Surveying for Ophidiomyces ophidiicola, the causal agent of Snake Fungal Disease in South Dakota.

For the past decade there has been an emerging disease plaguing wild snakes across the Eastern United States and Europe. In 2006, researchers started investigating the decline of Timber rattlesnake populations in New Hampshire. They discovered a fungal infection killing off the young to mid-juvenal snakes, thus know as Snake Fungal Disease or Ophidiomycosis. In 2011, San Deigo State University, identified the pathogen that causes infection, the fungus Ophidiomyces ophiodiicola. O. ophiodiicola has now affected 30 different snakes from six families within at least 20 different states since it’s discovery. This study pertains to determining the prevalence of Snake Fungal Disease within South Dakota.https://scholar.dsu.edu/research-symposium/1028/thumbnail.jp

Water facilities in retrospect and prospect: An illuminating tool for vehicle design

Water facilities play a fundamental role in the design of air, ground, and marine vehicles by providing a qualitative, and sometimes quantitative, description of complex flow phenomena. Water tunnels, channels, and tow tanks used as flow-diagnostic tools have experienced a renaissance in recent years in response to the increased complexity of designs suitable for advanced technology vehicles. These vehicles are frequently characterized by large regions of steady and unsteady three-dimensional flow separation and ensuing vortical flows. The visualization and interpretation of the complicated fluid motions about isolated vehicle components and complete configurations in a time and cost effective manner in hydrodynamic test facilities is a key element in the development of flow control concepts, and, hence, improved vehicle designs. A historical perspective of the role of water facilities in the vehicle design process is presented. The application of water facilities to specific aerodynamic and hydrodynamic flow problems is discussed, and the strengths and limitations of these important experimental tools are emphasized

The role of self-assessment in the facilitation of entrepreneurial competencies in learners who are studying on entrepreneurial learning courses in England

This study explored whether self-assessment facilitates the process of generating entrepreneurial competencies in learners who were studying on entrepreneurial learning courses in England. The focus was on how learners experience personal growth and transformation through the learning process and how this could be demonstrated through self-assessment practices. This was achieved by looking at the cognitive processes that a learner needs to engage with in order to conduct selfassessments and the relationship between these and self-regulation. The research was positioned within a holistic philosophy of education, where the learners’ physical, personal, social, emotional, and spiritual well-being, as well as cognitive aspects of learning, are equally important. This was a qualitative study framed by an interpretivist philosophical position. The chosen methods were semi-structured interviews of eight educators and seven learners and document analysis, which provide an understanding of the phenomenon by looking at how the participants interpret the events based on their individual thought processes. This research contributes to our understanding of self-assessment practices on entrepreneurial learning courses and the impact that this could have on higher education more broadly. This study made an original contribution to the knowledge by increasing our understanding of self assessment through the production of new information by identifying a typology of the forms of self-assessment that learners participate in on entrepreneurial learning courses. The typology identifies the skills that the learner requires in order to complete the self-assessments, outlining the benefits for learners who participate in self-assessments, discussing the factors that contribute to a successful self assessment, and describing the role of the educator as a facilitator in the process of self-assessment

ADRIC: Adverse Drug Reactions In Children - a programme of research using mixed methods

Aims To comprehensively investigate the incidence, nature and risk factors of adverse drug reactions (ADRs) in a hospital-based population of children, with rigorous assessment of causality, severity and avoidability, and to assess the consequent impact on children and families. We aimed to improve the assessment of ADRs by development of new tools to assess causality and avoidability, and to minimise the impact on families by developing better strategies for communication. Review methods Two prospective observational studies, each over 1 year, were conducted to assess ADRs in children associated with admission to hospital, and those occurring in children who were in hospital for longer than 48 hours. We conducted a comprehensive systematic review of ADRs in children. We used the findings from these studies to develop and validate tools to assess causality and avoidability of ADRs, and conducted interviews with parents and children who had experienced ADRs, using these findings to develop a leaflet for parents to inform a communication strategy about ADRs. Results The estimated incidence of ADRs detected in children on admission to hospital was 2.9% [95% confidence interval (CI) 2.5% to 3.3%]. Of the reactions, 22.1% (95% CI 17% to 28%) were either definitely or possibly avoidable. Prescriptions originating in the community accounted for 44 out of 249 (17.7%) of ADRs, the remainder originating from hospital. A total of 120 out of 249 (48.2%) reactions resulted from treatment for malignancies. Off-label and/or unlicensed (OLUL) medicines were more likely to be implicated in an ADR than authorised medicines [relative risk (RR) 1.67, 95% CI 1.38 to 2.02; p  48 hours, the overall incidence of definite and probable ADRs based on all admissions was 15.9% (95% CI 15.0 to 16.8). Opiate analgesic drugs and drugs used in general anaesthesia (GA) accounted for > 50% of all drugs implicated in ADRs. The odds ratio of an OLUL drug being implicated in an ADR compared with an authorised drug was 2.25 (95% CI 1.95 to 2.59; p < 0.001). Risk factors identified were exposure to a GA, age, oncology treatment and number of medicines. The systematic review estimated that the incidence rates for ADRs causing hospital admission ranged from 0.4% to 10.3% of all children [pooled estimate of 2.9% (95% CI 2.6% to 3.1%)] and from 0.6% to 16.8% of all children exposed to a drug during hospital stay. New tools to assess causality and avoidability of ADRs have been developed and validated. Many parents described being dissatisfied with clinician communication about ADRs, whereas parents of children with cancer emphasised confidence in clinician management of ADRs and the way clinicians communicated about medicines. The accounts of children and young people largely reflected parents’ accounts. Clinicians described using all of the features of communication that parents wanted to see, but made active decisions about when and what to communicate to families about suspected ADRs, which meant that communication may not always match families’ needs and expectations. We developed a leaflet to assist clinicians in communicating ADRs to parents. Conclusion The Adverse Drug Reactions In Children (ADRIC) programme has provided the most comprehensive assessment, to date, of the size and nature of ADRs in children presenting to, and cared for in, hospital, and the outputs that have resulted will improve the management and understanding of ADRs in children and adults within the NHS. Recommendations for future research: assess the values that parents and children place on the use of different medicines and the risks that they will find acceptable within these contexts; focusing on high-risk drugs identified in ADRIC, determine the optimum drug dose for children through the development of a gold standard practice for the extrapolation of adult drug doses, alongside targeted pharmacokinetic/pharmacodynamic studies; assess the research and clinical applications of the Liverpool Causality Assessment Tool and the Liverpool Avoidability Assessment Tool; evaluate, in more detail, morbidities associated with anaesthesia and surgery in children, including follow-up in the community and in the home setting and an assessment of the most appropriate treatment regimens to prevent pain, vomiting and other postoperative complications; further evaluate strategies for communication with families, children and young people about ADRs; and quantify ADRs in other settings, for example critical care and neonatology

Tungsten nuclear rocket, phase I, part 1 Final report

Tungsten water moderated nuclear rocket reactor experiments and analyse

Path Integrals in Polar Field Variables in QFT

We show how to transform a $d$-dimensional Euclidean path integral in terms of two (Cartesian) fields to a path integral in terms of polar field variables. First we present a conjecture that states how this transformation should be done. Then we show that this conjecture is correct in the case of two toy models. Finally the conjecture will be proven for a general QFT model with two fields