Neoliberalism in the North American University: Toward Integrating Divisions in Agent Orientation Via a Follettian Differentiated Relational Ontology

This paper uses observations from empirical articles and personal experiences of the authors to explore issues associated with the rise of neoliberalism and academic capitalism in the contemporary public university. It frames these issues as stemming from conflicting ontologies between academicians who adhere to the differentiated individual ontology and university administrators who favor the undifferentiated individual ontology. To overcome the disconnect, a differentiated relational ontology that adheres to principles of Mary Parker Follett and Alfred North Whitehead is proposed. The driving force behind this ontology can be highlighted through a communicated crisis, and a specific application of Follett’s differentiated relational ontology is Ensemble Learning Theory (ELT). A potential limitation of this study is generalizability, because the focus is centered on North American public universities and anecdotes are used to characterize a broader educational problem. This evolution is pertinent to academicians and administrators because the ontological impasse experienced in North American public universities threatens their existence as institutions, and has a broader and potentially negative impact on the quality of educational focus and output

Banjir Bandang di DAS Batang Kuranji Kec. Kuranji Kotapadang dengan Sistem Informasi Geografis (Sig)

The research aims to map hazard flash flood sand Inundation mapping the spatial distribution(affected by) flash floods and analyze the factors causing flash floods in Batang Kuranji Watershed Sub- District Kuranji Padang. The method used is a 3D analysis of data raster DEM, topographic slope, Slope, flood elevation data, and river network data, for mapping the spatial distribution affected by the flash floods using survey methods to map land units as mapping unit. GPS tracking is then performedin the field to produce spatial distribution maps Inundation (affected by) flash floods and flash floods causing factor data were analyzed using the scoring methodo fland characteristics as determinants offlash flood hazard. From this research, the proportion of flood hazard zones with high hazard category with abroad zone of 1320 ha, or 6,15% of the region Batang Kuranji. Medium hazard zones are an area of 1243 ha or 5,7% of the region Batang Kuranji, and low hazard zones in the study region has an area of 18 885ha with aproportion of 88,15% of the total land area ofresearch Batang Kuranji and spatial distribution of the inundations flash floods in the area along Kuranji watershed in Koto Tangah subdistrict, Kuranji subdistrict, Nanggalo subdistrict, North Padang subdistrict, and Pauh subdistrict. Causing factor flash flood in the research area are mass movement that of caused landform, slope, slopeform, long of slope, and geomorphology process

Synthesis of Novel Piperazine-linked Anthranilic Acids as Potential Small Molecule Kinase Inhibitors

Substituted anthranilic acid and piperazines were used as building blocks to prepare two libraries of  compounds, with the aim being that they would exhibit biochemical activity as small molecule kinase inhibitors. The synthesized anthranilamidepiperazine compounds were subsequently tested against a panel of kinases including EGFR, Abl, Akt and Aurora B.KEYWORDS: Small molecule kinase inhibitors, anthranilic acid, piperazines, EGFR

1-(3-Bromo-2-thien­yl)ethanone

In the title compound, C6H5BrOS, the non-H and aromatic H atoms lie on a crystallographic mirror plane. In the crystal, mol­ecules are linked into chains propagating along the c axis by inter­molecular C—H⋯O hydrogen bonds

QuantiFERON®-TB gold in-tube performance for diagnosing active tuberculosis in children and adults in a high burden setting.

To determine whether QuantiFERON®-TB Gold In-Tube (QFT) can contribute to the diagnosis of active tuberculosis (TB) in children in a high-burden setting and to assess the performance of QFT and tuberculin skin test (TST) in a prospective cohort of TB suspect children compared to adults with confirmed TB in Tanzania. Sensitivity and specificity of QFT and TST for diagnosing active TB as well as indeterminate QFT rates and IFN-γ levels were assessed in 211 TB suspect children in a Tanzanian district hospital and contrasted in 90 adults with confirmed pulmonary TB. Sensitivity of QFT and TST in children with confirmed TB was 19% (5/27) and 6% (2/31) respectively. In adults sensitivity of QFT and TST was 84% (73/87) and 85% (63/74). The QFT indeterminate rate in children and adults was 27% and 3%. Median levels of IFN-γ were lower in children than adults, particularly children <2 years and HIV infected. An indeterminate result was associated with age <2 years but not malnutrition or HIV status. Overall childhood mortality was 19% and associated with an indeterminate QFT result at baseline. QFT and TST showed poor performance and a surprisingly low sensitivity in children. In contrast the performance in Tanzanian adults was good and comparable to performance in high-income countries. Indeterminate results in children were associated with young age and increased mortality. Neither test can be recommended for diagnosing active TB in children with immature or impaired immunity in a high-burden setting

