The Impact of Stiffness in Bimanual Versus Dyadic Interactions Requiring Force Exchange.

During daily activities, humans routinely manipulate objects bimanually or with the help of a partner. This work explored how bimanual and dyadic coordination modes are impacted by the object's stiffness, which conditions inter-limb haptic communication. For this, we recruited twenty healthy participants who performed a virtual task inspired by object handling, where we looked at the initiation of force exchange and its continued maintenance while tracking. Our findings suggest that while individuals and dyads displayed different motor behaviours, which may stem from the dyad's need to estimate their partner's actions, they exhibited similar tracking accuracy. For both coordination modes, increased stiffness resulted in better tracking accuracy and more correlated motions, but required a larger effort through increased average torque. These results suggest that stiffness may be a key consideration in applications such as rehabilitation, where bimanual or external physical assistance is often provided

Environmental assessment of a new building envelope material derived from urban agriculture wastes: the case of the tomato plants stems

Purpose: Decarbonizing cities is one of today biggest challenges. In this regard, particular attention has been paid on improving the environmental performance of buildings. In this framework, this work consists in assessing the environmental impact of an innovative building envelope component derived from urban agriculture (UA) wastes. In fact, rooftop UA seems to be a possible solution to the rising food demand due to increasing urban demographic growth. Consequently, rooftop UA wastes need to be treated in sustainable ways. Methods: This study aims to determine the carbon footprint and embodied energy of a new infill wall material, derived from UA wastes produced by a building rooftop greenhouse tomato crop, and evaluate the potential biogenic carbon that such by-product could fix temporally until its end of life. After an initial description of the manufacturing process of the new material, its carbon footprint and embodied energy have been calculated by means of the life cycle assessment (LCA) methodology according to the ISO 14044 and the ISO 14067 guidelines adapted to the analyzed context. In particular, the inventory analysis is based on data collected from the production of samples of the new material at the laboratory scale. Results and discussion: The results of the LCA indicate that, when the biogenic carbon fixed in the UA wastes is considered, a negative carbon footprint of -0.2 kg CO2 eq. per kg of material can be obtained. Hence, it can be assumed that from a life cycle perspective the material is able to fix carbon emissions instead of emitting them. Specifically, for the considered scenario, approximately 0.42 kg CO2 eq./m2 per year could be sequestered. However, the crop area required to produce enough waste to manufacture a unit of material is quite high. Therefore, future studies should focus on individuate solutions to reduce the density of the new component, and also different urban crops with higher waste production rates. Conclusions: The outcomes of the study put in evidence the potential of the new proposed infill wall component in fixing carbon emissions from UA, allowing to also compensate those relating to the production and transportation stages of the component life cycle. Moreover, producing by-products with UA wastes, hence temporally storing the carbon fixed by crops, may contribute to reduce the carbon cycles speed conversely to traditional waste management solutions, other than lower new raw materials depletion

Autohydrolysis followed by ionic liquid treatment for Eucalyptus globulus wood fractionation

The 2030 Agenda for Sustainable Development recognises the need for a green and sustainable chemistry and engineering [1]. In this context, cleaner processes require the substitution of organic solvents by less harmful solvents. In addition, the solvent selection for a biomass processing is crucial for the environmental sustainability and feasibility of a biorefinery [2]. In this work, water and the ionic liquid 1-ethyl-3-methylimidazolium acetate ([C2mim][OAc]) were chosen as green solvents for a selective fractionation of Eucalyptus globulus wood in order to valorise their main fractions (hemicellulose, cellulose and lignin). Two sequential stages were proposed for the biomass processing. First, an autohydrolysis step allowed the hemicellulose solubilisation and its recovery as oligosaccharides in the aqueous liquid phase, yielding a solid phase composed by 60 % glucan and 34 % lignin. Second, a treatment with [C2mim][OAc] was evaluated for the delignification of the autohydrolysed biomass. Optimisation of operational conditions (temperature and time) of the ionic liquid treatment was performed to improve the enzymatic saccharification of cellulose remaining in the solid phase and to solubilise lignin. The proposed process configuration is expected to contribute towards the development of integrated biorefineries based on hardwood biomass.This study was supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UID/BIO/04469/2019 unit, BioTecNorte operation (NORTE-01-0145-FEDER-000004) funded by the European Regional Development Fund under the scope of Norte2020 - Programa Operacional Regional doNorte, the EcoTech project (POCI01-0145-FEDER-032206). Aloia Romaní thanks the Iacobus Program (European Territorial Cooperation Partnership Galicia – Norte de Portugal) for a mobility fellowship.info:eu-repo/semantics/publishedVersio

Avoidable Adverse Events Related to Ignoring the Do-Not-Do Recommendations: A Retrospective Cohort Study Conducted in the Spanish Primary Care Setting

