Solvability for a nonlinear coupled system of Kirchhoff type for the beam equations with nonlocal boundary conditions

In this paper, we investigate a mathematical model for a nonlinear coupled system of Kirchhoff type of beam equations with nonlocal boundary conditions. We establish existence, regularity and uniqueness of strong solutions. Furthermore, we prove the uniform rate of exponential decay. The uniform rate of polynomial decay is considered

Dapsone Hypersensitivity Syndrome In An Adolescent During Treatment Of Leprosy

A 12 y old girl was admitted 24 days after start a WHO multidrug therapy scheme for multibacillary leprosy (dapsone, clofazimine and rifampicin) with intense jaundice, generalized lymphadenopathy, hepatoesplenomegaly, oral erosions, conjunctivitis, morbiliform rash and edema of face, ankles and hands. The main laboratory data on admission included: hemoglobin, 8.4 g/dL; WBC, 15,710 cells/mm3; platelet count, 100,000 cells/mm3; INR = 1.49; increased serum levels of aspartate and alanine aminotransferases, gamma-glutamyl transpeptidase, alkaline phosphatase, direct and indirect bilirubin. Following, the clinical conditions had deteriorated, developing exfoliative dermatitis, shock, generalized edema, acute renal and hepatic failure, pancytopenia, intestinal bleeding, pneumonia, urinary tract infection and bacteremia, needing adrenergic drugs, replacement of fluids and blood product components, and antibiotics. Ten days after admission she started to improve, and was discharged to home at day 39th, after start new supervised treatment for leprosy with clofazimine and rifampicin, without adverse effects. This presentation fulfils the criteria for the diagnosis of dapsone hypersensitivity syndrome (fever, generalized lymphadenopathy, exfoliative rash, anemia and liver involvement with mixed hepatocellular and cholestatic features). Physicians, mainly in geographical areas with high prevalence rates of leprosy, should be aware to this severe, and probably not so rare, hypersensitivity reaction to dapsone.466331334Aldday, E.J., Barnes, J., Toxic effects of diaminodiphenylsulphone in leprosy (1951) Lancet, 2, pp. 205-206Andrade, Z.M.V., França, E.R., Teixeira, M.A.G., Santo, I.B., Síndrome sulfônica: Relato de um caso (1999) An. Bras. Derm., 74, pp. 59-61Barbosa, A.M., Martins Jr., E., Fleury, R.N., Opromolla, D.V.A., Mais um caso de síndrome da sulfona (2000) Hansenol. Int., 25, pp. 159-162Bluhm, R.E., Adedoyin, A., Mccarver, D.G., Branch, R.A., Development of dapsone toxicity in patients with inflammatory dermatoses: Activity of acetylation and hydroxylation of dapsone as risk factors (1999) Clin. Pharmacol. Ther., 65, pp. 598-605Bocquet, H., Bourgault-Villada, I., Delfau-Larue, M.H., Syndrome d'hypersensibilité à la dapsone. Clone T circulant transitoire (1995) Ann. Derm. Vénér., 122, pp. 514-516Brasil, M.T.L.R.F., Opromolla, D.V., Marzliak, M.L.C., Nogueira, W., Results of a surveillance system for adverse effects in leprosy's WHO/MDT (1996) Int. J. Leprosy, 64, pp. 97-104Chalasani, P., Baffoe-Bonnie, H., Jurado, R.I., Dapsone