Consumer Preferences and Willingness to Pay for Advanced Vehicle Technology Options and Fuel Types

At the time of publication J. Shin and C.R. Bhat were at the University of Texas at Ausitn. V.M. Garikapati and D. You at Arizona State University, and R.M. Pendyala at Georgia Institute of Technology.The automotive industry is witnessing a revolution with the advent of advanced vehicular technologies, smart vehicle options, and fuel alternatives. However, there is very limited research on consumer preferences for these types of vehicles. But the deployment and penetration of advanced vehicular technologies in the marketplace, and planning for possible market adoption scenarios, calls for collection and analysis of consumer preference data related to these emerging technologies. This study aims to address this gap, offering a detailed analysis of consumer preference for alternative fuel types and technology options using data collected in choice experiments conducted on a sample of consumers in South Korea. The results indicate that there is considerable heterogeneity in consumer preferences for various smart technology options such as wireless internet, vehicle connectivity, and voice command features, but relatively little heterogeneity in the preference for smart vehicle applications such as real-time traveler information on parking and traffic conditions.Civil, Architectural, and Environmental Engineerin

Understanding the Multiple Dimensions of Residential Choice

At the time of publication, X. Fu was at the Shanghai Jiao Tong University, C.R. Bhat at the University of Texas at Austin, R.M. Pendyala at Georgia Institute of Technology, S. Vladlamani and V.M Garikapati at Arizona State University.Residential choice may be characterized as a household’s simultaneous decisions of location, neighborhood, and dwelling. Traditional models do not account for the latent unmeasured constructs which capture individuals’ preferences for and attitudes towards residence and mode choice. This paper employs Bhat’s (2014) Generalized Heterogeneous Data Model (GHMD) to accommodate five inter-related residential choice dimensions, including residential location, neighborhood land-use pattern, public transportation availability, housing type, and dwelling ownership. Four latent variables including pro-driving, pro-public transportation, facility availability, and residential spaciousness are constructed to capture individuals’ attitudes towards travel modes and preferences for residential features. The inclusion of these latent constructs helps account for self-selection effects in residential choice processes. The determination of relationships among multiple dimensions of residential choice behavior, socio-demographics, and latent attitudes and preferences is critical to integrated land use – transport modeling and the formulation of policies as well as urban residential and neighborhood environments that cater to individual preferences and enhance quality of life.Civil, Architectural, and Environmental Engineerin

An Integrated Latent Construct Modeling Framework for Predicting Physical Activity Engagement and Health Outcomes

At the time of publication M.M Hoklas, S.K. Dubey, and C.R. Bhat were at the University of Texas at Austin. V.M Garikapati at Arizona State University, R.M. Pendyala at Georgia Institute of Technology, and D. Hyun You at Arizona State University.The health and well-being of individuals is related to their activity-travel patterns. Individuals who undertake physically active episodes such as walking and bicycling are likely to have improved health outcomes compared to individuals with sedentary auto-centric lifestyles. Activity-based travel demand models are able to predict activity-travel patterns of individuals at a high degree of fidelity, thus providing rich information for transportation and public health professionals to infer health outcomes that may be experienced by individuals in various geographic and demographic market segments. However, models of activity-travel demand do not account for the attitudinal factors and lifestyle preferences that affect activity-travel and mode use patterns. Such attitude and preference variables are virtually never collected explicitly in travel surveys, rendering it difficult to include them in model specifications. This paper applies Bhat’s (2014) Generalized Heterogeneous Data Model (GHDM) approach, whereby latent constructs representing the degree to which individuals are health conscious and inclined to pursue physical activities may be modeled as a function of observed socio-economic and demographic variables and then included as explanatory factors in models of activity-travel outcomes and walk and bicycle use. The model system is estimated on the 2005-2006 National Health and Nutrition Examination Survey (NHANES) sample, demonstrating the efficacy of the approach and the importance of including such latent constructs in model specifications that purport to forecast activity and time use patterns.Civil, Architectural, and Environmental Engineerin

A Comparison of Online and In-Person Activity Engagement: The Case of Shopping and Eating Meals

You're viewing a past Journal from the Good Systems Grand Challenge team at The University of Texas at Austin from February 2020.Office of the VP for Researc

Towards real-time topical detection and characterization of FDG dose infiltration prior to PET imaging

To dynamically detect and characterize 18F-fluorodeoxyglucose (FDG) dose infiltrations and evaluate their effects on positron emission tomography (PET) standardized uptake values (SUV) at the injection site and in control tissue

Oxaliplatin induces drug resistance more rapidly than cisplatin in H69 small cell lung cancer cells

Cisplatin produces good responses in solid tumours including small cell lung cancer (SCLC) but this is limited by the development of resistance. Oxaliplatin is reported to show activity against some cisplatin-resistant cancers but there is little known about oxaliplatin in SCLC and there are no reports of oxaliplatin resistant SCLC cell lines. Studies of drug resistance mainly focus on the cellular resistance mechanisms rather than how the cells develop resistance. This study examines the development of cisplatin and oxaliplatin resistance in H69 human SCLC cells in response to repeated treatment with clinically relevant doses of cisplatin or oxaliplatin for either 4 days or 2h. Treatments with 200ng/ml cisplatin or 400ng/ml oxaliplatin for 4 days produced sublines (H69CIS200 and H69OX400 respectively) that showed low level (approximately 2-fold) resistance after 8 treatments. Treatments with 1000ng/ml cisplatin or 2000ng/ml oxaliplatin for 2h also produced sublines, however these were not stably resistant suggesting shorter treatment pulses of drug may be more effective. Cells survived the first five treatments without any increase in resistance, by arresting their growth for a period and then regrowing. The period of growth arrest was reduced after the sixth treatment and the H69CIS200 and H69OX400 sublines showed a reduced growth arrest in response to cisplatin and oxaliplatin treatment suggesting that "regrowth resistance" initially protected against drug treatment and this was further upregulated and became part of the resistance phenotype of these sublines. Oxaliplatin dose escalation produced more surviving sublines than cisplatin dose escalation but neither set of sublines were associated with increased resistance as determined by 5-day cytotoxicity assays, also suggesting the involvement of regrowth resistance. The resistant sublines showed no change in platinum accumulation or glutathione levels even though the H69OX400 subline was more sensitive to buthionine sulfoximine treatment. The H69CIS200 cells were cross-resistant to oxaliplatin demonstrating that oxaliplatin does not have activity against low level cisplatin resistance. Relative to the H69 cells, the H69CIS200 and H69OX400 sublines were more sensitive to paclitaxel and taxotere suggests the taxanes may be useful in the treatment of platinum resistant SCLC. These novel cellular models of cisplatin and oxaliplatin resistant SCLC will be useful in developing strategies to treat platinum-resistant SCLC

