Algebraic Quantum Error-Correction Codes

Based on the group structure of a unitary Lie algebra, a scheme is provided to systematically and exhaustively generate quantum error correction codes, including the additive and nonadditive codes. The syndromes in the process of error-correction distinguished by different orthogonal vector subspaces, the coset subspaces. Moreover, the generated codes can be classified into four types with respect to the spinors in the unitary Lie algebra and a chosen initial quantum state

SK channels and ventricular arrhythmias in heart failure

Small-conductance Ca2+-activated K+ (SK) currents are important in the repolarization of normal atrial (but not ventricular) cardiomyocytes. However, recent studies showed that the SK currents are upregulated in failing ventricular cardiomyocytes, along with increased SK channel protein expression and enhanced sensitivity to intracellular Ca2+. The SK channel activation may be either antiarrhythmic or proarrhythmic, depending on the underlying clinical situations. While the SK channel is a new target of antiarrhythmic therapy, drug safety is still one of the major concerns

In Vitro Activities of Antibiotic Combinations Against Clinical Isolates of Pseudomonas Aeruginosa

Combination therapy has been recommended to treat Pseudomonas aeruginosa infections worldwide. The purpose of the present study was to determine the in vitro activities of piperacillin, cefepime, aztreonam, amikacin, and ciprofloxacin alone and in combination against 100 clinical isolates of P. aeruginosa from one medical center in southern Taiwan. The combination susceptibility assay was performed using the checkerboard technique. The percentage of resistance of P. aeruginosa to single agents in our study was relatively high for the Asia-Pacific area, except to aztreonam. Piperacillin plus amikacin exhibited the highest potential for synergy (59/100) in this study. Moreover, a high percentage of synergism was also noted with amikacin combined with cefepime (7/100) or aztreonam (16/100). The combination of two beta-lactams, such as cefepime with piperacillin, and aztreonam with cefepime or piperacillin, showed synergistic effects against some P. aeruginosa isolates. Although ciprofloxacin is a good anti-pseudomonal agent, a very low potential for synergy with other antibiotics was demonstrated in this study. No antagonism was exhibited by any combination in our study. Among piperacillin-resistant strains, there was synergy with a beta-lactam plus amikacin, including the combination of piperacillin and amikacin. However, the combination of two beta-lactams, such as piperacillin and cefepime or aztreonam, did not have any synergistic activity against these strains. In summary, the combinations of amikacin with the tested beta-lactams (piperacillin, aztreonam, cefepime) had a greater synergistic effect against P. aeruginosa, even piperacillin-resistant strains, than other combinations. Understanding the synergistic effect on clinical strains may help clinicians choose better empirical therapy in an area with high prevalence of multidrug-resistant P. aeruginosa

Therapeutic targets and functions of curcumol against COVID-19 and colon adenocarcinoma

Since 2019, the coronavirus disease (COVID-19) has caused 6,319,395 deaths worldwide. Although the COVID-19 vaccine is currently available, the latest variant of the virus, Omicron, spreads more easily than earlier strains, and its mortality rate is still high in patients with chronic diseases, especially cancer patients. So, identifying a novel compound for COVID-19 treatment could help reduce the lethal rate of the viral infection in patients with cancer. This study applied network pharmacology and systematic bioinformatics analysis to determine the possible use of curcumol for treating colon adenocarcinoma (COAD) in patients infected with COVID-19. Our results showed that COVID-19 and COAD in patients shared a cluster of genes commonly deregulated by curcumol. The clinical pathological analyses demonstrated that the expression of gamma-aminobutyric acid receptor subunit delta (GABRD) was associated with the patients' hazard ratio. More importantly, the high expression of GABRD was associated with poor survival rates and the late stages of COAD in patients. The network pharmacology result identified seven-core targets, including solute carrier family 6 member 3, gamma-aminobutyric acid receptor subunit pi, butyrylcholinesterase, cytochrome P450 3A4, 17-beta-hydroxysteroid dehydrogenase type 2, progesterone receptor, and GABRD of curcumol for treating patients with COVID-19 and COAD. The bioinformatic analysis further highlighted their importance in the biological processes and molecular functions in gland development, inflammation, retinol, and steroid metabolism. The findings of this study suggest that curcumol could be an alternative compound for treating patients with COVID-19 and COAD