therapy causing sulfone syndrome and lethal hepatic failure in an HIV-infected patient (1994) Sth. Med. J., 87, pp. 1145-1146Frey, H.M., Gershon, A.A., Borkowsky, W., Bullock, W.E., Fatal reaction to dapsone during treatment of leprosy (1981) Ann. Intern. Med., 94, pp. 777-779Gallo, M.E.N., Nery, J.A.C., Garcia, C.G., Interconências pelas drogas utilizadas nos esquemas poliquimioterápicos em hanseníase (1995) Hansenol. Int., 20, pp. 46-50Johnson, D.A., Cattau Jr., E.L., Kurltsky, J.N., Zimmerman, H.J., Liver involvement in the sulfone syndrome (1986) Arch. Intern. Med., 146, pp. 875-877Kaluarachchi, S.I., Fernandopulle, B.M., Gunawardane, B.P., Hepatic and haematological adverse reactions associated with the use of multidrug therapy in leprosy: A five year retrospective study (2001) Indian J. Leprosy, 73, pp. 121-129Kumar, R.H., Kumar, M.V., Thappa, D.M., Dapsone syndrome: A five year retrospective analysis (1998) Indian J. Leprosy, 70, pp. 271-276Lastória, J.C., De Mello, M.S., Putinatti, A., Souza, V., Síndrome de hipersensibilidade à dapsona (2004) Diagn. Tratam., 9, pp. 19-21Leta, G.C., Simas, M.E.P.A.S., Oliveira, M.L.W., Gomes, M.K., Síndrome de hipersensibilidade à dapsona: Revisão sistemática dos critérios diagnósticos (2003) Hansenol. Int., 28, pp. 79-84Lowe, J., Treatment of leprosy with diamino diphenylsulphone by mouth (1950) Lancet, 1, pp. 145-150Mandell, G.L., Petri Jr., W.A., Drugs used in the chemotherapy of tuberculosis, Mycobacterium avlum complex disease and leprosy (1996) Goodman & Gilman's Pharmacological Basis of Therapeutics. 9. International Ed., pp. 1155-1174. , Hardman, J.G.Limbird, L.E.Molinoff, P.B.Ruddon, R.W. & Gilman, A.G., ed. New York, McGraw HillOpromolla, D.V.A., Fleury, R.N., Sindrome da sulfona e reação reversa (1994) Hansenol. Int., 19, pp. 70-76Prussik, R., Shear, N.H., Dapsone hypersensitivity syndrome (1996) J. Amer. Acad. Derm., 35, pp. 346-349Rao, P.N., Lakshmi, T.S., Increase in the incidence of dapsone hypersensitivity syndrome: An appraisal (2001) Leprosy Rev., 72, pp. 57-62Reeve, P.A., Ala, J.L., Hall, J.J., Dapsone syndrome in Vanuatu: A high incidence during multidrug treatment (MDT) of leprosy (1992) J. Trop. Med. Hyg., 95, pp. 266-270Risse, L., Bernard, P., Brosset, A., Syndrome d'hypersensibilitȩ a la disulone® (1994) Ann. Derm. Vȩnȩr., 121, pp. 242-244Saito, S., Ikezawa, Z., Miyamoto, H., Kim, S., A case of dapsone syndrome (1994) Clin. Exp. Derm., 19, pp. 152-156Santos, M.E., Leta, G.C., Oliveira, M.L.W., Dapsone hypersensitivity syndrome (DHS): Not so rare to be minimized in endemic countries (2002) International Leprosy Congress, 16 (PART 16). , Salvador, Brazil. Book of abstractsThong, B.Y., Leong, K.P., Chng, H.H., Hypersensitivity syndrome associated with dapsone/pyrimethamine (Maloprim) antimalaria chemoprophylaxis (2002) Ann. Allergy Asthma Immunol., 88, pp. 527-529Tomecki, K.J., Catalano, C.J., Dapsone hypersensitivity. The sulfone syndrome revisited (1981) Arch. Derm., 117, pp. 38-39(2004) Leprosy Elimination Project. Status Report, 2003, , http://www.who.int/lep/Reports/s20042.pdf, WHO, Genev

