A review of the current treatment methods for posthaemorrhagic hydrocephalus of infants

Posthaemorrhagic hydrocephalus (PHH) is a major problem for premature infants, generally requiring lifelong care. It results from small blood clots inducing scarring within CSF channels impeding CSF circulation. Transforming growth factor – beta is released into CSF and cytokines stimulate deposition of extracellular matrix proteins which potentially obstruct CSF pathways. Prolonged raised pressures and free radical damage incur poor neurodevelopmental outcomes. The most common treatment involves permanent ventricular shunting with all its risks and consequences

Consensus statement from the international consensus meeting on post-traumatic cranioplasty

Abstract: Background: Due to the lack of high-quality evidence which has hindered the development of evidence-based guidelines, there is a need to provide general guidance on cranioplasty (CP) following traumatic brain injury (TBI), as well as identify areas of ongoing uncertainty via a consensus-based approach. Methods: The international consensus meeting on post-traumatic CP was held during the International Conference on Recent Advances in Neurotraumatology (ICRAN), in Naples, Italy, in June 2018. This meeting was endorsed by the Neurotrauma Committee of the World Federation of Neurosurgical Societies (WFNS), the NIHR Global Health Research Group on Neurotrauma, and several other neurotrauma organizations. Discussions and voting were organized around 5 pre-specified themes: (1) indications and technique, (2) materials, (3) timing, (4) hydrocephalus, and (5) paediatric CP. Results: The participants discussed published evidence on each topic and proposed consensus statements, which were subject to ratification using anonymous real-time voting. Statements required an agreement threshold of more than 70% for inclusion in the final recommendations. Conclusions: This document is the first set of practical consensus-based clinical recommendations on post-traumatic CP, focusing on timing, materials, complications, and surgical procedures. Future research directions are also presented

Starting point for benchmarking outcomes and reporting of pituitary adenoma surgery within the European Reference Network on Rare Endocrine Conditions (Endo-ERN): results from a meta-analysis and survey study

Objective: The European Reference Network on Rare Endocrine Conditions (Endo-ERN) aims to organize high-quality healthcare throughout Europe, inc luding care for pituitary adenoma patients. As surgery is the mainstay of treatment, we aimed to describe the current surgical practice and published surgical outcomes of pi tuitary adenoma within Endo-ERN. Design and Methods: Systematic review and meta-analysis of studies reporting surgical outcomes of pituitary adenoma patients within Endo-ERN MTG6 pituitary reference centers between 2010 and 2019. A survey was completed by refere nce centers on their current surgical practice. Results: A total of 18 out of 43 (42%) reference centers located in 7 of the 20 (35%) MTG6- represented countries published 48 articles. Remission rates we re 50% (95% CI: 42–59) for patients with acromegaly, 68% (95% CI: 60–75) for Cushing’s disease, and 53% (95% CI: 39–66%) for prolactinoma. Gross total resection was achieved in 49% (95% CI: 37–61%) of patients and visual improvement in 78% (95% CI: 68–87). Mort ality, hemorrhage, and carotid injury occurred in less than 1% of patients. New-onset hypopituitarism occurred in 16% (95% CI: 11–23), transient diabetes insipidus in 12% (95 % CI: 6–21), permanent diabetes insipidus in 4% (95% CI: 3–6), syndrome of inappropria te secretion of antidiuretic hormone (SIADH) in 9% (95% CI: 5–14), severe epist axis in 2% (95% CI: 0–4), and cerebrospinal fluid leak in 4% (95% CI: 2–6). Thirty-five (81 %) centers completed the survey: 54% were operated endoscopically and 57% were together with an ENT surgeon. Conclusion: The results of this study could be used as a first benchmark for the outcomes of pituitary adenoma surgery within Endo-ERN. However, the hete rogeneity between studies in the reporting of outcomes hampers comparability and warrants outcome collection through registries

Cherry loop: a new loop to move the mandibular molar mesially

Abstract: The aim of this study was to test the clinical efficacy of a new loop named ‘cherry loop’ in correcting the Class II relationship by the mesial movement of the first lower molars in the Tweed–Merrifield technique. We compared the amount of molar mesial movement in two groups of patients treated with upper first bicuspid and lower second bicuspid extractions. The study was conducted using two X-rays, one before treatment and one after the molars had moved. Mandibular molars and incisors were traced and their positions analyzed along a Cartesian coordinate system. Movements were related to stable structures: lower borders of the mandible and the symphysis. The cherry loop performance was compared to that of the shoehorn loop. Cherry loop averaged 5.25 mm of average mesial movement, whereas the shoehorn loop yielded only 3.28 mm. The vertical control of molars was better with the new loop; we had only 1.24 mm of extrusion compared to 3.24 mm with the usual loop. The anteroposterior stability of the incisors was better too; we had 1.54 mm of distal movement of the crowns compared to 2.24 mm with the shoehorn loop. A serendipitous finding was that the occlusal plane could be controlled by the cherry loop. It can be oriented to best fit the growth pattern. In turn, in the growing patient, a favorable skeletal response can be expected

Occlusal morphology one year after orthodontic and surgical-orthodontic therapy : a quantitative analysis of clinically successful patients

OBJECTIVE: To evaluate morphologic characteristics of occlusion (contact points, contact areas, and frequency of contact) in clinically successful patients 1 year after orthodontic and surgical-orthodontic therapy followed by passive retention. MATERIALS AND METHODS: Twenty-two orthodontic and 18 surgical-orthodontic patients were analyzed. All patients were treated with standard edgewise technique by the same orthodontist. Contact points and areas were evaluated using a new method of digital image analysis of occlusal impressions. Polivinylsyloxan impressions were taken, scanned, and turned into gray-scale images. The physic relationship of light absorbance through the polivinylsyloxan for known thickness was calculated to determine contact areas (less than 50 microm of thickness) and near contact areas (less than 350 microm of thickness). RESULTS: The contact area was significantly larger in the orthodontic than in the surgical-orthodontic patients (Student's t-test, P < .05). The surgical-orthodontic group had significantly fewer contact points than the orthodontic group only at 150 microm of thickness. In both groups of patients, the first molar had the largest contact surface. Occlusal support was distributed mainly in the posterior regions with an important role involving the first molars. CONCLUSION: Surgical-orthodontic patients appear to have smaller contact surfaces and fewer contact points than orthodontic patients do. However, there were no differences in the number of teeth in contact with opposing teeth