Objective This study aimed to measure the frequency and severity of avoidable adverse events (AAEs) related to ignoring do-not-do recommendations (DNDs) in primary care. Methods A retrospective cohort study analyzing the frequency and severity of AAEs related to ignoring DNDs (7 from family medicine and 3 from pediatrics) was conducted in Spain. Data were randomly extracted from computerized electronic medical records by a total of 20 general practitioners and 5 pediatricians acting as reviewers; data between February 2018 and September 2019 were analyzed. Results A total of 2557 records of adult and pediatric patients were reviewed. There were 1859 (72.7%) of 2557 (95% confidence interval [CI], 71.0%-74.4%) DNDs actions in 1307 patients (1507 were performed by general practitioners and 352 by pediatricians). Do-not-do recommendations were ignored more often in female patients (P < 0.0001). Sixty-nine AAEs were linked to ignoring DNDs (69/1307 [5.3%]; 95% CI, 4.1%-6.5%). Of those, 54 (5.1%) of 1062 were in adult patients (95% CI, 3.8%-6.4%) and 15 (6.1%) of 245 in pediatric patients (95% CI, 3.1%-9.1%). In adult patients, the majority of AAEs (51/901 [5.7%]; 95% CI, 4.2%-7.2%) occurred in patients 65 years or older. Most AAEs were characterized by temporary minor harm both in adult patients (28/54 [51.9%]; 95% CI, 38.5%-65.2%) and pediatric patients (15/15 [100%]). Conclusions These findings provide a new perspective about the consequences of low-value practices for the patients and the health care systems. Ignoring DNDs could place patients at risk, and their safety might be unnecessarily compromised

Characterization of a putative grapevine Zn transporter, VvZIP3, suggests its involvement in early reproductive development in Vitis vinifera L

Gonzalez, E (reprint author), Univ Talca, Inst Biol Vegetal & Biotecnol, Talca, Chile.Background: Zinc (Zn) deficiency is one of the most widespread mineral nutritional problems that affect normal development in plants. Because Zn cannot passively diffuse across cell membranes, it must be transported into intracellular compartments for all biological processes where Zn is required. Several members of the Zinc-regulated transporters, Iron-regulated transporter-like Protein (ZIP) gene family have been characterized in plants, and have shown to be involved in metal uptake and transport. This study describes the first putative Zn transporter in grapevine. Unravelling its function may explain an important symptom of Zn deficiency in grapevines, which is the production of clusters with fewer and usually smaller berries than normal. Results: We identified and characterized a putative Zn transporter from berries of Vitis vinifera L., named VvZIP3. Compared to other members of the ZIP family identified in the Vitis vinifera L. genome, VvZIP3 is mainly expressed in reproductive tissue - specifically in developing flowers - which correlates with the high Zn accumulation in these organs. Contrary to this, the low expression of VvZIP3 in parthenocarpic berries shows a relationship with the lower Zn accumulation in this tissue than in normal seeded berries where its expression is induced by Zn. The predicted protein sequence indicates strong similarity with several members of the ZIP family from Arabidopsis thaliana and other species. Moreover, VvZIP3 complemented the growth defect of a yeast Zn-uptake mutant, ZHY3, and is localized in the plasma membrane of plant cells, suggesting that VvZIP3 has the function of a Zn uptake transporter. Conclusions: Our results suggest that VvZIP3 encodes a putative plasma membrane Zn transporter protein member of the ZIP gene family that might play a role in Zn uptake and distribution during the early reproductive development in Vitis vinifera L., indicating that the availability of this micronutrient may be relevant for reproductive development

Removal of Cu2+ and Ni2+ from Aqueous Solution using SnO2 Nanomaterial effect of: pH, Time, Temperature, interfering cations

Tin oxide, SnO2, nanomaterial was synthesized and tested for the removal of Cu2+ and Ni2+ ions from aqueous solutions. Various parameters for the binding were investigated in batch studied, which included pH, time, temperature, and interferences. In addition, isotherm studied were performed to determine the maximum binding capacity for both Cu2+ and Ni2+ ions. The optimal binding pH determined from the effects of pH were to be at pH 5 for both the Cu2+ and Ni2+ ions. The isotherm studies were performed at temperatures of 4°C, 25 °C, and 45 °C for both the Cu2+ and Ni2+ ions and were found to follow the Langmuir isotherm model. The binding capacities for the Cu2+ ions were 2.63 mg/g, 2.95 mg/g and 3.27 mg/g at the aforementioned temperatures, respectively. Whereas the binding capacities for Ni2+ were 0.79 mg/g, 1.07 mg/g, and 1.46 mg/g at the respective temperatures. The determined thermodynamic parameters for the binding showed that the binding processes for the reactions were endothermic, as the ΔG was observed to decrease with decreasing temperatures. As well the ΔH was 28.73 kJ/mol for Cu2+ (III) and 13.37 kJ/mol for Ni2+. The ΔS was observed to be 92.65 J/mol for Cu2+ and 54.53 J/mol for Ni2+. The free energy of adsorption for the Cu2+ was determined to be 13.99 kJ/mol and the activation energy for the binding of Ni2+ was determined to be 8.09 KJ/mol. The activation energy data indicate that the reaction was occurring through chemisorptio