Adherend effect on the peel strength of a brittle adhesive

Peel tests are widely used to characterize the peel strength of bonded joints and control adhesion quality. There are various configurations of peel test, such as the T-peel test, peel testing at 180°, the floating roller peel test, and the climbing drum peel test. These methods have been widely used mainly in the aeronautical industry, as a way of assessing the peel strength of metallic joints. However, with the growing use of composite materials in industry, it is necessary to characterize bonded joints with these materials when subjected to peeling loads. In this research, the adherend effect on the peel strength of a brittle adhesive is experimentally studied using the floating roller peel test with the aim of evaluating how adherend changes affect adhesion properties of brittle adhesives and also to assess the viability of using the floating roller peel test in composite-to-composite and composite-to-aluminum joints, as well as make a comparison with aluminum-aluminum joint performance. It is also intended to prove the applicability of this test for quality control of adhesion and determination of peel strength in joints with composite materials. The results show the Araldite® AV138 performance falls within the characteristic values of peel strength of other structural adhesives, particularly when composite adherends are concerned, and with reasonable repeatability considering it is a brittle adhesive.info:eu-repo/semantics/publishedVersio

Recuperação De área Degradada No Domínio Floresta Estacional Semidecidual Sob Diferentes Tratamentos

It was aimed to evaluate three treatments for forest restoration in an area with periodic elevation of the groundwater, in the Corredor de Biodiversidade Santa Maria, located between the cities of Santa Teresinha de Itaipu and São Miguel do Iguaçu, in Paraná state. The treatments were: control, green manure and soil solarization. It was performed a monthly monitoring of mortality and development of 12 tree native species of the region and the persistence of two invasive species present in the area, Megathyrsus maximus (coloniao grass) and Cyperus rotundus (coco grass). Furthermore, it was evaluated the changes introduced in the soil by three soil samples during the experiment. After over a year of assessment, the treatments showed no statistically significant differences on the evaluations. The mortality was more pronounced in January (12.08%), with a higher percentage for Cabralea canjerana (canjarana) and lower for Luehea divaricata (açoita-cavalo). About the seedlings development, growth was higher for: Sapium glandulatum (leiteiro-do-banhado), Croton urucurana (sangra-d’água) and Luehea divaricata, with monthly increases in diameter of 3.66 mm to 4.12 mm, and height of 12.39 cm to 17.02 cm. Regarding the dry mass of ‘colonião’ grass and coco grass (nutsedge) in all treatments, the highest values were found in January (94.14 g m-2) and February (132.76 g m-2), remaining low throughout the experiment. Through soil analyzes, it was observed that treatments showed no significant differences, however, the physical and chemical changes in the soil were sensitive to the invasive species management, which may lead to new modifications during the growth of seedlings. © 2016, Universidade Federal de Santa Maria. All rights reserved.26369971

Orelha de Elefante Mexicana (Opuntia stricta [Haw.] Haw.) spineless cactus as an option in crossbred dairy cattle diet

new genotype of spineless cactus is being used in the diets of dairy cattle that are raised in semi-arid regions. However, little is known about its nutritional value. This study aimed to evaluate the effects of replacing Miúda (Nopalea cochenillifera Salm Dyck) with Orelha de Elefante Mexicana (Opuntia stricta [Haw.] Haw.) spineless cactus, on nutrient intake and digestibility, milk yield and composition, feeding behaviour, microbial protein synthesis, nitrogen balance, and ruminal and blood parameters of dairy cows. Ten Girolando cows, 500 ± 51.6 kg bodyweight, were distributed in a double Latin square design 5 x 5. The treatments consisted of replacement levels of Miúda (MIU) by Orelha de Elefante Mexicana (OEM) at 0, 25, 50, 75, and 100%. The intake and digestibility of dry matter (DM) (14.38–12.95 kg d-1, 716.3–658.9 g d-1), organic matter (OM) (13.01–11.43 kg d-1, 747.8–704.8 g d-1), crude protein (CP) (2.02–1.61 kg d-1, 863.8–845.2 g d-1) and total digestible nutrients (TDN) (9.38–7.92 kg d-1) decreased linearly with the increase in replacement. Despite the decrease in intake and digestibility, the supply of nutrients was sufficient to maintain a milk yield of 12.5 kg d-1. The average daily weight gain decreased linearly with the increase in replacement, while protein microbial efficiency (g microbial CP kg-1 TDN intake; 91.24 to 127.44 g kg-1) increased linearly. Thus, OEM could replace 100% MIU in diets with 48% of spineless cactus, for crossbred lactating cows with 12.5 kg d-1 milk yield. Therefore, OEM is a viable new option for producing milk in smallholder livestock systems in semi-arid regions.Keywords: Alternative forage, milk yield, ruminal parameter, semi-arid, smallholder livestock syste

