Determining sustainable tourism in regions

The goal of achieving sustainable tourism is now a priority for many tourism planners. It has been suggested that stakeholder analysis is an essential step in determining sustainable tourism in regions, given its highly contextual nature. However, previous research has tended to focus heavily on stakeholders with the assumption that attitudes within groups are homogeneous. This research questions this assumption and in doing so, takes a critical approach by examining attitudes towards sustainable tourism and then assesses whether attitudes align with stakeholder groups. The study was conducted in the island state of Tasmania, Australia, and utilised the Q-methodology to examine attitudes towards sustainable tourism in the Bay of Fires region. The results concur with recent research, which shows that attitudes do not always align with those of stakeholder groups. The critical and reflexive approach suggests that assumptions regarding stakeholder attitudes need to be reviewed and more attention given to people’s contextualised attitudes, rather than the stakeholder group in which they sit

Communicating Our Science to Our Customers:Drug Discovery in Five Simple Experiments

The complexities of modern drug discovery–an interdisciplinary process that often takes years and costs billions–can be extremely challenging to explain to a public audience. We present details of a 30 minute demonstrative lecture that uses well-known experiments to illustrate key concepts in drug discovery including synthesis, assay and metabolism

Key worker models: What key worker approaches, capacity and capabilities are important at different stages of the journey to employment?

This report focuses on the role of key workers (i.e. individuals providing one-to-one advice and support to beneficiaries) in employment programmes and the approaches, capacity and capabilities that are important at different stages of the journey to employment. It draws on findings from the Talent Match (TM) National Evaluation about how key worker support is being delivered, how it has evolved over the lifetime of TM and what key worker support looks like. Talent Match is a Big Lottery Fund strategic programme investing £108 million in 21 Local Enterprise Partnership (LEP) areas, which have experienced particularly high levels of youth unemployment. The focus of the programme is on developing holistic approaches to combating worklessness amongst long-term NEETs. A key aspect of the programme is to bring young people closer to, and into employment. Part One of this report outlines what key workers are and the different approaches they adopt in employment programmes. Part Two presents findings from a survey of all TM partnerships and case studies in four TM partnerships comprising qualitative interviews with partnership leads, key workers and beneficiaries. Based on these findings it presents a model of how key workers support young people on their journey to employment, highlighting the experience, attributes and skill sets needed by key workers at different stages of a young person’s journey to employment. Part Three sets out the learning on key worker approaches, capacity and capabilities emerging from this research

Key worker models : what key worker approaches, capacity and capabilities are important at different stages of the journey to employment? (Talent Match Case Study Theme Report)

This report focuses on the role of key workers (i.e. individuals providing one-to-one advice and support to beneficiaries) in employment programmes and the approaches, capacity and capabilities that are important at different stages of the journey to employment. It draws on findings from the Talent Match (TM) National Evaluation about how key worker support is being delivered, how it has evolved over the lifetime of TM and what key worker support looks like. Talent Match is a Big Lottery Fund strategic programme investing £108 million in 21 Local Enterprise Partnership (LEP) areas, which have experienced particularly high levels of youth unemployment. The focus of the programme is on developing holistic approaches to combating worklessness amongst long-term NEETs. A key aspect of the programme is to bring young people closer to, and into employment. Part One of this report outlines what key workers are and the different approaches they adopt in employment programmes. Part Two presents findings from a survey of all TM partnerships and case studies in four TM partnerships comprising qualitative interviews with partnership leads, key workers and beneficiaries. Based on these findings it presents a model of how key workers support young people on their journey to employment, highlighting the experience, attributes and skill sets needed by key workers at different stages of a young person’s journey to employment. Part Three sets out the learning on key worker approaches, capacity and capabilities emerging from this research

The crux of the matter: did the ABC's Catalyst program change statin use in Australia?

