A dual function of Drosophila capping protein on DE-cadherin maintains epithelial integrity and prevents JNK-mediated apoptosis

E-cadherin plays a pivotal role in epithelial cell polarity, cell signalling and tumour suppression. However, how E-cadherin dysfunction promotes tumour progression is poorly understood. Here we show that the actin-capping protein heterodimer, which regulates actin filament polymerization, has a dual function on DE-cadherin in restricted Drosophila epithelia. Knocking down capping protein in the distal wing disc epithelium disrupts DE-cadherin and Armadillo localization at adherens junctions and upregulates DE-cadherin transcription. In turn, DE-cadherin provides an active signal, which prevents Wingless signalling and promotes JNK-mediated apoptosis. However, when cells are kept alive with the Caspase inhibitor P35, the activity of the JNK pathway and of the Yorkie oncogene trigger massive proliferation of cells that fail to stably retain associations with their neighbours. Moreover, loss of capping protein cooperates with the Ras oncogene to induce massive tissue overgrowth. Taken together, our findings argue that in some epithelia, the dual effect of capping protein loss on DE-cadherin triggers the elimination of mutant cells, preventing them from proliferating. However, the appearance of a second mutation that blocks cell death may allow for the development of some epithelial tumour

Variação espaço-temporal das correntes de retorno em municípios da região metropolitana do Recife

Correntes de retorno são correntes por onde água retorna e flui rapidamente de maneira perpendicular a praiana direção do mar. Ocorrem em diversos tipos de praia, e são uma das maiores ameaças naturais a banhistas que são carregados por elas para águas mais profundas em pouco tempo, podendo causar afogamentos. Este trabalho teve como objetivo realizar o mapeamento espaço-temporal das correntes de retorno encontradas nas praias dos municípios de Cabo de Santo Agostinho, Jaboatão dos Guararapes e Recife do estado de Pernambuco. Para isso foram realizadas análises quali-quantitativas através de imagens aéreas oblíquas, obtidas por meio de sobrevoo de helicóptero e imagens de satélite, que levaram em conta, entre outras coisas, a existência de aberturas nos recifes, atividade da zona de surfe, presença de embaiamento na praia e ocorrência de plumas de sedimento. No total foram encontradas 77 correntes de retorno e 08 Indicadores de Circulação Transversal (ICT). As análises demonstraram que o maior número de fenômenos oceanográficos encontrados foram corrente de retorno móvel, 53 no total, seguidas das correntes de retorno fixas e dos ICTs. O município que mais apresentou a existência de correntes de retorno foi Cabo de Santo Agostinho, para o qual foram contabilizadas 37 correntes de retorno. Logo depois vem o município de Recife e Jaboatão com números absolutos de 15 e 09, respectivamente. Esses dados demonstram uma presença marcante de tais perigos praiais para os banhistas que frequentam as praias do estado de Pernambuco

Variação espaço-temporal das correntes de retorno em municípios da região metropolitana do Recife

Correntes de retorno são correntes por onde água retorna e flui rapidamente de maneira perpendicular a praiana direção do mar. Ocorrem em diversos tipos de praia, e são uma das maiores ameaças naturais a banhistas que são carregados por elas para águas mais profundas em pouco tempo, podendo causar afogamentos. Este trabalho teve como objetivo realizar o mapeamento espaço-temporal das correntes de retorno encontradas nas praias dos municípios de Cabo de Santo Agostinho, Jaboatão dos Guararapes e Recife do estado de Pernambuco. Para isso foram realizadas análises quali-quantitativas através de imagens aéreas oblíquas, obtidas por meio de sobrevoo de helicóptero e imagens de satélite, que levaram em conta, entre outras coisas, a existência de aberturas nos recifes, atividade da zona de surfe, presença de embaiamento na praia e ocorrência de plumas de sedimento. No total foram encontradas 77 correntes de retorno e 08 Indicadores de Circulação Transversal (ICT). As análises demonstraram que o maior número de fenômenos oceanográficos encontrados foram corrente de retorno móvel, 53 no total, seguidas das correntes de retorno fixas e dos ICTs. O município que mais apresentou a existência de correntes de retorno foi Cabo de Santo Agostinho, para o qual foram contabilizadas 37 correntes de retorno. Logo depois vem o município de Recife e Jaboatão com números absolutos de 15 e 09, respectivamente. Esses dados demonstram uma presença marcante de tais perigos praiais para os banhistas que frequentam as praias do estado de Pernambuco

Calcified Abdominal Pregnancy With Eighteen Years Of Evolution: Case Report.