New multisite observations of Delta Scuti stars V624 Tauri and HD 23194

The preliminary results of STEPHI 2006 campaign are reported.Comment: To be published in Communications in Asteroseismolgy: Special Issu

Hydrogeomorphological analysis and modelling for a comprehensive understanding of flash-flood damage processes: the 9 October 2018 event in northeastern Mallorca

[EN] A flash-flood event hit the northeastern part of Mallorca on 9 October 2018, causing 13 casualties. Mal- lorca is prone to catastrophic flash floods acting on a sce- nario of deep landscape transformation caused by Mediter- ranean tourist resorts. As global change may exacerbate dev- astating flash floods, analyses of catastrophic events are cru- cial to support effective prevention and mitigation measures. Field-based remote-sensing and modelling techniques were used in this study to evaluate rainfall¿runoff processes at the catchment scale linked to hydrological modelling. Continu- ous streamflow monitoring data revealed a peak discharge of 442 m³ s¿¹ with an unprecedented runoff response. This ex- ceptional behaviour triggered the natural disaster as a com- bination of heavy rainfall (249 mm in 10 h), karstic features and land cover disturbances in the Begura de Salma River catchment (23 km²). Topography-based connectivity indices and geomorphic change detection were used as rapid post- catastrophe decision-making tools, playing a key role dur- ing the rescue search. These hydrogeomorphological preci- sion techniques were combined with the Copernicus Emer- gency Management Service and ¿ground-based¿ damage as- sessment, which showed very accurately the damage-driving factors in the village of Sant Llorenç des Cardassar. The main challenges in the future are to readapt hydrological modelling to global change scenarios, implement an early flash-flood warning system and take adaptive and resilient measures on the catchment scale.This research was supported by the Spanish Ministry of Science, Innovation and Universities, the Spanish Agency of Research (AEI) and the European Regional Development Fund (ERDF) through the project CGL2017-88200-R "Functional hydrological and sediment connectivity at Mediterranean catchments: global change scenarios -MEDhyCON2".Estrany, J.; Ruiz-Perez, M.; Mutzner, R.; Fortesa, J.; Nacher Rodriguez, B.; Tomas-Burguera, M.; Garcia-Comendador, J.... (2020). Hydrogeomorphological analysis and modelling for a comprehensive understanding of flash-flood damage processes: the 9 October 2018 event in northeastern Mallorca. Natural Hazards and Earth System Sciences. 20(8):2195-2220. https://doi.org/10.5194/nhess-20-2195-2020S21952220208Adamovic, M., Branger, F., Braud, I., and Kralisch, S.: Development of a data-driven semi-distributed hydrological model for regional scale catchments prone to Mediterranean flash floods, J. Hydrol., 541, 173–189, https://doi.org/10.1016/j.jhydrol.2016.03.032, 2016.Agisoft Lens: Agisoft PhotoScan User Manual. Professional Edition, Version 1.4, available at: https://www.agisoft.com/pdf/photoscan-pro_1_4_en.pdf (last access: 12 September 2019), 2018.Ajuntament de Sant Llorenç des Cardassar: Minutes of the Plenary Session of Sant Llorenç des Cardassar City Council, Sant Llorenç des Cardassar, available at: https://ovac.santllorenc.es/absis/idi/arx/idiarxabsaweb/catala/asp/dlgVisor.asp?codigoVerificacion=176102aec9d248aab3b72deaad1e0beb001 (last access: 15 May 2020), 2018.Alfieri, L., Berenguer, M., Knechtl, V., Liechti, K., Sempere-Torres, D., and Zappa, M.: Flash Flood Forecasting Based on Rainfall Thresholds, in Handbook of Hydrometeorological Ensemble Forecasting, edited by: Duan, Q., Pappenberger, F., Wood, A., Cloke, H. L., and Schaake, J. C., 1–38, Springer, 2015.Álvaro, M., Del Olmo, P., and Anglada, E.: Mapa Geológico de España, 1:50 000, Hoja 700 (MANACOR), Madrid, available at: http://info.igme.es/cartografiadigital/datos/magna50/pdfs/d7_G50/Magna50_700.pdf (last access: 30 July 2020), 1991.Amirebrahimi, S., Rajabifard, A., Mendis, P., and Ngo, T.: A framework for a microscale flood damage assessment and visualization for a building using BIM–GIS integration, Int. J. Digit. Earth, 9, 363–386, https://doi.org/10.1080/17538947.2015.1034201, 2016.Amponsah, W., Marchi, L., Zoccatelli, D., Boni, G., Cavalli, M., Comiti, F., Crema, S., Lucía, A., Marra, F., and Borga, M.: Hydrometeorological Characterization of a Flash Flood Associated with Major Geomorphic Effects: Assessment of Peak Discharge Uncertainties and Analysis of the Runoff Response, J. Hydrometeorol., 17, 3063–3077, https://doi.org/10.1175/JHM-D-16-0081.1, 2016.Amponsah, W., Ayral, P.