Using temporary water to resupply fresh water (on example Kanaka SCC)

In boarding houses, located at the mouth of the Kanaka beam (SCC), the problem of provision with fresh drinking water worsened. So far, the provision with drinking water was carried out with water wells from the aquifer at a depth of up to 15 m from the earth surface

Socially efficient entry barriers?

Stagnation of the Russian economy lends a new urgency to the question of whether reserves of competition incentives can be used to overcome the current negative economic tendencies. The lowering of entry barriers is traditionally considered a universal instrument of promoting competition. However, lower entry barriers can be mistakenly associated with bringing the market closer to the state of the so-called "perfect" competition. The authors aim to show that the absence of entry barriers does not improve competition in certain markets. On the contrary, it may result in a decrease in social welfare. This is particularly true of capital-intensive goods, for instance, large diameter pipes for gas pipelines. Lack of proper competition in such sectors of the market necessitates entry barriers, for they help to achieve a separating equilibrium at the market. Since there are costs associated with creating a separating equilibrium, it is necessary to assess both costs and benefits of the pooling and separating equilibria

ЛОГІКА ВПЛИВУ НЕМОНЕТАРНИХ ІНФОРМАЦІЙНИХ СИГНАЛІВ США НА НАДЛИШКОВУ ДОХІДНІСТЬ РИНКУ АКЦІЙ УКРАЇНИ

The research was conducted to assess the changes in the excess return of Ukrainian stock market (using the example of the representative stock index PFTS) on the informational content of such major non-monetary signals of the USA as “Consumer Price Index”, “Personal Spending”, “Unemployment Rate”, “Gross Domestic Product”, “Industrial Production”, “Consumer Confidence” and “Housing Starts” on the basis of daily data for 2000—2017 (number of observations — 4436). We used the toolkit of vector autoregressive modelling to determine the sources of Ukrainian stock index PFTS response to the US non-monetary information signals, which is based on the decomposition of changes in stock market excess return through the channels of economic transmission (“expected future dividends”, “real interest rate” and “risk premium”) and takes into account the unexpected values of the informational context of selected non-monetary signals. Target time series are stationary according to the KPSS and ADF criteria. The results show that four of the six selected non-monetary information signals of the USA do not have a significant effect on the response of endogenous variables of econometric model. The existence of significant direct influence of US non-monetary informational signals “Personal Spending” and “Consumer Confidence” on the response of the excess return of Ukrainian stock index PFTS has been established. It is substantiated that the actual and forecast state of the USA national economy is considered by the participants of the local stock markets, in particular in Ukraine, as one of the most important sources of macroeconomic information while making strategic and tactical investment decisions. Thus, the increasing importance of the component of “surprise” of such non-monetary information signals of the USA is considered as “positive” news for the domestic stock market by investors, which increases the excess return of the stock index PFTS.Проведено исследование по оценке изменений избыточной доходности украинского рынка акций (на примере репрезентативного фондового индекса PFTS) на информационное содержание немонетарных сигналов США на основе ежедневных данных за 2000—2017 гг. Использован инструментарий векторного авторегрессионного моделирования для определения источников реакции фондового индекса PFTS, основанный на декомпозиции изменений избыточной доходности рынка акций. Установлено наличие значительного прямого влияния немонетарных информационных сигналов США «Personal Spending» и «Consumer Confidence» на реакцию избыточной доходности фондового индекса PFTS. Таким образом, рост значения компоненты «неожиданность» по таким немонетарным информационным сигналам США рассматривается инвесторами как «позитивная» новость, которая увеличивает избыточную доходность фондового индекса PFTS.Проведено дослідження щодо оцінювання змін надлишкової доходності українського ринку акцій (на прикладі репрезентативного фондового індексу PFTS) на інформаційний зміст таких основних немонетарних сигналів США, як «Consumer Price Index», «Personal Spending», «Unemployment Rate», «Gross Domestic Product», «Industrial Production», «Consumer Confidence» та «Housing Starts» на основі щоденних даних за 2000—2017 рр. (кількість спостережень — 4 436). Використано інструментарій векторного авторегресійного моделювання для визначення джерел реакції українського фондового індексу PFTS на немонетарні інформаційні сигнали США, що ґрунтується на декомпозиції змін надлишкової дохідності ринку акцій через канали економічної трансмісії («очікувані майбутні дивіденди», «реальна відсоткова ставка» і «премія за ризик») та враховує неочікувані значення інформаційного контексту відібраних немонетарних сигналів. Цільові часові ряди є стаціонарними відповідно до критеріїв KPSS та ADF. Отримані результати свідчать, що чотири із шести відібраних немонетарних інформаційних сигналів США не мають суттєвого впливу на реакцію ендогенних змінних економетричної моделі. Установлено наявність значного прямого впливу немонетарних інформаційних сигналів США «Personal Spending» і «Consumer Confidence» на реакцію надлишкової дохідності українського фондового індексу PFTS. Обґрунтовано, що фактичний і прогнозний стани національної економіки США розглядається учасниками локальних ринків акцій, зокрема України, як одне з найважливіших джерел макроекономічної інформації при ухваленні стратегічних і тактичних інвестиційних рішень. Таким чином, зростання значення компоненти «несподіванки» за такими немонетарними інформаційними сигналами США розглядається інвесторами як «позитивна» новина для вітчизняного ринку акцій, яка збільшує надлишкову дохідність фондового індексу PFTS

