Combining offshore wind and solar photovoltaic energy to stabilize energy supply under climate change scenarios: A case study on the western Iberian Peninsula

La expansión de la energía renovable marina es una importante alternativa para la reducción de las emisiones de gases de efecto invernadero. Sin embargo, en Europa, la alta penetración de la energía eólica marina introduce intermitencia y variabilidad de energía en la red eléctrica existente. La energía solar fotovoltaica marina es otra alternativa tecnológica en consideración en los planes de descarbonización. Sin embargo, las futuras variaciones en el viento, la temperatura del aire o la radiación solar debido al cambio climático tendrán un gran impacto en los recursos de energía renovable. En este contexto, este estudio se centra en la evaluación de la energía marina en la costa de la Península Ibérica occidental, una región europea que abarca Portugal y la parte noroccidental de España. Utilizando una amplia fuente de datos de 35 simulaciones de un proyecto de investigación llamado CORDEX, este estudio investiga la complementariedad de las fuentes de energía eólica y solar marina con el objetivo de mejorar la estabilidad del suministro de energía de esta región hasta 2040. Aunque se ha demostrado que el recurso de energía eólica marina es mayor que el recurso fotovoltaico solar a escala anual, ambos recursos renovables mostraron una variabilidad significativa en energía a lo largo de la Península Ibérica occidental. Cuando se combinan ambas fuentes renovables, la estabilidad del recurso energético aumenta considerablemente a lo largo del año. El esquema propuesto de combinación de energía eólica y solar se evalúa mediante un método de clasificación de rendimiento llamado Delphi, teniendo en cuenta la estabilidad, el recurso, el riesgo y los factores económicos. El índice de clasificación total aumenta cuando la estabilidad del recurso se mejora mediante la consideración de la producción híbrida de energía eólica-fotovoltaica solar, especialmente a lo largo de las aguas cercanas a la costa.The expansion of marine renewable power is a major alternative for the reduction of greenhouse gases emissions. In Europe, however, the high penetration of offshore wind brings intermittency and power variability into the existing power grid. Offshore solar photovoltaic power is another technological alternative under consideration in the plans for decarbonization. However, future variations in wind, air temperature or solar radiation due to climate change will have a great impact on both renewable energy resources. In this context, this study focusses on the offshore energy assessment off the coast of Western Iberia, a European region encompassing Portugal and the Northwestern part of Spain. Making use of a vast source of data from 35 simulations of a research project called CORDEX, this study investigates the complementarity of offshore wind and solar energy sources with the aim of improving the energy supply stability of this region up to 2040. Although the offshore wind energy resource has proven to be higher than solar photovoltaic resource at annual scale, both renewable resources showed significant spatiotemporal energy variability throughout the western Iberian Peninsula. When both renewable resources are combined, the stability of the energy resource increased considerably throughout the year. The proposed wind and solar combination scheme is assessed by a performance classification method called Delphi, considering stability, resource, risk, and economic factors. The total index classification increases when resource stability is improved by considering hybrid offshore wind-photovoltaic solar energy production, especially along the nearshore waters.Ministerio de Economía, Industria y Competitividad | Ref. FJCI-2017-32577Agencia Estatal de Investigación | Ref. PID2020-113245RB-I00Fundação para a Ciência e a Tecnologia | Ref. UIDB/50017/2020Fundação para a Ciência e a Tecnologia | Ref. UIDP/50017/2020Xunta de Galicia | Ref. ED431C 2021/4

Suitability of wave energy converters in northwestern Spain under the near future winter wave climate

Marine renewable energies can play a key role by reducing the dependency on fossil fuels and, therefore, mitigating climate change. Among them, it is expected that wave energy will experience rapid growth in the upcoming decades. Thus, it is important to know how wave climate will change and how suitable the wave energy converters (WECs) will be to the new wave conditions. This paper aims to evaluate the capability of four different WECs—a WaveRoller type device (WRTD), Atargis, AquaBuoy and RM5—to extract wave energy on the Northwest coast of Spain (NWCS). The analysis was performed using the high-resolution wave data obtained from the Simulating Waves Nearshore (SWAN) model over the near future winters (2026–2045). The energy output (PE), the power load factor (ε), the normalized capture width (NCw) and the operational time (OT) were analyzed. According to these parameters, among the devices that work for intermediate-deep waters, Atargis would be the best option (PE=1400 ± 56 kW, ε =55.4 ± 2.2%, NCw=35.5 ± 4.1% and OT =84.5 ± 3.3%). The WRTD would also be a good option for shallow nearshore areas with PE=427 ± 248 kW, ε =12.8 ± 7.4%, NCw = 48.9 ± 9.6% and OT = 88.7 ± 18.9%. A combination of Atargis and WRTDs is proposed to make up the future wave energy farms on the NWCS.Xunta de Galicia | Ref. ED431C 2021/44Ministerio de Ciencia e Innovación | Ref. PID2020-113245RB-I00Agencia Estatal de Investigación | Ref. TED2021-129479A-100Ministerio de Ciencia e Innovación | Ref. IJC2020-043745-IAgencia Estatal de Investigación | Ref. PRE2021-097580Universidade de Vigo/CISU

