HYDRA: multipurpose ship designs in engineering and education

The cornerstone of post-graduate naval architecture and marine engineering education at UCL is the Ship Design Exercise. This three-month full-time project sees students placed in small, multi-disciplinary teams and challenged with the concept design of a new vessel based on broad outline require-ments provided by the academic staff. This exercise exemplifies the use of design as an integrative teaching method, allowing engineering students to place their academic understanding of technical subjects in a whole-ship concept. This paper describes an innovative design – HYDRA – featuring a single core vessel capable of adaption during build to take on several military or civilian roles. This paper not only describes the technical aspects of the design solution itself, but also discusses the educational implications of setting students the challenge of designing ships to meet multiple, sometimes contradictory requirements. In addition to aligning well with some modern trends in ship design and construction, this type of problem is seen to offer potential benefits in engineering education. These benefits are discussed, in addition to the potential complications they bring to various aspects of the design exercise

An interactive layout exploration and optimisation method for early stage ship design

This paper presents a novel, highly interactive genetic algorithm-based layout exploration and optimisation method for generating spatial configurations of ships in the early stages of the design process. The method draws upon the principles of design-driven architecturally centred ship design processes by enabling the naval architects to make important decisions in a hybrid design process. The method utilises a genetic algorithm-based optimisation tool to rapidly generate and evaluate a diverse set of general arrangement options. It is approached in stages where each stage comprises two steps (manual and automatic). The new genetic algorithm-based layout optimisation tool is demonstrated by being applied to an Offshore Patrol Vessel test case. The advantages and disadvantages of the proposed tool are discussed, as well as the current limitations of the overall approach and future work

Designing Future Ships for Significantly Lower Energy Consumption

The likelihood of both increases in, and volatility of, the cost of conventional fuel in the coming decades combined with more stringent emission regulations, means that ships in the future will have to be significantly more efficient and make use of alternative sources of energy. Considering the regulatory aspect, it has been claimed that, if the IMO were to reduce international shipping’s carbon dioxide emissions to those consistent with limiting anthropogenic climate change to 2 degrees of warming, then ships in 2050 would have to reduce their carbon dioxide emissions by 75-90% compared to ships in 2012. To investigate what might be the appropriate mix of technologies and operational approaches for future ship designs the “Whole Ship Model” (WSM) was developed, which is a holistic ship design tool, primarily developed at UCL, that can generate many ship design options with different design, technology and fuel combinations. The Whole Ship model can be used to explore different arrangements and uses of energy efficiency measures on container ships, bulk carriers and tankers evaluating their performance over an operating profile. This paper will initially present some results from the Whole Ship Model, evaluating the potential performance of present-day ships and technologies and will then compare this to technically feasible future ship designs that use contemporary or near-term technology to achieve very high reductions in carbon dioxide emissions and energy consumption

Ship impact model for technical assessment and selection of Carbon dioxide Reducing Technologies (CRTs)

It is not unreasonable to imagine that the future may herald higher energy prices and greater regulation of shipping׳s Greenhouse Gas (GHG) emissions. With the introduction of the Energy Efficiency Design Index (EEDI) into MARPOL Annex VI, tools are needed to assist Naval Architects and Marine Engineers to select the best solutions to meet evolving requirements for reduced fuel consumption and associated carbon dioxide emissions. To that end, a concept design tool, the Ship Impact Model (SIM), has been developed for quickly calculating the technical performance of a vessel with one or more Carbon dioxide Reducing Technologies (CRTs) at an early design stage. The underlying basis for this model is the calculation of changes from known ‘baseline ships’. The Ship Impact Model has been used in two projects to assess which selection (individual or combination) of Carbon dioxide Reducing Technologies (CRTs) have the most potential, in terms of cost-effectiveness and under other technical, operational and regulatory influences

Congenital Anosmia and Facial Emotion Recognition

Major functions of the olfactory system include guiding ingestion and avoidance of environmental hazards. People with anosmia report reliance on others, for example to check the edibility of food, as their primary coping strategy. Facial expressions are a major source of non-verbal social information that can be used to guide approach and avoidance behaviour. Thus, it is of interest to explore whether a life-long absence of the sense of smell heightens sensitivity to others' facial emotions, particularly those depicting threat. In the present, online study 28 people with congenital anosmia (mean age 43.46) and 24 people reporting no olfactory dysfunction (mean age 42.75) completed a facial emotion recognition task whereby emotionally neutral faces (6 different identities) morphed, over 40 stages, to express one of 5 basic emotions: anger, disgust, fear, happiness, or sadness. Results showed that, while the groups did not differ in their ability to identify the final, full-strength emotional expressions, nor in the accuracy of their first response, the congenital anosmia group successfully identified the emotions at significantly lower intensity (i.e. an earlier stage of the morph) than the control group. Exploratory analysis showed this main effect was primarily driven by an advantage in detecting anger and disgust. These findings indicate the absence of a functioning sense of smell during development leads to compensatory changes in visual, social cognition. Future work should explore the neural and behavioural basis for this advantage

