Serum Beta HCG and uterine artery Doppler studies in second trimester to predict preeclampsia and eclampsia

Background: Hypertensive disorders during pregnancy remain amongst the most significant and intriguing unsolved problems in obstetrics. The study aims at testing the hypothesis that women with high serum beta hCG levels and alterations in waveforms in the uterine artery doppler in early second trimester have high risk of developing pre-eclampsia.Methods: Serum Beta hCG estimation was done by Sandwich chemiluminescence immunoassay method. All uterine artery waveforms were obtained using a Toshiba nemio ultrasound machine attached to a 3.5 MHz curvilinear transducer, with colour and pulsed Doppler abilities.Results: For prediction of preeclampsia or eclampsia uterine artery Doppler velocimetry alone shows specificity of 96.30%, sensitivity of 90%, positive predictive value of 94% and negative predictive value of 80%. When it is combined with serum beta HCG sensitivity and specificity are almost same, but alone serum beta HCG levels are showing sensitivity of 96% and specificity of just 76%.Conclusions: Abnormal waveforms on uterine Doppler studies are the better predictors for preeclampsia and eclampsia when done in early second trimester

Correlation of Griva Parinaah (GP) in Anguli Praman and BMI in Medovriddhi (Obesity) w.s.r. to Cardiovascular Risk

The prevalence of overweight and obesity in India is increasing faster than the world average Medovriddhi (obesity) shows the symptoms as increased size of buttocks, breast and abdomen, Shwasa (breathlessness) after slight movement also. Acharya Bhavprakash added one more symptom the oversize of the neck (Griva). Acharya Sushruta mentioned the Griva measurement should be 20 Angul for both males and females with their fingers (self-finger unit). In modern science, body mass index (BMI) is used to find out obesity. Obesity is the foremost cause of cardiovascular diseases. BMI is the generalized metric way but Grivaparinaah in Swangulpramaan is a personalized quantifying anthropometric measurement. Individuals of Medovriddhi having an age group of 20 to 70 years were selected. So, intending to the height the importance of Grivaparinaah described in Medodhatu Vruddhi correlation study having been carried out. A positive correlation was found in GP with BMI in both genders having r-value of 0.3533 (p<0.05) for males and 0.3137 (p<0.05) for females. Using ROC curve analysis GP is >21.63 Angul for males and females were determined to be the best cut-off level for identifying a subject with BMI as cardiovascular risk

Comparative evaluation of propofol-ketamine and propofol-fentanyl for minor surgical procedures

Background: Aim of the present study was to compare the clinical efficacy of combination of propofol-ketamine and propofol-fentanyl in terms of haemodynamic variables, recovery profile and side effects.Methods: The study enrolling 120 patients of (age 20-50 years) ASA grade I & II were randomly allocated in two groups of sixty each. They were undergoing short surgical procedures lasting up to 20 minutes. Group I received injection ketamine 0.5 mg/kg over 2 minutes followed by injection propofol at rate of 1 ml over 3 seconds till the end point of induction (till loss of consciousness and loss of eye lash reflex). Group II received injection fentanyl 1.5 µg/kg followed by 1 ml propofol till the end point of induction and maintenance of anesthesia. Hemodynamic variables were recorded pre, intra and postoperatively at regular intervals. Recovery and side effects was also assessed. The results were tabulated and analyzed statistically.Results: Patients in both the groups produce minor haemodynamic changes and did not differ significantly. The recovery time was longer in group I as compare to group II. We found no complications of serious type except vomiting and nausea in group II. Discharge criteria were significantly earlier in group I than group II.Conclusions: Both propofol-ketamine and propofol-fentanyl was useful for short surgical procedures but propofol-ketamine group offers more advantage.