Different approaches to analyze the impact of future climate change on the exploitation of wave energy

The increment of the share of renewable energies in the global mix implies that all renewable energies must be exploited. In this sense, it is necessary to make significant research and investment effort in the particular case of wave energy to reach the degree of maturity of other marine energies in the near future. Apart from the inherent factors that hinder the development of wave energy, such as the non-existence of a market-leading type of capturing device, uncertainties about the available future resource also hamper its growth. In this article, a review of the procedures followed in the literature to deal with the future wave energy resources and their subsequent exploitation is described. These procedures include the evaluation of the best future atmospheric models to drive wave models, the different downscaling techniques to evaluate the resource in large regions with high spatial resolution, and the analysis of the variability of the future energy resource and its future exploitability in a certain region taking into account different types of devices. Additionally, the current state of the art of previous studies dealing with future wave energy resources for different locations worldwide is described. Despite the difficulties involved in studying future wave energy resources, the high technological readiness level of the offshore wind industry, the creation of power generation farms with combined technologies, and the growth of marine aquaculture in the coming years could generate synergies that provide the definitive impulse to achieve the necessary technological development.Agencia Estatal de Investigación | Ref. PID2020‐113245RB‐I00Agencia Estatal de Investigación | Ref. TED2021-129479A-I00Xunta de Galicia | Ref. ED431C 2021/44Agencia Estatal de Investigación | Ref. IJC2020-043745-IAgencia Estatal de Investigación | Ref. PRE2021-097580European Cooperation in Science and TechnologyUniversidade de Vigo/CISU

Evaluating the economic viability of near-future wave energy development along the Galician coast using LCoE analysis for multiple wave energy devices

The economic profitability of future wave energy production along the Galician coast is assessed by analyzing the Levelized Cost of Energy (LCoE) under different Capital Expenditure (CapEx) scenarios and two discounts rates (5% and 10%). Wave resources for the near future under the RCP8.5 scenario are downscaled using SWAN, providing up to 75 m spatial resolution in coastal areas. The study’s goal is to enhance the cost-effectiveness by selecting the most suitable wave energy converter (WEC) for each location. Fourteen WECs operating at different depths are considered. This analysis reveals that the Atargis device boasts the lowest LCoE for 64.2% of the coastal area, mainly in deep waters, with an LCoE of 77 €/MWh. In addition, the Oyster and Wave Dragon devices exhibit the lowest LCoE for 12.4% and 15.0% of the coastal area, respectively, excelling in shallow waters and near the coast, with values of 50 €/MWh and 97 €/MWh. These findings demonstrate the profitability of wave energy production along the Galician coast, even when considering a more conservative CapEx of 3 M€/MW, resulting in a cost of 140 €/MWh. This conclusion takes into account the evolving electricity prices in Spain, which reached 0.2068 €/kWh in the second half of 2023Xunta de Galicia | Ref. ED431C 2021/44Agencia Estatal de Investigación | Ref. PID2020-113245RB-I00Agencia Estatal de Investigación | Ref. TED2021-129479A-100Agencia Estatal de Investigación | Ref. IJC2020-043745-IEuropean Cooperation in Science & Technology | Ref. COST Action CA17105 WECANetUniversidade de Vigo/CISU

Photovoltaic power resource at the Atacama Desert under climate change

The Atacama desert is a region with exceptional conditions for solar power production. However, despite its relevance, the impact of climate change on this resource in this region has barely been studied. Here, we use regional climate models to explore how climate change will affect the photovoltaic solar power resource per square meter ( ) in Atacama. Models project average reductions in of 1.5% and 1.7% under an RCP8.5 scenario, respectively, for 2021-2040 and 2041-2060. Under RCP2.6 and the same periods, reductions range between 1.2% and 0.5%. Also, we study the contribution to future changes in of the downwelling shortwave radiation, air temperature and wind velocity. We find that the contribution from changes in wind velocity is negligible. Future changes of downwelling shortwave radiation, under the RCP8.5 scenario, cause up to 87% of the decrease of for 2021-2040 and 84% for 2041-2060. Rising temperatures due to climate change are responsible for drops in ranging between 13%–19% under RCP2.6 and 14%–16% under RCP8.5.Xunta de Galicia | Ref. ED431C 2021/44Universidad de Vigo/CISUGMinisterio de Ciencia e Innovación | Ref. IJC2020-043745-IMinisterio de Universidade

The multikinase inhibitor EC‐70124 synergistically increased the antitumor activity of doxorubicin in sarcomas

