Outcomes in patients with acute and stable coronary syndromes: insights from the prospective NOBORI-2 study

BACKGROUND: Contemporary data remains limited regarding mortality and major adverse cardiac events (MACE) outcomes in patients undergoing PCI for different manifestations of coronary artery disease. OBJECTIVES: We evaluated mortality and MACE outcomes in patients treated with PCI for STEMI (ST-elevation myocardial infarction), NSTEMI (non ST-elevation myocardial infarction) and stable angina through analysis of data derived from the Nobori-2 study. METHODS: Clinical endpoints were cardiac mortality and MACE (a composite of cardiac death, myocardial infarction and target vessel revascularization). RESULTS: 1909 patients who underwent PCI were studied; 1332 with stable angina, 248 with STEMI and 329 with NSTEMI. Age-adjusted Charlson co-morbidity index was greatest in the NSTEMI cohort (3.78±1.91) and lowest in the stable angina cohort (3.00±1.69); P<0.0001. Following Cox multivariate analysis cardiac mortality was independently worse in the NSTEMI vs the stable angina cohort (HR 2.31 (1.10-4.87), p = 0.028) but not significantly different for STEMI vs stable angina cohort (HR 0.72 (0.16-3.19), p = 0.67). Similar observations were recorded for MACE (<180 days) (NSTEMI vs stable angina: HR 2.34 (1.21-4.55), p = 0.012; STEMI vs stable angina: HR 2.19 (0.97-4.98), p = 0.061. CONCLUSIONS: The longer-term Cardiac mortality and MACE were significantly worse for patients following PCI for NSTEMI even after adjustment of clinical demographics and Charlson co-morbidity index whilst the longer-term prognosis of patients following PCI STEMI was favorable, with similar outcomes as those patients with stable angina following PCI

Effect of WO3 Nanoparticle Loading on the Microstructural, Mechanical and Corrosion Resistance of Zn Matrix/TiO2-WO3 Nanocomposite Coatings for Marine Application

In this study, for marine application purposes, we evaluated the effect of process parameter and particle loading on the microstructure, mechanical reinforcement and corrosion resistance properties of a Zn-TiO2-WO3 nanocomposite produced via electrodeposition. We characterized the morphological properties of the composite coatings with a Scanning Electron Microscope (SEM) equipped with an Energy Dispersive Spectrometer (EDS). We carried out mechanical examination using a Dura Scan hardness tester and a CERT UMT-2 multi-functional tribological tester. We evaluated the corrosion properties by linear polarization in 3.5% NaCl. The results show that the coatings exhibited good stability and the quantitative particle loading greatly enhanced the structural and morphological properties, hardness behavior and corrosion resistance of the coatings. We observed the precipitation of this alloy on steel is greatly influenced by the composite characteristics

Morphogenic variability of some autochthonous plum cultivars in western Serbia

A study conducted over a period of two years in a Western Serbian valley included in situ identification of autochthonous plum cultivars. Observation and recording of their phenological and pomological traits were performed using IBPGR and UPOV methodologies. Fifteen cultivars derived from Prunus domestica L. and two cultivars derived from P. insititia L. were identified. Flowering started between 24 March and 7 April and fruit ripening between 12 July (Petrova&#269;a) and 16 September (Trnova&#269;a). Fruit weight ranged from 6.79± 0.018 to 36.62± 0.251 g and stone weight from 0.14± 0.002 to 1.95± 0.023 g. The cultivars were classified as being extremely small in terms of fruit size. Rounded fruit shape and light-yellow ground colour were dominant. Skin colour ranged from amber to black. Yellow green was a dominant flesh colour and medium flesh firmness predominated. The fruits of the above cultivars could be processed, particularly into plum brandy, or they could be used fresh or dried. The selected plum cultivars can be used both in breeding programmes and as rootstocks as well as in further disease-related systematic studies under field and laboratory conditions

A dopaminergic switch for fear to safety transitions

Overcoming aversive emotional memories requires neural systems that detect when fear responses are no longer appropriate. The midbrain ventral tegmental area (VTA) dopamine system has been implicated in reward and more broadly in signalling when a better than expected outcome has occurred. This suggests that it may be important in guiding fear to safety transitions. We report that when an expected aversive outcome does not occur, activity in midbrain dopamine neurons is necessary to extinguish behavioral fear responses and engage molecular signalling events in extinction learning circuits. Furthermore, a specific dopamine projection to the nucleus accumbens medial shell is partially responsible for this effect. By contrast, a separate dopamine projection to the medial prefrontal cortex opposes extinction learning. This demonstrates a novel function for the canonical VTA-dopamine reward system and reveals opposing behavioural roles for different dopamine neuron projections in fear extinction learning

Phenolic Profile and Antioxidant Activity of Pulp and Peel from Peach and Nectarine Fruits