Redetermination of kovdorskite, Mg2PO4(OH)·3H2O

The crystal structure of kovdorskite, ideally Mg2PO4(OH)·3H2O (dimagnesium phosphate hydroxide trihydrate), was reported previously with isotropic displacement paramaters only and without H-atom positions [Ovchinnikov et al. (1980 ▶). Dokl. Akad. Nauk SSSR. 255, 351–354]. In this study, the kovdorskite structure is redetermined based on single-crystal X-ray diffraction data from a sample from the type locality, the Kovdor massif, Kola Peninsula, Russia, with anisotropic displacement parameters for all non-H atoms, with all H-atom located and with higher precision. Moreover, inconsistencies of the previously published structural data with respect to reported and calculated X-ray powder patterns are also discussed. The structure of kovdorskite contains a set of four edge-sharing MgO6 octa­hedra inter­connected by PO4 tetra­hedra and O—H⋯O hydrogen bonds, forming columns and channels parallel to [001]. The hydrogen-bonding system in kovdorskite is formed through the water mol­ecules, with the OH− ions contributing little, if any, to the system, as indicated by the long H⋯A distances (>2.50 Å) to the nearest O atoms. The hydrogen-bond lengths determined from the structure refinement agree well with Raman spectroscopic data

Functional annotation of putative QTL associated with black tea quality and drought tolerance traits

The understanding of black tea quality and percent relative water content (%RWC) traits in tea (Camellia sinensis) by a quantitative trait loci (QTL) approach can be useful in elucidation and identification of candidate genes underlying the QTL which has remained to be difficult. The objective of the study was to identify putative QTL controlling black tea quality and percent relative water traits in two tea populations and their F1 progeny. A total of 1,421 DArTseq markers derived from the linkage map identified 53 DArTseq markers to be linked to black tea quality and %RWC. All 53 DArTseq markers with unique best hits were identified in the tea genome. A total of 5,592 unigenes were assigned gene ontology (GO) terms, 56% comprised biological processes, cellular component (29%) and molecular functions (15%), respectively. A total of 84 unigenes in 15 LGs were assigned to 25 different Kyoto Encyclopedia of Genes and Genomes (KEGG) database pathways based on categories of secondary metabolite biosynthesis. The three major enzymes identified were transferases (38.9%), hydrolases (29%) and oxidoreductases (18.3%). The putative candidate proteins identified were involved in flavonoid biosynthesis, alkaloid biosynthesis, ATPase family proteins related to abiotic/biotic stress response. The functional annotation of putative QTL identified in this current study will shed more light on the proteins associated with caffeine and catechins biosynthesis and % RWC. This study may help breeders in selection of parents with desirable DArTseq markers for development of new tea cultivars with desirable traits.http://www.nature.com/sreppm2020BiochemistryGeneticsMicrobiology and Plant Patholog

Epithelial-Cell-Derived Phospholipase A2 Group 1B Is an Endogenous Anthelmintic.

Immunity to intestinal helminth infections has been well studied, but the mechanism of helminth killing prior to expulsion remains unclear. Here we identify epithelial-cell-derived phospholipase A2 group 1B (PLA2g1B) as a host-derived endogenous anthelmintic. PLA2g1B is elevated in resistant mice and is responsible for killing tissue-embedded larvae. Despite comparable activities of other essential type-2-dependent immune mechanisms, Pla2g1b-/- mice failed to expel the intestinal helminths Heligmosomoides polygyrus or Nippostrongylus brasiliensis. Expression of Pla2g1b by epithelial cells was dependent upon intestinal microbiota, adaptive immunity, and common-gamma chain-dependent signaling. Notably, Pla2g1b was downregulated in susceptible mice and inhibited by IL-4R-signaling in vitro, uncoupling parasite killing from expulsion mechanisms. Resistance was restored in Pla2g1b-/- mice by treating infective H. polygyrus L3 larvae with PLA2g1B, which reduced larval phospholipid abundance. These findings uncover epithelial-cell-derived Pla2g1b as an essential mediator of helminth killing, highlighting a previously overlooked mechanism of anti-helminth immunity