A Systemic Approach to Proximity Through Design for Relations

Proximity has lately become a keyword to approach territorial enhancement goals. The most common representation of proximity at the urban level is the idea of the 15-minute city, which has gained massive attention in political, economic, social, and academic discourses. However, this idea is not new in the worldwide panorama and, during the COVID-19 pandemic, has gained renovate attention because of contextual extraordinaire conditions. Furthermore, under so-called normal circumstances, this concept of proximity has certain evident societal constraints. In our paper, we want to propose and discuss a wider systemic approach and consequent definitions of proximity in connection with the different actors that compose and drive our societies. In the design for relations, we will identify a systemic and valuable strategy to overcome the previously discussed limits

A Heckman selection model for the safety analysis of signalized intersections

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Design thinking for entrepreneurship: An explorative inquiry into its practical contributions

Design thinking (DT) is expanding its horizons across a variety of different domains. One of the early and debated contributions regarding DT addressed its relationship with the entrepreneurial field. Today, there are numerous contributions that design thinking can offer in the creation of new ventures. However, there are few examples in the literature that discuss the concrete impacts and benefits of adopting DT in this field, demonstrating it through entrepreneurial projects. This paper aims to explore practitioners’ experiences with the application of theories from design thinking inside an entrepreneurial context. The impacts of the learning and the relative application of the main design thinking principles are evaluated via a sample of 50 participants in an international summer academy that offered education on DT concepts and practices. Through this research, a deep understanding of how design thinking can contribute to entrepreneurship is provided, highlighting which specific DT abilities enable the development of entrepreneurial activity

Computation offloading and resource allocation for wireless powered mobile edge computing with latency constraint

In this letter, we consider a multi-user wireless powered mobile edge computing (MEC) system, in which a base station (BS) integrated with an MEC server transfers energy to wireless devices (WDs) as an incentive to encourage them to offload computing tasks to the MEC server. We formulate an optimization problem to contemporaneously maximize the data utility and minimize the energy consumption of the operator under the offloaded delay constraint, by jointly controlling wireless-power allocation at the BS as well as offloaded data size and power allocation at the WDs. To solve this problem, the offloaded delay constraint is first transformed into an offloaded data rate constraint. Then an iterative algorithm is designed to obtain the optimal offloaded data size and power allocation at the WDs by using Lagrangian dual method. The results are applied to derive the optimal wireless-power allocation at the BS. Finally, simulation results show that our algorithm outperforms existing schemes in terms of operator’s reward

Granulocyte, granulocyte–macrophage, and macrophage colony-stimulating factors can stimulate the invasive capacity of human lung cancer cells

We and other researchers have previously found that colony-stimulating factors (CSFs), which generally include granulocyte colony-stimulating factor (G-CSF), granulocyte–macrophage colony-stimulating factor (GM-CSF) and macrophage colony-stimulating factor (M-CSF), promote invasion by lung cancer cells. In the present study, we studied the effects of these CSFs on gelatinase production, urokinase plasminogen activator (uPA) production and their activity in human lung cancer cells. Gelatin zymographs of conditioned media derived from human lung adenocarcinoma cell lines revealed two major bands of gelatinase activity at 68 and 92 kDa, which were characterized as matrix metalloproteinase (MMP)-2 and MMP-9 respectively. Treatment with CSFs increased the 68- and 92-kDa activity and converted some of a 92-kDa proenzyme to an 82-kDa enzyme that was consistent with an active form of the MMP-9. Plasminogen activator zymographs of the conditioned media from the cancer cells showed that CSF treatment resulted in an increase in a 48–55 kDa plasminogen-dependent gelatinolytic activity that was characterized as human uPA. The conditioned medium from the cancer cells treated with CSFs stimulated the conversion of plasminogen to plasmin, providing a direct demonstration of the ability of enhanced uPA to increase plasmin-dependent proteolysis. The enhanced invasive behaviour of the cancer cells stimulated by CSFs was well correlated with the increase in MMPs and uPA activities. These data suggest that the enhanced production of extracellular matrix-degrading proteinases by the cancer cells in response to CSF treatment may represent a biochemical mechanism which promotes the invasive behaviour of the cancer cells. © 1999 Cancer Research Campaig

Exploring the Luminosity Boundaries of the IUCF Cooler

This research was sponsored by the National Science Foundation Grant NSF PHY-931478

Dust during the Reionization

The possibility that population III stars have reionized the Universe at redshifts greater than 6 has recently gained momentum with WMAP polarization results. Here we analyse the role of early dust produced by these stars and ejected into the intergalactic medium. We show that this dust, heated by the radiation from the same population III stars, produces a submillimetre excess. The electromagnetic spectrum of this excess could account for a significant fraction of the FIRAS (Far Infrared Absolute Spectrophotometer) cosmic far infrared background above 700 micron. This spectrum, a primary anisotropy ($\Delta T$) spectrum times the $\nu^2$ dust emissivity law, peaking in the submillimetre domain around 750 micron, is generic and does not depend on other detailed dust properties. Arcminute--scale anisotropies, coming from inhomogeneities in this early dust, could be detected by future submillimetre experiments such as Planck HFI.Comment: 6 pages, 8 figures, accepted by A&A; clarifications made, typos fixed, results more exactly calculate