On the van der Waals Gas, Contact Geometry and the Toda Chain

[EN] A Toda¿chain symmetry is shown to underlie the van derWaals gas and its close cousin, the ideal gas. Links to contact geometry are explored.This research was supported by Grant No. ENE2015-71333-R (Spain) and Convocatoria Abierta 2015 para Cursar Estudios de Doctorado, SENESCYT (Ecuador).Alarcon-Correa, D.; Fernández De Córdoba, P.; Isidro, J.; Orea, C. (2018). On the van der Waals Gas, Contact Geometry and the Toda Chain. Entropy. 20(8):554-558. https://doi.org/10.3390/e20080554S55455820

Mathematical modeling and numerical simulation of heat dissipation In LED bulbs

[EN] We present a detailed study of heating and cooling processes in LED luminaires with passive heat sinks. Our analysis is supported by numerical simulations as well as experimental measurements, carried on commercial systems used for outdoor lighting. We have focused our analysis on the common case of a single LED source in thermal contact with an aluminum passive heat sink, obtaining an excellent agreement with experimental measurements and the numerical simulations performed. Our results can be easily expanded, without loss of generality, to similar systems.D. A. acknowledges SENESCYT for financial support (Convocatoria Abierta 2015 para cursar estudios de doctorado). HM thanks funding from projects K133131H64102 and K044131H64502 Xunta de Galicia.P.F.C. and J.M.I. acknoweldges funding from grant MEC, grant RTI2018-102256-B-100 (Spain)Alarcon, D.; Balvis, E.; Bendaña, R.; Conejero, JA.; Fernández De Córdoba, P.; Higón Calvet, JL.; Isidro, J.... (2020). Mathematical modeling and numerical simulation of heat dissipation In LED bulbs. Thermal Science. 24(3A):1877-1884. https://doi.org/10.2298/TSCI190521076AS18771884243

Effect of tapping frequency and stimulation on yield and economic performance of rubber tree clones

Este trabalho teve como objetivo avaliar o desempenho produtivo e os aspectos econômicos de dez clones de seringueira [Hevea brasiliensis (Willd. ex Adr. de Juss.) Muell. Arg.] em diferentes frequências de sangria e com estimulação à base de ethefon. O experimento foi instalado na Fazenda Indiana, no município de Indiana, SP, sob o delineamento de blocos ao acaso com parcelas subdivididas. Os tratamentos principais foram os clones GT 1, RRIM 701, RRIM 600, PB 235, PR 261, PB 252, Fx 4098, Fx 2261, Fx 3864 e IAN 873, submetidos a três sistemas de sangria: 1/2S d/2 6d/7 (testemunha), 1/2S d/4 6d/7.10m/y. ET 5,0% Ba 10y e 1/2S d/6 6d/7.10m/y. ET 5,0% Ba 10/y. As variáveis estudadas foram: perímetro do caule, produção, secamento do painel e os aspectos econômicos. Os resultados mostraram superioridade no sistema 1/2S d/2 6d/7 na maioria dos clones, exceto o GT 1 e o PB 235, que no sistema 1/2S d/4 ET 5,0% apresentaram ganhos líquidos de 12,0% e 54,0%, respectivamente, acima do obtido no sistema testemunha. Somente os clones Fx 3864 e PB 235 apresentaram ganhos líquidos de 18,0% e 28,0% no sistema 1/2S d/6 ET 5% superiores em relação ao obtido no sistema testemunha. A maior porcentagem de secamento do painel foi observada no clone PB 235 no sistema 1/2S d/4 ET 5,0%.The objective of this paper was to evaluate yield of performance and economic aspects of ten clones of rubber tree [Hevea brasiliensis (Willd. ex. Adr. de Juss.) Muell. Arg.] in different frequencies of tapping and with stimulation with ethefon. The trial was placed at the Indiana farm, in the county of Indiana, SP, Brazil, under a split-plot design. The main treatments were the GT 1, RRIM 701, RRIM 600, PB 235, PR 261, PB 252, Fx 4098, Fx 2261, Fx 3864 and IAN 873 clones submitted to three systems of tapping 1/2S d/2 6d/7 (check), 1/2S d/4 6d/7.10m/y. ET 5.0% Ba 10y and 1/2S d/6 6d/7.10m/y. ET 5.0% Ba 10y. The variables were: girth increment, yield, panel desiccation and economic aspects. Results indicated superiority in the 1/2S d/2 6d/7 system in most of the clones, except for GT 1 and PB 235 clones, that in the 1/2S d/4 ET 5.0% system showed superiority of net gain of 12.0% and 54.0%, respectively, compared with the check tapping system. Only the Fx 3864 and PB 235 clones showed liquid gain of 18.0% and 28.0%, respectively, in the 1/2S d/6 ET 5.0% system, compared with the check. The highest incidence of panel desiccation was observed in the PB 235 clone in the 1/2S d/4 ET 5.0% system

