Thickness of the rim of an expanding lamella near the splash threshold

The evolution of the ejected liquid sheet, or lamella, created after impact of a liquid drop onto a solid surface is studied using high-speed video in order to observe the detailed time evolution of the thickness of the rim of the lamella. Since it has been suggested that splashing behavior is set at very early times after impact, we study early times up to D-0/U-0, where D-0 and U-0 are the diameter and speed of the impacting drop, respectively, for different liquid viscosities and impact speeds below the splashing threshold. Within the regime of our experiments, our results are not consistent with the idea that the lamella rim grows similar to the boundary layer thickness. Rather, we find that the rim thickness is always much larger than the boundary layer thickness, and that the rim thickness decreases with increasing impact speed. For lower impact speeds, the increase in the rim thickness is consistent with a root t response over the limited time range available, but the dependence is not simply proportional to root nu, where nu is the kinematic viscosity, and there is a strong dependence of the rim thickness on the impact speed U-0. Scaling of the rim height using a balance of inertial and surface tension forces provides some collapse of the data at lower impact speeds. We also observe an unusual plateau behavior in thickness versus time at higher impact speeds as we approach the splash threshold. (C) 2010 American Institute of Physics. [doi:10.1063/1.3313360

Long-term stability of planets in and around binary stars

Planets are observed to orbit the component star(s) of stellar binary systems on so-called circumprimary or circumsecondary orbits, as well as around the entire binary system on so-called circumbinary orbits. Depending on the orbital parameters of the binary system a planet will be dynamically stable if it orbits within some critical separation of the semimajor axis in the circumprimary case, or beyond some critical separation for the circumbinary case. We present N-body simulations of star-forming regions that contain populations of primordial binaries to determine the fraction of binary systems that can host stable planets at various semimajor axes, and how this fraction of stable systems evolves over time. Dynamical encounters in star-forming regions can alter the orbits of some binary systems, which can induce long-term dynamical instabilities in the planetary system and can even change the size of the habitable zone(s) of the component stars. However, the overall fraction of binaries that can host stable planetary systems is not greatly affected by either the assumed binary population, or the density of the star-forming region. Instead, the critical factor in determining how many stable planetary systems exist in the Galaxy is the stellar binary fraction – the more stars that are born as singles in stellar nurseries, the higher the fraction of stable planetary systems

Telomere fusion threshold identifies a poor prognostic subset of breast cancer patients

Telomere dysfunction and fusion can drive genomic instability and clonal evolution in human tumours, including breast cancer. Telomere length is a critical determinant of telomere function and has been evaluated as a prognostic marker in several tumour types, but it has yet to be used in the clinical setting. Here we show that high-resolution telomere length analysis, together with a specific telomere fusion threshold, is highly prognostic for overall survival in a cohort of patients diagnosed with invasive ductal carcinoma of the breast (n = 120). The telomere fusion threshold defined a small subset of patients with an extremely poor clinical outcome, with a median survival of less than 12 months (HR = 21.4 (7.9-57.6), P < 0.0001). Furthermore, this telomere length threshold was independent of ER, PGR, HER2 status, NPI, or grade and was the dominant variable in multivariate analysis. We conclude that the fusogenic telomere length threshold provides a powerful, independent prognostic marker with clinical utility in breast cancer. Larger prospective studies are now required to determine the optimal way to incorporate high-resolution telomere length analysis into multivariate prognostic algorithms for patients diagnosed with breast cancer

Thickness of the rim of an expanding lamella near the splash threshold

The evolution of the ejected liquid sheet, or lamella, created after impact of a liquid drop onto a solid surface is studied using high-speed video in order to observe the detailed time evolution of the thickness of the rim of the lamella. Since it has been suggested that splashing behavior is set at very early times after impact, we study early times up to D-0/U-0, where D-0 and U-0 are the diameter and speed of the impacting drop, respectively, for different liquid viscosities and impact speeds below the splashing threshold. Within the regime of our experiments, our results are not consistent with the idea that the lamella rim grows similar to the boundary layer thickness. Rather, we find that the rim thickness is always much larger than the boundary layer thickness, and that the rim thickness decreases with increasing impact speed. For lower impact speeds, the increase in the rim thickness is consistent with a root t response over the limited time range available, but the dependence is not simply proportional to root nu, where nu is the kinematic viscosity, and there is a strong dependence of the rim thickness on the impact speed U-0. Scaling of the rim height using a balance of inertial and surface tension forces provides some collapse of the data at lower impact speeds. We also observe an unusual plateau behavior in thickness versus time at higher impact speeds as we approach the splash threshold. (C) 2010 American Institute of Physics. [doi:10.1063/1.3313360

Desorption of organic species from the GaAs (100) surface at low temperatures using low energy electron irradiation in a hydrogen ambient

We present a technique for the controlled removal of organic adsorbates from the GaAs (100) surface incorporating hydrogen dosing (atomic or molecular) combined with low-energy electron irradiation. High-resolution electron energy-loss and Auger electron spectroscopes verify a considerable desorption of carbon/hydrocarbons following electron irradiation at 50 eV under a hydrogen atom flux even at room temperature. At a sample temperature of 500 degrees C, static secondary ion mass spectroscopy data demonstrate selective area removal of carbon from the surface following 25 eV electron irradiation in a molecular hydrogen ambient, with a desorption rate controlled by the incident electron flux. (C) 2000 American Institute of Physics. [S0003- 6951(00)03221-6]