1,037 research outputs found
Dynamical Characterization of Galaxies at z~4-6 via Tilted Ring Fitting to ALMA [CII] Observations
Until recently, determining the rotational properties of galaxies in the
early universe (z>4, Universe age <1.5Gyr) was impractical, with the exception
of a few strongly lensed systems. Combining the high resolution and sensitivity
of ALMA at (sub-) millimeter wavelengths with the typically high strength of
the [CII] 158um emission line from galaxies and long-developed dynamical
modeling tools raises the possibility of characterizing the gas dynamics in
both extreme starburst galaxies and normal star forming disk galaxies at z~4-7.
Using a procedure centered around GIPSY's ROTCUR task, we have fit tilted ring
models to some of the best available ALMA [CII] data of a small set of
galaxies: the MS galaxies HZ9 & HZ10, the Damped Lyman-alpha Absorber (DLA)
host galaxy ALMA J0817+1351, the submm galaxies AzTEC/C159 and COSMOS
J1000+0234, and the quasar host galaxy ULAS J1319+0950. This procedure directly
derives rotation curves and dynamical masses as functions of radius for each
object. In one case, we present evidence for a dark matter halo of O(10^11)
solar masses. We present an analysis of the possible velocity dispersions of
AzTEC/C159 and ULAS J1319+0950 based on matching simulated observations to the
integrated [CII] line profiles. Finally, we test the effects of observation
resolution and sensitivity on our results. While the conclusions remain limited
at the resolution and signal-to-noise ratios of these observations, the results
demonstrate the viability of the modeling tools at high redshift, and the
exciting potential for detailed dynamical analysis of the earliest galaxies, as
ALMA achieves full observational capabilities.Comment: 20 pages, 6 figures, Accepted for publication in Ap
Análisis y ejecución de estrategias en la industria de sensores mediante la simulación CAPSIM
Documento en el que se muestra el trabajo realizado en la dirección de una empresa de la industria de sensores dentro del simulador de negocios Capsim. Se presenta un análisis de la industria de los sensores, se describe la empresa en la que se trabajó, las estrategias de negocio y el proceso de su implementación, así como los resultados finales
An acetylation-mono-ubiquitination switch on lysine 120 of H2B.
Post-translational modifications (PTMs) of histones are crucial for transcriptional control, defining positive and negative chromatin territories. A switch of opposing functional significance between acetylation and methylation occurs on many residues. Lysine 120 of H2B is modified by two PTMs: ubiquitination, which is required for further trans-tail H3 methylations and elongation, and acetylation, whose role is less clear. ChIP-Seq with MNase I-treated chromatin indicates that H2BK120ac is present on nucleosomes immediately surrounding the TSS of transcribed or poised units, but not in core promoters. In kinetic ChIP analysis of ER-stress inducible genes, H2BK120ac precedes activation and H2B-ub deposition. Using in vitro acetylation assays, pharmacologic inhibition and RNAi, we established that KAT3 is responsible for H2BK120ac. Interestingly, the global levels of H2B-ub decreased in KAT3-inactivated cells. However, RNF20 recruitment was not impaired by KAT3-inactivation. Our data point at acetylation of Lysine 120 of H2B as an early mark of poised or active state and establish a temporal sequence between acetylation and mono-ubiquitination of this H2B residue
clinical and surgical features of lower brainstem hemangioblastomas in von hippel-Lindau disease
none5BACKGROUND: In the context of von Hippel-Lindau disease (VHL), the medulla oblongata is a relatively frequent site of growth of hemangioblastomas, posing related clinical and surgical difficulties. Their management requires a close correlation between clinical evolution and morphological surveillance. In order to describe their clinical and surgical features, we reviewed our experience in the treatment of these lesions.