Peach (Prunus persica L.) is a fruit of high nutritional and economic value. Carbohydrates, dietary fibers, minerals and organic acids are among the major constituents of peach fruit, which contribute to the nutritional quality of both fresh fruits and juice. Polyphenolic compounds found in peach may play an important role in physiological functions related to human health. Different polyphenolics may have varied biological activities including antioxidant activity. In this study antioxidant characteristics between peel and pulp of different peach cultivars (‘RadmilovÄanka’, ‘June Gold’, ‘Blake’, ‘Hale’, ‘Vesna’, ‘Adria’) and one of nectarine (‘Fantasia’) were investigated. The peel and pulp extracts showed a huge amount of total phenolics (TP), total flavonoids (TF), total hydroxycinnamates (TH) and total flavonols (TFL), ranging from 42.7-211.4, 11.1-128.5 mg GAE/100 g fresh weight (f.w.) (TP), 21.9 -94.9, 5.0-58.9 mg CE/100 g f.w. (TF), 28.4-389.2, 8.5-165.8 mg kg-1 f.w. (TH) and 17.3-54 mg kg-1 f.w. (TFL). High contents of phenolic compounds were significantly correlated with high antioxidant capacities. Peach pulp and peel differ significantly in their phenolic profiles: the pulp contains mainly chlorogenic, neochlorogenic and p-coumaric acids, whereas the peel possesses chlorogenic, neochlorogenic and p-coumaric acids together with several flavonol glycosides in huge amounts. Our results indicate that cultivar and extraction solvent play important roles in phenolic compositions and antioxidant properties of peach and nectarine extracts, which was shown using statistical analysis (ANOVA). There are high correlations between extracted phenolic compounds and peach and nectarine cultivars, and used solvent and part of the fruit (peel and pulp)

A NEW RECORDS OF EPEORUS YOUGOSLAVICUS (ŠAMAL, 1935) [EPHEMEROPTERA] IN SERBIA

ABSTRACT During hydrobiological investigations of diversity of rivers and brooks of Serbia an

HPLC ANALYSIS OF EXTRACTS OF FRESH PETALS OF PAPAVER RHOEAS L.

Papaver rhoeas L. (Papaveraceae) is an annual grass native to many regions of the world, which is known to possess several pharmacological properties. It is also known that represent a rich source of anthocyanins. In this study, the content of the anthocyanin was determined in the examined various extracts of fresh petals by HPLC analysis. The most represented anthocyanins in the extracts of Papaver rhoeas L. are delphinidin-3-O-glucoside, cyanidin-3-O-glucoside, cyanidin-3-O-rutinoside, peonidin-3-O-glucoside, petunidin-3-O-glucoside, petunidin-3-acetylglucoside, and delphinidin-3-p-coumaroylglucoside. Acyl derivatives of anthocyanins in the water extract have not been identified. By comparing the contents of individual anthocyanins, the glycosides (polar) are better extracted with 50% alcohol solution, and their acyl derivatives are better extracted with pure alcohol. The water solution is the least suitable for anthocyanin extraction

Thin PDMS Films Using Long Spin Times or Tert-Butyl Alcohol as a Solvent

Thin polydimethylsiloxane (PDMS) films are frequently used in “lab on a chip” devices as flexible membranes. The common solvent used to dilute the PDMS for thin films is hexane, but hexane can swell the underlying PDMS substrate. A better solvent would be one that dissolves uncured PDMS but doesn't swell the underlying substrate. Here, we present protocols and spin curves for two alternatives to hexane dilution: longer spin times and dilution in tert-butyl alcohol. The thickness of the PDMS membranes under different spin speeds, spin times, and PDMS concentrations was measured using an optical profilometer. The use of tert-butyl alcohol to spin thin PDMS films does not swell the underlying PDMS substrate, and we have used these films to construct multilayer PDMS devices

Kalcizacija kiselih zemljišta u centralnoj Srbiji

Acidic soils are preset over 60% of the total arable land in Central Serbia. Yields of the majority of field crops that are achieve on acid soils are low and poor quality. The introduction of control of soil fertility and application of amelioration measures, especially liming, are significantly influenced to improvement of fertility of acid soils and increase yields of cultivated plant species. Also, by neutralizing the acidity of the soil there were positive changes in the degree of weed infestation of crops, changes in the structure of weeds, as well as greater efficiency of protection of cultivated plants from weeds. A substantial portion of acid soils in Central Serbia is not under control of soil fertility and use of fertilizer and without implementation liming as a measure of amelioration. Also, in this area do not exist demonstration experiments in order to monitor changes that cause the application of liming in soils, as well as the promotion of this important amelioration measures.U radu je dat pregled najvažnijih rezultata neutralizacije kiselih zemljišta Centralne Srbije primenom pH melioranata, naročiro upotrebom krečnog đubriva "Njival Ca". Na osnovu dosadašnjih istraživanja utvrđen je veoma pozitivan efekat primene kalcizacije na podizanje nivoa plodnosti svih proučavanih tipova kiselih zemljišta i to preko: povećanja njihove pH vrednosti, sadržaja organske materije, ukupnog azota, lakopristupačnog fosfora i kalijuma, značajnog smanjenja sadržaja mobilnog aluminijuma, gvožđa i mangana, kao i sadržaja pristupačnih formi teških metala. Takođe, neutralizacijom kiselih zemljišta značajno su povećani prinosi gajenih biljnih vrsta (od 30% do nekoliko puta), naročito osetljivih na niske pH vrednosti i sadržaj mobilnog Al. Primenom ove pedomeliorativne mere na kiselim zemljištima utvrđeno je i smanjenje zakorovljenosti i pozitivne promene florističkog sastava korova u usevima pojedinih biljnih vrsta