoleucine, glycine, alanine or lysine at position 2, and glutamic or aspartic acid at position 11. Replacement of Pro at position 6 with any other residue turned the peptide inactive. Replacement of residues at positions 2 and 11 with amino-acid residues other than those required for activity resulted in compounds with a marked decrease in the immunomodulating properties described, or lacking these properties altogether

Inducible nitric oxide synthase in human lymphomononuclear cells activated by synthetic peptides derived from extracellular matrix proteins.

Synthetic peptides with sequences present in extracellular matrix proteins are capable of causing the expression of the inducible form of nitric oxide synthase (iNOS), detected by immunocytochemistry, and the release of NO by human lymphomononuclear cells incubated in their presence. Active peptides are 15-mers containing a characteristic 2-6-11 motif in which the amino acid residue at position 2 is Leu, Ile, Val, Gly, Ala or Lys; the residue at position 6 is always Pro; and residue 11 is Glu or Asp. The induction of iNOS in human monocytes and macrophages could be involved in the cytotoxicity against tumor cell lines also elicited by these peptides

Analysis of acoustic noise spectrum of domestic induction heating systems controlled by phase-accumulator modulators

In domestic induction heating (IH) applications, the modulation technique applied to the inverter has a high influence on the acoustic noise emissions. These noise emissions must be avoided since they may be audible and annoying to the final user. This paper analyzes the acoustic noise emissions that appear when a series half-bridge resonant inverter is operated with a phase-accumulator based modulator. This modulation technique has the advantage of operating in the frequency domain, and it is compared with the classical PWM modulator regarding the audible noise generated. The frequencies of the tones in the acoustic noise spectrum are theoretically calculated from the parameters of the phaseaccumulator based modulator. The SFM (Spectral Flatness Measure) is used to quantify the number of cases in which tones are generated by the modulation. Two techniques are applied to the phase-accumulator based modulator and their effect is tested. Theoretical results are experimentally verified