Desafíos de las metrópolis: Efectos ambientales y sociales. Tendencias geográficas II

El libro está conformado de estudios realizados por profesores-investigadores de la Universidad Autónoma del Estado de México, de la Universidad de Varsovia, así como de la Universidad Pedagógica Comisión de Educación Nacional de Cracovia. En esta obra se exponen algunas investigaciones sobre los cambios en los factores sociales, naturales, económicos y ambientales como principales desafios que presentan las zonas de México, Polonia y de contextos de Sudamérica, tales como Sao Paulo, Quito y Bogotá y ciudades medias y pequeñas.Universidad Autónoma del Estado de Méxic

Principais causas e diagnósticos de epistaxes na pediatria

A epistaxe é definida como qualquer hemorragia originada nas narinas, e toda a área nasal, como fossas, seios ou nasofaringe, na pediatria em geral, é visto em caráter benigno, sendo idiopática, auto-limitada e raramente severa. Por vezes, pode ser um sinal de condições que não estão apresentadas de forma clara, como por exemplo, tumores, agressões ou até mesmo discrasias hemorrágicas. As epistaxes são um problema comum, considerados pela otorrinolaringologia como a segunda urgência mais frequente, tendo como um número estimado de 10% da população que sofre esse tipo de ocorrência. A classificação da epistaxe é anterior ou posterior, baseada na localização primária da hemorragia, no plexo de Kiesselbach, localizado  na porção ântero-inferior do septo nasal, contendo vários vasos que se anastomosam entre si, ou plexo de Woodruff que se localiza na região póster-inferior, que é formado pelas anastomoses das artérias esfenopalatinas e faríngea.  Em geral, os casos de epistaxes na pediatria, se devem à traumas digitais ou alta fragilidade vascular, podendo ser induzido por uma inflamação ou infecção nasal. Quanto aos exames em paciente acometidos epistaxe, incialmente cabe avaliar o estado geral das vias aéreas e sinais vitais, seguido de uma observação de cabeça e pescoço, focando nas fossas nasais. Quando se tratar de um epistaxe de associação traumática, é necessário excluir fraturas dos ossos nasais e hematomas, já que estes podem levar a uma destruição cartilagínea gerando uma deformidade a longe prazo. Agregado ao exame nasal, a avaliação de cabeça e pescoço podem apresentar pistas diagnósticas importantes. O tratamento a partir das diversas abordagens terapêuticas podem ser feitas por médicos generalistas em casos mais comuns, pois a grande maioria dos casos é tratado de forma fácil com medidas conservadoras ou por cauterização, em geral os casos tem origem idiopática

First Colombian Multicentric Newborn Screening for Congenital Toxoplasmosis

Congenital toxoplasmosis can result in permanent sequel as blindness or neurological damage in children and it seems to be more severe in South America than in other continents. There is a lack of information about this frequency in Colombia, where no control program is established, although it is a recognized cause of potentially preventable congenital blindness. We propose the first Colombian multicentric study to determine the frequency and impact of congenital toxoplasmosis. More than 15,000 newborns in seven cities were studied. Newborns were tested at birth by doing a cord blood test for toxoplasmosis. Additionally, children from mothers with history of toxoplasmosis acquired during pregnancy were recalled for a follow-up. The program identified fifteen children otherwise undiagnosed; three of these children died as consequence of congenital toxoplasmosis. The frequency of the congenital infection varied significantly between cities, being higher in Armenia and Florencia, intermediate in Bogota, Bucaramanga and Barranquilla and very low in western cities such as Cucuta and Riohacha. For the first time a significant correlation was found between mean rainfall at the city and the incidence of this congenital infection

Durvalumab Plus Carboplatin/Paclitaxel Followed by Maintenance Durvalumab With or Without Olaparib as First-Line Treatment for Advanced Endometrial Cancer: The Phase III DUO-E Trial

