Candida auris : emergência e epidemiologia de uma levedura altamente patogênica

Candida auris, uma levedura emergente, multirresistente e causadora de surtos por infecções associadas aos cuidados de saúde, foi catalogada como uma nova espécie em 2009, após ser isolada de uma secreção do canal auditivo de um paciente no Japão. A partir da notificação dessa primeira ocorrência, vêm sendo relatados inúmeros casos por todo o mundo, inclusive no Brasil. C. auris acomete principalmente pacientes hospitalizados, internados em unidades de terapia intensiva, expostos a antifúngicos de amplo espectro e que fazem uso de cateteres vasculares. Essa levedura é responsável por infecções invasivas em hospitais e tem preocupando as autoridades e órgãos competentes pela sua rápida disseminação e difícil tratamento, em decorrência da baixa suscetibilidade aos antifúngicos tradicionalmente utilizados na prática clínica. Como contribuinte para a gravidade das infecções associadas à C. auris, o mecanismo de transmissão ainda é desconhecido, o que implica na falta de controle do microrganismo e em altos índices de mortalidade. Desse modo, esta revisão bibliográfica apresenta informações relevantes a fim de alertar sobre a importância de C. auris como agente etiológico de infecções sistêmicas, bem como sua epidemiologia e os reais desafios do tratamento.Candida auris, an emergent yeast, multidrug-resistant and responsible for nosocomial outbreaks was cataloged as a new species in 2009, after being isolated from a patient's ear canal secretion in Japan. Since the notification of this first occurrence, numerous cases have been reported throughout the world, including in Brazil. C. auris affects mainly hospitalized patients, patients in intensive care units, exposed to broad spectrum antifungal and using vascular catheters. Currently, this yeast is one of the main responsible for invasive infections in hospitals and has been worrying competent authorities and organs for their rapid dissemination and difficult treatment due to the low susceptibility to antifungal agents traditionally used in clinical practice. As a contributor to the severity of infections associated with C. auris, the mechanism of transmission is still unknown, which implies a lack of control of the microorganism and high mortality rates. Thus, this literature review presents relevant information in order to alert the importance of C. auris as an etiological agent of systemic infections, as well as its epidemiology and the real challenges of the treatment

Candida auris: emergence and epidemiology of a highly pathogenic yeast

Candida auris is a multidrug-resistant emerging yeast, which was responsible for healthcare-associated infection outbreaks, and was cataloged as a new species in 2009, after being isolated from a patient’s ear canal secretion in Japan. Since the notification of this first occurrence, numerous cases have been reported throughout the world, including Brazil. C. auris affects mainly inpatients, patients in intensive care units, exposed to broad-spectrum antifungal medications and who make use of vascular catheters. Currently, this yeast is one of the main responsible for invasive infections in hospitals and has been cause of concern by authorities and organs due to its rapid dissemination and difficult treatment caused by its low susceptibility to antifungal agents traditionally used in clinical practice. As a contributor to the severity of infections associated with C. auris, the transmission mechanism is still unknown, which implies in a lack of control of the microorganism and high mortality rates. Thus, this literature review presents relevant information in order to alert the importance of C. auris as an etiological agent of systemic infections, as well as its epidemiology and the real challenges of the treatment. Keywords: Candida auris; candidiasis; candidemia; multidrug-resistance; biofilm; epidemiology; diagnosi

Candida auris : emergência e epidemiologia de uma levedura altamente patogênica

Candida auris, uma levedura emergente, multirresistente e causadora de surtos por infecções associadas aos cuidados de saúde, foi catalogada como uma nova espécie em 2009, após ser isolada de uma secreção do canal auditivo de um paciente no Japão. A partir da notificação dessa primeira ocorrência, vêm sendo relatados inúmeros casos por todo o mundo, inclusive no Brasil. C. auris acomete principalmente pacientes hospitalizados, internados em unidades de terapia intensiva, expostos a antifúngicos de amplo espectro e que fazem uso de cateteres vasculares. Essa levedura é responsável por infecções invasivas em hospitais e tem preocupando as autoridades e órgãos competentes pela sua rápida disseminação e difícil tratamento, em decorrência da baixa suscetibilidade aos antifúngicos tradicionalmente utilizados na prática clínica. Como contribuinte para a gravidade das infecções associadas à C. auris, o mecanismo de transmissão ainda é desconhecido, o que implica na falta de controle do microrganismo e em altos índices de mortalidade. Desse modo, esta revisão bibliográfica apresenta informações relevantes a fim de alertar sobre a importância de C. auris como agente etiológico de infecções sistêmicas, bem como sua epidemiologia e os reais desafios do tratamento.Candida auris, an emergent yeast, multidrug-resistant and responsible for nosocomial outbreaks was cataloged as a new species in 2009, after being isolated from a patient's ear canal secretion in Japan. Since the notification of this first occurrence, numerous cases have been reported throughout the world, including in Brazil. C. auris affects mainly hospitalized patients, patients in intensive care units, exposed to broad spectrum antifungal and using vascular catheters. Currently, this yeast is one of the main responsible for invasive infections in hospitals and has been worrying competent authorities and organs for their rapid dissemination and difficult treatment due to the low susceptibility to antifungal agents traditionally used in clinical practice. As a contributor to the severity of infections associated with C. auris, the mechanism of transmission is still unknown, which implies a lack of control of the microorganism and high mortality rates. Thus, this literature review presents relevant information in order to alert the importance of C. auris as an etiological agent of systemic infections, as well as its epidemiology and the real challenges of the treatment

Candida auris : emergence and epidemiology of a highly pathogenic yeast

Candida auris is a multidrug-resistant emerging yeast, which was responsible for healthcare-associated infection outbreaks, and was cataloged as a new species in 2009, after being isolated from a patient’s ear canal secretion in Japan. Since the notification of this first occurrence, numerous cases have been reported throughout the world, including Brazil. C. auris affects mainly inpatients, patients in intensive care units, exposed to broad-spectrum antifungal medications and who make use of vascular catheters. Currently, this yeast is one of the main responsible for invasive infections in hospitals and has been cause of concern by authorities and organs due to its rapid dissemination and difficult treatment caused by its low susceptibility to antifungal agents traditionally used in clinical practice. As a contributor to the severity of infections associated with C. auris, the transmission mechanism is still unknown, which implies in a lack of control of the microorganism and high mortality rates. Thus, this literature review presents relevant information in order to alert the importance of C. auris as an etiological agent of systemic infections, as well as its epidemiology and the real challenges of the treatment

Candida auris : emergence and epidemiology of a highly pathogenic yeast

Candida auris is a multidrug-resistant emerging yeast, which was responsible for healthcare-associated infection outbreaks, and was cataloged as a new species in 2009, after being isolated from a patient’s ear canal secretion in Japan. Since the notification of this first occurrence, numerous cases have been reported throughout the world, including Brazil. C. auris affects mainly inpatients, patients in intensive care units, exposed to broad-spectrum antifungal medications and who make use of vascular catheters. Currently, this yeast is one of the main responsible for invasive infections in hospitals and has been cause of concern by authorities and organs due to its rapid dissemination and difficult treatment caused by its low susceptibility to antifungal agents traditionally used in clinical practice. As a contributor to the severity of infections associated with C. auris, the transmission mechanism is still unknown, which implies in a lack of control of the microorganism and high mortality rates. Thus, this literature review presents relevant information in order to alert the importance of C. auris as an etiological agent of systemic infections, as well as its epidemiology and the real challenges of the treatment