CONTEXT: The lithopedion (calcified abdominal pregnancy) is a rare phenomenon and there are less than 300 cases reported in the medical literature. CASE REPORT: In this case, a 40 year-old patient had had her only pregnancy 18 years earlier, without medical assistance since then. She came to our hospital with pain and tumoral mass of approximately 20 centimeters in diameter. Complementary examinations (abdominal X-ray, ultrasonography and computerized tomography) demonstrated an extra-uterine abdominal 31-week pregnancy with calcification areas. Exploratory laparotomy was performed, with extirpation of a well-conserved fetus with partially calcified ovular membranes.118619219

Differential cross section and recoil polarization measurements for the gamma p to K+ Lambda reaction using CLAS at Jefferson Lab

We present measurements of the differential cross section and Lambda recoil polarization for the gamma p to K+ Lambda reaction made using the CLAS detector at Jefferson Lab. These measurements cover the center-of-mass energy range from 1.62 to 2.84 GeV and a wide range of center-of-mass K+ production angles. Independent analyses were performed using the K+ p pi- and K+ p (missing pi -) final-state topologies; results from these analyses were found to exhibit good agreement. These differential cross section measurements show excellent agreement with previous CLAS and LEPS results and offer increased precision and a 300 MeV increase in energy coverage. The recoil polarization data agree well with previous results and offer a large increase in precision and a 500 MeV extension in energy range. The increased center-of-mass energy range that these data represent will allow for independent study of non-resonant K+ Lambda photoproduction mechanisms at all production angles.Comment: 22 pages, 16 figure

School dropout, problem behaviour and poor academic achievement : a longitudinal view of portuguese male offenders

This study examines school drop outs from the perspective of male adults themselves through interviews with offenders currently serving sentences. Participants were 10 Portuguese male inmates, between the ages of 19 and 46 years of age, incarcerated in two prison facilities of the Azores. Qualitative and interpretative methods were carried out using a semi-structured in-depth individual interview that was audiorecorded and conducted on the basis of a list of topics. Interview transcripts and thematic analysis were used in data treatment and analysis. The findings primarily indicate that poor academic achievement and emotional and behavioural difficulties of participants played a particular role in early school drop out. The trajectories these individuals followed within the education system presented problem behaviour, learning disabilities, and/or foster care interventions. While school drop out circumstances were apparently various, analysis showed that they were underpinned by three distinct sets of conditions generally not addressed by the education system. The analysis of the triggering factors and the maintenance dynamics of school drop outs indicated three distinct types: retention/absenteeism, life turning points and positive resolution. Implications for secondary prevention and screening practices are discussed.FCT (SFRH/ BD/ 44245/ 2008)CIEC - unidade de investigação 317 da FC

Coherent Photoproduction of pi^+ from 3^He

We have measured the differential cross section for the $\gamma$$^3$He$\rightarrow \pi^+ t$ reaction. This reaction was studied using the CEBAF Large Acceptance Spectrometer (CLAS) at Jefferson Lab. Real photons produced with the Hall-B bremsstrahlung tagging system in the energy range from 0.50 to 1.55 GeV were incident on a cryogenic liquid $^3$He target. The differential cross sections for the $\gamma$$^3$He$\rightarrow \pi^+ t$ reaction were measured as a function of photon-beam energy and pion-scattering angle. Theoretical predictions to date cannot explain the large cross sections except at backward angles, showing that additional components must be added to the model.Comment: 11 pages, 16 figure

A Bayesian analysis of pentaquark signals from CLAS data

We examine the results of two measurements by the CLAS collaboration, one of which claimed evidence for a $\Theta^{+}$ pentaquark, whilst the other found no such evidence. The unique feature of these two experiments was that they were performed with the same experimental setup. Using a Bayesian analysis we find that the results of the two experiments are in fact compatible with each other, but that the first measurement did not contain sufficient information to determine unambiguously the existence of a $\Theta^{+}$. Further, we suggest a means by which the existence of a new candidate particle can be tested in a rigorous manner.Comment: 5 pages, 3 figure

First measurement of direct f0(980)f_0(980) photoproduction on the proton

We report on the results of the first measurement of exclusive $f_0(980)$ meson photoproduction on protons for $E_\gamma=3.0 - 3.8$ GeV and $-t = 0.4-1.0$ GeV$^2$. Data were collected with the CLAS detector at the Thomas Jefferson National Accelerator Facility. The resonance was detected via its decay in the $\pi^+ \pi^-$ channel by performing a partial wave analysis of the reaction $\gamma p \to p \pi^+ \pi^-$. Clear evidence of the $f_0(980)$ meson was found in the interference between $P$ and $S$ waves at $M_{\pi^+ \pi^-}\sim 1$ GeV. The $S$-wave differential cross section integrated in the mass range of the $f_0(980)$ was found to be a factor of 50 smaller than the cross section for the $\rho$ meson. This is the first time the $f_0(980)$ meson has been measured in a photoproduction experiment