PURPOSE Immunotherapy and chemotherapy combinations have shown activity in endometrial cancer, with greater benefit in mismatch repair (MMR)-deficient (dMMR) than MMR-proficient (pMMR) disease. Adding a poly(ADP-ribose) polymerase inhibitor may improve outcomes, especially in pMMR disease. METHODS This phase III, global, double-blind, placebo-controlled trial randomly assigned eligible patients with newly diagnosed advanced or recurrent endometrial cancer 1:1:1 to: carboplatin/paclitaxel plus durvalumab placebo followed by placebo maintenance (control arm); carboplatin/paclitaxel plus durvalumab followed by maintenance durvalumab plus olaparib placebo (durvalumab arm); or carboplatin/paclitaxel plus durvalumab followed by maintenance durvalumab plus olaparib (durvalumab + olaparib arm). The primary end points were progression-free survival (PFS) in the durvalumab arm versus control and the durvalumab + olaparib arm versus control. RESULTS Seven hundred eighteen patients were randomly assigned. In the intention-to-treat population, statistically significant PFS benefit was observed in the durvalumab (hazard ratio [HR], 0.71 [95% CI, 0.57 to 0.89]; P = .003) and durvalumab + olaparib arms (HR, 0.55 [95% CI, 0.43 to 0.69]; P < .0001) versus control. Prespecified, exploratory subgroup analyses showed PFS benefit in dMMR (HR [durvalumab v control], 0.42 [95% CI, 0.22 to 0.80]; HR [durvalumab + olaparib v control], 0.41 [95% CI, 0.21 to 0.75]) and pMMR subgroups (HR [durvalumab v control], 0.77 [95% CI, 0.60 to 0.97]; HR [durvalumab + olaparib v control] 0.57; [95% CI, 0.44 to 0.73]); and in PD-L1-positive subgroups (HR [durvalumab v control], 0.63 [95% CI, 0.48 to 0.83]; HR [durvalumab + olaparib v control], 0.42 [95% CI, 0.31 to 0.57]). Interim overall survival results (maturity approximately 28%) were supportive of the primary outcomes (durvalumab v control: HR, 0.77 [95% CI, 0.56 to 1.07]; P = .120; durvalumab + olaparib v control: HR, 0.59 [95% CI, 0.42 to 0.83]; P = .003). The safety profiles of the experimental arms were generally consistent with individual agents. CONCLUSION Carboplatin/paclitaxel plus durvalumab followed by maintenance durvalumab with or without olaparib demonstrated a statistically significant and clinically meaningful PFS benefit in patients with advanced or recurrent endometrial cancer

PDRs4All III: JWST's NIR spectroscopic view of the Orion Bar

(Abridged) We investigate the impact of radiative feedback from massive stars on their natal cloud and focus on the transition from the HII region to the atomic PDR (crossing the ionisation front (IF)), and the subsequent transition to the molecular PDR (crossing the dissociation front (DF)). We use high-resolution near-IR integral field spectroscopic data from NIRSpec on JWST to observe the Orion Bar PDR as part of the PDRs4All JWST Early Release Science Program. The NIRSpec data reveal a forest of lines including, but not limited to, HeI, HI, and CI recombination lines, ionic lines, OI and NI fluorescence lines, Aromatic Infrared Bands (AIBs including aromatic CH, aliphatic CH, and their CD counterparts), CO2 ice, pure rotational and ro-vibrational lines from H2, and ro-vibrational lines HD, CO, and CH+, most of them detected for the first time towards a PDR. Their spatial distribution resolves the H and He ionisation structure in the Huygens region, gives insight into the geometry of the Bar, and confirms the large-scale stratification of PDRs. We observe numerous smaller scale structures whose typical size decreases with distance from Ori C and IR lines from CI, if solely arising from radiative recombination and cascade, reveal very high gas temperatures consistent with the hot irradiated surface of small-scale dense clumps deep inside the PDR. The H2 lines reveal multiple, prominent filaments which exhibit different characteristics. This leaves the impression of a "terraced" transition from the predominantly atomic surface region to the CO-rich molecular zone deeper in. This study showcases the discovery space created by JWST to further our understanding of the impact radiation from young stars has on their natal molecular cloud and proto-planetary disk, which touches on star- and planet formation as well as galaxy evolution.Comment: 52 pages, 30 figures, submitted to A&

A Deep Insight into the Sialotranscriptome of the Gulf Coast Tick, Amblyomma maculatum

Background: Saliva of blood sucking arthropods contains compounds that antagonize their hosts ’ hemostasis, which include platelet aggregation, vasoconstriction and blood clotting; saliva of these organisms also has anti-inflammatory and immunomodullatory properties. Perhaps because hosts mount an active immune response against these compounds, the diversity of these compounds is large even among related blood sucking species. Because of these properties, saliva helps blood feeding as well as help the establishment of pathogens that can be transmitted during blood feeding. Methodology/Principal Findings: We have obtained 1,626,969 reads by pyrosequencing a salivary gland cDNA library from adult females Amblyomma maculatum ticks at different times of feeding. Assembly of this data produced 72,441 sequences larger than 149 nucleotides from which 15,914 coding sequences were extracted. Of these, 5,353 had.75 % coverage to their best match in the non-redundant database from the National Center for Biotechnology information, allowing for the deposition of 4,850 sequences to GenBank. The annotated data sets are available as hyperlinked spreadsheets. Putative secreted proteins were classified in 133 families, most of which have no known function. Conclusions/Significance: This data set of proteins constitutes a mining platform for novel pharmacologically activ