Determination of optimal ultrasound planes for the initialisation of image registration during endoscopic ultrasound-guided procedures

Purpose Navigation of endoscopic ultrasound (EUS)-guided procedures of the upper gastrointestinal (GI) system can be technically challenging due to the small fields-of-view of ultrasound and optical devices, as well as the anatomical variability and limited number of orienting landmarks during navigation. Co-registration of an EUS device and a pre-procedure 3D image can enhance the ability to navigate. However, the fidelity of this contextual information depends on the accuracy of registration. The purpose of this study was to develop and test the feasibility of a simulation-based planning method for pre-selecting patient-specific EUS-visible anatomical landmark locations to maximise the accuracy and robustness of a feature-based multimodality registration method. Methods A registration approach was adopted in which landmarks are registered to anatomical structures segmented from the pre-procedure volume. The predicted target registration errors (TREs) of EUS-CT registration were estimated using simulated visible anatomical landmarks and a Monte Carlo simulation of landmark localisation error. The optimal planes were selected based on the 90th percentile of TREs, which provide a robust and more accurate EUS-CT registration initialisation. The method was evaluated by comparing the accuracy and robustness of registrations initialised using optimised planes versus non-optimised planes using manually segmented CT images and simulated (n=9) or retrospective clinical (n=1) EUS landmarks. Results The results show a lower 90th percentile TRE when registration is initialised using the optimised planes compared with a non-optimised initialisation approach (p value <0.01). Conclusions The proposed simulation-based method to find optimised EUS planes and landmarks for EUS-guided procedures may have the potential to improve registration accuracy. Further work will investigate applying the technique in a clinical setting

Lattice distortions in a sawtooth chain with Heisenberg and Ising bonds

An exactly solvable model of the sawtooth chain with Ising and Heisenberg bonds and with coupling to lattice distortion for Heisenberg bonds is considered in the magnetic field. Using the direct transfer-matrix formalism an exact description of the thermodynamic functions is obtained. The ground state phase diagrams for all regions of parameters values containing phases corresponding to the magnetization plateaus at $M=0,1/4$ and 1/2 have been obtained. Exact formulas for bond distortions for various ground states are presented. A novel mechanism of magnetization plateau stabilization corresponding to $M=1/4$ state is reported.Comment: 16 pages, 12 figure

Humeral chondrosarcoma associated with lung metastases in a young dog - case report

ABSTRACT Chondrosarcoma, an unusual malignant neoplasm, develops in cartilaginous tissue and presents low rate of metastasis, mainly affecting the axial skeleton from the adult to senile dogs. In the face of unusual occurrence of chondrosarcoma in the long bones of young dogs, the present report aimed to describe it in the right humerus of a two-and-a-half-year-old Siberian Husky, attended at the Veterinary Hospital of the University of Franca, with limping of the right thoracic limb, for 20 days. The radiographic examination of the humerus showed bone lysis and periosteal proliferation. In the incisional biopsy, proliferation of atypical chondrocytes with diffuse distribution, interspersed with compact bone matrix, was observed. The amputation of the limb was performed, and the fragment histopathological analysis showed grade I chondrosarcoma. Periodic returns were made for neoplastic staging, and at 240 days after surgery lung metastases were detected, however, the tutor did not authorize chemotherapy and radiotherapy for financial reasons and due to the absence of respiratory symptoms so far (410 days after surgery). Although uncommon, chondrosarcoma can affect the long bones of young dogs, with clinical signs similar to other bone neoplasms, and, even with the radical limb amputation, can demonstrate systemic metastasis