Paracoccidioidomicose: atualização epidemiológica, clínica e terapêutica Paracoccidioidomycosis: epidemiological, clinical and treatment up-date

São apresentados dados de atualização epidemiológica, clínica, diagnóstica e terapêutica relativos à paracoccidioidomicose. Discute-se a importância epidemiológica resultante do isolamento do Paracoccidioides brasiliensis a partir do tatu (Dasypus novemcinctus) em regiões do Brasil e Colômbia, assim como dos resultados de inquéritos soroepidemiológicos em cães e do surgimento do primeiro caso de paracoccidioidomicose doença em cão. As dificuldades de isolamento do fungo a partir do solo são correlacionadas com novos informes de investigação epidemiológica. São apresentados aspectos clínicos das manifestações da forma aguda da doença, assim como das manifestações da neuroparacoccidioidomicose e da enfermidade associada à infecção pelo HIV. Discute-se o papel da sorologia e da técnica da PCR no diagnóstico e dos possíveis avanços no tratamento da paracoccidioidomicose com os novos derivados triazólicos.<br>The present report provides new data related to the epidemiology, clinical aspects and treatment of paracoccidioidomycosis. The epidemiological impact of the isolation of Paracoccidioides brasiliensis from the armadillo (Dasypus novemcinctus) in areas of Brazil and Columbia, the results from seroepidemiologic study in dogs and the first case of paracoccidioidomycosis-disease on a dog are presented. New insights related to the classical difficulties of isolation of the fungus from soil are correlated with epidemiological data. Clinical manifestation of the acute form of the disease as well as aspects of the neuroparacoccidioidomycosis, and aspects of the association of the disease with the HIV infection are considered. The role of serology and PCR in the diagnosis, as well as the possible advances in the treatment of paracoccidioidomycosis with the new triazole derivatives are discussed

Amazonía y expansión mercantil capitalista : nueva frontera de recursos en el siglo XXI

La Amazonía es sujeto y objeto de múltiples y variados debates que tansitan desde su diversidad biológica y cultural, pasando por su papel para contrarrestar el efecto invernadero, hasta su potencial económico y la sostenibilidad de sus recursos naturales. Sin duda, la discución está aquí para quedarse y tiene que ser enriquecida con conocimiento cierto y pertinente a su(s) realidad(es). Es con este espíritu que el Centro de Estudios para el Desarrollo Laboral y Agrario (CEDLA) y el Consejo Latinoamericano de Ciencias Sociales (CLACSO), con el apoyo de la Embajada de Suecia en Bolivia, promovieron el concurso de investigación "Expansión mercantil capitalista y la Amazonía como nueva frontera de recursos en el siglo XXI". El propósito de esta convocatoria fue profundizar el conocimiento sobre las causas de las transformaciones socioeconómicas y espaciales que ocurren actualmente en la Amazonía, atendiendo a las dinámicas socioeconómicas de ocupación y uso del territorio, y destacando el papel de los Estados y los actores económicos y políticos presentes en el juego de intereses. Como parte del resultado de este trabajo, presentamos esta publicación, Amazonía y expansión mercantil capitalista. Nueva frontera de recursos en el siglo XXI, que esperamos contribuya a un mayor conocimiento acerca de lo que está aconteciendo en la Amazonía, sus procesos, actores y disputas

Mapping the human genetic architecture of COVID-19

The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3–7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease

ESICM LIVES 2016: part two : Milan, Italy. 1-5 October 2016.

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