-A., Boudevillain, B., Bouvier, C., Braud, I., Brunet, P., Delrieu, G., Didon-Lescot, J.-F., Gaume, E., Lebouc, L., Marchi, L., Marra, F., Morin, E., Nord, G., Payrastre, O., Zoccatelli, D., and Borga, M.: Integrated high-resolution dataset of high-intensity European and Mediterranean flash floods, Earth Syst. Sci. Data, 10, 1783–1794, https://doi.org/10.5194/essd-10-1783-2018, 2018.Artinyan, E., Vincendon, B., Kroumova, K., Nedkov, N., Tsarev, P., Balabanova, S., and Koshinchanov, G.: Flood forecasting and alert system for Arda River basin, J. Hydrol., 541, 457–470, https://doi.org/10.1016/j.jhydrol.2016.02.059, 2016.Barbosa, S., Silva, Á., and Narciso, P.: Analysis of the 1 November 2015 heavy rainfall episode in Algarve by using weather radar and rain gauge data, Nat. Hazards, 93, 61–76, https://doi.org/10.1007/s11069-017-3065-2, 2018.Barredo, J. I.: Major flood disasters in Europe: 1950–2005, Nat. Hazards, 42, 125–148, https://doi.org/10.1007/s11069-006-9065-2, 2007.BOE: Boletín Oficial del Estado (BOE No. 283) (23/11/2018). Decreto-ley 2/2018, de 18 de octubre, por el que se establecen ayudas y otras medidas urgentes para reparar las pérdidas y los daños producidos por las lluvias intensas y las inundaciones del día 9 de, Spain, available at: https://www.boe.es/boe/dias/2018/11/23/pdfs/BOE-A-2018-15970.pdf (last access: 15 May 2020), 2018.BOE: Boletín Oficial del Estado (BOE, No. 12) (26/01/2019), Real Decreto Ley 2/2019 de 25 de enero, por el que se adoptan medidas urgentes para paliar los daños causados por temporales y otras situaciones catastróficas, Spain, 2019.Borga, M., Boscolo, P., Zanon, F., and Sangati, M.: Hydrometeorological Analysis of the 29 August 2003 Flash Flood in the Eastern Italian Alps, J. Hydrometeorol., 8, 1049–1067, https://doi.org/10.1175/jhm593.1, 2007.Borga, M., Gaume, E., Creutin, J. D., and Marchi, L.: Surveying flash floods: gauging the ungauged extremes, Hydrol. Process., 22, 3883–3885, https://doi.org/10.1002/hyp.7111, 2008.Borselli, L., Cassi, P., and Torri, D.: Prolegomena to sediment and flow connectivity in the landscape: A GIS and field numerical assessment, CATENA, 75, 268–277, https://doi.org/10.1016/j.catena.2008.07.006, 2008.Braud, I., Ayral, P.-A., Bouvier, C., Branger, F., Delrieu, G., Le Coz, J., Nord, G., Vandervaere, J.-P., Anquetin, S., Adamovic, M., Andrieu, J., Batiot, C., Boudevillain, B., Brunet, P., Carreau, J., Confoland, A., Didon-Lescot, J.-F., Domergue, J.-M., Douvinet, J., Dramais, G., Freydier, R., Gérard, S., Huza, J., Leblois, E., Le Bourgeois, O., Le Boursicaud, R., Marchand, P., Martin, P., Nottale, L., Patris, N., Renard, B., Seidel, J.-L., Taupin, J.-D., Vannier, O., Vincendon, B., and Wijbrans, A.: Multi-scale hydrometeorological observation and modelling for flash flood understanding, Hydrol. Earth Syst. Sci., 18, 3733–3761, https://doi.org/10.5194/hess-18-3733-2014, 2014.Calsamiglia, A., García-Comendador, J., Fortesa, J., López-Tarazón, J. A., Crema, S., Cavalli, M., Calvo-Cases, A., and Estrany, J.: Effects of agricultural drainage systems on sediment connectivity in a small Mediterranean lowland catchment, Geomorphology, 318, 162–171, https://doi.org/10.1016/j.geomorph.2018.06.011, 2018.Calvo-Cases, A., Gago, J., Ruiz-Pérez, M., García-Comendador, J., Fortesa, J., Company, J., Nácher-Rodríguez, B., Vallés-Morán, F. J., and Estrany, J.: Spatial distribution of geomorphic changes after an extreme flash-flood compared with hydrological and sediment connectivity, in European Geosciences Uninon General Assembly 2020, Copernicus Publications, 2020.Cassola, F., Ferrari, F., Mazzino, A., and Miglietta, M. M.: The role of the sea on the flash floods events over Liguria (northwestern Italy), Geophys. Res. Lett., 43, 3534–3542, https://doi.org/10.1002/2016GL068265, 2016.Cavalli, M., Trevisani, S., Comiti, F., and Marchi, L.: Geomorphometric assessment of spatial sediment connectivity in small Alpine catchments, Geomorphology, 188, 31–41, https://doi.org/10.1016/j.geomorph.2012.05.007, 2013.CCS: Estudio Siniestralidades 2018, Inundación extraordinaria Mallorca: Sant Llorenç des Cardassar. Consorcio de Compensación de Seguros. Ministerio de Economía y Empresa. Gobierno de