Can contrast-enhanced MR imaging predict survival in breast cancer?

PURPOSE: To investigate the value of pre-operative contrast-enhanced MR imaging (CE-MRI) in predicting the disease-free and overall survival in breast cancer. MATERIAL AND METHODS: The study population consisted of 50 consecutive patients with histopathologically verified primary breast cancer who pre-operatively underwent CE-MRI examination between 1992 and 1993. A three-time point MR examination was performed where the enhancement rates (C1 and C2), signal enhancement ratio (SER=C1/C2) and washout (W=C1-C2) were calculated. The relation of these MR parameters to disease-free and overall survival was investigated. The median follow-up for surviving patients was 95 months. Univariate and multivariate statistical analyses were performed to evaluate the impact of different factors on prediction of survival. RESULTS: Of the MR parameters examined at univariate analysis, increased C1 (p=0.029), W (p=0.0081) and SER values (p=0.0081) were significantly associated with shorter disease-free survival, and only C1 (p=0.016) was related significantly to overall survival. Multivariate analysis for disease-free survival showed that the SER (p=0.014) and tumor size (p=0.001) were significant and independent predictors. Age (p=0.003), lymph node status (p=0.014), tumor size (p=0.039) and proliferating cell nuclear antigen index (p=0.053) remained independently associated with overall survival at multivariate analysis. C1 was not confirmed as an independent predictor of overall survival. CONCLUSION: Our findings support the presumption that CE-MRI is useful in predicting the disease-free survival in patients with breast cancer

20-Year Risks of Breast-Cancer Recurrence after Stopping Endocrine Therapy at 5 Years

The administration of endocrine therapy for 5 years substantially reduces recurrence rates during and after treatment in women with early-stage, estrogen-receptor (ER)-positive breast cancer. Extending such therapy beyond 5 years offers further protection but has additional side effects. Obtaining data on the absolute risk of subsequent distant recurrence if therapy stops at 5 years could help determine whether to extend treatment

Long-term outcomes for neoadjuvant versus adjuvant chemotherapy in early breast cancer: meta-analysis of individual patient data from ten randomised trials

Background Neoadjuvant chemotherapy (NACT) for early breast cancer can make breast-conserving surgery more feasible and might be more likely to eradicate micrometastatic disease than might the same chemotherapy given after surgery. We investigated the long-term benefits and risks of NACT and the influence of tumour characteristics on outcome with a collaborative meta-analysis of individual patient data from relevant randomised trials. Methods We obtained information about prerandomisation tumour characteristics, clinical tumour response, surgery, recurrence, and mortality for 4756 women in ten randomised trials in early breast cancer that began before 2005 and compared NACT with the same chemotherapy given postoperatively. Primary outcomes were tumour response, extent of local therapy, local and distant recurrence, breast cancer death, and overall mortality. Analyses by intention-to-treat used standard regression (for response and frequency of breast-conserving therapy) and log-rank methods (for recurrence and mortality). Findings Patients entered the trials from 1983 to 2002 and median follow-up was 9 years (IQR 5–14), with the last follow-up in 2013. Most chemotherapy was anthracycline based (3838 [81%] of 4756 women). More than two thirds (1349 [69%] of 1947) of women allocated NACT had a complete or partial clinical response. Patients allocated NACT had an increased frequency of breast-conserving therapy (1504 [65%] of 2320 treated with NACT vs 1135 [49%] of 2318 treated with adjuvant chemotherapy). NACT was associated with more frequent local recurrence than was adjuvant chemotherapy: the 15 year local recurrence was 21·4% for NACT versus 15·9% for adjuvant chemotherapy (5·5% increase [95% CI 2·4–8·6]; rate ratio 1·37 [95% CI 1·17–1·61]; p=0·0001). No significant difference between NACT and adjuvant chemotherapy was noted for distant recurrence (15 year risk 38·2% for NACT vs 38·0% for adjuvant chemotherapy; rate ratio 1·02 [95% CI 0·92–1·14]; p=0·66), breast cancer mortality (34·4% vs 33·7%; 1·06 [0·95–1·18]; p=0·31), or death from any cause (40·9% vs 41·2%; 1·04 [0·94–1·15]; p=0·45). Interpretation Tumours downsized by NACT might have higher local recurrence after breast-conserving therapy than might tumours of the same dimensions in women who have not received NACT. Strategies to mitigate the increased local recurrence after breast-conserving therapy in tumours downsized by NACT should be considered—eg, careful tumour localisation, detailed pathological assessment, and appropriate radiotherapy

Self

Demensions are 15 x 13 x 8 inches. Originally featured in the JCCC Student Center (First Floor).https://scholarspace.jccc.edu/student_art/1000/thumbnail.jp

: The school nurse’s experience of the interaction between mental health and physical activity from their work with high school students