Effect of Chandana Bala Lakshadi Taila Abhyanga with Poshaka Laddu & Nutri Recharge Powder in Bala Shosha (Kuposhana Janya Vyadhi)

Introduction: In Ayurveda Bala Shosha is known as Kuposhan Janya Vyadhi and it is viewed under Malnutritional or PEM disorder. Malnutrition is a common health problem in preschool children of developing countries including in India. As per WHO poor feeding of infant and young children resulting in under nutrition is the single and most important factor for diseases. The malnourished child needs proper Ahara and Aaushadh for normal growth and protecting disease. So, we have made suitable plan to a child.   Aim: To evaluate the effect of Candana Bala Lakshadi Taila Abhyanga, Poshaka Laddu, Nurticharge Powder internally in Bala Shosha (Kuposhana Janya Vyadhi). Material & Method: The clinical study was conducted in 30 Malnourished Children pre and post evaluation without control. The Study setting Department of Koumarbhritya (Bal-Roga), Shubhdeep Ayurved Medical College, Indore M.P. This study is come under the project of Govt. of M.P. in supervision of Indore collector and funded by Govt. of M.P. Result: The effect of Nuticharge powder, Poshak Laddu & Abhyanga on child weight and M.U.A.C is statistically significant (P= 0.01). It showed that the treatment significantly increases the weight and mid under arm circumference of malnourished children. Conclusion: Here in this study a small group was taken for the study which is equated with the PEM & Kuposhana Janya Vyadhi

IMPACT ON STROKE BECAUSE OF TYPE 2 DIABETES OCCURRENCE AND SUBTYPES: A COMPREHENSIVE CROSS-SECTIONAL STUDY

Substantial research indicates that Type 2 diabetes significantly increases the vulnerability to stroke. Despite the existing knowledge, there is still a gap in understanding the specific clinical attributes of strokes in diabetes patients. This study aims to contrast people with Type 2 diabetes with people without diabetes in terms of the frequency and patterns of strokes. Materials and Methodology: An 18-month cross-sectional observational study involved 160 patients diagnosed with either ischemic or haemorrhagic strokes. There were two groups of patients: one comprising individuals with diabetes (group 1) and the other without diabetes (group 2), based on specific criteria. The assessment process included a thorough examination of medical histories, physical assessments, and brain imaging. Various parameters, including blood pressure, cholesterol profiles, and types of strokes, were assessed through laboratory tests and statistical analyses. Results: Diabetes patients had considerably higher systolic and diastolic blood pressure readings than non-diabetics. The prevalence of ischemic strokes was significantly greater in the diabetes group as compared to the non-diabetic group (86.3%) (65%). Laboratory results revealed elevated levels of Diabetes patients' haemoglobin, random blood sugar, serum creatinine, LDL cholesterol, total cholesterol, and triglycerides. Conclusion: There is a link between type 2 diabetes and higher likelihood of hypertension and abnormal lipid profiles, and it considerably increases the risk of ischemic strokes. Identifying and managing these modifiable risk factors are essential in preventing various stroke types. Thorough assessments conducted by healthcare providers are vital in effectively managing complications for individuals with diabetes

Review on Secure Auditing, Preserving and Integrity of Data Using TPA on Cloud Storage

User should use the data storage without any loss as it is stored locally. Auditing process is important process to ensure integrity, user are not that skilful to maintain integrity of data and they are not aware about risk and security action. Hence so to perform user can depend on TPA (third party authentication), which will check integrity and privacy on cloud data which is stored locally.TPA audit the integrity and provides appropriate result to user. Results contain modified, deleted and uploaded information of files. User has to make sure that privacy is preserved from TPA with minimal consumption of cloud resources while auditing process. In this paper we propose a system that will provide integrity to locally stored data without downloading files avoiding additional resources and vulnerability. We further extend our result to enable the TPA to perform audits for multiple users simultaneously and efficiently. Extensive security and performance analysis show the proposed schemes are provably secure and highly efficient

