Responsible Research and Innovation in Science Education: the IRRESISTIBLE Project

The EU funded IRRESISTIBLE-project (Project Coordinator: Jan Apotheker, University of Groningen, Netherlands) develop activities designed to foster the involvement of high school and elementary students and the public in Responsible Research and Innovation (RRI). In the project, awareness about RRI is raised in two ways: increasing content knowledge about research by bringing topics of cutting edge research into the program; fostering a discussion among the students on RRI issues about the topics that are introduced. Responsible Research and Innovation focuses on six key issues: Engagement, Gender equality, Science education, Ethics, including societal relevance and acceptability of research and innovation outcomes , Open access, Governance. The project combines formal and informal teaching to familiarize schoolchildren with science. Sixteen partners in ten countries are involved and coordinated by Science LinX. Each participants will establish a community of learners (CoL). The communities include school teachers together with university experts in the field of science communication and science centre staff. Each CoL will develop materials that the teachers will use at their own schools and students will develop an exhibit for a science centre in their own country. Once they have completed their teaching module, the teachers will each train five colleagues, in using the developed modules from the first year. Ultimately, this project will train almost ten thousand pupils to consider the social impact of scientific research

Recent advances in understanding Cushing disease: resistance to glucocorticoid negative feedback and somatic USP8 mutations

Cushing’s disease is a rare disease with a characteristic phenotype due to significant hypercortisolism driven by over-secretion of adrenocorticotropic hormone and to high morbidity and mortality if untreated. It is caused by a corticotroph adenoma of the pituitary, but the exact mechanisms leading to tumorigenesis are not clear. Recent advances in molecular biology such as the discovery of somatic mutations of the ubiquitin-specific peptidase 8 (USP8) gene allow new insights into the pathogenesis, which could be translated into exciting and much-needed therapeutic applications

Covid-19 and the role of smoking: The protocol of the multicentric prospective study COSMO-IT (covid19 and smoking in italy)

The emergency caused by Covid-19 pandemic raised interest in studying lifestyles and comorbidities as important determinants of poor Covid-19 prognosis. Data on tobacco smoking, alcohol consumption and obesity are still limited, while no data are available on the role of e-cigarettes and heated tobacco products (HTP). To clarify the role of tobacco smoking and other lifestyle habits on COVID-19 severity and progression, we designed a longitudinal observational study titled COvid19 and SMOking in ITaly (COSMO-IT). About 30 Italian hospitals in North, Centre and South of Italy joined the study. Its main aims are: 1) to quantify the role of tobacco smoking and smoking cessation on the severity and progression of COVID-19 in hospitalized patients; 2) to compare smoking prevalence and severity of the disease in relation to smoking in hospitalized COVID-19 patients versus patients treated at home; 3) to quantify the association between other lifestyle factors, such as e-cigarette and HTP use, alcohol and obesity and the risk of unfavourable COVID-19 outcomes. Socio-demographic, lifestyle and medical history information will be gathered for around 3000 hospitalized and 700-1000 home-isolated, laboratory-confirmed, COVID-19 patients. Given the current absence of a vaccine against SARS-COV-2 and the lack of a specific treatment for COVID-19, prevention strategies are of extreme importance. This project, designed to highly contribute to the international scientific debate on the role of avoidable lifestyle habits on COVID-19 severity, will provide valuable epidemiological data in order to support important recommendations to prevent COVID-19 incidence, progression and mortality