Key Players in Reverse Cholesterol Transport: The Plasma Enzyme LCAT

Lecithin cholesterol acyltransferase (LCAT) is a plasma enzyme that remodels nascent high density lipoprotein (HDL) into a mature form called spherical HDL. The model will be used in the future to map the amino acid residues from LCAT and the protein component of nascent HDL (apoA1) involved in mutual interaction, and to identify LCAT residues interacting with the lipid phase of nascent HDL.https://engagedscholarship.csuohio.edu/u_poster_2012/1031/thumbnail.jp

Information support of joint activity of organizations: problems of accounting and analysis system

Joint activity enlarges on different types of organizations. The types can differ according to the sector of economy and legal structure. However, the economic essence of this type of integration has a historical and legal integrity. The study of historical and legal aspects of the development of joint activity will allow to scientifically substantiate the theoretical theses in order to consider joint activity as a mechanism for increasing the competitiveness of the Belarusian economy in the post-crisis period

Method of goat immunodiagnosis in arthritis-encephalitis

Currently, serological tests are used in the diagnosis of Caprine Arthritis Encephalitis (CAE), but a more accurate diagnosis of the disease requires the most reliable modern methods of immunodiagnosis. This is important for timely diagnosis and prevention of this disease, especially in commercial production of goat milk. At the present stage, the practice of infectious diseases immunodiagnosis in animals includes the determination of cytokines 6 and 10. The discovered cytokines allow for a different view on the infectious disease pathogenesis, while the previously used diagnostic methods are not excluded from the veterinary practice. At present, during the restoration and renewal of the goat population, new breeds purchased in foreign countries have appeared, and with them have come new diseases not previously prevalent in the Russian Federation. Therefore, practicing veterinarians need to develop the most effective immunodiagnostic tests for these diseases and work out effective control and prevention methods, as well as to be able to assess the risks of new infections or mixt infections. Immunophenotyping is performed in various infectious animal diseases, and immunological monitoring is also possible

Caprine arthritis-encephalitis in the Sverdlovsk region and the diagnostics importance

Goat breeding products (especially dairy products) are of great importance in human dietetic nutrition. In this connection the studies into infectious diseases and maintaining of well-being in terms of especially dangerous and social infections of animals on the territory of Russia are essential. Epizootological monitoring of caprine arthritis-encephalitis in the Russian Federation has shown that the central regions, including the Urals region, are unfavourable for this disease. Diagnostic tests for caprine arthritis-encephalitis (CAE) are understudied, and there are insufficient data on treatment and prevention, for this reason, the topic of CAE studies is highly relevant and of key importance for clarifying the identification of the causative agent and blood changes in biochemical and haematological tests, when clinical signs of infection are present

СИСТЕМА ЛІКУВАЛЬНО-ДІАГНОСТИЧНИХ ЗАХОДІВ ДЛЯ ЗАБЕЗПЕЧЕННЯ БЕЗПЕЧНОГО МАТЕРИНСТВА У ЖІНОК ФЕРТИЛЬНОГО ВІКУ З ПОРУШЕННЯМИ МЕНСТРУАЛЬНОГО ЦИКЛУ, МЕШКАНОК ПРОМИСЛОВОГО РЕГІОНУ УКРАЇНИ, ЯКІ ПЕРЕНЕСЛИ ФІЗІОЛОГІЧНІ ТА ПАТОЛОГІЧНІ ПОЛОГИ.

