Surrealism: Art of Subconscious

Surrealism establishes a bridge between the physical realm and the domain of dreams and illusions. In the surreal world, logic is paradoxical; physical principles and rules are defied, only limited by imagination. The expression is a reflection of the personal experience and psychological state of the creator. During my early works in thesis, I concentrated on studying the works of Hieronymus Bosch, Inka Essenhigh, and Julie Heffernan. In First Thesis Painting , I incorporated the creature in Bosch’s vision of limbo from Limbo and the dynamic form from Romantic Painting created by Essenhigh. I set the combined creature in a dark forest to unify the different tones of the two objects and enhance the contrast between the darkness of the background with the brightness of the green form as a light source

Efektivitas Pengendalian Internal Penjualan Kredit Rumah pada Perum Perumnas Cabang Kalimantan Timur

The purpose of this paper is to investigate and analyze the control in the sale of home loans in East Kalimantan branch Perumnas.In accordance with the purposes of this study the main issues pointed out "Is the internal control of credit sales Perumnas East Kalimantan branch has been carried out effectively."Based on the subject matter, the proposed hypothesis is as follows: "Internal control sale of home loans Perumnas East Kalimantan branch has not been effective".The analytical tool used in this study is the authors compare the internal control system of internal control systems theory with PerumnasAfter going through the stages of research, analysis and discussion in the know that the internal control of credit sales at Perumnas East Kalimantan branch has gone well, this in view of the results of research to get the "74%" which means the application of internal control is effective in supporting the granting procedure credit.Thus the hypothesis that the proposed sale of the internal control home loans Perumnas East Kalimantan branch has not been effectively rejected

EFEKTIVITAS PENGENDALIAN INTERNAL PENJUALAN KREDIT RUMAH PADA PERUM PERUMNAS CABANG KALIMANTAN TIMUR

The purpose of this paper is to investigate and analyze the control in the sale of home loans in East Kalimantan branch Perumnas.In accordance with the purposes of this study the main issues pointed out "Is the internal control of credit sales Perumnas East Kalimantan branch has been carried out effectively."Based on the subject matter, the proposed hypothesis is as follows: "Internal control sale of home loans Perumnas East Kalimantan branch has not been effective".The analytical tool used in this study is the authors compare the internal control system of internal control systems theory with PerumnasAfter going through the stages of research, analysis and discussion in the know that the internal control of credit sales at Perumnas East Kalimantan branch has gone well, this in view of the results of research to get the "74%" which means the application of internal control is effective in supporting the granting procedure credit.Thus the hypothesis that the proposed sale of the internal control home loans Perumnas East Kalimantan branch has not been effectively rejected

Responding to AIDS, Tuberculosis, Malaria, and Emerging Infectious Diseases in Burma: Dilemmas of Policy and Practice

Beyrer and colleagues discuss infectious disease threats in Burma and suggest policy options for responding to them

Prolyl isomerization of FAAP20 catalyzed by PIN1 regulates the Fanconi anemia pathway.

The Fanconi Anemia (FA) pathway is a multi-step DNA repair process at stalled replication forks in response to DNA interstrand cross-links (ICLs). Pathological mutation of key FA genes leads to the inherited disorder FA, characterized by progressive bone marrow failure and cancer predisposition. The study of FA is of great importance not only to children suffering from FA but also as a model to study cancer pathogenesis in light of genome instability among the general population. FANCD2 monoubiquitination by the FA core complex is an essential gateway that connects upstream DNA damage signaling to enzymatic steps of repair. FAAP20 is a key component of the FA core complex, and regulated proteolysis of FAAP20 mediated by the ubiquitin E3 ligase SCFFBW7 is critical for maintaining the integrity of the FA complex and FA pathway signaling. However, upstream regulatory mechanisms that govern this signaling remain unclear. Here, we show that PIN1, a phosphorylation-specific prolyl isomerase, regulates the integrity of the FA core complex, thus FA pathway activation. We demonstrate that PIN1 catalyzes cis-trans isomerization of the FAAP20 pSer48-Pro49 motif and promotes FAAP20 stability. Mechanistically, PIN1-induced conformational change of FAAP20 enhances its interaction with the PP2A phosphatase to counteract SCFFBW7-dependent proteolytic signaling at the phosphorylated degron motif. Accordingly, PIN1 deficiency impairs FANCD2 activation and the DNA ICL repair process. Together, our study establishes PIN1-dependent prolyl isomerization as a new regulator of the FA pathway and genomic integrity

Structural mechanism of a drug-binding process involving a large conformational change of the protein target

Atomic-level descriptions of protein–small molecule binding processes that involve a large conformational change of the protein have been elusive. Here, the authors report unguided molecular dynamics simulations of such a process—Abl kinase binding the cancer drug imatinib

IFITM proteins assist cellular uptake of diverse linked chemotypes

The search for cell-permeable drugs has conventionally focused on low-molecular weight (MW), nonpolar, rigid chemical structures. However, emerging therapeutic strategies break traditional drug design rules by employing flexibly linked chemical entities composed of more than one ligand. Using complementary genome-scale chemical-genetic approaches we identified an endogenous chemical uptake pathway involving interferon-induced transmembrane proteins (IFITMs) that modulates the cell permeability of a prototypical biopic inhibitor of MTOR (RapaLink-1, MW: 1784 g/mol). We devised additional linked inhibitors targeting BCR-ABL1 (DasatiLink-1, MW: 1518 g/mol) and EIF4A1 (BisRoc-1, MW: 1466 g/mol), uptake of which was facilitated by IFITMs. We also found that IFITMs moderately assisted some proteolysis-targeting chimeras and examined the physicochemical requirements for involvement of this uptake pathway

Political Economy of Southeast Asian Borderlands: Migration, Environment, and Developing Country Firms

Borderland zones in Southeast Asia have become sites of increased economic investment for developing country firms, intra-regional and transnational corporations. As a result of deregulation, these investment opportunities have led to the exploitation of natural and human resources in an unsustainable and unjust way. This article argues that the flows of people and natural resources across borders are connected intimately and that this has been facilitated politically by the acceptance of the porosity of territorial boundaries by all governments in the region and the imperative to export environmentally degrading development projects into neighbouring countries where political mobilisation on environmental issues is much less effective. Conveyed through a series of cases studies (on resource extraction, dam and reservoir construction, and working conditions in apparel companies), this article explores how developing country companies comply with the codes of conduct on corporate responsibility on human rights, labour standards and environmental sustainability) within the context of the governance of the global supply chain