An alternative account of anti-effeminacy bias: Reputation concerns and lack of coalitional value explain honor-oriented men’s reluctance to befriend feminine men

Anti-effeminacy bias follows a specific pattern with men showing stronger anti-effeminacy bias against male targets than women. Previous explanations focused on men’s higher tendency to stigmatize feminine men as homosexual and motives to maintain a dominant group status. Here, we suggest that certain expressions of anti-effeminacy bias may rather be a manifestation of men’s reputation management motives for coalition formation, and be amplified among high (vs. low) masculine honor-oriented men. In three studies with samples from the UK and Turkey, we showed that men perceived feminine (vs. masculine) male targets as lower on coalitional value and were more reluctant to befriend them, yet this applied only to high (not low) honor-oriented men. Honor-oriented men’s friendship reluctance was mediated by concern with losing reputation by association to targets lacking coalitional value. These findings extend understanding of anti-effeminacy bias by drawing attention to men’s reputation concerns for coalitional reasons and individual differences

Men's perceptions and emotional responses to becoming a caregiver father: The role of individual differences in masculine honor ideals and reputation concerns

Despite the rising number of men and women in counter-stereotypical roles, primary caregiver fathers and primary breadwinner mothers is a rare role division within families with dependent children. Previous analyses suggest that men’s lower contribution to childcare is due to their lack of interest in performing these tasks, which are primarily influenced by stereotypical expectations and men’s concern with reputation threat. Drawing our predictions from social role theory, shifting standards model, and masculine honor theories, in two studies conducted with British participants (N = 412), we examined people’s judgments of male and female targets who are caregivers and breadwinners, and their evaluative reactions to these targets. We further examined the moderating role of a perceiver characteristic – endorsement of masculine honor ideals – and the role of potential mediators of these relationships. Study 1 showed that male caregivers were rated higher on communal traits than female caregivers, and female breadwinners higher on agentic traits than male breadwinners, indicating gender stereotyping effects through mental shifts to within-sex judgement standards. Studies 1 and 2 showed that men reacted with more negative and less positive emotions to male caregivers (vs. breadwinners) as their endorsement of masculine honor ideals increased. Moderated mediation results of Study 2 further showed that higher endorsement of masculine honor ideals was linked with less positive and more negative emotional reactions to being a caregiver (vs. breadwinner), which was driven by perceived loss of reputation among male friends, whereas lower endorsement of masculine honor ideals was linked with more positive and less negative emotional reactions to being a caregiver (vs. breadwinner), which was driven by perceived gain of wife’s admiration. These findings offer nuanced explanations for why some men may react negatively whereas others may react positively to serving as caregiver fathers, when the stereotyped expectations are still in operation in society

An Extended Targeted Copy Number Variation Detection Array Including 187 Genes for the Diagnostics of Neuromuscular Disorders

Background: Our previous array, the Comparative Genomic Hybridisation design (CGH-array) for nemaline myopathy (NM), named the NM-CGH array, revealed pathogenic copy number variation (CNV) in the genes for nebulin (NEB) and tropomyosin 3 (TPM3), as well as recurrent CNVs in the segmental duplication (SD), i.e. triplicate, region of NEB (TRI, exons 82-89, 90-97, 98-105). In the light of this knowledge, we have designed and validated an extended CGH array, which includes a selection of 187 genes known to cause neuromuscular disorders (NMDs). Objective: Our aim was to develop a reliable method for CNV detection in genes related to neuromuscular disorders for routine mutation detection and analysis, as a much-needed complement to sequencing methods. Methods: We have developed a novel custom-made 4×180 k CGH array for the diagnostics of NMDs. It includes the same tiled ultra-high density coverage of the 12 known or putative NM genes as our 8×60 k NM-CGH-array but also comprises a selection of 175 additional genes associated with NMDs, including titin (TTN), at a high to very high coverage. The genes were divided into three coverage groups according to known and potential pathogenicity in neuromuscular disorders. Results: The array detected known and putative CNVs in all three gene coverage groups, including the repetitive regions of NEB and TTN. Conclusions: The targeted neuromuscular disorder 4×180 k array-CGH (NMD-CGH-array v1.0) design allows CNV detection for a broader spectrum of neuromuscular disorders at a high resolution. © 2018 - IOS Press and the authors. All rights reserved.Peer reviewe