Bakgrund: Många barn uppvisar symtom på psykisk ohälsa, samtidigt visar studier att barn får en alltmer stillasittande fritid. Exakt hur den fysiska aktiviteten påverkar den psykiska hälsan är oklart då det är en komplex fråga. I sitt arbete erhåller skolsköterskor nära relationer med barn och de får på så vis en inblick i hur den psykiska samt fysiska hälsan ser ut. Syfte: Syftet med studien var att belysa hur samspelet mellan psykisk hälsa och fysisk aktivitet uppfattas av skolsköterskor utifrån deras erfarenhet i elevhälsan bland högstadieelever. Metod: En empirisk kvalitativ intervjustudie med fenomenografisk ansats. Undersökningsgruppen bestod av åtta stycken skolsköterskor i Karlstads kommun som arbetar med elever på högstadiet. Huvudresultat: Skolsköterskorna hade en gemensam erfarenhet av att många barn har en dålig psykisk hälsa och att detta främst observeras bland flickor. De delade även uppfattningen av att den fysiska aktiviteten minskar bland barn. Något som framkom av skolsköterskornas berättelser var att kraven inom idrotten uppfattas av många barn som allt för höga. Konklusion: Många barn upplever allt för höga krav inom idrotten vilket kan leda till psykisk ohälsa hos vissa barn och framförallt bland flickor. För att få barn att öka sin fysiska aktivitet är det viktigt att se över synsättet inom idrotten så att det blir den roliga, sociala och avslappnande aktivitet den är tänkt att vara.Background There has been an increase in the proportion of adolescents who show symptoms of mental illness. It is clear from previous research that physical activity affects the mental health and it is a current issue. It is, however, unclear exactly how it affects the mental health then it is a complex issue. In their everyday work school nurses get close relationship to adolescents and get an insight of how the mental and physical health situation looks like among adolescents. Aim: The aim of this study was to highlight the interaction between mental health and physical activity based on the school nurses experience in the student health team among high school students. Method: The study is a qualitative interview study with phenomenographic analysis. Data was collected from interviews, the study group consisted of eight school nurses who worked within Karlstad kommun and were working with adolescents in high schools. Main result: The school nurses shared the common experience that many of the adolescents suffered from poor mental health, and it is mainly observed in girls. They also experienced that adolescents are less physical active and that the adolescents are having an increased sedentary behavior. Something that also emerged from the school nurses stories was that the demands of the sport has increased. Conclusion: Many are experiencing too high demands from their sport which can result in mental illness for some children, especially among girls. To get adolescents to increase their physical activity is it important to look over the approach within sport so that it becomes the fun, social and relaxing activity it is supposed to be

: The school nurse’s experience of the interaction between mental health and physical activity from their work with high school students

Bakgrund: Många barn uppvisar symtom på psykisk ohälsa, samtidigt visar studier att barn får en alltmer stillasittande fritid. Exakt hur den fysiska aktiviteten påverkar den psykiska hälsan är oklart då det är en komplex fråga. I sitt arbete erhåller skolsköterskor nära relationer med barn och de får på så vis en inblick i hur den psykiska samt fysiska hälsan ser ut. Syfte: Syftet med studien var att belysa hur samspelet mellan psykisk hälsa och fysisk aktivitet uppfattas av skolsköterskor utifrån deras erfarenhet i elevhälsan bland högstadieelever. Metod: En empirisk kvalitativ intervjustudie med fenomenografisk ansats. Undersökningsgruppen bestod av åtta stycken skolsköterskor i Karlstads kommun som arbetar med elever på högstadiet. Huvudresultat: Skolsköterskorna hade en gemensam erfarenhet av att många barn har en dålig psykisk hälsa och att detta främst observeras bland flickor. De delade även uppfattningen av att den fysiska aktiviteten minskar bland barn. Något som framkom av skolsköterskornas berättelser var att kraven inom idrotten uppfattas av många barn som allt för höga. Konklusion: Många barn upplever allt för höga krav inom idrotten vilket kan leda till psykisk ohälsa hos vissa barn och framförallt bland flickor. För att få barn att öka sin fysiska aktivitet är det viktigt att se över synsättet inom idrotten så att det blir den roliga, sociala och avslappnande aktivitet den är tänkt att vara.Background There has been an increase in the proportion of adolescents who show symptoms of mental illness. It is clear from previous research that physical activity affects the mental health and it is a current issue. It is, however, unclear exactly how it affects the mental health then it is a complex issue. In their everyday work school nurses get close relationship to adolescents and get an insight of how the mental and physical health situation looks like among adolescents. Aim: The aim of this study was to highlight the interaction between mental health and physical activity based on the school nurses experience in the student health team among high school students. Method: The study is a qualitative interview study with phenomenographic analysis. Data was collected from interviews, the study group consisted of eight school nurses who worked within Karlstad kommun and were working with adolescents in high schools. Main result: The school nurses shared the common experience that many of the adolescents suffered from poor mental health, and it is mainly observed in girls. They also experienced that adolescents are less physical active and that the adolescents are having an increased sedentary behavior. Something that also emerged from the school nurses stories was that the demands of the sport has increased. Conclusion: Many are experiencing too high demands from their sport which can result in mental illness for some children, especially among girls. To get adolescents to increase their physical activity is it important to look over the approach within sport so that it becomes the fun, social and relaxing activity it is supposed to be