This article argues that the ABC’s Catalyst program criticising statins affected people’s willingness to take these drugs. Abstract Objectives: To examine the impact of a two-part special edition of the Australian Broadcasting Corporation\u27s science journalism program Catalyst (titled Heart of the matter), aired in October 2013, that was critical of HMG-CoA reductase inhibitors (“statins”). Design, setting and participants: Population-based interrupted time-series analysis of a 10% sample of Australian long-term concessional beneficiaries who were dispensed statins under the Pharmaceutical Benefits Scheme (about 51% of all people who were dispensed a statin between 1 July 2009 and 30 June 2014); dispensing of proton pump inhibitors (PPIs) was used as a comparator. Main outcome measures: Change in weekly dispensings and discontinuation of use of statins and PPIs, adjusting for seasonal and long-term trends, overall and (for statins only) stratified by the use of cardiovascular and diabetes medicines. Results: In our sample, 191 833 people were dispensed an average of 26 946 statins weekly. Following the Catalyst program, there was a 2.60% (95% CI, 1.40%–3.77%; P < 0.001) reduction in statin dispensing, equivalent to 14 005 fewer dispensings Australia-wide every week. Dispensing decreased by 6.03% (95% CI, 3.73%–8.28%; P < 0.001) for people not dispensed other cardiovascular and diabetes medicines and 1.94% (0.42%–3.45%; P = 0.01) for those dispensed diabetes medicines. In the week the Catalyst program aired, there was a 28.8% (95% CI, 15.4%–43.7%; P < 0.001) increase in discontinuation of statin use, which decayed by 9% per week. An estimated 28 784 additional Australians ceased statin treatment. Discontinuation occurred regardless of the use of other cardiovascular and diabetes medicines. There were no significant changes in PPI use after the Catalyst program. Conclusions: Following airing of the Catalyst program, there was a temporary increase in discontinuation and a sustained decrease in overall statin dispensing. Up until 30 June 2014, there were 504 180 fewer dispensings of statins, and we estimate this to have affected 60 897 people

Adherence to prescribing restrictions for HER2-positive metastatic breast cancer in Australia: A national population-based observational study (2001-2016)

Background: Targeted cancer therapy is often complex, involving multiple agents and chemotherapeutic partners. In Australia, prescribing restrictions are put in place to reflect existing evidence of cost-effectiveness of these medicines. As therapeutic options continue to expand, these restrictions may not be perceived to align with best practice and it is not known if their use in the real-world clinic adheres to these restrictions. We examined the treatment of women receiving trastuzumab for HER2-positive metastatic breast cancer (HER2+MBC) to determine the extent to which treatment adhered to national prescribing restrictions. Patients and methods: Our population-based, retrospective cohort study used dispensing records for every Australian woman initiating publicly-subsidised trastuzumab for HER2+MBC between 2001±2013, followed through 2016. We used group-based trajectory models (GBTMs) to cluster patients, first on their patterns of trastuzumab exposure, and then on their patterns of lapatinib and chemotherapy exposure. We described the characteristics of patients within each cluster, and examined their treatments and combinations of treatments to determine restriction adherence. Results: Of 5,052 patients initiating trastuzumab, 1,795 (36%) received at least one non-adherent HER2-targeted treatment. The most common non-adherent treatments were trastuzumab combinations involving vinorelbine (24% of non-adherent treatments); capecitabine (24%); and anthracyclines (10%). Non-adherent lapatinib use was observed in 4% of patients. GBTM identified three trastuzumab exposure clusters, each containing three further subclusters. The largest proportions of non-adherent treatments were in sub-clusters with longer trastuzumab exposure and more non-taxane chemotherapy. Patients in these sub-clusters were younger than those in sub-clusters with less non-adherent treatment. Conclusions: Our study highlights that, even during the relatively simpler treatment era of our study period, a substantial amount of treatment did not adhere to prescribing restrictions. As more trials are conducted exploring pertuzumab and T-DM1 in combination with different chemotherapies and other HER2-targeted therapies, the regulation and funding of HER2-targeted treatment will become more challenging

Quantifying microbial utilization of petroleum hydrocarbons in salt-marsh sediments using the ^(13)C content of bacterial rRNA

Natural remediation of oil spills is catalyzed by complex microbial consortia. Here we take a whole-community approach to investigate bacterial incorporation of petroleum hydrocarbons from a simulated oil spill. We utilized the natural difference in carbon-isotopic abundance between a salt marsh ecosystem supported by the ^(13)C-enriched C4 grass, Spartina alterniflora, and the ^(13)C-depleted composition of petroleum to monitor changes in the ^(13)C content of biomass. Magnetic-bead capture methods for the selective recovery of bacterial RNA were used to monitor the ^(13)C content of bacterial biomass during a two-week experiment. The data show that by the end of the experiment, up to 26% of bacterial biomass derived from consumption of the freshly-spilled oil. The results contrast with the inertness of a nearby relict spill, which occurred in 1969 in West Falmouth, MA. Sequences of 16S rRNA genes from our experimental samples also were consistent with previous reports suggesting the importance of {gamma}- and {delta}-Proteobacteria and Firmicutes in the remineralization of hydrocarbons. The magnetic-bead capture approach makes it possible to quantify uptake of petroleum hydrocarbons by microbes in-situ. Although employed here at the Domain level, RNA-capture procedures can be highly specific. The same strategy could be used with genus-level specificity, something which is not currently possible using the ^(13)C content of biomarker lipids