Cultures of honor

Cultures of honor developed in contexts in which a person’s livelihood was easily stolen (such as a herd of animals) and the rule of law was weak. In such contexts, men were required to develop a reputation for toughness and willingness to retaliate quickly and aggressively when threatened, so that others would not consider stealing their property. Consequently, cultures of honor have developed ideologies, norms, and practices that reinforce the importance of maintaining social respect through aggressive means if necessary. In this chapter, we first briefly review the initial work by anthropologists, sociologists and historians that described cultures of honor in the Mediterranean region and southern US states. This early work formed the foundation of research by Nisbett, Cohen, and their colleagues, who carefully articulated a psychological theory of how concerns for honor may explain higher rates of aggression and violence in southern US states compared to northern states. We then summarize research on components of honor, behavioral and psychological consequences of honor, and socialization practices that maintain cultures of honor. We finish by discussing possible future directions and methodological considerations in research on cultures of honor. This research has extended the scope of cultural psychology by going beyond the more common east-west comparisons; it has the potential to help explain behavior of groups that have not been widely studied by social psychologists

Sector Expansion and Elliptical Modeling of Blue-Gray Ovoids for Basal Cell Carcinoma Discrimination in Dermoscopy Images

Background: Blue-gray ovoids (B-GOs), a critical dermoscopic structure for basal cell carcinoma (BCC), offer an opportunity for automatic detection of BCC. Due to variation in size and color, B-GOs can be easily mistaken for similar structures in benign lesions. Analysis of these structures could afford accurate characterization and automatic recognition of B-GOs, furthering the goal of automatic BCC detection. This study utilizes a novel segmentation method to discriminate B-GOs from their benign mimics. Methods: Contact dermoscopy images of 68 confirmed BCCs with B-GOs were obtained. Another set of 131 contact dermoscopic images of benign lesions possessing B-GO mimics provided a benign competitive set. A total of 22 B-GO features were analyzed for all structures: 21 color features and one size feature. Regarding segmentation, this study utilized a novel sector-based, non-recursive segmentation method to expand the masks applied to the B-GOs and mimicking structures. Results: Logistic regression analysis determined that blue chromaticity was the best feature for discriminating true B-GOs in BCC from benign, mimicking structures. Discrimination of malignant structures was optimal when the final B-GO border was approximated by a best-fit ellipse. Using this optimal configuration, logistic regression analysis discriminated the expanded and fitted malignant structures from similar benign structures with a classification rate as high as 96.5%. Conclusions: Experimental results show that color features allow accurate expansion and localization of structures from seed areas. Modeling these structures as ellipses allows high discrimination of B-GOs in BCCs from similar structures in benign images

Stimulation of Na⁺/H⁺ Exchanger Isoform 1 Promotes Microglial Migration

Regulation of microglial migration is not well understood. In this study, we proposed that Na+/H+ exchanger isoform 1 (NHE-1) is important in microglial migration. NHE-1 protein was co-localized with cytoskeletal protein ezrin in lamellipodia of microglia and maintained its more alkaline intracellular pH (pHi). Chemoattractant bradykinin (BK) stimulated microglial migration by increasing lamellipodial area and protrusion rate, but reducing lamellipodial persistence time. Interestingly, blocking NHE-1 activity with its potent inhibitor HOE 642 not only acidified microglia, abolished the BK-triggered dynamic changes of lamellipodia, but also reduced microglial motility and microchemotaxis in response to BK. In addition, NHE-1 activation resulted in intracellular Na+ loading as well as intracellular Ca2+ elevation mediated by stimulating reverse mode operation of Na+/Ca2+ exchange (NCXrev). Taken together, our study shows that NHE-1 protein is abundantly expressed in microglial lamellipodia and maintains alkaline pHi in response to BK stimulation. In addition, NHE-1 and NCXrev play a concerted role in BK-induced microglial migration via Na+ and Ca2+ signaling. © 2013 Shi et al

Dominantly inherited distal nemaline/cap myopathy caused by a large deletion in the nebulin gene

We report the first family with a dominantly inherited mutation of the nebulin gene (NEB). This 100kb in-frame deletion encompasses NEB exons 14-89, causing distal nemaline/cap myopathy in a three-generation family. It is the largest deletion characterized in NEB hitherto. The mutated allele was shown to be expressed at the mRNA level and furthermore, for the first time, a deletion was shown to cause the production of a smaller mutant nebulin protein. Thus, we suggest that this novel mutant nebulin protein has a dominant-negative effect, explaining the first documented dominant inheritance of nebulin-caused myopathy. The index patient, a young man, was more severely affected than his mother and grandmother. His first symptom was foot drop at the age of three, followed by distal muscle atrophy, slight hypomimia, high-arched palate, and weakness of the neck and elbow flexors, hands, tibialis anterior and toe extensors. Muscle biopsies showed myopathic features with type 1 fibre predominance in the index patient and nemaline bodies and cap-like structures in biopsies from his mother and grandmother. The muscle biopsy findings constitute a further example of nemaline bodies and cap-like structures being part of the same spectrum of pathological changes. (C) 2019 Elsevier B.V. All rights reserved.Peer reviewe