719 research outputs found
Corneal Biomechanical Response Alteration After Scleral Buckling Surgery for Rhegmatogenous Retinal Detachment
Purpose: To compare the corneal biomechanics of eyes that underwent scleral buckle (SB) for rhegmatogenous retinal detachment (RRD) with those of fellow eyes (fellow eyes) and to further investigate the effects of SB on intraocular pressure (IOP) values. Design: Retrospective, fellow-eye matched cohort study. Methods: A total of 18 consecutive patients (11 males and 7 females) treated with SB for RRD in 1 eye were enrolled. Goldmann applanation tonometry was used to measure IOP. Biomechanical properties of the cornea were investigated by using the Ocular Response Analyzer (ORA) (Reichert Instruments) for the calculation of corneal resistant factor (CRF), corneal hysteresis, Goldmann-correlated IOP, and corneal-compensated IOP. Customized software was used for analysis of the ORA infrared and pressure signals, and a significance threshold was set to a P value of. 05. Results: Operated eyes (OEs) showed significantly lower values of corneal hysteresis and CRF than fellow eyes (9.0 ± 1.8 vs 10.1 ± 1.8 mm Hg, respectively; P < .001; 10.0 ± 2.2 vs 10.9 ± 2.2 mm Hg; P < .001). GAT was significantly lower than corneal-compensated IOP in OEs (18.1 ± 4.9 vs 19.8 ± 4.8 mm Hg, respectively; P = .022) but not in fellow eyes. The second applanation event (A2) took place earlier in time, and the cornea was moving faster during A2 in the OEs than in the fellow eyes. Conclusions: SB for the treatment of RRD affects corneal biomechanical response, likely due to a less compliant sclera that limits corneal motion and reduces energy dissipation, reflected in a lower corneal hysteresis. This has potentially meaningful clinical implications as the accuracy of the measurement of IOP values may be affected in these eyes
Erratum to: The impact of benzodiazepine use in patients enrolled in opioid agonist therapy in Northern and rural Ontario
The effectiveness of the quality program Pac-IficO to improve pain management in hospitalized cancer patients: a before-after cluster phase II trial
Hot gas flows on global and nuclear galactic scales
Since its discovery as an X-ray source with the Einstein Observatory, the hot
X-ray emitting interstellar medium of early-type galaxies has been studied
intensively, with observations of improving quality, and with extensive
modeling by means of numerical simulations. The main features of the hot gas
evolution are outlined here, focussing on the mass and energy input rates, the
relationship between the hot gas flow and the main properties characterizing
its host galaxy, the flow behavior on the nuclear and global galactic scales,
and the sensitivity of the flow to the shape of the stellar mass distribution
and the mean rotation velocity of the stars.Comment: 22 pages. Abbreviated version of chapter 2 of the book "Hot
Interstellar Matter in Elliptical Galaxies", Springer 201
Systematic review of antiepileptic drugs’ safety and effectiveness in feline epilepsy
Understanding the efficacy and safety profile of antiepileptic drugs (AEDs) in feline epilepsy is a crucial consideration for managing this important brain disease. However, there is a lack of information about the treatment of feline epilepsy and therefore a systematic review was constructed to assess current evidence for the AEDs’ efficacy and tolerability in cats. The methods and materials of our former systematic reviews in canine epilepsy were mostly mirrored for the current systematic review in cats. Databases of PubMed, CAB Direct and Google scholar were searched to detect peer-reviewed studies reporting efficacy and/or adverse effects of AEDs in cats. The studies were assessed with regards to their quality of evidence, i.e. study design, study population, diagnostic criteria and overall risk of bias and the outcome measures reported, i.e. prevalence and 95% confidence interval of the successful and affected population in each study and in total
Dynamics and transport near quantum-critical points
The physics of non-zero temperature dynamics and transport near
quantum-critical points is discussed by a detailed study of the O(N)-symmetric,
relativistic, quantum field theory of a N-component scalar field in spatial
dimensions. A great deal of insight is gained from a simple, exact solution of
the long-time dynamics for the N=1 d=1 case: this model describes the critical
point of the Ising chain in a transverse field, and the dynamics in all the
distinct, limiting, physical regions of its finite temperature phase diagram is
obtained. The N=3, d=1 model describes insulating, gapped, spin chain
compounds: the exact, low temperature value of the spin diffusivity is
computed, and compared with NMR experiments. The N=3, d=2,3 models describe
Heisenberg antiferromagnets with collinear N\'{e}el correlations, and
experimental realizations of quantum-critical behavior in these systems are
discussed. Finally, the N=2, d=2 model describes the superfluid-insulator
transition in lattice boson systems: the frequency and temperature dependence
of the the conductivity at the quantum-critical coupling is described and
implications for experiments in two-dimensional thin films and inversion layers