España, available at: https://www.consorseguros.es/web/inicio (last access: 15 May 2020), 2018.Chapon, B., Delrieu, G., Gosset, M., and Boudevillain, B.: Variability of rain drop size distribution and its effect on the Z–R relationship: A case study for intense Mediterranean rainfall, Atmos. Res., 87, 52–65, https://doi.org/10.1016/j.atmosres.2007.07.003, 2008.Collier, C. G.: Flash flood forecasting: What are the limits of predictability?, Q. J. Roy. Meteor. Soc., 133, 3–23, https://doi.org/10.1002/qj.29, 2007.Copernicus Emergency Management Service: [EMSR323] Flood in Balearic Island, Spain, available at: https://emergency.copernicus.eu/mapping/list-of-components/EMSR323 (last access: 15 May 2020), 2018.Copernicus Emergency Management Service: Directorate Space, Security and Migration, European Commission Joint Research Centre, available at: https://emergency.copernicus.eu/ (last access: 14 August 2019), 2019.Corine Land Cover: Copernicus Land Monitoring Service, available at: https://land.copernicus.eu/pan-european/corine-land-cover/clc2018 (last access: 15 May 2020), 2018.Crema, S. and Cavalli, M.: SedInConnect: a stand-alone, free and open source tool for the assessment of sediment connectivity, Comput. Geosci., 111, 39–45, https://doi.org/10.1016/j.cageo.2017.10.009, 2018.Defossez, S. and Leone, F.: Assessing Vulnerability to Flooding: Progress and Limitations, Floods, 241–257, https://doi.org/10.1016/B978-1-78548-268-7.50014-6, 2017.Duo, E., Trembanis, A. C., Dohner, S., Grottoli, E., and Ciavola, P.: Local-scale post-event assessments with GPS and UAV-based quick-response surveys: a pilot case from the Emilia–Romagna (Italy) coast, Nat. Hazards Earth Syst. Sci., 18, 2969–2989, https://doi.org/10.5194/nhess-18-2969-2018, 2018.ESRI: Arc Hydro Tools, available at: https://www.esri.com/en-us/home (last access: 15 May 2020), 2019.Estrany, J. and Grimalt, M.: Catchment controls and human disturbances on the geomorphology of small Mediterranean estuarine systems, Estuar. Coast. Shelf Sci., 150, 1–12, https://doi.org/10.1016/j.ecss.2014.03.021, 2014.Estrany, J., Garcia, C., and Batalla, R. J.: Groundwater control on the suspended sediment load in the Na Borges River, Mallorca, Spain, Geomorphology, 106, 292–303, https://doi.org/10.1016/J.GEOMORPH.2008.11.008, 2009.Estrany, J., Ruiz, M., Calsamiglia, A., Carriquí, M., García-Comendador, J., Nadal, M., Fortesa, J., López-Tarazón, J. A., Medrano, H., and Gago, J.: Sediment connectivity linked to vegetation using UAVs: High-resolution imagery for ecosystem management, Sci. Total Environ., 671, 1192–1205, https://doi.org/10.1016/j.scitotenv.2019.03.399, 2019.Estrany, J., Ruiz-Pérez, M., Mutzner, R., Fortesa, J., Nácher-Rodríguez, B., Tomàs-Burguera, M., García-Comendador, J., Peña, X., Calvo-Cases, A., and Vallés-Morán, F. J.: Discharge data series of Begura de Salma River (Mallorca, Spain): January 2015–October 2018, PANGAEA, https://doi.org/10.1594/PANGAEA.921411 2020a.Estrany, J., Ruiz-Pérez, M., Mutzner, R., Fortesa, J., Nácher-Rodríguez, B., Tomàs-Burguera, M., García-Comendador, J., Peña, X., Calvo-Cases, A., and Vallés-Morán, F. J.: Monthly precipitation and runoff series of Begura de Salma River (Mallorca, Spain): January 2015–October 2018, PANGAEA, https://doi.org/10.1594/PANGAEA.921412, 2020b.Fortesa, J., García-Comendador, J., Calsamiglia, A., López-Tarazón, J. A., Latron, J., Alorda, B., and Estrany, J.: Comparison of stage/discharge rating curves derived from different recording systems: Consequences for streamflow data and water management in a Mediterranean island, Sci. Total Environ., 665, 968–981, https://doi.org/10.1016/j.scitotenv.2019.02.158, 2019.Fulton, R. A., Breidenbach, J. P., Seo, D.-J., Miller, D. A., and O'Bannon, T.: The WSR-88D Rainfall Algorithm, https://doi.org/10.1175/1520-0434(1998)013&amp;lt;0377:TWRA&amp;gt;2.0.CO;2, 1998.García-Hernández, J., Jordan, J., Dubois, J., Boillat, J., and Schleiss, A.: Routing System II: Flow modelling in hydraulic systems, Communication, 32, 1661–1179, 2007.Gaume, E., Bain, V., Bernardara, P., Newinger, O., Barbuc, M., Bateman, A., Blaškovičová, L., Blöschl, G., Borga, M., Dumitrescu, A., Daliakopoulos, I., Garcia, J., Irimescu, A., Kohnova, S., Koutroulis, A., Marchi, L., Matreata, S., Medina, V., Preciso, E., Sempere-Torres, D., Stancalie, G., Szolgay, J., Tsanis, I., Velasco, D., and Viglione, A.: A compilation of data on European flash