Tidal Decay and Stable Roche-Lobe Overflow of Short-Period Gaseous Exoplanets

Many gaseous exoplanets in short-period orbits are on the verge or are in the process of Roche-lobe overflow (RLO). Moreover, orbital stability analysis shows tides can drive many hot Jupiters to spiral inevitably toward their host stars. Thus, the coupled processes of orbital evolution and RLO likely shape the observed distribution of close-in exoplanets and may even be responsible for producing some of the short-period rocky planets. However, the exact outcome for an overflowing planet depends on its internal response to mass loss, and the accompanying orbital evolution can act to enhance or inhibit RLO. In this study, we apply the fully-featured and robust Modules for Experiments in Stellar Astrophysics (MESA) suite to model RLO of short-period gaseous planets. We show that, although the detailed evolution may depend on several properties of the planetary system, it is largely determined by the core mass of the overflowing gas giant. In particular, we find that the orbital expansion that accompanies RLO often stops and reverses at a specific maximum period that depends on the core mass. We suggest that RLO may often strand the remnant of a gas giant near this orbital period, which provides an observational prediction that can corroborate the hypothesis that short-period gas giants undergo RLO. We conduct a preliminary comparison of this prediction to the observed population of small, short-period planets and find some planets in orbits that may be consistent with this picture. To the extent that we can establish some short-period planets are indeed the remnants of gas giants, that population can elucidate the properties of gas giant cores, the properties of which remain largely unconstrained.Comment: Accepted to "Celestial Mechanics and Dynamical Astronomy" special issue on tides. Several changes based on referee comments, including to the title of the paper. Some new analysis of non-conservative (but still stable) mass transfer as well. Article repository and data files linked to here -- http://www.astrojack.com/research

Incorporation and release of macromolecules from biodegradable polymer vehicles

The initial objective of this work was to evaluate and introduce fabrication techniques based on W/0/W double emulsion and 0/W single emulsion systems with solvent evaporation for the incorporation of a surrogate macromolecule (BSA) into microspheres and microcapsules fabricated using P(HB-HV}, PEA and their blends. Biodegradation, expressed as changes in the gross and ultrastructural morphology of BSA loaded microparticulates with time was monitored using SEM concomitant with BSA release. Spherical microparticulates were successfully fabricated using both the W/0/W and 0/W emulsion systems. Both microspheres and microcapsules released BSA over a period of 24 to 26 days. BSA release from P(HB-HV)20% PCL 11 microcapsules increased steadily with time, while BSA release from all other microparticulates was characterised by an initial lag phase followed by exponential release lasting 6-11 days. Microcapsules were found to biodegrade more rapidly than microspheres fabricated from the same polymer. The incubation of microparticulates in newborn calf serum; synthetic gastric juice and pancreatin solution showed that microspheres and microcapsules were susceptible to enzymatic biodegradation. The in vitro incubation of microparticulates in Hank's buffer demonstrated limited biodegradation of microspheres and microcapsules by simple chemical hydrolysis. BSA release was thought to ocurr as a result of the macromolecule diffusing through either inherent micropores or via pores and channels generated in situ by previously dissolved BSA. However, in all cases, irrespective of percentage loading or fabrication polymer, low encapsulation efficiencies were obtained with W/0/W and 0/W techniques (4.2±0.9%- 15.5±0.5%,n=3), thus restricting the use of these techniques for the generation of microparticulate sustained drug delivery devices. In order to overcome this low encapsulation efficiency, a W/0 single emulsion technique was developed and evaluated in an attempt to minimise the loss of the macromolecule into the continuous aqueous phase and increase encapsulation efficiency. Poly(lactide-co-glycolide) [PLCG] 75:25 and 50:50, PEA alone and PEA blended with PLCG 50:50 to accelerate biodegradation, were used to microencapsulate the water soluble antibiotic vancomycin, a putative replacement for gentamicin in the control of bacterial infection in orthopaedic surgery especially during total hip replacement. Spherical microspheres (17.39±6.89~m,n=74-56.5±13.8~m,n=70) were successfully fabricated with vancomycin loadings of 10, 25 and 50%, regardless of the polymer blend used. All microspheres remained structurally intact over the period of vancomycin release and exhibited high percentage yields( 40. 75±2 .86%- 97.16±4.3%,n=3)and encapsulation efficiencies (47.75±9.0%- 96.74±13.2%,n=12). PLCG 75:25 microspheres with a vancomycin loading of 50% were judged to be the most useful since they had an encapsulation efficiency of 96.74+13.2%, n=12 and sustained therapeutically significant vancomycin release (15-25μg/ml) for up to 26 days. This work has provided the means for the fabrication of a spectrum of prototype biodegradable microparticulates, whose biodegradation has been characterised in physiological media and which have the potential for the sustained delivery of therapeutically useful macromolecules including water soluble antibiotics for orthopaedic applications