are noted.Comment: Lectures presented at the NATO Advanced Study Institute on "Dynamical
properties of unconventional magnetic systems", Geilo, Norway, April 2-12,
1997, edited by A. Skjeltorp and D. Sherrington, Kluwer Academic, to be
published. 46 page
Identifying Cognate Binding Pairs among a Large Set of Paralogs: The Case of PE/PPE Proteins of Mycobacterium tuberculosis
We consider the problem of how to detect cognate pairs of proteins that bind when each belongs to a large family of paralogs. To illustrate the problem, we have undertaken a genomewide analysis of interactions of members of the PE and PPE protein families of Mycobacterium tuberculosis. Our computational method uses structural information, operon organization, and protein coevolution to infer the interaction of PE and PPE proteins. Some 289 PE/PPE complexes were predicted out of a possible 5,590 PE/PPE pairs genomewide. Thirty-five of these predicted complexes were also found to have correlated mRNA expression, providing additional evidence for these interactions. We show that our method is applicable to other protein families, by analyzing interactions of the Esx family of proteins. Our resulting set of predictions is a starting point for genomewide experimental interaction screens of the PE and PPE families, and our method may be generally useful for detecting interactions of proteins within families having many paralogs
New numerical results and novel effective string predictions for Wilson loops
We compute the prediction of the Nambu-Goto effective string model for a
rectangular Wilson loop up to three loops. This is done through the use of an
operatorial, first order formulation and of the open string analogues of
boundary states. This result is interesting since there are universality
theorems stating that the predictions up to three loops are common to all
effective string models. To test the effective string prediction, we set up the
Montecarlo evaluation, in the 3d Ising gauge model, of an observable (the ratio
of two Wilson loops with the same perimeter) for which boundary effects are
relatively small. Our simulation attains a level of precision which is
sufficient to test the two-loop correction. The three-loop correction seems to
go in the right direction, but is actually yet beyond the reach of our
simulation, since its effect is comparable with the statistical errors of the
latter.Comment: 27 pages, LaTeX2e, 5 figures - Revised version which corrects a few
misprints present in the published version, regarding Eq.s (4.30), (4.35),
(A.4) and (A.6). Plots and results of the paper are not affected since they
were derived from the correct formula
Generation of Long Insert Pairs Using a Cre-LoxP Inverse PCR Approach
Large insert mate pair reads have a major impact on the overall success of de novo assembly and the discovery of inherited and acquired structural variants. The positional information of mate pair reads generally improves genome assembly by resolving repeat elements and/or ordering contigs. Currently available methods for building such libraries have one or more of limitations, such as relatively small insert size; unable to distinguish the junction of two ends; and/or low throughput. We developed a new approach, Cre-LoxP Inverse PCR Paired-End (CLIP-PE), which exploits the advantages of (1) Cre-LoxP recombination system to efficiently circularize large DNA fragments, (2) inverse PCR to enrich for the desired products that contain both ends of the large DNA fragments, and (3) the use of restriction enzymes to introduce a recognizable junction site between ligated fragment ends and to improve the self-ligation efficiency. We have successfully created CLIP-PE libraries up to 22 kb that are rich in informative read pairs and low in small fragment background. These libraries have demonstrated the ability to improve genome assemblies. The CLIP-PE methodology can be implemented with existing and future next-generation sequencing platforms
Dynamics of a Quantum Phase Transition and Relaxation to a Steady State
We review recent theoretical work on two closely related issues: excitation
of an isolated quantum condensed matter system driven adiabatically across a
continuous quantum phase transition or a gapless phase, and apparent relaxation
of an excited system after a sudden quench of a parameter in its Hamiltonian.
Accordingly the review is divided into two parts. The first part revolves
around a quantum version of the Kibble-Zurek mechanism including also phenomena
that go beyond this simple paradigm. What they have in common is that
excitation of a gapless many-body system scales with a power of the driving
rate. The second part attempts a systematic presentation of recent results and
conjectures on apparent relaxation of a pure state of an isolated quantum
many-body system after its excitation by a sudden quench. This research is
motivated in part by recent experimental developments in the physics of
ultracold atoms with potential applications in the adiabatic quantum state
preparation and quantum computation.Comment: 117 pages; review accepted in Advances in Physic
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