METHODS:
Between 2001 and 2009, 14 patients (9 female and 5 male, mean age 34 years) underwent removal of 15 lower brain stem hemangioblastomas. Based on the review of the clinical records and outpatient long-term follow-up visits, their clinical course was analyzed. Functional evaluation was measured with the Karnofsky Performance Scale (KPS) on admission, at discharge and at the last follow-up. The mean follow-up period was 30.8 months (range 4-99).
RESULTS:
All the operated hemangioblastomas were located in the dorsal medulla oblongata, in the context of multiple lesions, cerebellar and/or spinal. In ten patients hemangioblastomas were located in a median position at the obex area; in four cases a lateral location was observed. Cystic component was absent in two cases. Clinical onset preceded surgery by a mean of 8.5 months. Preoperatively three patients showed a KPS lower than 80, ten patients between 80 and 90, and one patient scored 100 (asymptomatic). There was no surgical mortality. Nine out of 14 patients showed a temporary surgical morbidity. One patient required a tracheostomy. At follow-up ten patients scored a KPS better than before the operation, while the other four patients remained stable. Permanent morbidity was observed in three patients.
CONCLUSIONS:
Lower brain stem hemangioblastomas in the context of VHL show an often gradual onset of signs and symptoms except for patients who develop an obstructive hydrocephalus. Although transient surgical complications are possible, surgery provides favorable long-term results.nonePAVESI G; BERLUCCHI S; MUNARI M; MANARA R; SCIENZA R; OPOCHER G.Pavesi, G; Berlucchi, S; Munari, M; Manara, R; Scienza, R; Opocher, Giusepp
Vacancy complexes in nonequilibrium germanium-tin semiconductors
Understanding the nature and behavior of vacancy-like defects in epitaxial
GeSn metastable alloys is crucial to elucidate the structural and
optoelectronic properties of these emerging semiconductors. The formation of
vacancies and their complexes is expected to be promoted by the relatively low
substrate temperature required for the epitaxial growth of GeSn layers with Sn
contents significantly above the equilibrium solubility of 1 at.%. These
defects can impact both the microstructure and charge carrier lifetime. Herein,
to identify the vacancy-related complexes and probe their evolution as a
function of Sn content, depth-profiled pulsed low-energy positron annihilation
lifetime spectroscopy and Doppler broadening spectroscopy were combined to
investigate GeSn epitaxial layers with Sn content in the 6.5-13.0 at.% range.
The samples were grown by chemical vapor deposition method at temperatures
between 300 and 330 {\deg}C. Regardless of the Sn content, all GeSn samples
showed the same depth-dependent increase in the positron annihilation line
broadening parameters, which confirmed the presence of open volume defects. The
measured average positron lifetimes were the highest (380-395 ps) in the region
near the surface and monotonically decrease across the analyzed thickness, but
remain above 350 ps. All GeSn layers exhibit lifetimes that are 85 to 110 ps
higher than the Ge reference layers. Surprisingly, these lifetimes were found
to decrease as Sn content increases in GeSn layers. These measurements indicate
that divacancies are the dominant defect in the as-grown GeSn layers. However,
their corresponding lifetime was found to be shorter than in epitaxial Ge thus
suggesting that the presence of Sn may alter the structure of divacancies.
Additionally, GeSn layers were found to also contain a small fraction of
vacancy clusters, which become less important as Sn content increases
Monte-Carlo simulations of the recombination dynamics in porous silicon
A simple lattice model describing the recombination dynamics in visible light
emitting porous Silicon is presented. In the model, each occupied lattice site
represents a Si crystal of nanometer size. The disordered structure of porous
Silicon is modeled by modified random percolation networks in two and three
dimensions. Both correlated (excitons) and uncorrelated electron-hole pairs
have been studied. Radiative and non-radiative processes as well as hopping
between nearest neighbor occupied sites are taken into account. By means of
extensive Monte-Carlo simulations, we show that the recombination dynamics in
porous Silicon is due to a dispersive diffusion of excitons in a disordered
arrangement of interconnected Si quantum dots. The simulated luminescence decay
for the excitons shows a stretched exponential lineshape while for uncorrelated
electron-hole pairs a power law decay is suggested. Our results successfully
account for the recombination dynamics recently observed in the experiments.
