Results on a pedagogic approach for tailoring public health interventions to minimise opportunistic infections.

We are performing curriculum modifications on the first year BSc (Hons) Biomedical Science module “Basic Microbiology” (De Montfort University, UK) to increase students’ knowledge of basic medical parasitology and infectious diseases, so these students can acquire the necessary skills to tackle their final degree module “Medical Microbiology”. Following student feedback on a novel short intervention in 2017/18 to promote awareness about human immunodeficiency virus (HIV), we have created an engaging workshop session to cover not only HIV but also the opportunistic infections that can affect HIV patients that have developed acquired immune deficiency syndrome (AIDS) and how to prevent them. The objective of this work was to evaluate the effectiveness of the improved workshop developed and to collect students’ impressions to perform further modifications if needed. Briefly, students were required to develop public health measures for HIV positive patients with two different degrees of immunosuppression (i.e. with CD4+ T cells in peripheral blood above and below 200 cells/μl) to prevent exposure and infection from opportunistic pathogens such as Cryptosporidium spp., Toxoplasma gondii or Pneumocystis jirovecii from: a) sexual exposures; b) intravenous drug use; b) environment and work; c) food and water; d) foreign travel. Students, following evidence-based public health methodology, tailored their measures or interventions using the most up-to-date information reported in the literature regarding HIV chemoprophylaxis and recent guidelines published by US Department of Health and Human Services on HIV/AIDS treatment and prevention. Interventions were critically analysed with all students in the last 20 min. of the workshop, which was repeated several times due to the number of students (n=203). The objectives of this workshop were evaluated by careful analysis of a specific feedback questionnaire (n=46 out of 203) voluntarily completed by students at the end of the workshop. The questionnaire showed the following feedback: 80.4% (65.2% agreed; 15.2% strongly agreed) indicated that they learnt how to identify public health interventions; and 95.7% (56.5% agreed; 39.1% strongly agreed) indicated that they would be able to establish measures to reduce HIV transmission and prevent opportunistic infections. Additionally, 95.7% (39.1% agreed; 56.5% strongly agreed) indicated that the workshop helped them to understand the relevance of local and global interventions. Finally, 97.8% of responders considered that the content (52.2% agreed; 45.7% strongly agreed) and duration (60.9% agreed; 37% strongly agreed) of the workshop was appropriate; and 89.1% (58.7% agreed; 30.4% strongly agreed) and 73.9% (41.3% agreed; 32.6% strongly agreed) enjoyed and were satisfied with the workshop provided, respectively. In conclusion, the improved workshop developed would seem to be effective for promoting sexual and public health education to minimise opportunistic pathogen infections in relevant patients when delivered to students with a basic knowledge of microbiology and parasitology

Twisted mass QCD and the ΔI=1/2\Delta I=1/2 rule

We show that the application of twisted mass QCD (tmQCD) with four (Wilson) quark flavours to the computation of lattice weak matrix elements relevant to $\Delta I=1/2$ transitions has important advantages: the renormalisation of $K \to \pi$ matrix elements does not require the subtraction of other dimension six operators, the divergence arising from the subtraction of lower dimensional operators is softened by one power of the lattice spacing and quenched simulations do not suffer from exceptional configurations at small pion mass. This last feature is also retained in the tmQCD computation of $K \to \pi\pi$ matrix elements, which, as far as renormalisation and power subtractions are concerned, has properties analogous to the standard Wilson case.Comment: Lattice2002(matrixel). Eq.(11) correcte

N=1 Supersymmetric Yang-Mills on the lattice at strong coupling

We study N=1 supersymmetric SU(N) Yang-Mills theory on the lattice at strong coupling. Our method is based on the hopping parameter expansion in terms of random walks, resummed for any value of the Wilson parameter r in the small hopping parameter region. Results are given for the mesonic (2-gluino) and fermionic (3-gluino) propagators and spectrum.Comment: Latex file. 43 pages. Minor additional comments, references added, typos corrected. Accepted for publication in Int. J. Mod. Phys.