RELATIONSHIP BETWEEN SINGLE NUCLEOTIDE POLYMORPHISMS IN CYTOKINE GENES AND CLINICAL LABORATORY PARAMETERS IN PATIENTS WITH MULTIPLE MYELOMA

Multiple myeloma is the most common form of paraproteinemic hemoblastosis, which is characterized by variability of clinical manifestations, forms, and variants. Limited efficiency of antitumor immune protection in the patient plays an important role in progression of this disease. Survival of myeloma cells is promoted by some growth factors, including a number of interleukins. Cytokines and chemokines are secreted in response to intercellular interactions and stimulate tumor growth, inhibition of osteoblasts and increase of the osteoclastic activity. Cytokine genes show a significant allelic polymorphism. A single gene may exhibit numerous polymorphic sites located in exons, introns and promoter regulatory areas. Single nucleotide substitutions in the promoter region of cytokine genes are known to have a huge impact upon secretion and biological activity of these factors. Therefore, a study of allelic gene variants determining the levels of cytokine production will allow of establishing new immunogenetic factors associated with a high risk of disease development, including multiple myeloma. We have studied single nucleotide polymorphism in cytokine genes (IL-1α -889 TT, IL-1β +3962 TT, IL-6 -174 GG, and IL-6 nt565 GG), and clinical laboratory parameters (serum levels of albumin, β2-microglobulin, and hemoglobin) determining severity grade of multiple myeloma in 80 patients living in the North-Western region of Russia. It was found that the presence of certain cytokine gene variants, i.e., IL-1α -889 TT, IL-1β +3962 TT, IL-6 -174 GG, IL-6 nt565 GG or IL-1α -889 TT, IL- 1β +3962 TT or IL-6 -174 GG, IL-6 nt565 GG was associated with low albumin levels (< 3.5 g/DL), and high levels of β2-microglobulin (> 5.5 mg/l). A combination of all the four negative variants in homozygous state (IL- 1α TT -889, IL-1β +3962 TT, IL-6 -174 GG and IL-6 nt565 GG) increases the chance of six-fold reduction of albumin levels (p < 0.05); combinations of homozygous IL-1α TT -889, IL-1β +3962 TT, IL-6-174 GG. and IL-6 nt565 GG are associated with increased chance of high-level β2-microglobulin (> 5.5 mg/l) by more than two times. This data allow to consider IL-1α -889 TT, IL-1β +3962 TT, IL-6 -174 GG, and IL-6 nt565 GG genotypes additional negative immunogenetic factors in the prognosis of multiple myeloma

Preferences of Hungarian consumers for quality, access and price attributes of health care services — result of a discrete choice experiment

In 2010, a household survey was carried out in Hungary among 1037 respondents to study consumer preferences and willingness to pay for health care services. In this paper, we use the data from the discrete choice experiments included in the survey, to elicit the preferences of health care consumers about the choice of health care providers. Regression analysis is used to estimate the effect of the improvement of service attributes (quality, access, and price) on patients’ choice, as well as the differences among the socio-demographic groups. We also estimate the marginal willingness to pay for the improvement in attribute levels by calculating marginal rates of substitution. The results show that respondents from a village or the capital, with low education and bad health status are more driven by the changes in the price attribute when choosing between health care providers. Respondents value the good skills and reputation of the physician and the attitude of the personnel most, followed by modern equipment and maintenance of the office/hospital. Access attributes (travelling and waiting time) are less important. The method of discrete choice experiment is useful to reveal patients’ preferences, and might support the development of an evidence-based and sustainable health policy on patient payments

Production technology of ceramic roof tiles based on raw materials of Ural region

The technology of production of ceramic roof tiles on the basis of low-melting red-burning clay, namely on the basis of clay from the Sadovoye deposit of the Sverdlovsk region, is proposed. The samples of ceramic roof tiles, molded by plastic and semi-dry way, were obtained with the properties that meet the requirements of Russian standards and correspond to the quality of the Röben ceramic roof tiles. The water absorption of such products is 6.2-6.9%, the apparent density is 2.19-2.31 g/cm3, the products are waterproof for more than 4 hours, and withstand frost resistance for more than 150 cycles. The production technology involves the use of high-speed firing way in the temperature range of 1150-1200°C. The production technology provides for grinding the clay to a grain size of less than 0.3 mm. Molding of products can be done both in a plastic or semi-dry way. The use of high-speed firing is allowed. There is no destruction of products made on the basis of Sadovoye deposit clay. © 2019 IOP Publishing Ltd. All rights reserved

Biomedical aspects of student`s health activity at the State college of Olympic reserve and physical education

This research highlights the importance of health-improving exercises for students during their training sessions in the gym. The main idea is to show how exercising choice depends on body type. According to our research it was discovered that body type plays a big role in choosing definite program for students and helps them to reach the best resultsПредставлено исследование организации оздоровительных занятий студентов ГУОР в условиях тренажерного зала в зависимости от типов телосложения. Показано, что знание своего типа телосложения оказывает значимое влияние на выбор соответствующей тренировочной программ