In-vivo measurement of the human soft tissues constitutive laws. Applications to Computer Aided Surgery

In the 80's, biomechanicians were asked to work on Computer Aided Surgery applications since orthopaedic surgeons were looking for numerical tools able to predict risks of fractures. More recently, biomechanicians started to address soft tissues arguing that most of the human body is made of such tissues that can move as well as deform during surgical gestures [1]. An intra-operative use of a continuous Finite Element (FE) Model of a given tissue mainly faces two problems: (1) the numerical simulations have to be "interactive", i.e. sufficiently fast to provide results during surgery (which can be a strong issue in the context of hyperelastic models for example) and (2) during the intervention, the surgeon needs a device that can be used to provide to the model an estimation of the patient-specific constitutive behaviour of the soft tissues. This work proposes an answer to the second point, with the design of a new aspiration device aiming at characterizing the in vivo constitutive laws of human soft tissues. The device was defined in order to permit sterilization as well an easy intra-operative use

Co‐existing monophasic teratoma and uterine adenocarcinoma in a female dog

Ovarian teratomas are occasionally reported in dogs; the rarest type is the monophasic teratoma,composed of tissues originating from only one germ layer. Canine endometrial adenocarcinomas are also rare in dogs and mainly affect geriatric females. This report describes case of co-existing ovarian teratoma and uterine adenocarcinoma in a 10-year old nulliparous female Boxer presented with lethargy, anorexia and purulent vaginal discharge. Abdominal ultrasonography evidenced pyometra and a mass in the left ovary. This was composed of a uniform whitish tissue with multiple cystic structures. The histology revealed an atrophy of the ovarian parenchyma, compressed by a proliferation of well-differentiated nervous tissue staining positively to vimentin, S100 and neuronal specific enolase (NSE), and negatively to keratin and inhibin. The left uterine horn, whose diameter was markedly increased, showed foci of endometrial cellular atypia, evident nucleoli and mitoses, at light microscopy. To our best knowledge, this is the first report of a coexisting ovarian monophasic teratoma and endometrial adenocarcinoma, two rare reproductive neoplasia in dogs

Probing material nonlinearity at various depths by time reversal mirrors

International audienceIn this letter, the time reversal mirror is used to focus elastic energy at a prescribed location and to analyze the amplitude dependence of the focus signal, thus providing the nonlinearity of the medium. By varying the frequency content of the focused waveforms, the technique can be used to probe the surface, by penetrating to a depth defined by the wavelength of the focused waves. The validity of this concept is shown in the presence of gradual and distributed damage in concrete by comparing actual results with a reference nonlinear measurement and X ray tomography images

Implementation of fatigue model for unidirectional laminate based on finite element analysis : theory and practice

The aim of this study is to deal with the simulation of intra-laminar fatigue damage in unidirectional composite under multi-axial and variable amplitude loadings. The variable amplitude and multi-axial loading is accounted for by using the damage hysteresis operator based on Brokate method [6]. The proposed damage model for fatigue is based on stiffness degradation laws from Van Paepegem combined with the 'damage' cycle jump approach extended to deal with unidirectional carbon fibres. The parameter identification method is here presented and parameter sensitivities are discussed. The initial static damage of the material is accounted for by using the LadevSze damage model and the permanent shear strain accumulation based on Van Paepegem's formulation. This approach is implemented into commercial software (Siemens PLM). The validation case is run on a bending test coupon (with arbitrary stacking sequence and load level) in order to minimise the risk of inter-laminar damages. This intra-laminar fatigue damage model combined efficient methods with a low number of tests to identify the parameters of the stiffness degradation law, this overall procedure for fatigue life prediction is demonstrated to be cost efficient at industrial level. This work concludes on the next challenges to be addressed (validation tests, multiple-loadings validation, failure criteria, inter-laminar damages...)

A light sterilizable pipette device for the in vivo estimation of human soft tissues constitutive laws

Abstract-This paper introduces a new light device for the in vivo estimation of human soft tissues constitutive laws. It consists of an aspiration pipette able to meet the very severe sterilization and handling issues imposed during surgery. The simplicity of the device, free of any electronic circuitry, allows using it as an ancillary instrument. The deformation of the aspired tissue is imaged via a mirror using an external camera. The paper describes the experimental setup as well as the protocol that should be used during surgery. First feasibility measurements are shown for human tongue and forearm skin

Validation and data characteristics of methane and nitrous oxide profiles observed by MIPAS and processed with Version 4.61 algorithm

The ENVISAT validation programme for the atmospheric instruments MIPAS, SCIAMACHY and GOMOS is based on a number of balloon-borne, aircraft, satellite and ground-based correlative measurements. In particular the activities of validation scientists were coordinated by ESA within the ENVISAT Stratospheric Aircraft and Balloon Campaign or ESABC. As part of a series of similar papers on other species [this issue] and in parallel to the contribution of the individual validation teams, the present paper provides a synthesis of comparisons performed between MIPAS CH4 and N2O profiles produced by the current ESA operational software (Instrument Processing Facility version 4.61 or IPF v4.61, full resolution MIPAS data covering the period 9 July 2002 to 26 March 2004) and correlative measurements obtained from balloon and aircraft experiments as well as from satellite sensors or from ground-based instruments. In the middle stratosphere, no significant bias is observed between MIPAS and correlative measurements, and MIPAS is providing a very consistent and global picture of the distribution of CH4 and N2O in this region. In average, the MIPAS CH4 values show a small positive bias in the lower stratosphere of about 5%. A similar situation is observed for N2O with a positive bias of 4%. In the lower stratosphere/upper troposphere (UT/LS) the individual used MIPAS data version 4.61 still exhibits some unphysical oscillations in individual CH4 and N2O profiles caused by the processing algorithm (with almost no regularization). Taking these problems into account, the MIPAS CH4 and N2O profiles are behaving as expected from the internal error estimation of IPF v4.61 and the estimated errors of the correlative measurements

A progessive damage fatigue model for unidirectional laminated composites based on finite element analysis: theory and practice

The simulation of the fatigue damage of laminated composites under multi-axial and variable amplitude loadings has to deal with several new challenges and several methods of damage modelling. In this paper we present how to account for the complex loading by using the damage hysteresis operator approach for fatigue. It is applied to a fatigue model for intra-laminar damage based on stiffness degradation laws from Van Paepegem and has been extended to deal with unidirectional carbon fibres. The parameter identification method is presented here and parameter sensitivities are discussed. The initial static damage of the material is accounted for by using the Ladevèze damage model and the permanent shear strain accumulation based on Van Paepegem’s formulation. This approach has been implemented into commercial software. The intra-laminar fatigue damage model combines efficient methods with a low number of tests to identify the parameters of the stiffness degradation law, this overall procedure for fatigue life prediction is demonstrated to be cost efficient at industrial level