Renormalization of HQET ΔB=2\Delta B=2 operators: O(aa) improvement and 1/m1/m matching with QCD

We determine a basis of dimension-7 operators which arise at O($a$) in the Symanzik expansion of the $\Delta B=2$ operators with static heavy quarks. We consider both Wilson-like and Ginsparg-Wilson light quarks. Exact chiral symmetry reduces the number of these O($a$) counterterms by a factor of two. Only a subset of these operators has previously appeared in the literature. We then extend the analysis to the O($1/m$) operators contributing beyond the static approximation.Comment: 7 pages, presented at the 31st International Symposium on Lattice Field Theory (Lattice 2013), 29 July - 3 August 2013, Mainz, German

Virtual libraries of tissue and clinical samples: potential role of a 3-D microscope.

Our international innovative teaching group from different European Universities (De Montfort University, DMU, UK; and the Spanish University of Alcalá, University Miguel Hernández and University of San Pablo CEU), in conjunction with practicing biomedical scientists in the National Health Service (UK) and biomedical researchers, are developing two complete e-learning packages for teaching and learning medical parasitology, named DMU e-Parasitology (accessible at: http://parasitology.dmu.ac.uk), and biology and chemistry, named DMU e-Biology (accessible at: http://parasitology.dmu.ac.uk/ebiology/index.htm), respectively. Both packages will include a virtual microscope with a complete library of digitised tissue images, clinical slides and cell culture slides/mini-videos for enhancing the teaching and learning of a myriad of techniques applicable to health science undergraduate and postgraduate students. Thus, these packages include detecting human parasites, by becoming familiar with their infective structures and/or organs (e.g. eggs, cysts) and/or explore pathogenic tissues stained with traditional (e.g. haematoxylin & eosin) or more modern (e.g. immunohistochemistry) techniques. The Virtual Microscope (VM) module in the DMU e-Parasitology package is almost completed (accessible at: http://parasitology.dmu.ac.uk/learn/microscope.htm) and contains a section for the three major groups of human-pathogenic parasites (Peña-Fernández et al., 2018) [1]. Digitised slides are provided with the functionality of a microscope by using the gadget Zoomify®, and we consider that they can enhance learning, as previous studies reported in the literature have reported similar sensitivity and specificity rates for identification of parasites for both digitised and real slides. The DMU e-Biology’s VM, currently in development, will provide healthy and pathological tissue samples from a range of mammalian tissues and organs. This communication will provide a description of both virtual libraries and the process of developing them. In conjunction, we will use a three-dimensional (3D) super-resolution microscopy, 3D Cell Explorer (Nanolive, Lausanne, Switzerland), to incorporate potential 3D microscopic photographs/short videos of cells to provide students with information about the spatial arrangement and morphologies of cells that are essential for life

Solar Neutrinos

The study of solar neutrinos has given since ever a fundamental contribution both to astroparticle and to elementary particle physics, offering an ideal test of solar models and offering at the same time relevant indications on the fundamental interactions among particles. After reviewing the striking results of the last two decades, which were determinant to solve the long standing solar neutrino puzzle and refine the Standard Solar Model, we focus our attention on the more recent results in this field and on the experiments presently running or planned for the near future. The main focus at the moment is to improve the knowledge of the mass and mixing pattern and especially to study in detail the lowest energy part of the spectrum, which represents most of solar neutrino spectrum but is still a partially unexplored realm. We discuss this research project and the way in which present and future experiments could contribute to make the theoretical framemork more complete and stable, understanding the origin of some "anomalies" that seem to emerge from the data and contributing to answer some present questions, like the exact mechanism of the vacuum to matter transition and the solution of the so called solar metallicity problem.Comment: 51 pages, to be published in Special Issue on Neutrino Physics, Advances in High Energy Physics Hindawi Publishing Corporation 201