Extravascular lipid deposition and morphology of atherosclerosis in heterozygous WHHL rabbits fed vegetable (n-6) and marine (11-3) oils

The aim of this experiment was to test the cholesterol-fed heterozugous WHHL rabbit as a model for investigation of atherogenicity of different fats. Twentytwo rabbits of both sexes, 8—9.5 months old were randomized in 3 groups, and fed 100 g diet daily: cholesterol enriched standard diet (group I, n=8), cholesterol enriched diet with added vegetable (group II, n=7). or marine (group III, n=7) oils during 14 weeks. The vegetable oil (n-6 = 33 %, n—3 less than 1 %) and a marine oil(n-6 = 18 %, n-3 = 17 %) were adjusted to contain equal amounts of saturated and monounsaturated fatty acids. One percent cholesterol in the diet caused a pronounced hypercholesterolemia which was significantly enhanced by addition of oils.The increase in total cholesterol was especially reflected in the increase in the VLDL concentration. The blood cholesterol and triglyceride levels were comparable between the two of fed groups apart from a transitory lowering in the marine oilfed rabbits. The atherosclerotie lesions caused by 1 % cholesterol in the diet were fibrous plaques and plaques with foam cells. The added oils aggravated the atherosclerosis caused by cholesterol. Based on morphological appearance of the aorticand coronary atherosclerosis the marine oil was more atherogcnic than the vegetable oil. In pulmonary arteries, however, the less severe atherosclerotic changes were found in the marine oil group. In this group no lipid infiltrations were seen in the myocardium but very severe infiltrations were seen in the liver. In the vegetable oil group these infiltrations were severe in the myocardium and less pronounced in the liver. The massive hypereholesterolemia and extravascular lipid deposition in different parenchymatous organs suggest that lower doses of dietary cholesterol should be used when the cholesterol-fed heterozygous WHHL rabbit is chosen to study the ellect ot'van'ous fats on blood lipids and developmentof atherosclerosis

Morbidity and mortality after robot-assisted radical cystectomy with intracorporeal urinary diversion in octogenarians: results from the European Association of Urology Robotic Urology Section Scientific Working Group

OBJECTIVES: To evaluate the postoperative complication and mortality rate following laparoscopic radical cystectomy (RARC) with intracorporeal urinary diversion (ICUD) in octogenarians. PATIENTS AND METHODS: We conducted a retrospective analysis comparing postoperative complication and mortality rates depending on age in a consecutive series of 1890 patients who underwent RARC with ICUD for bladder cancer between 2004 and 2018 in 10 European centres. Outcomes of patients aged <80 years and those aged ≥80 years were compared with regard to postoperative complications (Clavien–Dindo grading) and mortality rate. Cancer-specific mortality (CSM) and other-cause mortality (OCM) after surgery were calculated using the non-parametric Aalen-Johansen estimator. RESULTS: A total of 1726 patients aged <80 years and 164 aged ≥80 years were included in the analysis. The 30- and 90-day rate for high-grade (Clavien–Dindo grades III–V) complications were 15% and 21% for patients aged <80 years compared to 11% and 13% for patients aged ≥80 years (P = 0.2 and P = 0.03), respectively. In a multivariable logistic regression analysis adjusting for pre- and postoperative variables, age ≥80 years was not an independent predictor of high-grade complications (odds ratio 0.6, 95% confidence interval 0.3–1.1; P = 0.12). The non-cancer-related 90-day mortality was 2.3% for patients aged ≥80 years and 1.8% for those aged <80 years, respectively (P = 0.7). The estimated 12-month CSM and OCM rates for those aged <80 years were 8% and 3%, and for those aged ≥80 years, 15% and 8%, respectively (P = 0.009 and P < 0.001). CONCLUSIONS: The minimally invasive approach to RARC with ICUD for bladder cancer in well-selected elderly patients (aged ≥80 years) achieved a tolerable high-grade complication rate; the 90-day postoperative mortality rate was driven by cancer progression and the non-cancer-related rate was equivalent to that of patients aged <80 years. However, an increased OCM rate in this elderly group after the first year should be taken into account. These results will support clinicians and patients when balancing cancer-related vs treatment-related risks and benefits

Совершенствование экспортной стратегии деятельности предприятия (на примере ОАО «Речицкий метизный завод»)

Photoluminescence (PL) properties are reported for a set of m-plane GaN films with Mg doping varied from mid 1018cm-3 to well above 1019 cm-3. The samples were grown with MOCVD at reduced pressure on low defect density m-plane bulk GaN templates. The sharp line near bandgap bound exciton (BE) spectra observed below 50 K, as well as the broader donor-acceptor pair (DAP) PL bands at 2.9 eV to 3.3 eV give evidence of several Mg related acceptors, similar to the case of c-plane GaN. The dependence of the low temperature BE spectra on excitation intensity as well as the transient decay behavior demonstrate acoustic phonon assisted transfer between the acceptor BE states. The lower energy donor-acceptor pair spectra suggest the presence of deep acceptors, in addition to the two main shallower ones at about 0.23 eV. Similar spectra from Mg-doped GaN nanowires (NWs) grown by MOCVD are also demonstrated and briefly discussed

Musikk og religion

Music plays an important role in many religions and in a variety of religious contexts. Music and Religion: Texts on Music in Religion and Religion in Music takes a look at the intersections between music and religion. We experience religion in music, and in religion we encounter musical expression. Although music and religion are unquestionably mutually pervasive, we can also come across gaps between them: Is it possible to move beyond a musical experience toward a religious one without having to hop over this gap? And is there any direct route from religion into music as an acoustic phenomenon? Without a religious interpretation of the music remaining? There is a wealth of research about music and religion, but little on how they meet. That is what this anthology seeks to remedy. Music and Religion will be relevant for anyone with an interest in encounters between these two phenomena. It will be especially relevant for students in performing, composing and scientific music education, as well as theology and religious studies. The anthology has been edited by Henrik Holm (associate professor in education at Oslo Metropolitan University and professor in philosophy at Rudolf Steiner University College) and Øivind Varkøy (professor in music education and music sciences at the Norwegian Academy of Music and professor II in music at Oslo Metropolitan University)

Structuring social complexities in natural resource governance : exploring a new model for adaptive co-management

Godkänd; 2011; 20110908 (ysko