floods, J. Hydrol., 367, 70–78, https://doi.org/10.1016/J.JHYDROL.2008.12.028, 2009.Gaume, E., Borga, M., Llasat, M. C., Maouche, S., Lang, M., and Diakakis, M.: Mediterranean extreme floods and flash floods, in The Mediterranean Region under Climate Change. A Scientific Update, edited by: French National Alliance for Environmental Research – ALLENVI, 133–144, available at: https://hal.archives-ouvertes.fr/hal-01465740v2/document (last access: 15 May 2020), 2016.Georgakakos, K. P.: On the Design of National, Real-Time Warning Systems with Capability for Site-Specific, Flash-Flood Forecasts, B. Am. Meteorol. Soc., 67, 1233–1239, https://doi.org/10.1175/1520-0477(1986)067&amp;lt;1233:OTDONR&amp;gt;2.0.CO;2, 1986.Germann, U. and Joss, J.: Operational Measurement of Precipitation in Mountainous Terrain, Springer, Berlin, Heidelberg, 52–77, 2004.GOIB: Mapas de peligrosidad y riesgo de inundación en la demarcación hidrográfica de Baleares. Conselleria de Medi Ambient, Agricultura i Pesca-Direcció General de Recursos Hídrics, available at: https://www.caib.es/sites/aigua/es/plan_de_ gestion_ del_riesgo_ de_ inundacion_de_ la_ demarcacion_hidrografica_ de_ las_islas_ baleares/ (last access: 15 May 2020), 2016.GOIB: Boletín Oficial de las Islas Baleares (BOIB No. 130) (18/10/2018), Decreto-ley 2/2018, de 18 de octubre, por el que se establecen ayudas y otras medidas urgentes para reparar las pérdidas y los daños producidos por las lluvias intensas y las inundaciones, available at: http://www.caib.es/eboibfront/pdf/ca/2018/130/101958 (last access: 15 May 2020), 2018.GOIB: El Govern ja ha abonat 30,4 milions d'euros en ajuts i actuacions de preparació de danys produïts per les inundacions del Llevant, English version: The Balearic Government has already paid 30.4 million euros in aid and actions for the damage caused by the floods in the Llevant county, available at: https://www.caib.es/pidip2front/jsp/ca/fitxa-convocatoria/strongel-govern-ja-ha-abonat-304-milions-drsquoeuros-en-ajuts-i-actuacions-de-reparacioacute-de-danys-produiumlts-per-les-inundacions-del-llevantstrongnbsp (last access: 15 May 2020), 2019.Gourley, J. J., Giangrande, S. E., Hong, Y., Flamig, Z. L., Schuur, T., and Vrugt, J. A.: Impacts of Polarimetric Radar Observations on Hydrologic Simulation, J. Hydrometeorol., 11, 781–796, https://doi.org/10.1175/2010JHM1218.1, 2010.Guijarro, J. A.: Contribución a la Bioclimatología de Baleares, Universitat de les Illes Balears, PhD thesis, available at: http://hdl.handle.net/20.500.11765/5369 (last access: 30 July 2020), 1986.Hardy, J., Gourley, J., Kirstetter, P., Hong, Y., Kong, F., and Flamig, Z.: A method for probabilistic flash flood forecasting, J. Hydrol., 541, 480–494 2016.Harrison, D., Driscoll, S., and Kitchen, M.: Improving precipitation estimates from weather radar using quality control and correction techniques, Meteorol. Appl., 7, 135–144, https://doi.org/https://doi.org/10.1017/S1350482700001468, 2000.Instituto Geográfico Nacional: Digital Terrain Model for Spain obtained from lidar flights, available at: http://centrodedescargas.cnig.es/CentroDescargas/locale?request_locale=en (last access: 15 May 2020), 2014.Jordan, F.: Modèle de prévision et de gestion des crues-optimisation des opérations des aménagements hydroélectriques à accumulation pour la réduction des débits de crue, Laboratory of Hydraulic Construction, Ecole Polytechnique Fédérale de Lausanne, Lausanne, 2007.Kalantari, Z., Cavalli, M., Cantone, C., Crema, S., and Destouni, G.: Flood probability quantification for road infrastructure: Data-driven spatial-statistical approach and case study applications, Sci. Total Environ., 581–582, 386–398, https://doi.org/10.1016/J.SCITOTENV.2016.12.147, 2017.Langhammer, J. and Vacková, T.: Detection and Mapping of the Geomorphic Effects of Flooding Using UAV Photogrammetry, Pure Appl. Geophys., 175, 3223–3245, https://doi.org/10.1007/s00024-018-1874-1, 2018.Laudan, J., Rözer, V., Sieg, T., Vogel, K., and Thieken, A. H.: Damage assessment in Braunsbach 2016: data collection and analysis for an improved understanding of damaging processes during flash floods, Nat. Hazards Earth Syst. Sci., 17, 2163–2179, https://doi.org/10.5194/nhess-17-2163-2017, 2017.Li, Z., Xu, X., Zhu, J., Xu, C., and Wang, K.: Effects of lithology and geomorphology on sediment yield in karst mountainous catchments, Geomorphology, 343, 119–128, https://doi.org/10.1016/j.geomorph.2019.07.001, 