In article are stated results of the research on study of the condition of the reproductive health beside women of fertile age of the typical industrial region, forecasting of its breaches (breaches of menstrual cycle) and on the base of it the system of preventive maintenance and treatment were worked out. The created system action was carried in practical person of the work of the obstetrical institutions in Dneprovsky region of Kiev and has allowed to provide greatly to perfect the factors of women’s.health.В статье изложены результаты исследований по изучению состояния репродуктивного здоровья у женщин фертильного возраста типичного промышленного региона, с прогнозированием его нарушений, в частности (нарушений менструльного цикла), на основании которого разработана система мероприятий по их профилактике и лечению. Созданная система мероприятий была введена в практику работы родовспомогательныхучреждений в Днепровском районе г. Киева и позволила существенно улучшить показатели здоровья женщин фертильного возраста.В статті викладено результати досліджень з вивчення стану репродуктивного здоров’я у жінок фертильного віку типового промислового регіону, прогнозуванням його порушень, зокрема (порушень менструального циклу), на основі якого розроблена система заходів з'їх профілактики і лікування. Створена система заходів була впроваджена в практику роботи родопомічних закладів в Дніпровському районі м. Києва та дозволила суттєво покращити показники здоров’я жінок фертильного віку

Developing Health-Based Pre-Planning Clearance Goals for Airport Remediation Following Chemical Terrorist Attack: Introduction and Key Assessment Considerations

In the event of a chemical terrorist attack on a transportation hub, post-event remediation and restoration activities necessary to attain unrestricted facility reuse and re-entry could require hours to multiple days. While restoration timeframes are dependent on numerous variables, a primary controlling factor is the level of pre-planning and decision-making completed prior to chemical terrorist release. What follows is the first of a two-part analysis identifying key considerations, critical information, and decision criteria to facilitate post-attack and post-decontamination consequence management activities. A conceptual site model and human health-based exposure guidelines are developed and reported as an aid to site-specific pre-planning in the current absence of U.S. state or Federal values designated as compound-specific remediation or re-entry concentrations, and to safely expedite facility recovery to full operational status. Chemicals of concern include chemical warfare nerve and vesicant agents and the toxic industrial compounds phosgene, hydrogen cyanide, and cyanogen chloride. This work has been performed as a national case study conducted in partnership with the Los Angeles International Airport and The Bradley International Terminal. All recommended guidelines have been selected for consistency with airport scenario release parameters of a one-time, short-duration, finite airborne release from a single source followed by compound-specific decontamination

The BraveNet prospective observational study on integrative medicine treatment approaches for pain

BACKGROUND: Chronic pain affects nearly 116 million American adults at an estimated cost of up to $635 billion annually and is the No. 1 condition for which patients seek care at integrative medicine clinics. In our Study on Integrative Medicine Treatment Approaches for Pain (SIMTAP), we observed the impact of an integrative approach on chronic pain and a number of other related patient-reported outcome measures. METHODS: Our prospective, non-randomized, open-label observational evaluation was conducted over six months, at nine clinical sites. Participants received a non-standardized, personalized, multimodal approach to chronic pain. Validated instruments for pain (severity and interference levels), quality of life, mood, stress, sleep, fatigue, sense of control, overall well-being, and work productivity were completed at baseline and at six, 12, and 24 weeks. Blood was collected at baseline and week 12 for analysis of high-sensitivity C-reactive protein and 25-hydroxyvitamin D levels. Repeated-measures analysis was performed on data to assess change from baseline at 24 weeks. RESULTS: Of 409 participants initially enrolled, 252 completed all follow-up visits during the 6 month evaluation. Participants were predominantly white (81%) and female (73%), with a mean age of 49.1 years (15.44) and an average of 8.0 (9.26) years of chronic pain. At baseline, 52% of patients reported symptoms consistent with depression. At 24 weeks, significantly decreased pain severity (−23%) and interference (−28%) were seen. Significant improvements in mood, stress, quality of life, fatigue, sleep and well-being were also observed. Mean 25-hydroxyvitamin D levels increased from 33.4 (17.05) ng/mL at baseline to 39.6 (16.68) ng/mL at week 12. CONCLUSIONS: Among participants completing an integrative medicine program for chronic pain, significant improvements were seen in pain as well as other relevant patient-reported outcome measures. TRIAL REGISTRATION: ClinicalTrials.gov, NCT0118634