Pomegranate Fruit Separation Using MATLAB Based on Size

This paper aims at presenting the concept of fruit quality management, a system which determines the quality of fruit by its size. Sorting tons of fruits manually is a time consuming, costly, and an inaccurate process. Automation of quality assessment of fruits is important in order to reduce human efforts and save time. In this work the identification of good and bad Fruits is focused on the methods using MATLAB. India is an agricultural country, where about 70% of people spend their lives by agriculture

Importance of calculating various casting indices in predicting radiological outcomes of paediatric forearm fractures

Background: The present study is aimed at determining the importance of various casting indices in predicting the outcome of paediatric forearm fractures treated with closed reduction and plaster application in our department.Methods: Thirty children, aged 5 to 15 years, with closed forearm fractures not requiring surgical fixation were included to assess their casting indices and radiological outcomes using X-rays. After satisfactory casting, patients were followed up weekly till 6 weeks with anteroposterior (AP) and lateral X-ray.Results: Acceptable reduction was achieved in 26 cases, while re-manipulation was done in 4 cases. Cast Index ranged from 0.80±0.09 at first week to 0.78±0.09 at 6 weeks, Padding Index was 0.30±0.04 at first week and increased to 0.31±0.03 at 6 weeks, Canterbury Index was 1.07±0.24 at first week and 1.07±0.78 at 6 weeks, Gap Index 0.15±0.02 remained the same throughout, and Three Point Index changed from 0.81±0.08 at first week to 0.77±0.18 six weeks. Radial bow of children showed no significant change at various time points of assessment. Rotational mal-alignment was observed in 5 patients, one had a 0.5 cm radial overlap, while none had an ulnar overlap. Radial angulation was observed in five and six children on AP and lateral X-ray respectively. Ulnar angulation was seen in two and one child on AP and lateral X-ray respectively.Conclusions: Continued use of these casting indices to assess paediatric forearm cast adequacy is supported by this study

Polyherbal decoction modulates redox homeostasis during Malachite green induced metabolic stress in Saccharomyces cerevisiae

17-26Malachite green (MG) is aquatic pollutant that induces oxidative stress when comes in contact with the living organisms. In Saccharomyces cerevisiae, MG produces intracellular reactive oxygen species (ROS) and these ROS disturb redox homeostasis and cellular functions leading to early cell death. Exogenous supply of natural antioxidants containing polyherbal decoction may play a crucial role in re-establishment of redox homeostasis by ensuring the cell survival. Exposure of MG to Saccharomyces cerevisiae resulted in a significant decrease (97.8%) in colony forming units (CFU). An Ayurvedic polyherbal formulation ‘Vayasthapana Rasayana’ (VR) which contains natural antioxidants from plants viz. Terminalia chebula, Clitoria ternatea, Boerhaavia diffusa, Centella asiatica, Phyllanthus emblica, Asparagus racemossus and Tinospora cordifolia at 1.0 mg/mL concentration could arrest the oxidative stress during MG exposure. Levels of ROS elevated up to 67.3% on MG exposure; while VR supplementation reduced it by 54.7%. MG induced cellular apoptosis in 38% and necrosis in 27% cells, while VR augmentation reduced it to 8%. Activities of antioxidant enzymes like catalase, superoxide dismutase and glutathione peroxidase in MG exposed cells were induced by 408, 144 and 140%, respectively, whereas, VR supplementation lowered the expressions to 102, 57 and 111%, respectively. Induction in caspases 3/7 activity was also found to be reduced by 65.39% after VR augmentation. Similarly, VR modulated activities of oxido-reductases like lignin peroxidase, laccase, NADH-DCIP reductase and MG reductase. VR supplementation also maintained the MG utilization potential of S. cerevisiae up to 20th exposure cycle which was otherwise arrested to 8th cycle. The treatment also decreased the ROS accumulation and nuclear damage, restoring the cell viability up to 94% and retained normal growth dynamics. Thus, VR supplementation could significantly decrease oxidative stress, enhance cell viability and ultimately protect the dying S. cerevisiae cells during MG exposure