Implementation of a pilot parent-focused physical activity program with Latino families in a Head Start program

Introduction and Background. Physical activity (PA), even at young age, is associated with physical and psychological health. This study determined the feasibility of implementing a parent-led PA intervention and evaluated potential outcomes. Methods. Parent-child pairs from a Head Start center were randomized into intervention (N=20) and control (N=18) groups. All families received a bag of play equipment. Parents completed questionnaires assessing their own and their children’s PA, as well as self-efficacy, social control (SC), and social support (SS) regarding their provision of PA to their children. Parents in the intervention were trained in self-regulatory skills, facilitation of PA, and attended two playdates. Parents rated the playdates, activity sheet and equipment on a 5-point Likert scale. Results. Parents rated the playdates (M=4.9, SD=0.3), the activity sheet (M=4.7, SD=0.7) and the equipment bag (M=5, SD=0.0) highly. Child’s PA, parent’s moderate-to-vigorous PA, total PA, parental efficacy, SC, and SS showed no significant intervention effects. Overall, child and parent PA increased significantly over time (p=.02 for both). Conclusions. The intervention was positively received, with 90% completion rate and high ratings of the intervention materials. Longer interventions with more contact may be needed to influence potential outcomes

Méthodes de machine learning pour la prédiction de trajets de fissures dans les matériaux cimentaires sur la base de descripteurs morphologiques locaux

National audienceLa construction d'un matériau numérique repose sur des descripteurs morphologiques qui caractérisent un matériau réel à l'aide d'informations statistiques et géométriques. La microstructure numérique générée est qualifié statistiquement semblable par rapport à la réalité. Or deux microstructures statistiquement semblables peuvent présenter des comportements de fissuration différents. Ces différences peuvent avoir une influence sur la perméabilité des enceintes. Pour contourner cette limitation, nous proposons dans ce travail un nouvelle approche qui combine descripteurs morphologiques et modèle de prédiction de fissure pour évaluer la similarité entre 2 microstructures

Modélisation de la prédiction de trajets de fissures sur la base de descripteurs morphologiques locaux : application à la génération de microstructures équivalentes dans les études du vieillissement des matériaux cimentaires

National audienc

Randomized Clinical Trials of obesity treatments in Mexican population. Systematic Review and Meta-Analysis

Background: Mexicans and Mexican Americans share similar culture, genetic background, and predisposition for obesity and diabetes. Randomized clinical trials (RCT) assessing obesity treatments (ObT) are reliable to assess efficacy. To date, there is no systematic review to investigate ObT tested by RCT in Mexican adults. Methods: We conducted systematic searches in Pubmed, Scopus, and Web of Science to retrieve ObT RCT from 1990 to 2019. The ObT included alternative medicine, pharmacological, nutritional, behavioral, and surgical interventions. The analyzed RCT were at least three months of duration, and reported: BMI, weight, waist circumference, triglycerides, glucose and blood pressure. Results: We found 634 entries; after removal of duplicates and exclusions based on eligibility criteria, we analyzed 43 and 2 multinational-collaborative studies. Most of the national studies had small sample sizes, and did not have replications from other studies. The nutrition/behavioral interventions were difficult to blind, and most studies had medium to high risk of bias. Random effects meta-analysis of nutritional/behavioral interventions and medications showed effects on BMI, waist circumference, and blood pressure. Simple measures like plain water instead of sweet beverages decreased triglycerides and systolic blood pressure. Participants with obesity and hypertension had beneficial effects with antioxidants, and the treatment with insulin increased weight in those with T2D. Conclusions: The RCT’s in Mexico reported effects on metabolic components despite small sample sizes and lack of replication. In the future we should analyze ObT in population living on the U.S.-Mexico border; therefore, bi-national collaboration is desirable to disentangle cultural effects on ObT response

Looking for Crumbs in the Obesity Forest: Anti-obesity Interventions and Obesity-Associated Cardiometabolic Traits in the Mexican Population. History and Systematic Review With Meta-Analyses

