Urinary proteomics using capillary electrophoresis coupled to mass spectrometry for diagnosis and prognosis in kidney diseases

Purpose of review: Urine is the most useful of body fluids for biomarker research. Therefore, we have focused on urinary proteomics, using capillary electrophoresis coupled to mass spectrometry, to investigate kidney diseases in recent years. Recent findings: Several urinary proteomics studies for the detection of various kidney diseases have indicated the potential of this approach aimed at diagnostic and prognostic assessment. Urinary protein biomarkers such as collagen fragments, serum albumin, [alpha]-1-antitrypsin, and uromodulin can help to explain the processes involved during disease progression. Summary: Urinary proteomics has been used in several studies in order to identify and validate biomarkers associated with different kidney diseases. These biomarkers, with improved sensitivity and specificity when compared with the current gold standards, provide a significant alternative for diagnosis and prognosis, as well as improving clinical decision-making

Referendum Design, Quorum Rules and Turnout

In this article, we focus on the consequences of quorum requirements for turnout in referendums. We use a rational choice, decision theoretic voting model to demonstrate that participation quorums change the incentives some electors face, inducing those who oppose changes in the status quo and expect to be in the minority to abstain. As a result, paradoxically, participation quorums decrease electoral participation. We test our model’s predictions using data for all referendums held in current European Union countries from 1970 until 2007, and show that the existence of a participation quorums increases abstention by more than ten percentage points.Referendum Design; Voter turnout

Growth, Centrism and Semi-Presidentialism: Forecasting the Portuguese General Elections

Electoral behaviour in recently established democracies has been more frequently treated from the point of view of its unpredictability, volatility and personalistic elements than that of its "fundamentals". In this paper, we wish to contribute to redress this imbalance by advancing a forecasting model for general elections in a young democracy, Portugal. Building on the very familiar notion that the vote for the incumbent can be predicted on the basis of "economics" and "politics", we capture "economics" through a nonlinear specification of economic growth. Furthermore, we include two structural features of Portuguese politics, which have entailed a systematic electoral punishment for the centre-left Socialist Party as the incumbent and for all incumbents involved in political conflicts with the elected president in Portugal's semi-presidentialism.Forecasting; Portuguese general elections; Economics and elections; Semi-Presidentialism

How quorum rules distort referendum outcomes: evidence from a pivotal voter model

In many jurisdictions, whether referendum results are binding depend on certain legally defined quorum requirements. With a pivotal-voter model, we examine how quorum requirements affect voter’s behavior. We conclude that quorums can be the cause of lower turnout and that they can deliver outcomes that are an inadequate basis to make inferences about collective preferences. We further conclude that quorums may help minorities to impose their will on majorities and that they may create a bias against the status quo. Finally, they generate situations under which the secrecy of the vote is called into question.

HAGR: the Human Ageing Genomic Resources

The Human Ageing Genomic Resources (HAGR) is a collection of online resources for studying the biology of human ageing. HAGR features two main databases: GenAge and AnAge. GenAge is a curated database of genes related to human ageing. Entries were primarily selected based on genetic perturbations in animal models and human diseases as well as an extensive literature review. Each entry includes a variety of automated and manually curated information, including, where available, protein–protein interactions, the relevant literature, and a description of the gene and how it relates to human ageing. The goal of GenAge is to provide the most complete and comprehensive database of genes related to human ageing on the Internet as well as render an overview of the genetics of human ageing. AnAge is an integrative database describing the ageing process in several organisms and featuring, if available, maximum life span, taxonomy, developmental schedules and metabolic rate, making AnAge a unique resource for the comparative biology of ageing. Associated with the databases are data-mining tools and software designed to investigate the role of genes and proteins in the human ageing process as well as analyse ageing across different taxa. HAGR is freely available to the academic community at http://genomics.senescence.info

Promise and Failure : Nationalism in the Interwar Thought of Carl Schmitt and Eric Voegelin

This article analyses the role played by the concept of nation in the interwar writings of Carl Schmitt (1888-1985) and Eric Voegelin (1901-1985). It contends that, although these conservative thinkers were drawn in different ways to the anti-progressive potential of nationalist ideas, the centre of their political and theoretical horizons in that period is occupied by the problems of political unity and authority. Therefore, their nationalism is fundamentally determined by, and instrumental to, their adherence to a monistic and authoritarian conception of the state. This, in turn, leads them to embrace, though not without some reservations, the solutions put forward by the emergent far-right 'strongmen' to the interwar crisis of liberal democracy. Each author tested in his own way the porous borders between conservatism, nationalism, and fascism - a topic whose scholarly and political relevance is far from being exhausted.Peer reviewe

Democracy and the Body Politic : From Sovereign Power to Indeterminacy

As a political technology, camps materialize the ominous potential of modern democracy understood as sovereign power. Indeed, although one usually associates the massive projects of segregation, reeducation and extermination carried out in and through camps to the totalitarian regimes of the 20th century, the more puzzling truth is that the reasoning justifying them is not incompatible with the concept of popular sovereignty. The popular collective subject in whose name divine-right monarchs were deposed, and whose constituent power brought forth new, more egalitarian political institutions, can also turn out to be a force that closes in on itself and fosters a quest for transparent, homogeneous identity that does not shy away from employing the most ruthless coercive means. In this paper, I turn to Claude Lefort’s concept of indeterminacy as an alternative reading of the modern democratic endeavour that preserves a self-critical awareness of democracy’s ominous side. My contention is that Lefort’s concept proves to be fruitful in two ways. On the one hand, it allows us to grasp why the camp – and, for that matter, the populist strongman – is an ever-present possibility of democratic politics. On the other hand, and most importantly, it equips us with the tools to challenge these sovereigntist drifts from a specifically democratic perspective.Non peer reviewe

When corruption investigations come to nothing: A natural experiment on trust in courts

Corruption scandals and their investigation have been shown to undermine support not only for the allegedly involved public officials but also for political actors and institutions more generally. However, we know little about what happens when those investigations end up failing to result in punishments. Is citizens' trust in the legal authorities in charge of prosecuting and punishing corruption also undermined? Do those effects spill over to political actors, institutions, and even the political regime? We address these questions by taking advantage of an April 2021 judicial decision to drop corruption charges against former Portuguese Prime Minister José Sócrates during the fieldwork of a public opinion survey. We show that the decision had a substantial negative impact on public trust in the courts. Furthermore, although political trust was not immediately affected, its overall levels also became lower in comparison to periods before the judicial decision, suggesting a spillover effect.info:eu-repo/semantics/publishedVersio

The Problem of Legitimacy in Late Modern Political Thought (1905-1933)

UID/CPO/04627/2013publishersversionpublishe

Spiritual and strategic leadership in pastoral ministry

https://place.asburyseminary.edu/ecommonsatsdissertations/1394/thumbnail.jp