The Information-Leveling Role of Voluntary Disclosure Quality in Facilitating Investment Efficiency

This study examines whether and under what conditions voluntary disclosure quality plays an information-leveling role in facilitating investment efficiency. Measuring voluntary disclosure quality as the (inverse) standard deviation of managers’ prior earnings forecast errors (i.e., management forecast consistency), we document a positive association between management forecast consistency and investment efficiency that strengthens when the information environment becomes more constrained and when there are negative shocks to financial reporting quality. We also find that the management forecast consistency/investment efficiency association strengthens when firms are younger, faster growing, and financially constrained, but not when firms are weakly governed and financially unconstrained, which suggests that voluntary disclosure quality facilitates investment efficiency by mitigating adverse selection (but not moral hazard) frictions. Last, when we employ a changes-based model, we find that increases in management forecast consistency are associated with increases in investment efficiency, which mitigates concerns that voluntary disclosure quality’s empirical link to investment efficiency is purely driven by managers’ inherent forecasting abilities. Overall, we show that voluntary disclosure quality can facilitate investment efficiency when financial reporting and other elements of the information environment are constrained in their ability to mitigate market frictions that impede efficiency

Dual pathways in social evolution: Population genetic structure of group-living and solitary species of kleptoparasitic spiders (Argyrodinae: Theridiidae)

Group-living behavior is taxonomically widespread but rare in spiders. The conventional view is that the main pathways to group-living in spiders are either sub-social, where extended maternal care leads to prolonged sibling association; or communal living, where individuals aggregate to exploit a common resource. Female egg-sac guarding behavior occurs throughout kleptoparasitic spiders in the subfamily Argyrodinae (Theridiidae), while individuals in group-living species cohabit in the resource rich webs of their host spiders. These attributes fit both sub-social and communal routes to group-living, which offers new insights to study the early stages of social evolution. We investigated whether members of kleptoparasitic groups in natural populations comprise related individuals by comparing the population structure of two group-living species, Argyrodes miniaceus and A. cf. fissifrons, and two solitary species, A. fasciatus and Neospintharus trigonum. We found that: (1) genetic-spatial autocorrelation in group-living species was highest among spiders sharing the same host web and declined steeply with increasing distance, but no significant autocorrelation at any scale for solitary species; (2) there was high relatedness among group members in two cases of group-living species, which indicated relatedness was not an adhesive agent in most of the groups, but no high relatedness in solitary species; and (3) the host web boundary was not the sole predictor of genetic structures in group-living species. These results suggest that population genetic structure in the group-living species is caused by limited dispersal of group members that is favored by ecological conditions, including the nature and size of resources. In contrast, the absence of genetic structuring in populations of solitary species indicates a high level of dispersal with individual interactions unlikely to have fitness benefits.2006353KMU-Q107006MOST107-2621- B-037-001-MY

[N,N′-Bis(3-meth­oxy-2-oxidobenzyl­idene)ethyl­enediammonium-κ4 O,O′,O′′,O′′′]tris­(nitrato-κ2 O,O′)dysprosium(III)

In the title mononuclear Schiff base complex, [Dy(NO3)3(C18H20N2O4)], the DyIII ion is ten-coordinated in a distorted hexa­deca­hedral geometry by six O atoms of three nitrate anions and four O atoms of the Schiff base ligand. An intra­molecular N—H⋯O hydrogen bond occurs. The crystal structure is stabilized by inter­molecular C—H⋯O hydrogen bonds