379 research outputs found

    Sound propagation over uneven ground and irregular topography

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    The acoustic impedance of the surface coverings used in the laboratory experiments on sound diffraction by topographical ridges was determined. The model, which was developed, takes into account full wave effects and the possibility of surface waves and predicts the sound pressure level at the receiver location relative to what would be expected if the flat surface were not present. The sound pressure level can be regarded as a function of frequency, sound speed in air, heights of source and receiver, and horizontal distance from source to receiver, as well as the real and imaginary parts of the surface impedance

    Artificial Coal: Facile and Green Production Method via Low-Temperature Hydrothermal Carbonization of Lignocellulose

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    A new concept is proposed for the production of artificial coal under HTC conditions using Mg(NO3)2 as an oxidant in a short time, which is found to enhance the coalification degree of hydrochar from lignocellulosic materials. Pressure promotes decarboxylation reactions of lignocellulose to form hollow smooth-faced regular spherical particles, avoiding the agglomeration of hydrochar particles. In parallel, oxidation can break down the biopolymer structure to form low-molecular-weight compounds, which is found to be a key step during artificial coal formation. The artificial coal synthesized has a high degree of coalification

    Optimization of Clostridium tyrobutyricum encapsulation by extrusion method and characterization of the formulation

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    Purpose: To optimize the process parameters for the encapsulation of Clostridium tyrobutyricum (Ct) and to determine its in vitro characteristics.Methods: The process parameters, including the concentration of the wall and hardening material, Ct to gelatin ratio and hardening time, were studied by single factor analysis, while optimization was performed by orthogonal experimental design for the encapsulation rate of Ct.Results: Optimal conditions exhibited by orthogonal experimental design at a 92.17 % encapsulation rate with a viable count of 9.61 ± 0.06 lgCFU/g were: 6 % modified starch, 3 % sodium alginate, and 2 % CaCl2 at a Ct to gelatin ratio of 1:1 with a hardening time of 30 min. The survival rates of encapsulated Ct were higher than free Ct in simulated gastric (6.22 %) and intestinal juices (15.55 %). Reduction in viable counts of Ct at 90 °C were higher for free cells (44.76 %) than encapsulated cells (28.09 %) after 30 min of heat treatment. Correspondingly, encapsulation boosted the capacity of Ct to withstand the strong acidic conditions of the stomach and improved the storage properties of Ct.Conclusion: The results suggested that extrusion is a good technique for the encapsulation of Ct, as it enhances the viability of Ct during their transit through the gastrointestinal tract. Furthermore, encapsulation is favorable for Ct if planned for use in formulations where high temperature treatment is required

    Engineering medium-range order and polyamorphism in a nanostructured amorphous alloy

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    Like crystalline materials, the properties of amorphous materials can be tailored by tuning the local atomic-to-nanoscale structural configurations. Polyamorphism is evident by the coexistence of kinetically stabilized amorphous structures with tailorable short-to-medium-range orders, providing a viable means to engineer the degree of local order and heterogeneity. Here, we report experimental evidence of the coexistence of liquid-like and solid-like amorphous phases in a Ni82_{82}P18_{18} amorphous alloy with enhanced thermal stability and plasticity prepared by pulsed electrodeposition. The two amorphous phases, of comparable volume fraction of ~50% each, have similar short-range order but are distinguished by packing at the medium-range length scale (>6 Ã…). Upon heating, a structure crossover at ~450 K was observed, where the liquid-like structure transforms to the solid-like structure, as evidenced by the enthalpy release and an anomalous contraction of atomic structure over the medium-range length scale, due to the metastable nature of the liquid-like structure

    Size-dependent in vivo toxicity of PEG-coated gold nanoparticles

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    Xiao-Dong Zhang, Di Wu, Xiu Shen, Pei-Xun Liu, Na Yang, Bin Zhao, Hao Zhang, Yuan-Ming Sun, Liang-An Zhang, Fei-Yue FanInstitute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin Key Laboratory of Molecular Nuclear Medicine, Tianjin, People’s Republic of ChinaBackground: Gold nanoparticle toxicity research is currently leading towards the in vivo experiment. Most toxicology data show that the surface chemistry and physical dimensions of gold nanoparticles play an important role in toxicity. Here, we present the in vivo toxicity of 5, 10, 30, and 60 nm PEG-coated gold nanoparticles in mice.Methods: Animal survival, weight, hematology, morphology, organ index, and biochemistry were characterized at a concentration of 4000 µg/kg over 28 days.Results: The PEG-coated gold particles did not cause an obvious decrease in body weight or appreciable toxicity even after their breakdown in vivo. Biodistribution results show that 5 nm and 10 nm particles accumulated in the liver and that 30 nm particles accumulated in the spleen, while the 60 nm particles did not accumulate to an appreciable extent in either organ. Transmission electron microscopic observations showed that the 5, 10, 30, and 60 nm particles located in the blood and bone marrow cells, and that the 5 and 60 nm particles aggregated preferentially in the blood cells. The increase in spleen index and thymus index shows that the immune system can be affected by these small nanoparticles. The 10 nm gold particles induced an increase in white blood cells, while the 5 nm and 30 nm particles induced a decrease in white blood cells and red blood cells. The biochemistry results show that the 10 nm and 60 nm PEG-coated gold nanoparticles caused a significant increase in alanine transaminase and aspartate transaminase levels, indicating slight damage to the liver.Conclusion: The toxicity of PEG-coated gold particles is complex, and it cannot be concluded that the smaller particles have greater toxicity. The toxicity of the 10 nm and 60 nm particles was obviously higher than that of the 5 nm and 30 nm particles. The metabolism of these particles and protection of the liver will be more important issues for medical applications of gold-based nanomaterials in future.Keywords: gold nanoparticles, in vivo, toxicity, siz
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