Cytotoxic drugs like doxorubicin remain as the most utilized agents in sarcoma treatment. However, advanced sarcomas are often resistant, thus stressing the need for new therapies aimed to overcome this resistance. Multikinase inhibitors provide an efficient way to target several pro-tumorigenic pathways using a single agent and may constitute a valuable strategy in the treatment of sarcomas, which frequently show an aberrant activation of pro-tumoral kinases. Therefore, we studied the antitumor activity of EC-70124, an indolocarbazole analog that have demonstrated a robust ability to inhibit a wide range of pro-survival kinases. Evaluation of the phospho-kinase profile in cell-of-origin sarcoma models and/or sarcoma primary cell lines evidenced that PI3K/AKT/mTOR, JAK/STAT or SRC were among the most highly activated pathways. In striking contrast with the structurally related drug midostaurin, EC-70124 efficiently prevented the phosphorylation of these targets and robustly inhibited proliferation through a mechanism associated to the induction of DNA damage, cell cycle arrest and apoptosis. In addition, EC-70124 was able to partially reduce tumor growth in vivo. Importantly, this compound inhibited the expression and activity of ABC efflux pumps involved in drug resistance. In line with this ability, we found that the combined treatment of EC-70124 with doxorubicin resulted in a synergistic cytotoxic effect in vitro and an increased antitumor activity of this cytotoxic drug in vivo. Altogether, these results uncover the capability of the novel multikinase inhibitor EC-70124 to counteract drug resistance in sarcoma and highlight its therapeutic potential when combined with current treatmentsPeer ReviewedPostprint (author's final draft

Qué necesitan los estudiantes de Periodismo para su inserción laboral. Análisis de la demanda del mercado laboral de las empresas de comunicación.

PIMCD nº 176, realizado por el grupo Research and Learning of Media and Communications Management. Investigación y Enseñanza de la Gestión de los Medios y la Comunicación (MediaCom UCM) www.ccinf.es/mediacom/Primera fase de trabajo para fijar descriptores que identifiquen comportamientos formativos de entrada en el mercado laboral. En esta fase se han encontrado 442 oferentes de contratos en prácticas para estudiantes de Periodismo. Los datos obtenidos se articulan de acuerdo a dos subsecciones: sectores empresariales y empresas; a su vez, cada subsector, atendiendo al índice de recepción de alumnos y la descripción cualitativa de los puestos.Depto. de Periodismo y Comunicación GlobalFac. de Ciencias de la InformaciónFALSEsubmitte

Shoc2/Sur8 Protein Regulates Neurite Outgrowth

The Shoc2 protein has been implicated in the positive regulation of the Ras-ERK pathway by increasing the functional binding interaction between Ras and Raf, leading to increased ERK activity. Here we found that Shoc2 overexpression induced sustained ERK phosphorylation, notably in the case of EGF stimulation, and Shoc2 knockdown inhibited ERK activation. We demonstrate that ectopic overexpression of human Shoc2 in PC12 cells significantly promotes neurite extension in the presence of EGF, a stimulus that induces proliferation rather than differentiation in these cells. Finally, Shoc2 depletion reduces both NGF-induced neurite outgrowth and ERK activation in PC12 cells. Our data indicate that Shoc2 is essential to modulate the Ras-ERK signaling outcome in cell differentiation processes involved in neurite outgrowth.This work was supported by FIS grant (PI10/00815) to JLO; CIBERNED to MC; SAF2008-01951, Comunidad Autónoma de Madrid (CAM) S-SAL-0202-2006-01 and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED) to TI; FIS grant PI12/00775 and ISCIII-RETIC (Red Temática de Investigación Cooperativa en Cáncer) RD12/0036/0027 from the Instituto de Salud Carlos III to PSG; and FIS grants (PI09/0562 and PI13/00703), ISCIII-RETIC (RD06/0020/0003 and RD12/0036/0021), and the Spanish Association Against Cancer (AECC) to JMR. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.S

A correlative biomarker study and integrative prognostic model in chemotherapy-naïve metastatic castration-resistant prostate cancer treated with enzalutamide

There is a considerable need to incorporate biomarkers of resistance to new antiandrogen agents in the management of castration-resistant prostate cancer (CRPC). We conducted a phase II trial of enzalutamide in first-line chemo-naïve asymptomatic or minimally symptomatic mCRPC and analyzed the prognostic value of TMPRSS2-ERG and other biomarkers, including circulating tumor cells (CTCs), androgen receptor splice variant (AR-V7) in CTCs and plasma Androgen Receptor copy number gain (AR-gain). These biomarkers were correlated with treatment response and survival outcomes and developed a clinical-molecular prognostic model using penalized cox-proportional hazard model. This model was validated in an independent cohort. Ninety-eight patients were included. TMPRSS2-ERG fusion gene was detected in 32 patients with no differences observed in efficacy outcomes. CTC detection was associated with worse outcome and AR-V7 in CTCs was associated with increased rate of progression as best response. Plasma AR gain was strongly associated with an adverse outcome, with worse median prostate specific antigen (PSA)-PFS (4.2 vs. 14.7 m; p < 0.0001), rad-PFS (4.5 vs. 27.6 m; p < 0.0001), and OS (12.7 vs. 38.1 m; p < 0.0001). The clinical prognostic model developed in PREVAIL was validated (C-Index 0.70) and the addition of plasma AR (C-Index 0.79; p < 0.001) increased its prognostic ability. We generated a parsimonious model including alkaline phosphatase (ALP); PSA and AR gain (C-index 0.78) that was validated in an independent cohort. TMPRSS2-ERG detection did not correlate with differential activity of enzalutamide in first-line mCRPC. However, we observed that CTCs and plasma AR gain were the most relevant biomarkers