Characterisation of the semi-volatile component of Dissolved Organic Matter by Thermal Desorption – Proton Transfer Reaction – Mass Spectrometry

Proton Transfer Reaction – Mass Spectrometry (PTR-MS) is a sensitive, soft ionisation method suitable for qualitative and quantitative analysis of volatile and semi-volatile organic vapours. PTR-MS is used for various environmental applications including monitoring of volatile organic compounds (VOCs) emitted from natural and anthropogenic sources, chemical composition measurements of aerosols, etc. Here we apply thermal desorption PTR-MS for the frst time to characterise the chemical composition of dissolved organic matter (DOM). We developed a clean, low-pressure evaporation/sublimation system to remove water from samples and coupled it to a custom-made thermal desorption unit to introduce the samples to the PTR-MS. Using this system, we analysed waters from intact and degraded peat swamp forest of Kalimantan, Indonesian Borneo, and an oil palm plantation and natural forest in Sarawak, Malaysian Borneo. We detected more than 200 organic ions from these samples and principal component analysis allowed clear separation of the diferent sample origins based on the composition of organic compounds. The method is sensitive, reproducible, and provides a new and comparatively cheap tool for a rapid characterisation of water and soil DOM

HAZMAT VI: The Evolution of Extreme Ultraviolet Radiation Emitted from Early M Star

Quantifying the evolution of stellar extreme ultraviolet (EUV, 100 -- 1000 $\overset{\circ}{A}$) emission is critical for assessing the evolution of planetary atmospheres and the habitability of M dwarf systems. Previous studies from the HAbitable Zones and M dwarf Activity across Time (HAZMAT) program showed the far- and near-UV (FUV, NUV) emission from M stars at various stages of a stellar lifetime through photometric measurements from the Galaxy Evolution Explorer (GALEX). The results revealed increased levels of short-wavelength emission that remain elevated for hundreds of millions of years. The trend for EUV flux as a function of age could not be determined empirically because absorption by the interstellar medium prevents access to the EUV wavelengths for the vast majority of stars. In this paper, we model the evolution of EUV flux from early M stars to address this observational gap. We present synthetic spectra spanning EUV to infrared wavelengths of 0.4 $\pm$ 0.05 M$_{\odot}$ stars at five distinct ages between 10 and 5000 Myr, computed with the PHOENIX atmosphere code and guided by the GALEX photometry. We model a range of EUV fluxes spanning two orders of magnitude, consistent with the observed spread in X-ray, FUV, and NUV flux at each epoch. Our results show that the stellar EUV emission from young M stars is 100 times stronger than field age M stars, and decreases as t$^{-1}$ after remaining constant for a few hundred million years. This decline stems from changes in the chromospheric temperature structure, which steadily shifts outward with time. Our models reconstruct the full spectrally and temporally resolved history of an M star's UV radiation, including the unobservable EUV radiation, which drives planetary atmospheric escape, directly impacting a planet's potential for habitability.Comment: 23 pages, 15 figures, accepted to Ap