Characterizing genomic alterations in cancer by complementary functional associations.

Systematic efforts to sequence the cancer genome have identified large numbers of mutations and copy number alterations in human cancers. However, elucidating the functional consequences of these variants, and their interactions to drive or maintain oncogenic states, remains a challenge in cancer research. We developed REVEALER, a computational method that identifies combinations of mutually exclusive genomic alterations correlated with functional phenotypes, such as the activation or gene dependency of oncogenic pathways or sensitivity to a drug treatment. We used REVEALER to uncover complementary genomic alterations associated with the transcriptional activation of β-catenin and NRF2, MEK-inhibitor sensitivity, and KRAS dependency. REVEALER successfully identified both known and new associations, demonstrating the power of combining functional profiles with extensive characterization of genomic alterations in cancer genomes

The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs

The platinum drugs, cisplatin, carboplatin, and oxaliplatin, prevail in the treatment of cancer, but new platinum agents have been very slow to enter the clinic. Recently, however, there has been a surge of activity, based on a great deal of mechanistic information, aimed at developing nonclassical platinum complexes that operate via mechanisms of action distinct from those of the approved drugs. The use of nanodelivery devices has also grown, and many different strategies have been explored to incorporate platinum warheads into nanomedicine constructs. In this Review, we discuss these efforts to create the next generation of platinum anticancer drugs. The introduction provides the reader with a brief overview of the use, development, and mechanism of action of the approved platinum drugs to provide the context in which more recent research has flourished. We then describe approaches that explore nonclassical platinum(II) complexes with trans geometry or with a monofunctional coordination mode, polynuclear platinum(II) compounds, platinum(IV) prodrugs, dual-threat agents, and photoactivatable platinum(IV) complexes. Nanoparticles designed to deliver platinum(IV) complexes will also be discussed, including carbon nanotubes, carbon nanoparticles, gold nanoparticles, quantum dots, upconversion nanoparticles, and polymeric micelles. Additional nanoformulations, including supramolecular self-assembled structures, proteins, peptides, metal–organic frameworks, and coordination polymers, will then be described. Finally, the significant clinical progress made by nanoparticle formulations of platinum(II) agents will be reviewed. We anticipate that such a synthesis of disparate research efforts will not only help to generate new drug development ideas and strategies, but also will reflect our optimism that the next generation of approved platinum cancer drugs is about to arrive.National Cancer Institute (U.S.) (CA034992

Evolution of Mode Use During the COVID-19 Pandemic in the United States: Implications for the Future of Transit

The COVID-19 pandemic has brought about transformative changes in human activity-travel patterns. These lifestyle changes were naturally accompanied by and associated with changes in transportation mode use and work modalities. In the United States, most transit agencies are still grappling with lower ridership levels, thus signifying the onset of a new normal for the future of transit. This paper addresses this challenge using a novel panel survey data set collected from a representative sample of individuals across the United States. The study involved the estimation of a panel multinomial probit model of mode choice to capture both socio-economic effects and period (pre-, during-, and post-COVID) effects that contribute to changes in mode choice. This paper provides rich insights into the evolution of commute mode use as a result of the pandemic, with a particular focus on public transit. Through a rigorous modeling approach, this paper provides a deep understanding of how transit use has evolved, how it is likely to evolve into the future, and the socio-economic and demographic characteristics that affect the evolution (and expected future use) of public transit. Results suggest that transit patronage is likely to remain depressed by about 30% for the foreseeable future, in the absence of substantial changes in service configurations. This study also shows that minority groups and those living in higher density regions are more likely to exhibit a return to transit use in the post-pandemic period

Effect of Composition on Electrical and Optical Properties of Thin Films of Amorphous GaxSe100−x Nanorods

We report the electrical and optical studies of thin films of a-GaxSe100−x nanorods (x = 3, 6, 9 and 12). Thin films of a-GaxSe100−x nanorods have been synthesized thermal evaporation technique. DC electrical conductivity of deposited thin films of a-GaxSe100−x nanorods is measured as a function of temperature range from 298 to 383 K. An exponential increase in the dc conductivity is observed with the increase in temperature, suggesting thereby a semiconducting behavior. The estimated value of activation energy decreases on incorporation of dopant (Ga) content in the Se system. The calculated value of pre-exponential factor (σ0) is of the order of 101 Ω−1 cm−1, which suggests that the conduction takes place in the band tails of localized states. It is suggested that the conduction is due to thermally assisted tunneling of the carriers in the localized states near the band edges. On the basis of the optical absorption measurements, an indirect optical band gap is observed in this system, and the value of optical band gap decreases on increasing Ga concentration