Liver Resections for Metastases from Intraabdominal Leiomyosarcoma

This paper discusses liver resection for intraabdominal leiomyosarcoma metastases as a therapy for carefully selected patients. Of the 83 hepatectomies performed from 1992 to 1996, five were resections for liver metastases due to intraabdominal leiomyosarcoma, in 3 patients. The surgical indication was single liver metastases, without any evidence of extrahepatic disease. No mortality occurred during surgery and the longest survival was 38 months. We concluded that liver resection for leiomyosarcoma metastases can be performed, allowing a long term survival in an occasional patient

Chronic obstrutive pancreatitis and caudal pancreatojejunostomy

Apresenta-se uma técnica de pancreatojejunostomia caudal, que consiste fundamentalmente em incisar por 2cm a parede anterior do dueto de Wirsung e suturar os bordos incisados à cápsula pancreática. O restante da anastomose é realizado de maneira invaginante. O objetivo do procedimento é manter patente a anastomose, que pode ser indicada em casos de pancreatite crônica obstrutiva.A technique to perform distai pancreatojejunostomy is presented. lt consist in opening the anterior wa/1 of the main pancreatic duct by 2cm and suturing the cut edges of the duct to the pancreatic capsule. The aim of the procedure is to maintain the permeability of the anastomosis that is indicated in chronic obstructive pancreatitis

Ursolic acid induces cell death and modulates autophagy through JNK pathway in apoptosis-resistant colorectal cancer cells

Colorectal carcinomas (CRCs) with P53 mutations have been shown to be resistant to chemotherapy with 5-fluorouracil (5-FU), the most widely used chemotherapeutic drug for CRC treatment. Autophagy is emerging as a promising therapeutic target for drug-resistant tumors. In the present study, we tested the effects of ursolic acid (UA), a natural triterpenoid, on cell death mechanisms and its effects in combination with 5-FU in the HCT15 p53 mutant apoptosis-resistant CRC cell line. The involvement of UA in autophagy and its in vivo efficacy were evaluated. Our data show that UA induces apoptosis independent of caspases in HCT15 cells and enhances 5-FU effects associated with an activation of c-jun N-terminal kinase (JNK). In this cell line, where this compound has a more pronounced effect on the induction of cell death compared to 5-FU, apoptosis corresponds only to a small percentage of the total cell death induced by UA. UA also modulated autophagy by inducing the accumulation of LC3 and p62 levels with involvement of JNK pathway, which indicates a contribution of autophagy on JNK-dependent induction of cell death by UA. By using nude mice xenografted with HCT15 cells, we verified that UA was also active in vivo decreasing tumor growth rate. In conclusion, this study shows UA's anticancer potential both in vitro and in vivo. Induction of cell death and modulation of autophagy in CRC-resistant cells were shown to involve JNK signaling.C.P.R.X. and D.F.N.P. were supported by the Foundation for Science and Technology (FCT), Portugal, through grants SFRH/BD/27524/2006 and SFRH/BD/64817/2009, respectively. C.P.W. was guest professor at University of Copenhagen through the grant SFRH/BSAB/918/2009. The work was supported by FCT research grants PTDC/QUI-BIQ/101392/2008 (NaturAge) and PEst-C/BIA/UI4050/2011. All projects are co-funded by the program COMPETE from QREN with co-participation from the European Community fund FEDER

The influence of climatic conditions on the phenolic composition of tropical Brazilian wines.

Resumo. IUFoST 2012

Unified dark energy thermodynamics: varying w and the -1-crossing

We investigate, in a unified and general way, the thermodynamic properties of dark energy with an arbitrary, varying equation-of-state parameter w(a). We find that all quantities are well defined and regular for every w(a), including at the -1-crossing, with the temperature being negative in the phantom regime (w(a)-1). The density and entropy are always positive while the chemical potential can be arbitrary. At the -1-crossing, both temperature and chemical potential are zero. The temperature negativity can only be interpreted in the quantum framework. The regular behavior of all quantities at the -1-crossing, leads to the conclusion that such a crossing does not correspond to a phase transition, but rather to a smooth cross-over.Comment: 5 pages, version published in Class. Quant. Gra

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Reproductive aspects of Macrobrachium amazonicum (Decapoda: Palaemonidae) in the State of Amapá, Amazon River mouth.

Macrobrachium amazonicum is an indigenous prawn vastly distributed in basins of South America, widely exploited by artisanal fisheries in northern and northeastern Brazil and, with great potential for aquaculture. This study aimed to investigate general aspects of population structure and reproductive characteristics (size at first maturity, fecundity and reproductive output) of M. amazonicum from two important areas to artisanal prawn fishing located at the mouth of the Amazon River, State of Amapá. The specimens were captured using 20 handcrafted traps called ?matapi?. A number of 5,179 prawns were captured, 2,975 females and 2,195 males resulting in 1.35:1 female to male ratio. Santana Island and Mazagão Velho showed females predominated in the population. A reproductive peak period was observed from January to April/2009 and in December/2010, coinciding with the period of higher rainfall. The recruitment peak occurred in June and July/2009. Egg-bearing females ranged in size (carapace length) from 11.10 to 29.6 mm. Fecundity increased with female size and reached up to 7,417 eggs. This amount of eggs is considered low if compared with other Macrobrachium estuarine species. Mean egg volume increased gradually from 0.121 to 0.24 mm3 during embryogenesis, representing 68.5% of overall increase from Stage I to Stage III. Eggs of M. amazonicum are small; this is typical for Macrobrachium species, which depends on brackish water to complete the larval development. Irrespective of female size, reproductive output of M. amazonicum varied between 4.8 and 21.85% of their body weight into eggs production

Estratégias utilizadas pela equipe de enfermagem aos clientes submetidos à antineoplásicos

Durante o tratamento com antineoplásicos, os pacientes além de defrontar-se com os efeitos adversos, possuem também dúvidas, ansiedade e medo, para isso a enfermagem deve realizar uma abordagem não somente técnica, mas também humanizada. Objetivamos em compreender como a equipe de enfermagem assiste os pacientes submetidos ao tratamento antineoplásico. Desenvolvemos um estudo bibliográfico com abordagem quanti-qualitativa, onde as produções científicas foram consultadas através da base de dados do SCIELO, LILACS e BDENF. Realizou-se uma análise explicativa dos textos em relação à assistência de enfermagem concomitante aos profissionais de saúde e pacientes em tratamento com antineoplásicos. Utilizando os seguintes descritores: antineoplásicos, assistência de enfermagem e reações adversas. Identificamos 26 produções relacionadas ao tema, sendo 72% encontradas no LILACS, 21% no BDENF e 7% no SCIELO. As temáticas que tiveram maior relevância foram extravasamento de antineoplásicos e caquexia, ambas correspondendo a 37,5% das publicações científicas abordadas. Concluímos com essa pesquisa que se faz necessário a compreensão da equipe de enfermagem acerca da temática abordada, e a capacitação dos mesmos a fim de diminuir os problemas ocasionados durante o tratamento