Stories at Work: Writing to Learn, Care, and Collaborate in Radiation Therapy

Narrative writing has shown potential to foster skilled, compassionate care among health professionals. We describe the process and effects of a project that introduced experiential narrative writing to professionals and students at a large Canadian cancer centre. Four 90-minute introductory workshops in experiential narrative writing were offered to radiation therapy students (9), radiation therapists (28), and oncology nurses (1). These workshops were followed by an in-depth narrative writing course consisting of four 60-minute sessions. The course was offered twice with a total of 11 participants (all radiation therapists). Participants were prompted to write about their experiences, share their writing, and respond to each other’s writing. Writing was not focused on professional experiences. All sessions were led by an experienced facilitator and researcher. In order to describe the process and effects of these courses, we used a combination of observations, reflective writing, ongoing dialogue with participants, and follow-up interviews (8 radiation therapists and 3 students). We describe five “active elements” of the narrative writing sessions: stories at (but not about) work, challenge, trust, quality of engagement, and continuity. We then discuss perceived effects of the narrative writing sessions, which we have termed pleasure, perspective, community, presence, craft, and collective artwork. These findings suggest potential for narrative writing to support the work, well-being, and community of health professionals in radiation therapy

A New Model of Roche-Lobe Overflow for Short-Period Gaseous Planets and Binary Stars

Some close-in gaseous exoplanets are nearly in Roche-lobe contact, and previous studies show tidal decay can drive hot Jupiters into contact during the main sequence of their host stars. Improving upon a previous model, we present a revised model for mass transfer in a semi-detached binary system that incorporates an extended atmosphere around the donor and allows for an arbitrary mass ratio. We apply this new formalism to hypothetical, confirmed, and candidate planetary systems to estimate mass loss rates and compare with models of evaporative mass loss. Overflow may be significant for hot Neptunes out to periods of ∼ 2 days, while for hot Jupiters, it may only be important inward of 0.5 days. We find that CoRoT-24 b may be losing mass at a rate of more than an Earth mass in a Gyr. The hot Jupiter WASP-12 b may lose an Earth mass in a Myr, while the putative planet orbiting a T-Tauri star PTFO8-8695 might shed its atmosphere in a few Myrs. We point out that the orbital expansion that can accompany mass transfer may be less effective than previously considered because the gas accreted by the host star removes some of the system’s angular momentum from the orbit, but simple scaling arguments suggest that the Roche-lobe overflow might remain stable. Consequently, the recently discovered small planets in ultra-short-periods (\u3c 1 day) may not be the remnants of hot Jupiters/Neptunes. The new model presented here has been incorporated into Modules for Experiments in Stellar Astrophysics (MESA)

The impact of universal newborn hearing screening on long-term literacy outcomes: a prospective cohort study

Objective: To determine whether the benefits of universal newborn hearing screening (UNHS) seen at age 8?years persist through the second decade.Design: Prospective cohort study of a population sample of children with permanent childhood hearing impairment (PCHI) followed up for 17?years since birth in periods with (or without) UNHS.Setting: Birth cohort of 100?000 in southern England.Participants: 114 teenagers aged 13-19?years, 76 with PCHI and 38 with normal hearing. All had previously their reading assessed aged 6-10?years.Interventions: Birth in periods with and without UNHS; confirmation of PCHI before and after age 9?months.Main outcome measure: Reading comprehension ability. Regression modelling took account of severity of hearing loss, non-verbal ability, maternal education and main language.Results: Confirmation of PCHI by age 9?months was associated with significantly higher mean z-scores for reading comprehension (adjusted mean difference 1.17, 95% CI 0.36 to 1.97) although birth during periods with UNHS was not (adjusted mean difference 0.15, 95% CI -0.75 to 1.06). The gap between the reading comprehension z-scores of teenagers with early compared with late confirmed PCHI had widened at an adjusted mean rate of 0.06 per year (95% CI -0.02 to 0.13) during the 9.2-year mean interval since the previous assessment.Conclusions: The benefit to reading comprehension of confirmation of PCHI by age 9?months increases during the teenage years. This strengthens the case for UNHS programmes that lead to early confirmation of permanent hearing loss