The present model is a prototype for a larger class of models describing
diffusion of particles in a complex disordered system.Comment: 33 pages, RevTeX, 19 figures available on request to
[email protected]
Coupled-resonator-induced-transparency concept for wavelength routing applications
The presence of coupled resonators induced transparency (CRIT) effects in side-coupled integrated spaced sequence of resonators (SCISSOR) of different radii has been studied. By controlling the rings radii and their center to center distance, it is possible to form transmission channels within the SCISSOR stop-band. Two different methods to exploit the CRIT effect in add/drop filters are proposed. Their performances, e. g. linewidth, crosstalk and losses, are examined also for random variations in the structural parameters. Finally, few examples of high performances mux/demux structures and 2 × 2 routers based on these modified SCISSOR are presented. CRIT based SCISSOR optical devices are particularly promising for ultra-dense wavelength division multiplexing applications
NF-Y co-associates with FOS at promoters, enhancers, repetitive elements, and inactive chromatin regions, and is stereo-positioned with growth-controlling transcription factors.
NF-Y, a trimeric transcription factor (TF) composed of two histone-like subunits (NF-YB and NF-YC) and a sequence-specific subunit (NF-YA), binds to the CCAAT motif, a common promoter element. Genome-wide mapping reveals 5,000-15,000 NF-Y binding sites depending on the cell type, with the NF-YA and NF-YB subunits binding asymmetrically with respect to the CCAAT motif. Despite being characterized as a proximal promoter TF, only 25% of NF-Y sites map to promoters. A comparable number of NF-Y sites are located at enhancers, many of which are tissue specific, and nearly half of the NF-Y sites are in select subclasses of HERV LTR repeats. Unlike most TFs, NF-Y can access its target DNA motif in inactive (non-modified) or polycomb-repressed chromatin domains. Unexpectedly, NF-Y extensively co-localizes with FOS in all genomic contexts, and this often occurs in the absence of JUN and the AP-1 motif. NF-Y also co-associates with a select cluster of growth-controlling and oncogenic TFs, consistent with the abundance of CCAAT motifs in the promoters of genes overexpressed in cancer. Interestingly, NF-Y and several growth-controlling TFs bind in a stereo-specific manner, suggesting a mechanism for cooperative action at promoters and enhancers. Our results indicate that NF-Y is not merely a commonly-used, proximal promoter TF, but rather performs a more diverse set of biological functions, many of which are likely to involve co-association with FOS
ALMA suggests outflows in z ~ 5.5 galaxies
We present the first attempt to detect outflows from galaxies approaching the
Epoch of Reionization (EoR) using a sample of 9 star-forming () galaxies for which the [CII]158m line
has been previously obtained with ALMA. We first fit each line with a Gaussian
function and compute the residuals by subtracting the best fitting model from
the data. We combine the residuals of all sample galaxies and find that the
total signal is characterised by a flux excess of mJy extended over
km~s. Although we cannot exclude that part of this signal is
due to emission from faint satellite galaxies, we show that the most probable
explanation for the detected flux excess is the presence of broad wings in the
[CII] lines, signatures of starburst-driven outflows. We infer an average
outflow rate of , providing a loading
factor in agreement with observed local
starbursts. Our interpretation is consistent with outcomes from zoomed
hydro-simulations of {\it Dahlia}, a galaxy () whose feedback-regulated star formation results into an
outflow rate . The quality of the ALMA
data is not sufficient for a detailed analysis of the [CII] line profile in
individual galaxies. Nevertheless, our results suggest that starburst-driven
outflows are in place in the EoR and provide useful indications for future ALMA
campaigns. Deeper observations of the [CII] line in this sample are required to
better characterise feedback at high- and to understand the role of outflows
in shaping early galaxy formation
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