2019.Llasat, M. C., Llasat-Botija, M., Petrucci, O., Pasqua, A. A., Rosselló, J., Vinet, F., and Boissier, L.: Towards a database on societal impact of Mediterranean floods within the framework of the HYMEX project, Nat. Hazards Earth Syst. Sci., 13, 1337–1350, https://doi.org/10.5194/nhess-13-1337-2013, 2013.Lorenzo-Lacruz, J., Amengual, A., Garcia, C., Morán-Tejeda, E., Homar, V., Maimó-Far, A., Hermoso, A., Ramis, C., and Romero, R.: Hydro-meteorological reconstruction and geomorphological impact assessment of the October 2018 catastrophic flash flood at Sant Llorenç, Mallorca (Spain), Nat. Hazards Earth Syst. Sci., 19, 2597–2617, https://doi.org/10.5194/nhess-19-2597-2019, 2019.Lowe, D.: Distinctive Image Features from Scale-Invariant Keypoints, Vancouver, available at: https://robo.fish/wiki/images/5/58/Image_Features_ From_ Scale_Invariant_ Keypoints_ Lowe_2004.pdf (last access: 11 September 2019), 2004.Marchi, L., Borga, M., Preciso, E., and Gaume, E.: Characterisation of selected extreme flash floods in Europe and implications for flood risk management, J. Hydrol., 394, 118–133, https://doi.org/10.1016/j.jhydrol.2010.07.017, 2010.Marshall, J. S. and Palmer, W. M. K.: The distribution of raindrops with size, J. Meteorol., 5, 165–166, https://doi.org/10.1175/1520-0469(1948)005&amp;lt;0165:TDORWS&amp;gt;2.0.CO;2, 1948.Merheb, M., Moussa, R., Abdallah, C., Colin, F., Perrin, C., and Baghdadi, N.: Hydrological response characteristics of Mediterranean catchments at different time scales: a meta-analysis, Hydrolog. Sci. J., 61, 2520–2539, https://doi.org/10.1080/02626667.2016.1140174, 2016.Miao, Q., Yang, D., Yang, H., and Li, Z.: Establishing a rainfall threshold for flash flood warnings in China's mountainous areas based on a distributed hydrological model, J. Hydrol., 541, 371–386, https://doi.org/10.1016/j.jhydrol.2016.04.054, 2016.Nguyen, P., Thorstensen, A., Sorooshian, S., Hsu, K., AghaKouchak, A., Sanders, B., Koren, V., Cui, Z., and Smith, M.: A high resolution coupled hydrologic–hydraulic model (HiResFlood-UCI) for flash flood modeling, J. Hydrol., 541, 401–420, https://doi.org/10.1016/j.jhydrol.2015.10.047, 2016.Petrus, J. M., Ruiz, M., and Estrany, J.: Interactions between Geomorphology and Urban Evolution since Neolithic Times in a Mediterranean City, in: Urban Geomorphology, Landforms and Processes in Cities, edited by: Thornbush, M. J. and Allen, C. D., 9–35, https://doi.org/10.1016/B978-0-12-811951-8.00002-3, 2018.Piaggesi, D., Sund, K. J., and Castelnovo, W.: Global strategy and practice of e-governance?: examples from around the world, Information Science Reference, available at: https://www.igi-global.com/book/global-strategy-practice-governance/46168 (last access: 30 July 2020), 2011.Plank, S.: Rapid Damage Assessment by Means of Multi-Temporal SAR – A Comprehensive Review and Outlook to Sentinel-1, Remote Sens., 6, 4870–4906, https://doi.org/10.3390/rs6064870, 2014.PNOA: Plan Nacional de Ortofotografía Aérea, Instituto Geográfico Nacional, Ministerio de Fomento, Gobierno de España, available at: https://pnoa.ign.es/productos_lidar (last access: 15 May 2020), 2015.Pol, J.: Informe INUNBAL Llevant Mallorca 2018, ISO 271/2018, available at: http://www.caib.es/pidip2front/jsp/adjunto?codi=2243620&amp;amp;idioma=ca (last access: 30 July 2020), Marratxí, 2019a.Pol, J.: Predicción y Gestión de Emergencias por Inundaciones, in: International Seminar of Planning and Management of Flood Risks in Mediterranean Environments, INAGEA, University of the Balearic Islands, Palma, 2019b.Pons Esteva, A.: Evolució dels usos del sòl a les illes Balears, 1956–2000, Territoris, 4, 129–145, 2003.Schaefli, B., Hingray, B., Niggli, M., and Musy, A.: A conceptual glacio-hydrological model for high mountainous catchments, Hydrol. Earth Syst. Sci., 9, 95–109, https://doi.org/10.5194/hess-9-95-2005, 2005.Segura-Beltrán, F., Sanchis-Ibor, C., Morales-Hernández, M., González-Sanchis, M., Bussi, G., and Ortiz, E.: Using post-flood surveys and geomorphologic mapping to evaluate hydrological and hydraulic models: The flash flood of the Girona River (Spain) in 2007, J. Hydrol., 541, 310–329, https://doi.org/10.1016/J.JHYDROL.2016.04.039, 2016.Seo, B. C., Krajewski, W. F., and Qi, Y.: Utility of Vertically Integrated Liquid Water Content for Radar-Rainfall Estimation: Quality Control and Precipitation Type Classification, Atmos. Res., 236, 104800, https

