Knickpoints and crescentic bedform interactions in submarine channels

Submarine channels deliver globally important volumes of sediments, nutrients, contaminants and organic carbon into the deep sea. Knickpoints are significant topographic features found within numerous submarine channels, which most likely play an important role in channel evolution and the behaviour of the submarine sediment-laden flows (turbidity currents) that traverse them. Although prior research has linked supercritical turbidity currents to the formation of both knickpoints and smaller crescentic bedforms, the relationship between flows and the dynamics of these seafloor features remains poorly constrained at field-scale. This study investigates the distribution, variation and interaction of knickpoints and crescentic bedforms along the 44km long submarine channel system in Bute Inlet, British Columbia. Wavelet analyses on a series of repeated bathymetric surveys reveal that the floor of the submarine channel is composed of a series of knickpoints that have superimposed, higher-frequency, crescentic bedforms. Individual knickpoints are separated by hundreds to thousands of metres, with the smaller superimposed crescentic bedforms varying in wavelengths from ca 16m to ca 128m through the channel system. Knickpoint migration is driven by the passage of frequent turbidity currents, and acts to redistribute and reorganize the crescentic bedforms. Direct measurements of turbidity currents indicate the seafloor reorganization caused by knickpoint migration can modify the flow field and, in turn, control the location and morphometry of crescentic bedforms. A transect of sediment cores obtained across one of the knickpoints show sand–mud laminations of deposits with higher aggradation rates in regions just downstream of the knickpoint. The interactions between flows, knickpoints and bedforms that are documented here are important because they likely dominate the character of preserved submarine channel-bed deposits

Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci

To identify genetic factors contributing to type 2 diabetes (T2D), we performed large-scale meta-analyses by using a custom similar to 50,000 SNP genotyping array (the ITMAT-Broad-CARe array) with similar to 2000 candidate genes in 39 multiethnic population-based studies, case-control studies, and clinical trials totaling 17,418 cases and 70,298 controls. First, meta-analysis of 25 studies comprising 14,073 cases and 57,489 controls of European descent confirmed eight established T2D loci at genome-wide significance. In silico follow-up analysis of putative association signals found in independent genome-wide association studies (including 8,130 cases and 38,987 controls) performed by the DIAGRAM consortium identified a T2D locus at genome-wide significance (GATAD2A/CILP2/PBX4; p = 5.7 x 10(-9)) and two loci exceeding study-wide significance (SREBF1, and TH/INS; p < 2.4 x 10(-6)). Second, meta-analyses of 1,986 cases and 7,695 controls from eight African-American studies identified study-wide-significant (p = 2.4 x 10(-7)) variants in HMGA2 and replicated variants in TCF7L2 (p = 5.1 x 10(-15)). Third, conditional analysis revealed multiple known and novel independent signals within five T2D-associated genes in samples of European ancestry and within HMGA2 in African-American samples. Fourth, a multiethnic meta-analysis of all 39 studies identified T2D-associated variants in BCL2 (p = 2.1 x 10(-8)). Finally, a composite genetic score of SNPs from new and established T2D signals was significantly associated with increased risk of diabetes in African-American, Hispanic, and Asian populations. In summary, large-scale meta-analysis involving a dense gene-centric approach has uncovered additional loci and variants that contribute to T2D risk and suggests substantial overlap of T2D association signals across multiple ethnic groups

Circulating microRNAs in sera correlate with soluble biomarkers of immune activation but do not predict mortality in ART treated individuals with HIV-1 infection: A case control study

10.1371/journal.pone.0139981PLoS ONE1010e013998