Mexicans and Mexican Americans share culture, genetic background, and predisposition for chronic complications associated with obesity and diabetes making imperative efficacious treatments and prevention. Obesity has been treated for centuries focused-on weight loss while other treatments on associated conditions like gout, diabetes (T2D), and hypertriglyceridemia. To date, there is no systematic review that synthesizes the origin of obesity clinics in Mexico and the efforts to investigate treatments for obesity tested by randomized clinical trials (RCT). We conducted systematic searches in Pubmed, Scopus, and Web of Science to retrieve anti-obesity RCT through 2019 and without an inferior temporal limit. The systematic review included RCT of anti-obesity treatments in the Mexican adult population, covering alternative medicine, pharmacological, nutritional, behavioral, and surgical interventions reporting metabolism-associated traits such as BMI, weight, waist circumference, triglycerides, glucose, among others. Only the studies with at least 3 months of treatment were included in the meta-analyses in order to reduce placebo effects. We found 634 entries, after removal of duplicates and screening the studies based on eligibility criteria, we analyzed 43 national, and 2 multinational-collaborative studies. Most of the national studies had small sample sizes, and the implemented strategies do not have replications in the population. The nutrition/behavioral interventions were difficult to blind, and most studies have medium-to-high risk of bias. Nutritional/behavioral interventions and medications showed effects on BMI, waist circumference, and blood pressure. Simple measures like pure water instead of sweet beverages decrease triglycerides and systolic blood pressure. Dark chocolate showed the highest effect for BMI and high blood pressure, and treatment with insulin increased weight in those with T2D. The study of obesity in Mexico has been on-going for more than four decades, the interest on RCT just increased until this millennium, but with small sample sizes and lack of replication. The interventions affect different cardiometabolic associated traits, which should be analyzed in detail in the population living near the Mexico-U.S. border; therefore, bi-national collaboration is desirable to disentangle the cultural effects on this population\u27s treatment response

Arizona\u27s Vulnerable Populations

Arizona’s vulnerable populations are struggling on a daily basis but usually do so in silence, undetected by traditional radar and rankings, often unaware themselves of their high risk for being pushed or pulled into a full crisis. Ineligible for financial assistance under strict eligibility guidelines, they don’t qualify as poor because vulnerable populations are not yet in full crisis. To be clear, this report is not about the “poor,” at least not in the limited sense of the word. It is about our underemployed wage earners, our single-parent households, our deployed or returning military members, our under-educated and unskilled workforce, our debt-ridden neighbors, our uninsured friends, our family members with no savings for an emergency, much less retirement

Complement lectin pathway activation is associated with COVID-19 disease severity, independent of MBL2 genotype subgroups

IntroductionWhile complement is a contributor to disease severity in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, all three complement pathways might be activated by the virus. Lectin pathway activation occurs through different pattern recognition molecules, including mannan binding lectin (MBL), a protein shown to interact with SARS-CoV-2 proteins. However, the exact role of lectin pathway activation and its key pattern recognition molecule MBL in COVID-19 is still not fully understood.MethodsWe therefore investigated activation of the lectin pathway in two independent cohorts of SARS-CoV-2 infected patients, while also analysing MBL protein levels and potential effects of the six major single nucleotide polymorphisms (SNPs) found in the MBL2 gene on COVID-19 severity and outcome.ResultsWe show that the lectin pathway is activated in acute COVID-19, indicated by the correlation between complement activation product levels of the MASP-1/C1-INH complex (p=0.0011) and C4d (p<0.0001) and COVID-19 severity. Despite this, genetic variations in MBL2 are not associated with susceptibility to SARS-CoV-2 infection or disease outcomes such as mortality and the development of Long COVID.ConclusionIn conclusion, activation of the MBL-LP only plays a minor role in COVID-19 pathogenesis, since no clinically meaningful, consistent associations with disease outcomes were noted

Modélisation de la prédiction de trajets de fissures sur la base de descripteurs morphologiques locaux : application à la génération de microstructures équivalentes dans les études du vieillissement des matériaux cimentaires

National audienc

Modélisation de la prédiction de trajets de fissures sur la base de descripteurs morphologiques locaux : application à la génération de microstructures équivalentes dans les études du vieillissement des matériaux cimentaires

National audienc

Méthodes de machine learning pour la prédiction de trajets de fissures dans les matériaux cimentaires sur la base de descripteurs morphologiques locaux

National audienceLa construction d'un matériau numérique repose sur des descripteurs morphologiques qui caractérisent un matériau réel à l'aide d'informations statistiques et géométriques. La microstructure numérique générée est qualifié statistiquement semblable par rapport à la réalité. Or deux microstructures statistiquement semblables peuvent présenter des comportements de fissuration différents. Ces différences peuvent avoir une influence sur la perméabilité des enceintes. Pour contourner cette limitation, nous proposons dans ce travail un nouvelle approche qui combine descripteurs morphologiques et modèle de prédiction de fissure pour évaluer la similarité entre 2 microstructures