Hydrogen on board ship: a first analysis of key parameters and implications

Shipping Green House Gas (GHG) emissions could increase significantly in the future, and hydrogen fuel for ships could theoretically lower the operational carbon dioxide emissions of a ship to zero. In addition the hydrogen and fuel cell combination could have a higher efficiency compared to the current marine diesel engines. This paper examines the implications of using hydrogen as a fuel for ships. Two hydrogen storage methods, 350 bar compressed hydrogen gas tanks and cryogenic liquid hydrogen tanks, are evaluated in terms of cargo, volume and mass impact in comparison with a conventional HFO tank and a LNG tank. Moreover, the potential loss of cargo capacity for each of them are estimated in relation with the desired range and power. A Panamax container ship was used as a reference ship, in order to visually examine the impact of different fuel storage choices on cargo. A further method has been applied to estimate the relative loss of cargo capacity. It was found that Hydrogen storage systems have a high volume requirement which has implications for both stability and available deadweight. Liquid hydrogen has a lower impact on cargo capacity mainly due to its higher volumetric density than the compressed hydrogen tank. Such conclusions, however, are the result of this early work on the study of hydrogen fuelling as so many of other more detailed issues have yet to be addressed

Association of a marker of N-acetylglucosamine with progressive multiple sclerosis and neurodegeneration

IMPORTANCE: N-glycan branching modulates cell surface receptor availability, and its deficiency in mice promotes inflammatory demyelination, reduced myelination, and neurodegeneration. N-acetylglucosamine (GlcNAc) is a rate-limiting substrate for N-glycan branching, but, to our knowledge, endogenous serum levels in patients with multiple sclerosis (MS) are unknown. OBJECTIVE: To investigate a marker of endogenous serum GlcNAc levels in patients with MS. DESIGN, SETTING, AND PARTICIPANTS: A cross-sectional discovery study and cross-sectional confirmatory study were conducted at 2 academic MS centers in the US and Germany. The discovery study recruited 54 patients with MS from an outpatient clinic as well as 66 healthy controls between April 20, 2010, and June 21, 2013. The confirmatory study recruited 180 patients with MS from screening visits at an academic MS study center between April 9, 2007, and February 29, 2016. Serum samples were analyzed from December 2, 2013, to March 2, 2015. Statistical analysis was performed from February 23, 2020, to March 18, 2021. MAIN OUTCOMES AND MEASURES: Serum levels of GlcNAc plus its stereoisomers, termed N-acetylhexosamine (HexNAc), were assessed using targeted tandem mass spectroscopy. Secondary outcomes (confirmatory study) comprised imaging and clinical disease markers. RESULTS: The discovery cohort included 66 healthy controls (38 women; mean [SD] age, 42 [20] years), 33 patients with relapsing-remitting MS (RRMS; 25 women; mean [SD] age, 50 [11] years), and 21 patients with progressive MS (PMS; 14 women; mean [SD] age, 55 [7] years). The confirmatory cohort included 125 patients with RRMS (83 women; mean [SD] age, 40 [9] years) and 55 patients with PMS (22 women; mean [SD] age, 49 [80] years). In the discovery cohort, the mean (SD) serum level of GlcNAc plus its stereoisomers (HexNAc) was 710 (174) nM in healthy controls and marginally reduced in patients with RRMS (mean [SD] level, 682 [173] nM; P = .04), whereas patients with PMS displayed markedly reduced levels compared with healthy controls (mean [SD] level, 548 [101] nM; P = 9.55 × 10(-9)) and patients with RRMS (P = 1.83 × 10(-4)). The difference between patients with RRMS (mean [SD] level, 709 [193] nM) and those with PMS (mean [SD] level, 405 [161] nM; P = 7.6 × 10(-18)) was confirmed in the independent confirmatory cohort. Lower HexNAc serum levels correlated with worse expanded disability status scale scores (ρ = -0.485; P = 4.73 × 10(-12)), lower thalamic volume (t = 1.7; P = .04), and thinner retinal nerve fiber layer (B = 0.012 [SE = 7.5 × 10(-11)]; P = .008). Low baseline serum HexNAc levels correlated with a greater percentage of brain volume loss at 18 months (t = 1.8; P = .04). CONCLUSIONS AND RELEVANCE: This study suggests that deficiency of GlcNAc plus its stereoisomers (HexNAc) may be a biomarker for PMS. Previous preclinical, human genetic, and ex vivo human mechanistic studies revealed that N-glycan branching and/or GlcNAc may reduce proinflammatory responses, promote myelin repair, and decrease neurodegeneration. Combined, the data suggest that GlcNAc deficiency may be associated with progressive disease and neurodegeneration in patients with MS

