14,168 research outputs found
Microduplication 10q24.31 in a Spanish girl with scoliosis and myopathy:the critical role of LBX
Temblor ortostático como causa de inestabilidad
Orthostatic tremor (OT) is a neurological disease of unknown aetiology. It is defined
by the presence of a 10-20 Hz tremor in the legs while standing still. Symptoms described are
dizziness and instability that diminish if the patient sits down or leans on something; drinking
small amounts of alcohol significantly reduces OT. Due to the dizziness and/or unsteadiness,
these patients are usually referred to the neuro-otology department. We report 4 cases diagnosed
with OT. The diagnosis of OT should be considered for patients with instability. The
clinical history is a key factor to suspect this entity, and the diagnosis is given by the register of
10-20 Hz contractions on limb electromyography. Treatment for this disease consists of medical
treatment; the first option is clonazepam.
© 2011 Elsevier España, S.L. All rights reserved
Resolving galaxies in time and space: II: Uncertainties in the spectral synthesis of datacubes
In a companion paper we have presented many products derived from the
application of the spectral synthesis code STARLIGHT to datacubes from the
CALIFA survey, including 2D maps of stellar population properties and 1D
averages in the temporal and spatial dimensions. Here we evaluate the
uncertainties in these products. Uncertainties due to noise and spectral shape
calibration errors and to the synthesis method are investigated by means of a
suite of simulations based on 1638 CALIFA spectra for NGC 2916, with
perturbations amplitudes gauged in terms of the expected errors. A separate
study was conducted to assess uncertainties related to the choice of
evolutionary synthesis models. We compare results obtained with the Bruzual &
Charlot models, a preliminary update of them, and a combination of spectra
derived from the Granada and MILES models. About 100k CALIFA spectra are used
in this comparison.
Noise and shape-related errors at the level expected for CALIFA propagate to
0.10-0.15 dex uncertainties in stellar masses, mean ages and metallicities.
Uncertainties in A_V increase from 0.06 mag in the case of random noise to 0.16
mag for shape errors. Higher order products such as SFHs are more uncertain,
but still relatively stable. Due to the large number statistics of datacubes,
spatial averaging reduces uncertainties while preserving information on the
history and structure of stellar populations. Radial profiles of global
properties, as well as SFHs averaged over different regions are much more
stable than for individual spaxels. Uncertainties related to the choice of base
models are larger than those associated with data and method. Differences in
mean age, mass and metallicity are ~ 0.15 to 0.25 dex, and 0.1 mag in A_V.
Spectral residuals are ~ 1% on average, but with systematic features of up to
4%. The origin of these features is discussed. (Abridged)Comment: A&A, accepte
Microgrids Views From a Geographic Information System
Currently, Ecuador advocates a change in the energy matrix, academic centers should develop a strategy that allows them to short and medium-term training specialists give technical responses to this proposal it must create the conditions in college so that future generations be able to link the processes of investment in energy with the territorial space. The Technical University of ManabĂ (UTM) has proposed a research project funded by the National Secretary of Planning and Development of Ecuador (Senplades), aimed at boosting sustainable energy solutions that are based on the technical philosophy of microgrids with the use of renewable energy sources (RES). In this paper the spatial information related to solar energy potential of the province of ManabĂ, Ecuador\u27s, managed by a geographic information system (GIS) as an integration tool that provides information on objectives that interact with microgrids shown, also the importance of its use as a management tool projects related to the use of RES and instrumentation aimed at ensuring innovative solutions to support the change of energy matrix from a territorial perspective is exposed
Histopathological reaction in the vestibule after cochlear implantation in Macaca fascicularis.
Cochlear implantation surgery (CI) is considered a safe procedure and is the standard treatment for the auditory
rehabilitation in patients with severe-to-profound sensorineural hearing loss. Although the development of
minimally traumatic surgical concepts (MTSC) have enabled the preservation of residual hearing after the implantation, there is scarce literature regarding the vestibular affection following MTCS.
The aim of the study is to analyze histopathologic changes in the vestibule after CI in an animal model (Macaca
fascicularis). Cochlear implantation was performed successfully in 14 ears following MTCS. They were classified
in two groups upon type of electrode array used. Group A (n = 6) with a FLEX 28 electrode array and Group B (n
= 8) with HL14 array. A 6-month follow-up was carried out with periodic objective auditory testing. After their
sacrifice, histological processing and subsequent analysis was carried out. Intracochlear findings, vestibular
presence of fibrosis, obliteration or collapse is analyzed. Saccule and utricle dimensions and neuroepithelium
width is measured.
Cochlear implantation was performed successfully in all 14 ears through a round window approach. Mean
angle of insertion was >270◦ for group A and 180–270◦ for group B. In group A auditory deterioration was
observed in Mf 1A, Mf2A and Mf5A with histopathological signs of scala tympani ossification, saccule collapse
(Mf1A and Mf2A) and cochlear aqueduct obliteration (Mf5A). Besides, signs of endolymphatic sinus dilatation
was seen for Mf2B and Mf5A. Regarding group B, no auditory deterioration was observed. Histopathological
signs of endolymphatic sinus dilatation were seen in Mf 2B and Mf 8B.
In conclusion, the risk of histological damage of the vestibular organs following minimally traumatic surgical
concepts and the soft surgery principles is very low. CI surgery is a safe procedure and it can be done preserving
the vestibular structures
CHK1 expression in gastric cancer is modulated by p53 and RB1/E2F1: Implications in chemo/radiotherapy response
Radiation has a limited but relevant role in the adjuvant therapy of gastric cancer (GC) patients. Since Chk1 plays a critical function in cellular response to genotoxic agents, we aimed to analyze the role of Chk1 in GC as a biomarker for radiotherapy resistance. We analyzed Chk1 expression in AGS and MKN45 human GC cell lines by RT-QPCR and WB and in a small cohort of human patient’s samples. We demonstrated that Chk1 overexpression specifically increases resistance to radiation in GC cells. Accordingly, abrogation of Chk1 activity with UCN-01 and its expression with shChk1 increased sensitivity to bleomycin and radiation. Furthermore, when we assessed Chk1 expression in human samples, we found a correlation between nuclear Chk1 accumulation and a decrease in progression free survival. Moreover, using a luciferase assay we found that Chk1’s expression is controlled by p53 and RB/E2F1 at the transcriptional level. Additionally, we present preliminary data suggesting a posttranscriptional regulation mechanism, involving miR-195 and miR-503, which are inversely correlated with expression of Chk1 in radioresistant cells. In conclusion, Chk1/microRNA axis is involved in resistance to radiation in GC, and suggests Chk1 as a potential tool for optimal stratification of patients susceptible to receive adjuvant radiotherapy after surgeryThis work was supported by Instituto de Salud Carlos III–Fondo de Investigación Sanitaria (PS09/1988 to ISP; PI11-00949, pI014-1495 and Feder Funds to RP); Comunidad Autónoma de Madrid-Universidad Autónoma de Madrid (CCG10-UAM/BIO-5871 to ISP); Fundación Leticia Castillejo Castillo and Ministerio de Ciencia e Innovación (SAF2012-30862 to RSP), Spain
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