Evaluation of the anti-diabetic activity of some common herbs and spices : providing new insights with inverse virtual screening

Culinary herbs and spices are widely used as a traditional medicine in the treatment of diabetes and its complications, and there are several scientific studies in the literature supporting the use of these medicinal plants. However, there is often a lack of knowledge on the bioactive compounds of these herbs and spices and their mechanisms of action. The aim of this study was to use inverse virtual screening to provide insights into the bioactive compounds of common herbs and spices, and their potential molecular mechanisms of action in the treatment of diabetes. In this study, a library of over 2300 compounds derived from 30 common herbs and spices were screened in silico with the DIA-DB web server against 18 known diabetes drug targets. Over 900 compounds from the herbs and spices library were observed to have potential anti-diabetic activity and liquorice, hops, fennel, rosemary, and fenugreek were observed to be particularly enriched with potential anti-diabetic compounds. A large percentage of the compounds were observed to be potential polypharmacological agents regulating three or more anti-diabetic drug targets and included compounds such as achillin B from yarrow, asparasaponin I from fenugreek, bisdemethoxycurcumin from turmeric, carlinoside from lemongrass, cinnamtannin B1 from cinnamon, crocin from sa ron and glabridin from liquorice. The major targets identified for the herbs and spices compounds were dipeptidyl peptidase-4 (DPP4), intestinal maltase-glucoamylase (MGAM), liver receptor homolog-1 (NR5A2), pancreatic alpha-amylase (AM2A), peroxisome proliferator-activated receptor alpha (PPARA), protein tyrosine phosphatase non-receptor type 9 (PTPN9), and retinol binding protein-4 (RBP4) with over 250 compounds observed to be potential inhibitors of these particular protein targets. Only bay leaves, liquorice and thyme were found to contain compounds that could potentially regulate all 18 protein targets followed by black pepper, cumin, dill, hops and marjoram with 17 protein targets. In most cases more than one compound within a given plant could potentially regulate a particular protein target. It was observed that through this multi-compound-multi target regulation of these specific protein targets that the major anti-diabetic e ects of reduced hyperglycemia and hyperlipidemia of the herbs and spices could be explained. The results of this study, taken together with the known scientific literature, indicated that the anti-diabetic potential of common culinary herbs and spices was the result of the collective action of more than one bioactive compound regulating and restoring several dysregulated and interconnected diabetic biological processes.The National Research Foundation of South Africa, the Spanish Ministry of Economy and Competitiveness (CTQ2017-87974-R) and by the Fundación Séneca del Centro de Coordinación de la Investigación de la Región de Murcia under Project 20988/PI/18.http://www.mdpi.com/journal/moleculesam2020BiochemistryGeneticsMicrobiology and Plant Patholog