N-acetylglucosamine drives myelination by triggering oligodendrocyte precursor cell differentiation

Myelination plays an important role in cognitive development and in demyelinating diseases like multiple sclerosis (MS), where failure of re-myelination promotes permanent neuro-axonal damage.  Modification of cell surface receptors with branched N-glycans coordinates cell growth and differentiation by controlling glycoprotein clustering, signaling and endocytosis. N-acetylglucosamine (GlcNAc) is a rate-limiting metabolite for N-glycan branching. Here we report that GlcNAc and N-glycan branching trigger oligodendrogenesis from precursor cells by inhibiting PDGF receptor-α cell endocytosis. Supplying oral GlcNAc to lactating mice drives primary myelination in newborn pups via secretion in breast milk, while genetically blocking N-glycan branching markedly inhibits primary myelination. In adult mice with toxin (cuprizone) induced demyelination, oral GlcNAc prevents neuro-axonal damage by driving myelin repair. In MS patients, endogenous serum GlcNAc levels inversely correlated with imaging measures of demyelination and microstructural damage.   Our data identifies N-glycan branching and GlcNAc as critical regulators of primary myelination and myelin repair and suggests oral GlcNAc may be neuro-protective in demyelinating diseases like MS

C-tactile afferent stimulating touch carries a positive affective value

The rewarding sensation of touch in affiliative interactions is hypothesized to be underpinned by a specialized system of nerve fibers called C-Tactile afferents (CTs), which respond optimally to slowly moving, gentle touch, typical of a caress. However, empirical evidence to support the theory that CTs encode socially relevant, rewarding tactile information in humans is currently limited. While in healthy participants, touch applied at CT optimal velocities (1-10cm/sec) is reliably rated as subjectively pleasant, neuronopathy patients lacking large myelinated afferents, but with intact C-fibres, report that the conscious sensation elicited by stimulation of CTs is rather vague. Given this weak perceptual impact the value of self-report measures for assessing the specific affective value of CT activating touch appears limited. Therefore, we combined subjective ratings of touch pleasantness with implicit measures of affective state (facial electromyography) and autonomic arousal (heart rate) to determine whether CT activation carries a positive affective value. We recorded the activity of two key emotion-relevant facial muscle sites (zygomaticus major—smile muscle, positive affect & corrugator supercilii—frown muscle, negative affect) while participants evaluated the pleasantness of experimenter administered stroking touch, delivered using a soft brush, at two velocities (CT optimal 3cm/sec & CT non-optimal 30cm/sec), on two skin sites (CT innervated forearm & non-CT innervated palm). On both sites, 3cm/sec stroking touch was rated as more pleasant and produced greater heart rate deceleration than 30cm/sec stimulation. However, neither self-report ratings nor heart rate responses discriminated stimulation on the CT innervated arm from stroking of the non-CT innervated palm. In contrast, significantly greater activation of the zygomaticus major (smiling muscle) was seen specifically to CT optimal, 3cm/sec, stroking on the forearm in comparison to all other stimuli. These results offer the first empirical evidence in humans that tactile stimulation that optimally activates CTs carries a positive affective valence that can be measured implicitly

Facial mimcry and emotion consistency : Influences of memory and context.

This study investigates whether mimicry of facial emotions is a stable response or can instead be modulated and influenced by memory of the context in which the emotion was initially observed, and therefore the meaning of the expression. The study manipulated emotion consistency implicitly, where a face expressing smiles or frowns was irrelevant and to be ignored while participants categorised target scenes. Some face identities always expressed emotions consistent with the scene (e.g., smiling with a positive scene), whilst others were always inconsistent (e.g., frowning with a positive scene). During this implicit learning of face identity and emotion consistency there was evidence for encoding of face-scene emotion consistency, with slower RTs, a reduction in trust, and inhibited facial EMG for faces expressing incompatible emotions. However, in a later task where the faces were subsequently viewed expressing emotions with no additional context, there was no evidence for retrieval of prior emotion consistency, as mimicry of emotion was similar for consistent and inconsistent individuals. We conclude that facial mimicry can be influenced by current emotion context, but there is little evidence of learning, as subsequent mimicry of emotionally consistent and inconsistent faces is similar